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The map label for this gene is czcS [H]

Identifier: 77456431

GI number: 77456431

Start: 241469

End: 242857

Strand: Direct

Name: czcS [H]

Synonym: Pfl01_0203

Alternate gene names: 77456431

Gene position: 241469-242857 (Clockwise)

Preceding gene: 77456430

Following gene: 77456432

Centisome position: 3.75

GC content: 64.43

Gene sequence:

>1389_bases
ATGCGCGCTAGGTCGATTGCCTGGCGCCTGGCCCTGGCGTTCGCTGCTGTCTGTGCGTTGGTACTCAGTGCGATTGGCGT
GTTCCTGTATCGCTCGCTGGCTGCGGAAATCGCCTGGCGCGACGACATGGCGTTGCTCGGTCGCCTGGAACAGGTGCGCG
CGCTGCTCGCCGACAGCGACAGCCTCGACGCCCTGCAGGCGCGGCCACGGCTGTACCAGAACATGCTCGGCAACCTCGAC
AGTCTGCTGCTGGTGCAACGAGCGGACGGCTCGAACGTGATCACGATCAACCCTCGCCAACGCGCACTGCCGTCCGTGCA
GGCCATCCCCCGGGATCAACCGCCGCAACGCCGCGATGTGCTGACCTGGCAGGCGGCGGACGGTGTCGAGCTGGCCCTGT
TGTCAGGTCAGGCCCAAGGGCCGAACGGCGAAGCACTGACCGTGATCGCCGGCAAGGTCTTGAGCGAGCGCGAGCAGATG
CTCGGCAGCTATCGCCTGCGCTTGTATCTGGCCGTCGGCTTGGGTGCCGTGCTCGCCTTCACGCTGGGTCTGGTGCTGTT
GCGCCGAGGTTTGCGGCCTCTGCGCAAGCTGAGTGAAGCGCTGCGCGGCATCGACCTGCGCAGCCTCGACCAACGCGTTC
CCACCGCCGGCACGCCAGCGGAATTGCTGGAGCCGGTGCATGCGTTGAACGGCATGCTCGGGCGGCTGGACGACGGCTTC
CAGCGCCTCTCACAGTTTTCCGCCGACCTCGCCCACGAAATCCGCACGCCCCTGCATACCTTGCTCGCGAGCAACGGCCA
GGCACTGAATTACCCGCGCAGCAGCGCCGAGTATCAGGAAGTGCTGGCTTCAAACATGGAAGAGTTTGAACGGCTCAAGC
GCATGGCCGAAAACCTGATGTTTCTCGCCCGCGCCGAGCAAGCTGAGCGAGCGCTCGATCTGCGCACGCTGGAACTGCAC
GAAATCGGCGATGAGTTGTGCGACTACTTCGAAGCCCTGGCGGATGACCGGGAAATCCGCCTCGAAAACACGTTCAGCGG
AGAATTGCTGGCGGATCAGCAACTGCTGCAACGCGCCTTGGGCAATCTGCTGGCCAACGCCGTACGCCATGCCGATGCCG
GCTCGGTCATCAGCCTGCGCCGACGCGATGAGCCAGGCCTGTGCTGGCTGCAAGTCCACAACCTCGGCCCGGTGATCGCG
GATGAGCATCTGGGCAAACTGTTCGACCGCTTCTACCGCGTCGACCCGTCCCGCGCGGAGCCAGGAGACTCCGGCGGATT
GGGACTGGCGATCGTGCAGTCGATCATGCGGTTGCATGGTGGGCAGGTGCGGGTCAGCAGTGATGCAACGGGTACGGTTT
TTGAGCTTGGATTTGTAACCAGTCGCTAA

Upstream 100 bases:

>100_bases
GTCGCGGTGCGCCGGCTGCGTTCGAAAGTCGATGATCCGTACATGCCCAAACTGATTCACACCGTGCGCGGGGTCGGCTA
TCAACTCGAAGCGCCCGACG

Downstream 100 bases:

