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The map label for this gene is cobA-2 [H]

Identifier: 76818114

GI number: 76818114

Start: 366907

End: 367929

Strand: Direct

Name: cobA-2 [H]

Synonym: BURPS1710b_A0245

Alternate gene names: 76818114

Gene position: 366907-367929 (Clockwise)

Preceding gene: 76818629

Following gene: 76818547

Centisome position: 11.53

GC content: 73.31

Gene sequence:

>1023_bases
ATGTGCAGCGTCATCGGCAACGGCGCCGGTGCCGCATCGCAAGACAGCTTTCGGGCCGTCCGCCGACGGGCGGCCCCTTT
GGACAACGGTGTCCCGCGCGTTCGGCCGCCTCGTCGGCCGGGTGCGCCGGACGCCGTTCTTTTTTGGCGGGGCGCATTCG
TCGCGAATGCGCCGCACGCACGGCATGGGAACACGAAGATGAACACGATGGGCAAAGTCACACTGCTCGGCGCCGGCCCC
GGCGATCTGGATCTGCTGACGATGAAGGCGGCGAAGGCGCTCGCGGCCGCGGACGTGCTGCTGCTCGACGATCTCGTCGA
TCCGGGCATCGTCGCGCTCGCGCCGCGCGCGCGCGTGATCCGCGTCGGCAAGCGCGGCGGCTGCCGCTCGACGCCTCAGG
CGTTCATCGAGCGGCTGATGTGCCGCTACGCGCTGCGCGGCGCGCACGTCGTGCGCGTGAAGGGCGGCGACGTGCTGCTG
TTCGGCCGCGCGGGCGAGGAACTCGCCGCGTTGCGCGCGGCGCGCGTGCCGGTCGAGATCGTCAACGGCATCTCGTCGGG
CTTCGCGGCCGCGGCGAGCCTCGGCGTGTCGCTCACGCACCGCGATCACTGCCAGGGCGTGACGTTCGTCACCGCGCACC
TGCAGGACCATGGCGAGCCCGACTGGGCAAGCCTCGCCGCGACCGGCACGACGCTCGCGATCTACATGGGAATGAGCCGC
ATCGAGCGGATCGCGGCGGGGCTGCTGTCGACGCTCGACGACAAGACGCCCGCGGCCGTCGTCCAGTGGGCGGGCGCGCC
GGCCGAGCGGCGCTGGACCGGCACGCTCGGGCACCTTGCATCCGGCGCCGCCGAAGCGGGGCTCGGCAGCCCGGCCGTGA
TCTTCGTCGGCCGCGCGATCGGCGAGGCGCTCGCGATCGGCGACGCGCACGCGGCGCCGCATGCGAATGCGCACGCGCTT
GCGGACGACGCGCACGCCGCCTTGCACGCGGCCGAGCGCCGCCGAATCTCGCACGCGGCCTGA

Upstream 100 bases:

>100_bases
ACGCACGACGCGCCGGCACGCCCGCCCGTGACGGCGCCCGCCGGCCGCCGTCGCCCCGCGTCGCCCAGCGCGCGCCGCAC
GCTGGCCCGGATATTGCTCG

Downstream 100 bases:

>100_bases
TCGGCGCGAGCCGGCGCGGCGCACCGCGCCCGCGCGCGTATGGTAGAAACAAAGGCATGGGCGAGCGCCGCCGCGACGCG
CCCGCCTCTTCCGTCTGACA

Product: uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM [H]

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MCSVIGNGAGAASQDSFRAVRRRAAPLDNGVPRVRPPRRPGAPDAVLFWRGAFVANAPHARHGNTKMNTMGKVTLLGAGP
GDLDLLTMKAAKALAAADVLLLDDLVDPGIVALAPRARVIRVGKRGGCRSTPQAFIERLMCRYALRGAHVVRVKGGDVLL
FGRAGEELAALRAARVPVEIVNGISSGFAAAASLGVSLTHRDHCQGVTFVTAHLQDHGEPDWASLAATGTTLAIYMGMSR
IERIAAGLLSTLDDKTPAAVVQWAGAPAERRWTGTLGHLASGAAEAGLGSPAVIFVGRAIGEALAIGDAHAAPHANAHAL
ADDAHAALHAAERRRISHAA

Sequences:

