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The map label for this gene is degS [H]

Identifier: 76818354

GI number: 76818354

Start: 153824

End: 155683

Strand: Direct

Name: degS [H]

Synonym: BURPS1710b_A0126

Alternate gene names: 76818354

Gene position: 153824-155683 (Clockwise)

Preceding gene: 76818726

Following gene: 76819050

Centisome position: 4.83

GC content: 71.02

Gene sequence:

>1860_bases
ATGACGACGACGCTGCGCCAAGAGCTGCTGACGACCGCGACCGTGCTGCGCGGCGCGCGCGGCATGCTCGGCGAGCGCGC
GTCGCCCGCCTCCGTCGGCTGGACGAACTATCAGGCGCAGCTCGATCTCGACCGCGCGCGCTCGCCGATCCGCTCGCTCG
GCTTTGTCGATGCGAAGACCGTCATCGGCGCCGGCGCGCAGACCGGCGCCGATCCTCAGACGCGCGCGGCGCTGTTGCGC
GCCGCGGATTCCGGCCTGGCGACGCTCGACGCGCACGCGGCGCCCTCCGACGGCGCCTACGCGCCGGACAGCGGCGCGGG
CGCGCTCGCGCTGTACCTGCCCGTCTACGCGGCGAACGGCCCGCTGCCCGCCGCCGAGCGCCGCCGCGCGGACACGGCCG
GCTTCGTCGTGGCGACGCTCGATGCGCGCCGCTTGGTCGAGCTGTCGAGCGCGAACGATCGCGACATCGACCTGCGCCTG
AGCGCGGGCGAGGCGGGCCTGCTCGTCTACACGACCGAGCGCGACTACAGCGGCGCGGACGCGTCGCATCCGCCGCTCGT
GCGCACGGATTCGCTCAACTTCGGCGGCACGCCGCTCACGCTCGCCTATACGACCGAAAACCGCTGGGCGGCGATCCGCT
CGAACGCCGTCGCGACCACGGTGTTCGTCGCCGGCGCGGCGACCTCCGCGCTGCTCGCGGTGCTCGCGTATCTGCTCGTC
GGCGCGCGCGAACGCGCCGCGGACGACAGCCCGCTCAACGAAGCGCGGATGATGGGCATCATCCGCTCGTCGATGGAGGC
GATCATCACGGTCGACGAAACGCAGACGATCGTGATCTTCAACCCGGCCGCCGAGCGCGTGTTCGGCGTGTCCGCGATGG
ACGCGATCGGCTCGCCGCTCGCGCGCTTCATTCCCGAGCGCTTTCGCGCGGCGCACGCGAAGCACGTCGAGCAGTTCGGC
GTGACGGGCGTGTCCGAGCGGCAGATGGGCCGCCAGCGCGTGCTGTTCGGGCTGCGCGAGAACGGCGAGGAGTTTCCGAT
CGAGGCGTCGATCTCGCAGATCCGCGACGGCTCCGGCAAGCTGTACACGGTGATGCTGCGCGACGTCACCGAGCGGGTGC
GCAACGAGAACGCGCTGCGGCAATCGCGCGAGGAACTGCGCGAGCTGTCCGCGAACCTGCAGAACGTGCGCGAGGAAGAG
AAGACGCGGATCGCGCGCGAACTGCACGACGACCTCGGCCAGCAACTGACCGCGCTCAAGATGGACGTGTCGGCGGTCGC
GATCGCGCTCGCCCGCTATCGCGACACGCAGGCCGACGCGCCGCCGATCGCGGCCGTCGAGCAGCAATTGCACGGCATGC
GGCGGCTCATCGATTCGACGGTCGCGTCGGTGCGGCGCATCGCGGCCGACCTGCGGCCCGTGATGCTCGACGATCTCGGC
CTCGTGCCGGCGATCGAATGGCTCGTGAACGATTTCACCAATCGCTACGGGATCGACGTCGAGCGCCGGCTCGACACCGC
CGACACGAGCTTCTCGAACGCCGGCGCGACCACGCTGTTTCGCATCGTCCAGGAGGCGCTGACGAACGTCGCGCGCCACG
CGGACGCGACTCGCGTCGACCTCACGCTCGCGATCGACCAGGACTTCTGCCTGCTGCAGATCAGGGACGACGGACGCGGC
GTGCCATCCGACGAACGCCGCGACGCGAACGGCGACAAGTCGTTCGGCCTCATCGGCATCCGCGAGCGCGCGCACATGCT
GAGCGGCACGGTCACGATCGACTCGGCGCCCGGGCAGGGTTTCTCGATCAAGGTCGCGCTGCCGCTCGCCGCGATCCGGC
AGACGGACGCGCTCCTATGA

Upstream 100 bases:

>100_bases
CGCCGCGCTGGGCGTTGCCGCGTCGTACGGCGTCGCGCGGCTCGTGCTGCAGCAGGAGCGCCATGCCGCGCAGGCGCGTT
TCGAGCGCCGCGCCGCGCAT

Downstream 100 bases:

>100_bases
TCAAGGTCCTGATCGCAGACGATCACGCGCTCGTGCGCGACGGGCTGCGCCACATCCTCGGCGCCGAGACGGGTTTCGAA
GTGGTCGGCGAGGCGTGCGA

Product: sensory box histidine kinase/response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 619; Mature: 618

Protein sequence:

>619_residues
MTTTLRQELLTTATVLRGARGMLGERASPASVGWTNYQAQLDLDRARSPIRSLGFVDAKTVIGAGAQTGADPQTRAALLR
AADSGLATLDAHAAPSDGAYAPDSGAGALALYLPVYAANGPLPAAERRRADTAGFVVATLDARRLVELSSANDRDIDLRL
SAGEAGLLVYTTERDYSGADASHPPLVRTDSLNFGGTPLTLAYTTENRWAAIRSNAVATTVFVAGAATSALLAVLAYLLV
GARERAADDSPLNEARMMGIIRSSMEAIITVDETQTIVIFNPAAERVFGVSAMDAIGSPLARFIPERFRAAHAKHVEQFG
VTGVSERQMGRQRVLFGLRENGEEFPIEASISQIRDGSGKLYTVMLRDVTERVRNENALRQSREELRELSANLQNVREEE
KTRIARELHDDLGQQLTALKMDVSAVAIALARYRDTQADAPPIAAVEQQLHGMRRLIDSTVASVRRIAADLRPVMLDDLG
LVPAIEWLVNDFTNRYGIDVERRLDTADTSFSNAGATTLFRIVQEALTNVARHADATRVDLTLAIDQDFCLLQIRDDGRG
VPSDERRDANGDKSFGLIGIRERAHMLSGTVTIDSAPGQGFSIKVALPLAAIRQTDALL

Sequences:

>Translated_619_residues
MTTTLRQELLTTATVLRGARGMLGERASPASVGWTNYQAQLDLDRARSPIRSLGFVDAKTVIGAGAQTGADPQTRAALLR
AADSGLATLDAHAAPSDGAYAPDSGAGALALYLPVYAANGPLPAAERRRADTAGFVVATLDARRLVELSSANDRDIDLRL
SAGEAGLLVYTTERDYSGADASHPPLVRTDSLNFGGTPLTLAYTTENRWAAIRSNAVATTVFVAGAATSALLAVLAYLLV
GARERAADDSPLNEARMMGIIRSSMEAIITVDETQTIVIFNPAAERVFGVSAMDAIGSPLARFIPERFRAAHAKHVEQFG
VTGVSERQMGRQRVLFGLRENGEEFPIEASISQIRDGSGKLYTVMLRDVTERVRNENALRQSREELRELSANLQNVREEE
KTRIARELHDDLGQQLTALKMDVSAVAIALARYRDTQADAPPIAAVEQQLHGMRRLIDSTVASVRRIAADLRPVMLDDLG
LVPAIEWLVNDFTNRYGIDVERRLDTADTSFSNAGATTLFRIVQEALTNVARHADATRVDLTLAIDQDFCLLQIRDDGRG
VPSDERRDANGDKSFGLIGIRERAHMLSGTVTIDSAPGQGFSIKVALPLAAIRQTDALL
>Mature_618_residues
TTTLRQELLTTATVLRGARGMLGERASPASVGWTNYQAQLDLDRARSPIRSLGFVDAKTVIGAGAQTGADPQTRAALLRA
ADSGLATLDAHAAPSDGAYAPDSGAGALALYLPVYAANGPLPAAERRRADTAGFVVATLDARRLVELSSANDRDIDLRLS
AGEAGLLVYTTERDYSGADASHPPLVRTDSLNFGGTPLTLAYTTENRWAAIRSNAVATTVFVAGAATSALLAVLAYLLVG
ARERAADDSPLNEARMMGIIRSSMEAIITVDETQTIVIFNPAAERVFGVSAMDAIGSPLARFIPERFRAAHAKHVEQFGV
TGVSERQMGRQRVLFGLRENGEEFPIEASISQIRDGSGKLYTVMLRDVTERVRNENALRQSREELRELSANLQNVREEEK
TRIARELHDDLGQQLTALKMDVSAVAIALARYRDTQADAPPIAAVEQQLHGMRRLIDSTVASVRRIAADLRPVMLDDLGL
VPAIEWLVNDFTNRYGIDVERRLDTADTSFSNAGATTLFRIVQEALTNVARHADATRVDLTLAIDQDFCLLQIRDDGRGV
PSDERRDANGDKSFGLIGIRERAHMLSGTVTIDSAPGQGFSIKVALPLAAIRQTDALL

Specific function: Member of the two-component regulatory system degS/degU. Involved in a sensory transduction pathway that affect the production of enzymes that degrade polymeric carbon and nitrogen sources. DegS probably acts as a kinase that phosphorylates degU [H]