>100_bases
TCGACCCGCACATGCCGTTTCATCTGAGCTAGACTCGCCCTGAATTGGCATCAAATGCGATGCGTAAACGTAGAATTACG
ATTTTTTGCACTGTATATAA

Product: heavy metal sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MRARSIAWRLALAFAAVCALVLSAIGVFLYRSLAAEIAWRDDMALLGRLEQVRALLADSDSLDALQARPRLYQNMLGNLD
SLLLVQRADGSNVITINPRQRALPSVQAIPRDQPPQRRDVLTWQAADGVELALLSGQAQGPNGEALTVIAGKVLSEREQM
LGSYRLRLYLAVGLGAVLAFTLGLVLLRRGLRPLRKLSEALRGIDLRSLDQRVPTAGTPAELLEPVHALNGMLGRLDDGF
QRLSQFSADLAHEIRTPLHTLLASNGQALNYPRSSAEYQEVLASNMEEFERLKRMAENLMFLARAEQAERALDLRTLELH
EIGDELCDYFEALADDREIRLENTFSGELLADQQLLQRALGNLLANAVRHADAGSVISLRRRDEPGLCWLQVHNLGPVIA
DEHLGKLFDRFYRVDPSRAEPGDSGGLGLAIVQSIMRLHGGQVRVSSDATGTVFELGFVTSR

Sequences:

>Translated_462_residues
MRARSIAWRLALAFAAVCALVLSAIGVFLYRSLAAEIAWRDDMALLGRLEQVRALLADSDSLDALQARPRLYQNMLGNLD
SLLLVQRADGSNVITINPRQRALPSVQAIPRDQPPQRRDVLTWQAADGVELALLSGQAQGPNGEALTVIAGKVLSEREQM
LGSYRLRLYLAVGLGAVLAFTLGLVLLRRGLRPLRKLSEALRGIDLRSLDQRVPTAGTPAELLEPVHALNGMLGRLDDGF
QRLSQFSADLAHEIRTPLHTLLASNGQALNYPRSSAEYQEVLASNMEEFERLKRMAENLMFLARAEQAERALDLRTLELH
EIGDELCDYFEALADDREIRLENTFSGELLADQQLLQRALGNLLANAVRHADAGSVISLRRRDEPGLCWLQVHNLGPVIA
DEHLGKLFDRFYRVDPSRAEPGDSGGLGLAIVQSIMRLHGGQVRVSSDATGTVFELGFVTSR
>Mature_462_residues
MRARSIAWRLALAFAAVCALVLSAIGVFLYRSLAAEIAWRDDMALLGRLEQVRALLADSDSLDALQARPRLYQNMLGNLD
SLLLVQRADGSNVITINPRQRALPSVQAIPRDQPPQRRDVLTWQAADGVELALLSGQAQGPNGEALTVIAGKVLSEREQM
LGSYRLRLYLAVGLGAVLAFTLGLVLLRRGLRPLRKLSEALRGIDLRSLDQRVPTAGTPAELLEPVHALNGMLGRLDDGF
QRLSQFSADLAHEIRTPLHTLLASNGQALNYPRSSAEYQEVLASNMEEFERLKRMAENLMFLARAEQAERALDLRTLELH
EIGDELCDYFEALADDREIRLENTFSGELLADQQLLQRALGNLLANAVRHADAGSVISLRRRDEPGLCWLQVHNLGPVIA
DEHLGKLFDRFYRVDPSRAEPGDSGGLGLAIVQSIMRLHGGQVRVSSDATGTVFELGFVTSR

