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The map label for this gene is czcR [H]

Identifier: 77456430

GI number: 77456430

Start: 240799

End: 241479

Strand: Direct

Name: czcR [H]

Synonym: Pfl01_0202

Alternate gene names: 77456430

Gene position: 240799-241479 (Clockwise)

Preceding gene: 77456427

Following gene: 77456431

Centisome position: 3.74

GC content: 62.41

Gene sequence:

>681_bases
ATGCGTTTGCTGGTCGTAGAAGATGAAGCCAAAACCGCGAACTTCATCGCCAAAGGGCTGGGTGAGTCGGGTTTTGCCGT
GGACGTGGCGCTGAATGGCCTCGACGGTCGCTACTTTATTGAGCAGCAGGAATATGACCTGATCATCCTCGACGTGATGC
TGCCGGGCCTCAACGGCTGGCAATTGCTCCAGCTGATCCGCCAGCGCGGCGCCACGCCGGTGCTGTTCCTGACGGCGAAG
GACGCCATCGAAGACCGCGTGCGCGGCCTCGAACTGGGGGCCGATGACTATTTGCTCAAGCCGTTCGCCTTCGCCGAATT
GCTGGCGCGGGTGCGCACGTTGTTGCGGCGCGGCCCCCTGCGTGAAGCCGAGTCGTACAACATCGCCGATCTCGAAATCG
ACGTACTGCGCCGCCGGGTCAGCCGGGGCGGCCAGCGCATCGCCCTGACCAACAAGGAATTCGCTCTCCTGCATCTGCTC
GCCAGCCGTCAGGGTGAAGTGCTGTCGCGCACGCTGATCGCCTCGCAGGTGTGGAACCTGAATTTCGACAGCGACACCAA
CATGGTCGAAGTCGCGGTGCGCCGGCTGCGTTCGAAAGTCGATGATCCGTACATGCCCAAACTGATTCACACCGTGCGCG
GGGTCGGCTATCAACTCGAAGCGCCCGACGATGCGCGCTAG

Upstream 100 bases:

>100_bases
GCCGGTCCCCGTCGAAACCTCGTCAGTCGGATTACAAGTTTGTAATGGGCAACGTCGCCGAAGGGGCCTAGCCTGTGTCT
CTGATCAATCGAGGTGTGCC

Downstream 100 bases:

>100_bases
GTCGATTGCCTGGCGCCTGGCCCTGGCGTTCGCTGCTGTCTGTGCGTTGGTACTCAGTGCGATTGGCGTGTTCCTGTATC
GCTCGCTGGCTGCGGAAATC

Product: two component heavy metal response transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 226; Mature: 226

Protein sequence:

>226_residues
MRLLVVEDEAKTANFIAKGLGESGFAVDVALNGLDGRYFIEQQEYDLIILDVMLPGLNGWQLLQLIRQRGATPVLFLTAK
DAIEDRVRGLELGADDYLLKPFAFAELLARVRTLLRRGPLREAESYNIADLEIDVLRRRVSRGGQRIALTNKEFALLHLL
ASRQGEVLSRTLIASQVWNLNFDSDTNMVEVAVRRLRSKVDDPYMPKLIHTVRGVGYQLEAPDDAR

Sequences:

>Translated_226_residues
MRLLVVEDEAKTANFIAKGLGESGFAVDVALNGLDGRYFIEQQEYDLIILDVMLPGLNGWQLLQLIRQRGATPVLFLTAK
DAIEDRVRGLELGADDYLLKPFAFAELLARVRTLLRRGPLREAESYNIADLEIDVLRRRVSRGGQRIALTNKEFALLHLL
ASRQGEVLSRTLIASQVWNLNFDSDTNMVEVAVRRLRSKVDDPYMPKLIHTVRGVGYQLEAPDDAR
>Mature_226_residues
MRLLVVEDEAKTANFIAKGLGESGFAVDVALNGLDGRYFIEQQEYDLIILDVMLPGLNGWQLLQLIRQRGATPVLFLTAK
DAIEDRVRGLELGADDYLLKPFAFAELLARVRTLLRRGPLREAESYNIADLEIDVLRRRVSRGGQRIALTNKEFALLHLL
ASRQGEVLSRTLIASQVWNLNFDSDTNMVEVAVRRLRSKVDDPYMPKLIHTVRGVGYQLEAPDDAR

