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The map label for this gene is arpA [H]

Identifier: 77454602

GI number: 77454602

Start: 43414

End: 44052

Strand: Direct

Name: arpA [H]

Synonym: pREL1_0035

Alternate gene names: 77454602

Gene position: 43414-44052 (Clockwise)

Preceding gene: 77454601

Following gene: 77454603

Centisome position: 15.99

GC content: 55.24

Gene sequence:

>639_bases
ATGAGTCCAGGTCATTTCGGTTCACCCAGCCCATCCGTCGTCGGGGGCGCGGTCAAAGGAAGGCGACGGCAGAAACGGGC
GGGGATTACTCGCGAGAAAATCGTCGACGCCGCCGCACGTCAGTTCGATGCTTGTGGATTTGCCGCGGCAAGTATCAACA
CCATCATCGAAAATGGGAACCTGACCAAAGGTGCAATATATTTCCATTTCTCTTCCAAAGAGGAACTGGCACAACAGGTT
ATCGAACGATGGTCAGATATGGTGAATGACGAGTACGTGGCTCTCGGAGAGGCTGGTGATAGGTCCCCCTACCGCCAGCT
GGTGCGGTTCTGCAGCGAGATGGCGCACCGTATCGATGCCGATCCCATCCTGCGTGCTGGGTTACTTCTCACTGTCGAAC
CATCCGTTACGGGCGGGAAAACTGCATATATGAAGTGGCACAAGAGCATTGATGAATTGGTTGTCCGCTCCATAGAGTCA
GGCGAGATAAGCGACCGTCCCGCAAGCTACCGACTATCTGATCAGGTGTGCGCGACATTCATTGGCGGGGCTCAACTTCA
TTCGGTTGATGTGGGCTCACCCAATCTGCGAACACGGATAGTCGACGTGTTCGACGGACTTACCGGCGGTCCGGACTAG

Upstream 100 bases:

>100_bases
AGGCAGATTGCAAATGCTTCCGTTGTTTCTGCAGGATGTAGCGAGAAGACACTGCTGAAAGTGAGAGGGAATGCGTGAAA
CCGTCGTCCAATCAGAGCCG

Downstream 100 bases:

>100_bases
CCGAAGCCTCGCCTTCTACGCCGCCCCGCAGAGGCCCTGGATCTTCCCACGGAGCCTGAAAATCTACCGCTCCCGTGTAT
GCACGTGAGCGGACTCGAAT

Product: TetR family transcriptional regulator

Products: NA

Alternate protein names: A-factor-binding protein [H]

Number of amino acids: Translated: 212; Mature: 211

Protein sequence:

>212_residues
MSPGHFGSPSPSVVGGAVKGRRRQKRAGITREKIVDAAARQFDACGFAAASINTIIENGNLTKGAIYFHFSSKEELAQQV
IERWSDMVNDEYVALGEAGDRSPYRQLVRFCSEMAHRIDADPILRAGLLLTVEPSVTGGKTAYMKWHKSIDELVVRSIES
GEISDRPASYRLSDQVCATFIGGAQLHSVDVGSPNLRTRIVDVFDGLTGGPD

Sequences:

>Translated_212_residues
MSPGHFGSPSPSVVGGAVKGRRRQKRAGITREKIVDAAARQFDACGFAAASINTIIENGNLTKGAIYFHFSSKEELAQQV
IERWSDMVNDEYVALGEAGDRSPYRQLVRFCSEMAHRIDADPILRAGLLLTVEPSVTGGKTAYMKWHKSIDELVVRSIES
GEISDRPASYRLSDQVCATFIGGAQLHSVDVGSPNLRTRIVDVFDGLTGGPD
>Mature_211_residues
SPGHFGSPSPSVVGGAVKGRRRQKRAGITREKIVDAAARQFDACGFAAASINTIIENGNLTKGAIYFHFSSKEELAQQVI
ERWSDMVNDEYVALGEAGDRSPYRQLVRFCSEMAHRIDADPILRAGLLLTVEPSVTGGKTAYMKWHKSIDELVVRSIESG
EISDRPASYRLSDQVCATFIGGAQLHSVDVGSPNLRTRIVDVFDGLTGGPD

Specific function: Represses adpA expression by binding to the promoter region in the absence of A-factor, causing repression of streptomycin production and of sporulation [H]

COG id: COG1309

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR001647 [H]

Pfam domain/function: PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 23011; Mature: 22880

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: PS01081 HTH_TETR_1 ; PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPGHFGSPSPSVVGGAVKGRRRQKRAGITREKIVDAAARQFDACGFAAASINTIIENGN
CCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
LTKGAIYFHFSSKEELAQQVIERWSDMVNDEYVALGEAGDRSPYRQLVRFCSEMAHRIDA
CCEEEEEEEECCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCC
DPILRAGLLLTVEPSVTGGKTAYMKWHKSIDELVVRSIESGEISDRPASYRLSDQVCATF
CHHHHCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHH
IGGAQLHSVDVGSPNLRTRIVDVFDGLTGGPD
HCCCEEEEECCCCCCHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SPGHFGSPSPSVVGGAVKGRRRQKRAGITREKIVDAAARQFDACGFAAASINTIIENGN
CCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
LTKGAIYFHFSSKEELAQQVIERWSDMVNDEYVALGEAGDRSPYRQLVRFCSEMAHRIDA
CCEEEEEEEECCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCC
DPILRAGLLLTVEPSVTGGKTAYMKWHKSIDELVVRSIESGEISDRPASYRLSDQVCATF
CHHHHCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHH
IGGAQLHSVDVGSPNLRTRIVDVFDGLTGGPD
HCCCEEEEECCCCCCHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7592371; 9813285; 2502536; 2111804; 9220006; 10540289; 9098075 [H]