Specific function: Member of the two-component regulatory system CzcS/CzcR involved in the control of cobalt, zinc and cadmium homeostasis. Probably activates CzcR by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788279, Length=460, Percent_Identity=33.0434782608696, Blast_Score=214, Evalue=7e-57,
Organism=Escherichia coli, GI1786783, Length=291, Percent_Identity=40.5498281786942, Blast_Score=211, Evalue=9e-56,
Organism=Escherichia coli, GI1786600, Length=220, Percent_Identity=29.0909090909091, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1789403, Length=301, Percent_Identity=29.5681063122924, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1788393, Length=265, Percent_Identity=25.6603773584906, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1790346, Length=264, Percent_Identity=29.1666666666667, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1787894, Length=304, Percent_Identity=28.6184210526316, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1790551, Length=264, Percent_Identity=29.9242424242424, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1790436, Length=219, Percent_Identity=29.6803652968037, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI48994928, Length=232, Percent_Identity=25.4310344827586, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI1790861, Length=246, Percent_Identity=27.2357723577236, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1786912, Length=208, Percent_Identity=31.25, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI145693157, Length=214, Percent_Identity=26.1682242990654, Blast_Score=62, Evalue=7e-11,
Organism=Escherichia coli, GI87082128, Length=318, Percent_Identity=26.1006289308176, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR006290
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50912; Mature: 50912

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRARSIAWRLALAFAAVCALVLSAIGVFLYRSLAAEIAWRDDMALLGRLEQVRALLADSD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCC
SLDALQARPRLYQNMLGNLDSLLLVQRADGSNVITINPRQRALPSVQAIPRDQPPQRRDV
CHHHHHHHHHHHHHHHCCHHHEEEEEECCCCCEEEECCHHHHCCCHHCCCCCCCCCCCCC
LTWQAADGVELALLSGQAQGPNGEALTVIAGKVLSEREQMLGSYRLRLYLAVGLGAVLAF
EEEECCCCCEEEEEECCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLGLVLLRRGLRPLRKLSEALRGIDLRSLDQRVPTAGTPAELLEPVHALNGMLGRLDDGF
HHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
QRLSQFSADLAHEIRTPLHTLLASNGQALNYPRSSAEYQEVLASNMEEFERLKRMAENLM
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHH
FLARAEQAERALDLRTLELHEIGDELCDYFEALADDREIRLENTFSGELLADQQLLQRAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHH
GNLLANAVRHADAGSVISLRRRDEPGLCWLQVHNLGPVIADEHLGKLFDRFYRVDPSRAE
HHHHHHHHHHCCCCCEEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCC
PGDSGGLGLAIVQSIMRLHGGQVRVSSDATGTVFELGFVTSR
CCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCEEEECCCCCC
>Mature Secondary Structure
MRARSIAWRLALAFAAVCALVLSAIGVFLYRSLAAEIAWRDDMALLGRLEQVRALLADSD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCC
SLDALQARPRLYQNMLGNLDSLLLVQRADGSNVITINPRQRALPSVQAIPRDQPPQRRDV
CHHHHHHHHHHHHHHHCCHHHEEEEEECCCCCEEEECCHHHHCCCHHCCCCCCCCCCCCC
LTWQAADGVELALLSGQAQGPNGEALTVIAGKVLSEREQMLGSYRLRLYLAVGLGAVLAF
EEEECCCCCEEEEEECCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLGLVLLRRGLRPLRKLSEALRGIDLRSLDQRVPTAGTPAELLEPVHALNGMLGRLDDGF
HHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
QRLSQFSADLAHEIRTPLHTLLASNGQALNYPRSSAEYQEVLASNMEEFERLKRMAENLM
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHH
FLARAEQAERALDLRTLELHEIGDELCDYFEALADDREIRLENTFSGELLADQQLLQRAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHH
GNLLANAVRHADAGSVISLRRRDEPGLCWLQVHNLGPVIADEHLGKLFDRFYRVDPSRAE
HHHHHHHHHHCCCCCEEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCC
PGDSGGLGLAIVQSIMRLHGGQVRVSSDATGTVFELGFVTSR
CCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9044283 [H]