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The map label for this gene is mmlH [H]

Identifier: 76817573

GI number: 76817573

Start: 499425

End: 500849

Strand: Direct

Name: mmlH [H]

Synonym: BURPS1710b_A0350

Alternate gene names: 76817573

Gene position: 499425-500849 (Clockwise)

Preceding gene: 76819582

Following gene: 76819553

Centisome position: 15.7

GC content: 72.07

Gene sequence:

>1425_bases
ATGGAGCGGCGTGCGGCGCGCATGGCGAGCAGCGCCCGACAGGAGACGACAGTGTTCACATGGTTCGCCGCCGTATCGCC
GCGCGAACGGCGCACGTTCTGGGCCTGCTTCGGCGGCTGGGCGCTCGATGCGCTCGACATGCAGATGTTCAGCCTCGTGA
TCCCCGCGATCGTCGCCGAATGGTCGCTGTCGCGCACGCAGGCGGGCTTCGTCGGCGGCGCGACGCTCGTCGCGTCGGCG
CTCGGCGGCTGGGTGGCCGGCATGCTGTCCGACCGCTTCGGCCGCGTGCGGGCGCTGCAATGGACGATCGCGTGCTTCTC
GGTCGGCACGTTCGCCTGCGCGTTCGCGACGAGCTACCCGCAATTCGTGACCCTGAAGACGCTGCAGGGCCTCGGCTTCG
GCGGCGAATGGGCGGCGGGCGCCGTGCTGATGGCGGAGACGATCCGCGCCGAGCACCGCGGCAAGGCGATGGGCGCCGTG
CAGAGCGCATGGGCGCTCGGCTGGGGGAGCGCCGTGCTGCTTTATGCGCTCGCGTTCTCGCTGCTGCCCGCCGAGCTCGC
ATGGCGCGTGATGTTCGCCATCGGGCTGCTGCCGGCGCTGCTGATCGTCTATGTGCGGCGCGGGATCGCCGAGCCTTCGG
CGCGCGCCTTGAATCCGTCCGGGCCGTGCGATCCGCCCGAGCCGCCCAATTCGCCGGACGGAGCGCCCCCGTCGGGCGCG
TCGCCGGCGGTGCGGGCGAGCGCCCCGCTCGTCGGCATCTTCTCGCGCGGCACCCGGCGCATGACGCTGATCGGCGCGCT
GCTCGGCGTCGGCGCGCACGGCGGCTATTACGCGCTGATGACGTGGCTGCCGACCTATCTGAAAACCGAGCGGCATCTGT
CGGTGCTCGGCACGGGCGGCTATCTCGCCGTCATCATCGTCGCGTTCTTCTGCGGCTGCCTCGCGAGCGCGCAGTTGCTC
GACCGCATCGGTCGACGCGGCACGATCCTCGCGTTCGCGGCGTGCTGCGTCGGCACGGTGATCCTCTACCTGTTCGCGCC
GCTCGGCAACGCGGCGATGCTCGCGCTCGGCTTTGCGCTCGGCTTTTTCGCGGCGGGCATCCCGGCAAGCATGGGCGCGC
TGTTCAACGAAATGTATCCGCGCGGCACGCGCGGCACGGGCGTCGGCTTTTGCTACAACTTCGGGCGCGTCGCATCGGCG
GGCTTTCCGGTGCTGGTCGGGCACATGTCGGCCGGCATGCCGCTCGGCACCGCGATCGGCATCGGCGCGGCGGTCGCCTA
TTCGATCGTCGTCGTCGCCGTGCTGATGCTGCCCGAGACGCGCGGGCGCACGCTCGACGATTGCGCGAGCGCGGATGCCG
ACGCCGCCCGCGCGGGCGCCGGGCGCATCGGTGCGCCGGCAGCGCCGGGCGCGCGGCATCGCTGA

Upstream 100 bases:

>100_bases
GCCCCGCGAGCGAATTCATCTATCAGGCGGAAATCCGCTAGCGGCCGGCTCGCGCGACAGCGGAGCTCGCGCACGGGCCG
CGCGCTCGCGCGAGCAACGC

Downstream 100 bases:

>100_bases
AGTTCGCGCCGGATTCAGGTCGGCGGTTCGTGGCATGAGGAGCATCGAGCATTGAGCGAGCAAGAATGGAACGCGTTCGC
GCCCGCGGCGGCGGCGCCGC

Product: major facilitator family transporter

Products: Proton [Cytoplasm]; N-acetylneuraminate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 474; Mature: 474

Protein sequence:

>474_residues
MERRAARMASSARQETTVFTWFAAVSPRERRTFWACFGGWALDALDMQMFSLVIPAIVAEWSLSRTQAGFVGGATLVASA
LGGWVAGMLSDRFGRVRALQWTIACFSVGTFACAFATSYPQFVTLKTLQGLGFGGEWAAGAVLMAETIRAEHRGKAMGAV
QSAWALGWGSAVLLYALAFSLLPAELAWRVMFAIGLLPALLIVYVRRGIAEPSARALNPSGPCDPPEPPNSPDGAPPSGA
SPAVRASAPLVGIFSRGTRRMTLIGALLGVGAHGGYYALMTWLPTYLKTERHLSVLGTGGYLAVIIVAFFCGCLASAQLL
DRIGRRGTILAFAACCVGTVILYLFAPLGNAAMLALGFALGFFAAGIPASMGALFNEMYPRGTRGTGVGFCYNFGRVASA
GFPVLVGHMSAGMPLGTAIGIGAAVAYSIVVVAVLMLPETRGRTLDDCASADADAARAGAGRIGAPAAPGARHR

Sequences:

>Translated_474_residues
MERRAARMASSARQETTVFTWFAAVSPRERRTFWACFGGWALDALDMQMFSLVIPAIVAEWSLSRTQAGFVGGATLVASA
LGGWVAGMLSDRFGRVRALQWTIACFSVGTFACAFATSYPQFVTLKTLQGLGFGGEWAAGAVLMAETIRAEHRGKAMGAV
QSAWALGWGSAVLLYALAFSLLPAELAWRVMFAIGLLPALLIVYVRRGIAEPSARALNPSGPCDPPEPPNSPDGAPPSGA
SPAVRASAPLVGIFSRGTRRMTLIGALLGVGAHGGYYALMTWLPTYLKTERHLSVLGTGGYLAVIIVAFFCGCLASAQLL
DRIGRRGTILAFAACCVGTVILYLFAPLGNAAMLALGFALGFFAAGIPASMGALFNEMYPRGTRGTGVGFCYNFGRVASA
GFPVLVGHMSAGMPLGTAIGIGAAVAYSIVVVAVLMLPETRGRTLDDCASADADAARAGAGRIGAPAAPGARHR
>Mature_474_residues
MERRAARMASSARQETTVFTWFAAVSPRERRTFWACFGGWALDALDMQMFSLVIPAIVAEWSLSRTQAGFVGGATLVASA
LGGWVAGMLSDRFGRVRALQWTIACFSVGTFACAFATSYPQFVTLKTLQGLGFGGEWAAGAVLMAETIRAEHRGKAMGAV
QSAWALGWGSAVLLYALAFSLLPAELAWRVMFAIGLLPALLIVYVRRGIAEPSARALNPSGPCDPPEPPNSPDGAPPSGA
SPAVRASAPLVGIFSRGTRRMTLIGALLGVGAHGGYYALMTWLPTYLKTERHLSVLGTGGYLAVIIVAFFCGCLASAQLL
DRIGRRGTILAFAACCVGTVILYLFAPLGNAAMLALGFALGFFAAGIPASMGALFNEMYPRGTRGTGVGFCYNFGRVASA
GFPVLVGHMSAGMPLGTAIGIGAAVAYSIVVVAVLMLPETRGRTLDDCASADADAARAGAGRIGAPAAPGARHR