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787474, Length=195, Percent_Identity=30.2564102564103, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI87082311, Length=246, Percent_Identity=33.739837398374, Blast_Score=87, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR008595
- InterPro:   IPR011712
- InterPro:   IPR005467
- InterPro:   IPR016381 [H]

Pfam domain/function: PF05384 DegS; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 66793; Mature: 66662

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS50839 CHASE ; PS50112 PAS ; PS50113 PAC ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTTLRQELLTTATVLRGARGMLGERASPASVGWTNYQAQLDLDRARSPIRSLGFVDAKT
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEHHHHHCHHHHCCCCCHHH
VIGAGAQTGADPQTRAALLRAADSGLATLDAHAAPSDGAYAPDSGAGALALYLPVYAANG
HHCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCEEEEEEEHEECCC
PLPAAERRRADTAGFVVATLDARRLVELSSANDRDIDLRLSAGEAGLLVYTTERDYSGAD
CCCHHHHCCCCCCCEEEEEECHHHHHHHCCCCCCCEEEEEECCCCEEEEEEECCCCCCCC
ASHPPLVRTDSLNFGGTPLTLAYTTENRWAAIRSNAVATTVFVAGAATSALLAVLAYLLV
CCCCCEEEECCCCCCCCEEEEEEECCCCEEEHHCCCCEEEEEEHHHHHHHHHHHHHHHHH
GARERAADDSPLNEARMMGIIRSSMEAIITVDETQTIVIFNPAAERVFGVSAMDAIGSPL
CCHHHCCCCCCHHHHHHHHHHHHCCCEEEEECCCCEEEEECCHHHHHHCCHHHHHHCCHH
ARFIPERFRAAHAKHVEQFGVTGVSERQMGRQRVLFGLRENGEEFPIEASISQIRDGSGK
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHCHHHHHHHHHCCCCCCCCHHHHHHHCCCCCC
LYTVMLRDVTERVRNENALRQSREELRELSANLQNVREEEKTRIARELHDDLGQQLTALK
EEEHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MDVSAVAIALARYRDTQADAPPIAAVEQQLHGMRRLIDSTVASVRRIAADLRPVMLDDLG
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCC
LVPAIEWLVNDFTNRYGIDVERRLDTADTSFSNAGATTLFRIVQEALTNVARHADATRVD
HHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEE
LTLAIDQDFCLLQIRDDGRGVPSDERRDANGDKSFGLIGIRERAHMLSGTVTIDSAPGQG
EEEEECCCEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHCCEEEEECCCCCC
FSIKVALPLAAIRQTDALL
EEEEEECCHHHHHHHHCCC
>Mature Secondary Structure 
TTTLRQELLTTATVLRGARGMLGERASPASVGWTNYQAQLDLDRARSPIRSLGFVDAKT
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEHHHHHCHHHHCCCCCHHH
VIGAGAQTGADPQTRAALLRAADSGLATLDAHAAPSDGAYAPDSGAGALALYLPVYAANG
HHCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCEEEEEEEHEECCC
PLPAAERRRADTAGFVVATLDARRLVELSSANDRDIDLRLSAGEAGLLVYTTERDYSGAD
CCCHHHHCCCCCCCEEEEEECHHHHHHHCCCCCCCEEEEEECCCCEEEEEEECCCCCCCC
ASHPPLVRTDSLNFGGTPLTLAYTTENRWAAIRSNAVATTVFVAGAATSALLAVLAYLLV
CCCCCEEEECCCCCCCCEEEEEEECCCCEEEHHCCCCEEEEEEHHHHHHHHHHHHHHHHH
GARERAADDSPLNEARMMGIIRSSMEAIITVDETQTIVIFNPAAERVFGVSAMDAIGSPL
CCHHHCCCCCCHHHHHHHHHHHHCCCEEEEECCCCEEEEECCHHHHHHCCHHHHHHCCHH
ARFIPERFRAAHAKHVEQFGVTGVSERQMGRQRVLFGLRENGEEFPIEASISQIRDGSGK
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHCHHHHHHHHHCCCCCCCCHHHHHHHCCCCCC
LYTVMLRDVTERVRNENALRQSREELRELSANLQNVREEEKTRIARELHDDLGQQLTALK
EEEHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MDVSAVAIALARYRDTQADAPPIAAVEQQLHGMRRLIDSTVASVRRIAADLRPVMLDDLG
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCC
LVPAIEWLVNDFTNRYGIDVERRLDTADTSFSNAGATTLFRIVQEALTNVARHADATRVD
HHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEE
LTLAIDQDFCLLQIRDDGRGVPSDERRDANGDKSFGLIGIRERAHMLSGTVTIDSAPGQG
EEEEECCCEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHCCEEEEECCCCCC
FSIKVALPLAAIRQTDALL
EEEEEECCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3141378; 3141377; 9384377; 3136143 [H]