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The map label for this gene is mmgC [H]

Identifier: 77456345

GI number: 77456345

Start: 118408

End: 119589

Strand: Direct

Name: mmgC [H]

Synonym: Pfl01_0117

Alternate gene names: 77456345

Gene position: 118408-119589 (Clockwise)

Preceding gene: 77456343

Following gene: 77456346

Centisome position: 1.84

GC content: 59.98

Gene sequence:

>1182_bases
ATGGGCGGCAAAGCTAGCTTCAACTGGATCGATCCCCTGCTGCTGGATCAACAGCTGACTGAAGAAGAACGCATGATCCG
CGACACTGCCGAGCAATTCGCCCAGCAGAGCCTCGCGCCGCGCGTTCTCGAAGCCTTCCGCCATGAGAAGACCGATCCGG
CGATCTTCCGTGAGATGGGTGAGGTCGGCCTGTTGGGCGCGACCATCCCCGAGCAGTACGGTGGCAGCGGCCTCAACTAC
GTCAGCTATGGCCTGATTGCCCGTGAAGTCGAGCGTGTCGACTCTGGCTACCGTTCGATGATGAGCGTGCAGTCTTCGCT
GGTGATGGTGCCGATCAACGAATTCGGTACTGAAGCACAGAAGCAGAAGTACCTGCCGAAGCTGGCGTCCGGCGAGTGGA
TCGGCTGCTTCGGACTGACCGAGCCGAACCACGGTTCCGACCCGGGCGCGATGATTACGCGTGCACGCAAAGTCGACGGC
GGCTACAGCCTGACCGGTGCCAAGATGTGGATCACCAACAGCCCGATCGCCGATGTGTTCGTGGTCTGGGCCAAGGACGA
TGCCGGCGACATCCGTGGTTTCGTACTGGAGAAGGGCTGGAAAGGCCTGAGTGCCCCGGCGATTCACGGCAAGGTCGGCC
TGCGGGCTTCGATCACCGGCGAAATTGTCATGGACAATGTGTTCGTGCCGGAAGAGAACATCTTCCCGGATGTGCGTGGA
CTGAAAGGTCCGTTCACCTGCCTCAACTCCGCACGTTATGGCATCTCCTGGGGGGCGCTGGGTGCTGCCGAGTTCTGCTG
GCACACCGCTCGCCAGTACACCCTGGATCGTCAGCAGTTCGGTCGTCCGTTGGCTGCCACTCAGTTGATCCAGAAGAAGC
TGGCTGACATGCAGACCGAGATCACTTTGGCACTGCAAGGCTGTCTGCGTCTGGGTCGCATGAAGGACGAAGGCACTGCT
GCGGTTGAAATCACATCCATCATGAAGCGCAACTCTTGCGGCAAGTCTCTCGAGATCGCCCGCATGGCGCGTGACATGTT
GGGCGGCAACGGGATCTCTGATGAGTTCGGTGTGGCCCGTCACCTGGTCAACCTGGAAGTGGTGAATACCTATGAAGGTA
CTCACGACGTTCACGCGCTGATCCTCGGTCGTGCGCAGACCGGCCTGCAGGCGTTCTATTAA

Upstream 100 bases:

>100_bases
AAATTAGCACAACAGGATGCGAAAACCTCGTTTGCCGGGATGGCGAAGCGGGCCTAGGATCAATGCCACGTTAATTCACC
CGATTTGCGAGGACTCACTC

Downstream 100 bases:

>100_bases
CAGGAGAGCGACCATGGGCGCGCTGTCGCATCTACGGGTACTGGATTTATCGCGAGTGCTGGCCGGCCCATGGGCTGGTC
AGATTCTGGCTGATCTTGGG

Product: acyl-CoA dehydrogenase-like protein

Products: crotonoyl-CoA; CO2; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MGGKASFNWIDPLLLDQQLTEEERMIRDTAEQFAQQSLAPRVLEAFRHEKTDPAIFREMGEVGLLGATIPEQYGGSGLNY
VSYGLIAREVERVDSGYRSMMSVQSSLVMVPINEFGTEAQKQKYLPKLASGEWIGCFGLTEPNHGSDPGAMITRARKVDG
GYSLTGAKMWITNSPIADVFVVWAKDDAGDIRGFVLEKGWKGLSAPAIHGKVGLRASITGEIVMDNVFVPEENIFPDVRG
LKGPFTCLNSARYGISWGALGAAEFCWHTARQYTLDRQQFGRPLAATQLIQKKLADMQTEITLALQGCLRLGRMKDEGTA
AVEITSIMKRNSCGKSLEIARMARDMLGGNGISDEFGVARHLVNLEVVNTYEGTHDVHALILGRAQTGLQAFY

