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The map label for this gene is fabF [H]

Identifier: 77456650

GI number: 77456650

Start: 481493

End: 482728

Strand: Reverse

Name: fabF [H]

Synonym: Pfl01_0422

Alternate gene names: 77456650

Gene position: 482728-481493 (Counterclockwise)

Preceding gene: 77456651

Following gene: 77456649

Centisome position: 7.5

GC content: 64.56

Gene sequence:

>1236_bases
ATGAAGCGCGTCGTCGTCACCGGCATGGCCGGCATTACCTCGCTGGGCAGCGACTGGGACACCATCGCCGGCAATTTCGC
CGCCAACCGCAGCGGCATCCGCCGGATGGACGAGTGGGATCGCTTCAGCGAGCTCAACACGCGCCTGGCCGGGCCTATCG
ATGATTTCCAGGTGCCGGCGCACTGGACTCGCAAACAGCTGCGCAGCATGGGCCGTGTCTCGCGGCTGGCTGTCGGCGCG
GCGGAAAAAGCGCTGGCCGATGCCGGCCTGCTCGGCGACGAGTCGATCAAGGACGGGCGCATGGGCGTGGCCTGTGGTTC
GTCCACCGGCAGCACCGACGAAATCAAGGCGTTCGGCAACATGCTGCTCAACTCGGTGGCCGAGGGCCTCAACGCCAACT
CCTACGTGCGCATGATGCCGCACACCACGGCGGCGAACATCAGCATCTTCTTCGGCCTTACCGGCCGCTTGATCCCGACC
TCCAGCGCCTGCACCAGTGGCAGCCAGGGCATCGGTTACGCCTACGAGGCGATCAAGTTCGGACGCCTACCGCTGATGCT
CGCCGGCGGCGCCGAAGAACTGTGCCCGACGGAAGCCATGGTGTTCGACGCGCTGTACGCCACCAGCCTGAAAAACGATG
CACCGCACACCTCGCCACGCCCGTACGACAAGGACCGCGACGGTCTGGTGATCGGTGAAGGCGGCGGCATGCTGGTACTT
GAAGAACTGGAACATGCCCTGGCGCGCGGTGCGCACATTCACGCCGAGATCGTCGGTTTCGGCAGCAACGCCGACGGCCA
GCACACCACCCGCCCCGAACAAATCACCATGCGCCGGGCAATGGAACTGGCGCTGGAAGATGCAGGCCTTGCGCCGGACG
TCATCGGCTACGTCAACGGCCACGGCACCGCCACCGAACAGGGCGATGTCGCTGAAACCCTGGCCACCAGTGCCCTGTTC
GGCGAACGCATGCCGATCAGTTCGCAAAAGAGCTTCCTGGGCCACACCCTCGGCGCCTGCGGGGCGCTGGAGTCGTGGTT
CAGCATCGAGATGCTCAACCGCGACCTGTACGTGCACACGCTCAACCTCGACGAGGTCGACCCGCACTGCGGCAAACTTG
ACTACCTGCGCGGCGAATTCCGCCAGATGAGCCACGACTACGTGATGAACAACAACTTCGCTTTCGGCGGGGTCAACACC
TCGCTGATTTTCCGTCGCTGGCCCCAACCGAATTAA

Upstream 100 bases:

>100_bases
GCACGCCTGAAGAGGTGGCCGGTGCGGTGAATTTCCTGATGTCGGCGGAAGCGTCGTACATCACCCGCCAGGTGCTGGCG
GTCAACGGAGGCTTGTGCTG

Downstream 100 bases:

>100_bases
TCCAGGTCAAGGAGACCTCCATGCACTTCAAGAAACTCGCTGCCACCCTGCTCATCTGCGCCATGCCGGCCGTCAGCCAG
GCCCGTGACACGGCGGTCTA

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 411; Mature: 411

Protein sequence:

>411_residues
MKRVVVTGMAGITSLGSDWDTIAGNFAANRSGIRRMDEWDRFSELNTRLAGPIDDFQVPAHWTRKQLRSMGRVSRLAVGA
AEKALADAGLLGDESIKDGRMGVACGSSTGSTDEIKAFGNMLLNSVAEGLNANSYVRMMPHTTAANISIFFGLTGRLIPT
SSACTSGSQGIGYAYEAIKFGRLPLMLAGGAEELCPTEAMVFDALYATSLKNDAPHTSPRPYDKDRDGLVIGEGGGMLVL
EELEHALARGAHIHAEIVGFGSNADGQHTTRPEQITMRRAMELALEDAGLAPDVIGYVNGHGTATEQGDVAETLATSALF
GERMPISSQKSFLGHTLGACGALESWFSIEMLNRDLYVHTLNLDEVDPHCGKLDYLRGEFRQMSHDYVMNNNFAFGGVNT
SLIFRRWPQPN

Sequences:

>Translated_411_residues
MKRVVVTGMAGITSLGSDWDTIAGNFAANRSGIRRMDEWDRFSELNTRLAGPIDDFQVPAHWTRKQLRSMGRVSRLAVGA
AEKALADAGLLGDESIKDGRMGVACGSSTGSTDEIKAFGNMLLNSVAEGLNANSYVRMMPHTTAANISIFFGLTGRLIPT
SSACTSGSQGIGYAYEAIKFGRLPLMLAGGAEELCPTEAMVFDALYATSLKNDAPHTSPRPYDKDRDGLVIGEGGGMLVL
EELEHALARGAHIHAEIVGFGSNADGQHTTRPEQITMRRAMELALEDAGLAPDVIGYVNGHGTATEQGDVAETLATSALF
GERMPISSQKSFLGHTLGACGALESWFSIEMLNRDLYVHTLNLDEVDPHCGKLDYLRGEFRQMSHDYVMNNNFAFGGVNT
SLIFRRWPQPN
>Mature_411_residues
MKRVVVTGMAGITSLGSDWDTIAGNFAANRSGIRRMDEWDRFSELNTRLAGPIDDFQVPAHWTRKQLRSMGRVSRLAVGA
AEKALADAGLLGDESIKDGRMGVACGSSTGSTDEIKAFGNMLLNSVAEGLNANSYVRMMPHTTAANISIFFGLTGRLIPT
SSACTSGSQGIGYAYEAIKFGRLPLMLAGGAEELCPTEAMVFDALYATSLKNDAPHTSPRPYDKDRDGLVIGEGGGMLVL
EELEHALARGAHIHAEIVGFGSNADGQHTTRPEQITMRRAMELALEDAGLAPDVIGYVNGHGTATEQGDVAETLATSALF
GERMPISSQKSFLGHTLGACGALESWFSIEMLNRDLYVHTLNLDEVDPHCGKLDYLRGEFRQMSHDYVMNNNFAFGGVNT
SLIFRRWPQPN

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=425, Percent_Identity=32, Blast_Score=179, Evalue=6e-45,
Organism=Homo sapiens, GI41872631, Length=427, Percent_Identity=27.4004683840749, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI223972627, Length=165, Percent_Identity=35.7575757575758, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1787337, Length=412, Percent_Identity=40.2912621359223, Blast_Score=243, Evalue=1e-65,
Organism=Escherichia coli, GI1788663, Length=411, Percent_Identity=37.2262773722628, Blast_Score=230, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI71983541, Length=416, Percent_Identity=31.7307692307692, Blast_Score=181, Evalue=8e-46,
Organism=Caenorhabditis elegans, GI71983535, Length=264, Percent_Identity=37.5, Blast_Score=148, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI212642053, Length=365, Percent_Identity=27.3972602739726, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17550940, Length=286, Percent_Identity=26.2237762237762, Blast_Score=76, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6320904, Length=443, Percent_Identity=34.3115124153499, Blast_Score=199, Evalue=5e-52,
Organism=Drosophila melanogaster, GI24644341, Length=422, Percent_Identity=34.8341232227488, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI19920632, Length=370, Percent_Identity=24.8648648648649, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI221330659, Length=370, Percent_Identity=24.8648648648649, Blast_Score=83, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 44354; Mature: 44354

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRVVVTGMAGITSLGSDWDTIAGNFAANRSGIRRMDEWDRFSELNTRLAGPIDDFQVPA
CCEEEEECCHHHHHCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCH
HWTRKQLRSMGRVSRLAVGAAEKALADAGLLGDESIKDGRMGVACGSSTGSTDEIKAFGN
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHH
MLLNSVAEGLNANSYVRMMPHTTAANISIFFGLTGRLIPTSSACTSGSQGIGYAYEAIKF
HHHHHHHHCCCCCCEEEECCCCCCCCEEEEEECCCCEECCCCCCCCCCCCCCHHHHHHHH
GRLPLMLAGGAEELCPTEAMVFDALYATSLKNDAPHTSPRPYDKDRDGLVIGEGGGMLVL
CCCCEEEECCCHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCEEEH
EELEHALARGAHIHAEIVGFGSNADGQHTTRPEQITMRRAMELALEDAGLAPDVIGYVNG
HHHHHHHHCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHEEECC
HGTATEQGDVAETLATSALFGERMPISSQKSFLGHTLGACGALESWFSIEMLNRDLYVHT
CCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEECCEEEEEE
LNLDEVDPHCGKLDYLRGEFRQMSHDYVMNNNFAFGGVNTSLIFRRWPQPN
ECCCCCCCCCCCHHHHHHHHHHCCCCEEECCCEEECCCCCEEEEECCCCCC
>Mature Secondary Structure
MKRVVVTGMAGITSLGSDWDTIAGNFAANRSGIRRMDEWDRFSELNTRLAGPIDDFQVPA
CCEEEEECCHHHHHCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCH
HWTRKQLRSMGRVSRLAVGAAEKALADAGLLGDESIKDGRMGVACGSSTGSTDEIKAFGN
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHH
MLLNSVAEGLNANSYVRMMPHTTAANISIFFGLTGRLIPTSSACTSGSQGIGYAYEAIKF
HHHHHHHHCCCCCCEEEECCCCCCCCEEEEEECCCCEECCCCCCCCCCCCCCHHHHHHHH
GRLPLMLAGGAEELCPTEAMVFDALYATSLKNDAPHTSPRPYDKDRDGLVIGEGGGMLVL
CCCCEEEECCCHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCEEEH
EELEHALARGAHIHAEIVGFGSNADGQHTTRPEQITMRRAMELALEDAGLAPDVIGYVNG
HHHHHHHHCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHEEECC
HGTATEQGDVAETLATSALFGERMPISSQKSFLGHTLGACGALESWFSIEMLNRDLYVHT
CCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEECCEEEEEE
LNLDEVDPHCGKLDYLRGEFRQMSHDYVMNNNFAFGGVNTSLIFRRWPQPN
ECCCCCCCCCCCHHHHHHHHHHCCCCEEECCCEEECCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]