>Translated_340_residues
MCSVIGNGAGAASQDSFRAVRRRAAPLDNGVPRVRPPRRPGAPDAVLFWRGAFVANAPHARHGNTKMNTMGKVTLLGAGP
GDLDLLTMKAAKALAAADVLLLDDLVDPGIVALAPRARVIRVGKRGGCRSTPQAFIERLMCRYALRGAHVVRVKGGDVLL
FGRAGEELAALRAARVPVEIVNGISSGFAAAASLGVSLTHRDHCQGVTFVTAHLQDHGEPDWASLAATGTTLAIYMGMSR
IERIAAGLLSTLDDKTPAAVVQWAGAPAERRWTGTLGHLASGAAEAGLGSPAVIFVGRAIGEALAIGDAHAAPHANAHAL
ADDAHAALHAAERRRISHAA
>Mature_340_residues
MCSVIGNGAGAASQDSFRAVRRRAAPLDNGVPRVRPPRRPGAPDAVLFWRGAFVANAPHARHGNTKMNTMGKVTLLGAGP
GDLDLLTMKAAKALAAADVLLLDDLVDPGIVALAPRARVIRVGKRGGCRSTPQAFIERLMCRYALRGAHVVRVKGGDVLL
FGRAGEELAALRAARVPVEIVNGISSGFAAAASLGVSLTHRDHCQGVTFVTAHLQDHGEPDWASLAATGTTLAIYMGMSR
IERIAAGLLSTLDDKTPAAVVQWAGAPAERRWTGTLGHLASGAAEAGLGSPAVIFVGRAIGEALAIGDAHAAPHANAHAL
ADDAHAALHAAERRRISHAA

Specific function: Catalyzes both methylations at C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin [H]

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=240, Percent_Identity=40.4166666666667, Blast_Score=171, Evalue=9e-44,
Organism=Saccharomyces cerevisiae, GI6322922, Length=236, Percent_Identity=29.6610169491525, Blast_Score=90, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR003043 [H]

Pfam domain/function: PF00590 TP_methylase [H]

EC number: =2.1.1.107 [H]

Molecular weight: Translated: 35173; Mature: 35173

Theoretical pI: Translated: 10.67; Mature: 10.67

Prosite motif: PS00839 SUMT_1 ; PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCSVIGNGAGAASQDSFRAVRRRAAPLDNGVPRVRPPRRPGAPDAVLFWRGAFVANAPHA
CCEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECEEEECCCCC
RHGNTKMNTMGKVTLLGAGPGDLDLLTMKAAKALAAADVLLLDDLVDPGIVALAPRARVI
CCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCEEE
RVGKRGGCRSTPQAFIERLMCRYALRGAHVVRVKGGDVLLFGRAGEELAALRAARVPVEI
EECCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCEEEECCCCHHHHHHHHHCCCHHH
VNGISSGFAAAASLGVSLTHRDHCQGVTFVTAHLQDHGEPDWASLAATGTTLAIYMGMSR
HHHHHHHHHHHHHHCEEEECHHHCCCEEEEEEEHHCCCCCCHHHHHHCCCHHHHHHHHHH
IERIAAGLLSTLDDKTPAAVVQWAGAPAERRWTGTLGHLASGAAEAGLGSPAVIFVGRAI
HHHHHHHHHHHHCCCCCHHHEEECCCCCCCCCCCHHHHHHCCHHHCCCCCCCEEEEEHHH
GEALAIGDAHAAPHANAHALADDAHAALHAAERRRISHAA
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MCSVIGNGAGAASQDSFRAVRRRAAPLDNGVPRVRPPRRPGAPDAVLFWRGAFVANAPHA
CCEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECEEEECCCCC
RHGNTKMNTMGKVTLLGAGPGDLDLLTMKAAKALAAADVLLLDDLVDPGIVALAPRARVI
CCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCEEE
RVGKRGGCRSTPQAFIERLMCRYALRGAHVVRVKGGDVLLFGRAGEELAALRAARVPVEI
EECCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCEEEECCCCHHHHHHHHHCCCHHH
VNGISSGFAAAASLGVSLTHRDHCQGVTFVTAHLQDHGEPDWASLAATGTTLAIYMGMSR
HHHHHHHHHHHHHHCEEEECHHHCCCEEEEEEEHHCCCCCCHHHHHHCCCHHHHHHHHHH
IERIAAGLLSTLDDKTPAAVVQWAGAPAERRWTGTLGHLASGAAEAGLGSPAVIFVGRAI
HHHHHHHHHHHHCCCCCHHHEEECCCCCCCCCCCHHHHHHCCHHHCCCCCCCEEEEEHHH
GEALAIGDAHAAPHANAHALADDAHAALHAAERRRISHAA
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]