Specific function: Member of the two-component regulatory system CzcS/CzcR involved in the control of cobalt, zinc and cadmium homeostasis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=225, Percent_Identity=60.4444444444444, Blast_Score=276, Evalue=9e-76,
Organism=Escherichia coli, GI87082012, Length=221, Percent_Identity=52.4886877828054, Blast_Score=243, Evalue=7e-66,
Organism=Escherichia coli, GI1789402, Length=220, Percent_Identity=40.4545454545455, Blast_Score=153, Evalue=8e-39,
Organism=Escherichia coli, GI1790552, Length=225, Percent_Identity=37.3333333333333, Blast_Score=142, Evalue=1e-35,
Organism=Escherichia coli, GI1786599, Length=228, Percent_Identity=36.8421052631579, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1789809, Length=234, Percent_Identity=33.3333333333333, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1790860, Length=220, Percent_Identity=39.5454545454545, Blast_Score=120, Evalue=5e-29,
Organism=Escherichia coli, GI1787375, Length=221, Percent_Identity=31.6742081447964, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1788394, Length=223, Percent_Identity=35.4260089686099, Blast_Score=118, Evalue=3e-28,
Organism=Escherichia coli, GI1786911, Length=220, Percent_Identity=34.5454545454545, Blast_Score=117, Evalue=4e-28,
Organism=Escherichia coli, GI1787229, Length=231, Percent_Identity=34.1991341991342, Blast_Score=114, Evalue=4e-27,
Organism=Escherichia coli, GI1790863, Length=229, Percent_Identity=32.3144104803493, Blast_Score=114, Evalue=6e-27,
Organism=Escherichia coli, GI2367329, Length=229, Percent_Identity=37.5545851528384, Blast_Score=113, Evalue=9e-27,
Organism=Escherichia coli, GI145693140, Length=233, Percent_Identity=30.4721030042918, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI145693157, Length=102, Percent_Identity=36.2745098039216, Blast_Score=67, Evalue=9e-13,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=30.8411214953271, Blast_Score=64, Evalue=6e-12,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=35.6435643564356, Blast_Score=63, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322000, Length=126, Percent_Identity=30.952380952381, Blast_Score=65, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25489; Mature: 25489

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLLVVEDEAKTANFIAKGLGESGFAVDVALNGLDGRYFIEQQEYDLIILDVMLPGLNGW
CEEEEEECCCHHHHHHHHHCCCCCCEEEEEEECCCCEEEEECCCCCEEEEEEECCCCCHH
QLLQLIRQRGATPVLFLTAKDAIEDRVRGLELGADDYLLKPFAFAELLARVRTLLRRGPL
HHHHHHHHCCCCEEEEEECHHHHHHHHHCCCCCCCCHHCCHHHHHHHHHHHHHHHHHCCC
REAESYNIADLEIDVLRRRVSRGGQRIALTNKEFALLHLLASRQGEVLSRTLIASQVWNL
CCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHCCCHHHHHHHHHHHHHCC
NFDSDTNMVEVAVRRLRSKVDDPYMPKLIHTVRGVGYQLEAPDDAR
CCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEECCCCCCC
>Mature Secondary Structure
MRLLVVEDEAKTANFIAKGLGESGFAVDVALNGLDGRYFIEQQEYDLIILDVMLPGLNGW
CEEEEEECCCHHHHHHHHHCCCCCCEEEEEEECCCCEEEEECCCCCEEEEEEECCCCCHH
QLLQLIRQRGATPVLFLTAKDAIEDRVRGLELGADDYLLKPFAFAELLARVRTLLRRGPL
HHHHHHHHCCCCEEEEEECHHHHHHHHHCCCCCCCCHHCCHHHHHHHHHHHHHHHHHCCC
REAESYNIADLEIDVLRRRVSRGGQRIALTNKEFALLHLLASRQGEVLSRTLIASQVWNL
CCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHCCCHHHHHHHHHHHHHCC
NFDSDTNMVEVAVRRLRSKVDDPYMPKLIHTVRGVGYQLEAPDDAR
CCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9044283 [H]