Sequences:

>Translated_393_residues
MGGKASFNWIDPLLLDQQLTEEERMIRDTAEQFAQQSLAPRVLEAFRHEKTDPAIFREMGEVGLLGATIPEQYGGSGLNY
VSYGLIAREVERVDSGYRSMMSVQSSLVMVPINEFGTEAQKQKYLPKLASGEWIGCFGLTEPNHGSDPGAMITRARKVDG
GYSLTGAKMWITNSPIADVFVVWAKDDAGDIRGFVLEKGWKGLSAPAIHGKVGLRASITGEIVMDNVFVPEENIFPDVRG
LKGPFTCLNSARYGISWGALGAAEFCWHTARQYTLDRQQFGRPLAATQLIQKKLADMQTEITLALQGCLRLGRMKDEGTA
AVEITSIMKRNSCGKSLEIARMARDMLGGNGISDEFGVARHLVNLEVVNTYEGTHDVHALILGRAQTGLQAFY
>Mature_392_residues
GGKASFNWIDPLLLDQQLTEEERMIRDTAEQFAQQSLAPRVLEAFRHEKTDPAIFREMGEVGLLGATIPEQYGGSGLNYV
SYGLIAREVERVDSGYRSMMSVQSSLVMVPINEFGTEAQKQKYLPKLASGEWIGCFGLTEPNHGSDPGAMITRARKVDGG
YSLTGAKMWITNSPIADVFVVWAKDDAGDIRGFVLEKGWKGLSAPAIHGKVGLRASITGEIVMDNVFVPEENIFPDVRGL
KGPFTCLNSARYGISWGALGAAEFCWHTARQYTLDRQQFGRPLAATQLIQKKLADMQTEITLALQGCLRLGRMKDEGTAA
VEITSIMKRNSCGKSLEIARMARDMLGGNGISDEFGVARHLVNLEVVNTYEGTHDVHALILGRAQTGLQAFY

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4503943, Length=391, Percent_Identity=64.9616368286445, Blast_Score=523, Evalue=1e-149,
Organism=Homo sapiens, GI7669494, Length=371, Percent_Identity=63.8814016172507, Blast_Score=487, Evalue=1e-138,
Organism=Homo sapiens, GI226958412, Length=376, Percent_Identity=34.0425531914894, Blast_Score=209, Evalue=5e-54,
Organism=Homo sapiens, GI4557233, Length=371, Percent_Identity=32.3450134770889, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI226958414, Length=344, Percent_Identity=33.4302325581395, Blast_Score=188, Evalue=6e-48,
Organism=Homo sapiens, GI4501859, Length=367, Percent_Identity=30.7901907356948, Blast_Score=181, Evalue=8e-46,
Organism=Homo sapiens, GI4557235, Length=384, Percent_Identity=30.9895833333333, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI76496475, Length=384, Percent_Identity=30.9895833333333, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI4557231, Length=375, Percent_Identity=29.8666666666667, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI187960098, Length=375, Percent_Identity=29.8666666666667, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI21361497, Length=373, Percent_Identity=30.5630026809651, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI7656849, Length=389, Percent_Identity=28.2776349614396, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI4501857, Length=378, Percent_Identity=27.2486772486773, Blast_Score=136, Evalue=3e-32,
Organism=Escherichia coli, GI1786223, Length=373, Percent_Identity=24.9329758713137, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI87081958, Length=383, Percent_Identity=24.0208877284595, Blast_Score=93, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17534353, Length=395, Percent_Identity=63.7974683544304, Blast_Score=511, Evalue=1e-145,
Organism=Caenorhabditis elegans, GI17538396, Length=374, Percent_Identity=34.2245989304813, Blast_Score=194, Evalue=7e-50,
Organism=Caenorhabditis elegans, GI17508101, Length=367, Percent_Identity=33.7874659400545, Blast_Score=191, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI17506239, Length=365, Percent_Identity=32.0547945205479, Blast_Score=188, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI71990804, Length=288, Percent_Identity=35.0694444444444, Blast_Score=165, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI71985184, Length=407, Percent_Identity=30.2211302211302, Blast_Score=158, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI17569725, Length=375, Percent_Identity=29.0666666666667, Blast_Score=150, Evalue=9e-37,
Organism=Caenorhabditis elegans, GI71985192, Length=259, Percent_Identity=34.3629343629344, Blast_Score=144, Evalue=7e-35,
Organism=Caenorhabditis elegans, GI17534899, Length=376, Percent_Identity=28.7234042553192, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI71982178, Length=273, Percent_Identity=31.8681318681319, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=35.0649350649351, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17570075, Length=378, Percent_Identity=27.7777777777778, Blast_Score=138, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI17533517, Length=374, Percent_Identity=25.1336898395722, Blast_Score=117, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI17551932, Length=395, Percent_Identity=25.5696202531646, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17505929, Length=395, Percent_Identity=25.5696202531646, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI19920834, Length=390, Percent_Identity=61.5384615384615, Blast_Score=481, Evalue=1e-136,
Organism=Drosophila melanogaster, GI21356377, Length=370, Percent_Identity=31.3513513513514, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI24666513, Length=365, Percent_Identity=32.0547945205479, Blast_Score=195, Evalue=4e-50,
Organism=Drosophila melanogaster, GI24646207, Length=372, Percent_Identity=32.5268817204301, Blast_Score=192, Evalue=4e-49,
Organism=Drosophila melanogaster, GI21355753, Length=375, Percent_Identity=30.4, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI281363737, Length=356, Percent_Identity=30.0561797752809, Blast_Score=155, Evalue=4e-38,
Organism=Drosophila melanogaster, GI24660351, Length=388, Percent_Identity=28.3505154639175, Blast_Score=154, Evalue=7e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.7