Specific function: Probable uptake of 4-methylmuconolactone [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI24308167, Length=469, Percent_Identity=25.5863539445629, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI213021148, Length=442, Percent_Identity=22.1719457013575, Blast_Score=65, Evalue=1e-10,
Organism=Escherichia coli, GI87082231, Length=484, Percent_Identity=25.4132231404959, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI87082404, Length=425, Percent_Identity=24.2352941176471, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI87081723, Length=420, Percent_Identity=27.8571428571429, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1786229, Length=444, Percent_Identity=22.972972972973, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1790550, Length=414, Percent_Identity=24.8792270531401, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI87082159, Length=366, Percent_Identity=25.4098360655738, Blast_Score=76, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI32564663, Length=439, Percent_Identity=23.6902050113895, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 49373; Mature: 49373

Theoretical pI: Translated: 9.74; Mature: 9.74

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1 ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERRAARMASSARQETTVFTWFAAVSPRERRTFWACFGGWALDALDMQMFSLVIPAIVAE
CCHHHHHHHHHHHHHHEEEEEEECCCCHHHCEEEEECCCHHHHHHHHHHHHHHHHHHHHH
WSLSRTQAGFVGGATLVASALGGWVAGMLSDRFGRVRALQWTIACFSVGTFACAFATSYP
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCC
QFVTLKTLQGLGFGGEWAAGAVLMAETIRAEHRGKAMGAVQSAWALGWGSAVLLYALAFS
CEEEHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LLPAELAWRVMFAIGLLPALLIVYVRRGIAEPSARALNPSGPCDPPEPPNSPDGAPPSGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
SPAVRASAPLVGIFSRGTRRMTLIGALLGVGAHGGYYALMTWLPTYLKTERHLSVLGTGG
CCCCCCCCCEEEHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEECCH
YLAVIIVAFFCGCLASAQLLDRIGRRGTILAFAACCVGTVILYLFAPLGNAAMLALGFAL
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
GFFAAGIPASMGALFNEMYPRGTRGTGVGFCYNFGRVASAGFPVLVGHMSAGMPLGTAIG
HHHHHCCHHHHHHHHHHHCCCCCCCCCCHHHHCCHHHHCCCCCEEEHHHHCCCCCHHHHH
IGAAVAYSIVVVAVLMLPETRGRTLDDCASADADAARAGAGRIGAPAAPGARHR
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MERRAARMASSARQETTVFTWFAAVSPRERRTFWACFGGWALDALDMQMFSLVIPAIVAE
CCHHHHHHHHHHHHHHEEEEEEECCCCHHHCEEEEECCCHHHHHHHHHHHHHHHHHHHHH
WSLSRTQAGFVGGATLVASALGGWVAGMLSDRFGRVRALQWTIACFSVGTFACAFATSYP
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCC
QFVTLKTLQGLGFGGEWAAGAVLMAETIRAEHRGKAMGAVQSAWALGWGSAVLLYALAFS
CEEEHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LLPAELAWRVMFAIGLLPALLIVYVRRGIAEPSARALNPSGPCDPPEPPNSPDGAPPSGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
SPAVRASAPLVGIFSRGTRRMTLIGALLGVGAHGGYYALMTWLPTYLKTERHLSVLGTGG
CCCCCCCCCEEEHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEECCH
YLAVIIVAFFCGCLASAQLLDRIGRRGTILAFAACCVGTVILYLFAPLGNAAMLALGFAL
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
GFFAAGIPASMGALFNEMYPRGTRGTGVGFCYNFGRVASAGFPVLVGHMSAGMPLGTAIG
HHHHHCCHHHHHHHHHHHCCCCCCCCCCHHHHCCHHHHCCCCCEEEHHHHCCCCCHHHHH
IGAAVAYSIVVVAVLMLPETRGRTLDDCASADADAARAGAGRIGAPAAPGARHR
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; N-acetylneuraminate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + N-acetylneuraminate [Periplasm] = Proton [Cytoplasm] + N-acetylneuraminate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9461415 [H]