Molecular weight: Translated: 43129; Mature: 42998

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGGKASFNWIDPLLLDQQLTEEERMIRDTAEQFAQQSLAPRVLEAFRHEKTDPAIFREMG
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHC
EVGLLGATIPEQYGGSGLNYVSYGLIAREVERVDSGYRSMMSVQSSLVMVPINEFGTEAQ
CCCEECCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECHHHCCHHH
KQKYLPKLASGEWIGCFGLTEPNHGSDPGAMITRARKVDGGYSLTGAKMWITNSPIADVF
HHHHCCHHCCCCEEEEEECCCCCCCCCCHHHHHHHHCCCCCEEECCCEEEEECCCCCCEE
VVWAKDDAGDIRGFVLEKGWKGLSAPAIHGKVGLRASITGEIVMDNVFVPEENIFPDVRG
EEEECCCCCCHHHHHHHCCCCCCCCCCCCCCCCCEEECCCEEEECCEECCCCCCCCCCCC
LKGPFTCLNSARYGISWGALGAAEFCWHTARQYTLDRQQFGRPLAATQLIQKKLADMQTE
CCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHH
ITLALQGCLRLGRMKDEGTAAVEITSIMKRNSCGKSLEIARMARDMLGGNGISDEFGVAR
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHH
HLVNLEVVNTYEGTHDVHALILGRAQTGLQAFY
HHHEEEEEECCCCCCCEEHHEEHHHHHHHHHCC
>Mature Secondary Structure 
GGKASFNWIDPLLLDQQLTEEERMIRDTAEQFAQQSLAPRVLEAFRHEKTDPAIFREMG
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHC
EVGLLGATIPEQYGGSGLNYVSYGLIAREVERVDSGYRSMMSVQSSLVMVPINEFGTEAQ
CCCEECCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECHHHCCHHH
KQKYLPKLASGEWIGCFGLTEPNHGSDPGAMITRARKVDGGYSLTGAKMWITNSPIADVF
HHHHCCHHCCCCEEEEEECCCCCCCCCCHHHHHHHHCCCCCEEECCCEEEEECCCCCCEE
VVWAKDDAGDIRGFVLEKGWKGLSAPAIHGKVGLRASITGEIVMDNVFVPEENIFPDVRG
EEEECCCCCCHHHHHHHCCCCCCCCCCCCCCCCCEEECCCEEEECCEECCCCCCCCCCCC
LKGPFTCLNSARYGISWGALGAAEFCWHTARQYTLDRQQFGRPLAATQLIQKKLADMQTE
CCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHH
ITLALQGCLRLGRMKDEGTAAVEITSIMKRNSCGKSLEIARMARDMLGGNGISDEFGVAR
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHH
HLVNLEVVNTYEGTHDVHALILGRAQTGLQAFY
HHHEEEEEECCCCCCCEEHHEEHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glutaryl-CoA; acceptor

Specific reaction: glutaryl-CoA + acceptor = crotonoyl-CoA + CO2 + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]