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The map label for this gene is msrA1 [H]

Identifier: 75909986

GI number: 75909986

Start: 4712719

End: 4713216

Strand: Direct

Name: msrA1 [H]

Synonym: Ava_3782

Alternate gene names: 75909986

Gene position: 4712719-4713216 (Clockwise)

Preceding gene: 75909983

Following gene: 75909987

Centisome position: 74.03

GC content: 44.58

Gene sequence:

>498_bases
ATGAAGATGGAGTTAAAAAGTGGGAGTACAGAAACACCTATGGAGAAAGCAACATTTGGGGCTGGCTGTTTTTGGGGCGT
GGAGGCGGCATTTCGCCAGGTAAAAGGAGTAGTATCAACCTCAGTCGGCTATATGGGAGGGCATTTCCCTAACCCTTGCT
ACCTTGATGTATTGTCGAGGATAACTGGTCATGCTGAGGTGGTGCAAATAGAATATGACCCTCAACTTGTTAGTTATGAA
GATTTGTTAGCAGTTTTTTGGGATATTCATGACCCGACAACCCTAAACCGCCAGGGGCCAGATAAAGGAGAACAGTACAG
GTCTGTGATCTTTTTTCACAATGAGCAGCAAGCAGAAGCAGCACGGCAGTCAAAAGCCAAGCTTCAGGTATCGGGCAGAT
TTGAACGTGATATTGTGACCGAGATTAAGCACAAGAGTGAATATTACTTAGCAACAGAAGAACATCAACAGTATTTTGAG
AAGCAGGCAAAACGCTAA

Upstream 100 bases:

>100_bases
AAATTAAGAATCAAGAGAGGACAAGCGTTTGGGGTTGTACATCTGTCACATTCTTTTTTCAAATTGGTATCACCTTTATG
AATTATCTATTTGTGCATAG

Downstream 100 bases:

>100_bases
TTGAAAAAGGCAGTCCTGATGAAGCAAGTTTCACAGTCAAATAAGGTGATACGCACCTAAATCAAATATTCTTGCGTCAG
GGCTGTCCATAGTCAAGAGT

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase 1; Peptide-methionine (S)-S-oxide reductase 1; Peptide Met(O) reductase 1 [H]

Number of amino acids: Translated: 165; Mature: 165

Protein sequence:

>165_residues
MKMELKSGSTETPMEKATFGAGCFWGVEAAFRQVKGVVSTSVGYMGGHFPNPCYLDVLSRITGHAEVVQIEYDPQLVSYE
DLLAVFWDIHDPTTLNRQGPDKGEQYRSVIFFHNEQQAEAARQSKAKLQVSGRFERDIVTEIKHKSEYYLATEEHQQYFE
KQAKR

Sequences:

>Translated_165_residues
MKMELKSGSTETPMEKATFGAGCFWGVEAAFRQVKGVVSTSVGYMGGHFPNPCYLDVLSRITGHAEVVQIEYDPQLVSYE
DLLAVFWDIHDPTTLNRQGPDKGEQYRSVIFFHNEQQAEAARQSKAKLQVSGRFERDIVTEIKHKSEYYLATEEHQQYFE
KQAKR
>Mature_165_residues
MKMELKSGSTETPMEKATFGAGCFWGVEAAFRQVKGVVSTSVGYMGGHFPNPCYLDVLSRITGHAEVVQIEYDPQLVSYE
DLLAVFWDIHDPTTLNRQGPDKGEQYRSVIFFHNEQQAEAARQSKAKLQVSGRFERDIVTEIKHKSEYYLATEEHQQYFE
KQAKR

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=150, Percent_Identity=48, Blast_Score=137, Evalue=5e-33,
Organism=Homo sapiens, GI208609995, Length=148, Percent_Identity=48.6486486486487, Blast_Score=137, Evalue=6e-33,
Organism=Homo sapiens, GI208609993, Length=116, Percent_Identity=43.9655172413793, Blast_Score=90, Evalue=1e-18,
Organism=Escherichia coli, GI1790665, Length=152, Percent_Identity=50, Blast_Score=152, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17533973, Length=151, Percent_Identity=37.0860927152318, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6320881, Length=153, Percent_Identity=37.2549019607843, Blast_Score=97, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24664627, Length=145, Percent_Identity=39.3103448275862, Blast_Score=104, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24664631, Length=146, Percent_Identity=39.7260273972603, Blast_Score=100, Evalue=5e-22,
Organism=Drosophila melanogaster, GI45553131, Length=140, Percent_Identity=37.8571428571429, Blast_Score=96, Evalue=9e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 18872; Mature: 18872

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMELKSGSTETPMEKATFGAGCFWGVEAAFRQVKGVVSTSVGYMGGHFPNPCYLDVLSR
CCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
ITGHAEVVQIEYDPQLVSYEDLLAVFWDIHDPTTLNRQGPDKGEQYRSVIFFHNEQQAEA
HCCCEEEEEEECCCCEECHHHHHHHHHCCCCCCCCCCCCCCCCHHHEEEEEEECCHHHHH
ARQSKAKLQVSGRFERDIVTEIKHKSEYYLATEEHQQYFEKQAKR
HHHHHHEEEECCCCHHHHHHHHHCCCCEEEECHHHHHHHHHHHCC
>Mature Secondary Structure
MKMELKSGSTETPMEKATFGAGCFWGVEAAFRQVKGVVSTSVGYMGGHFPNPCYLDVLSR
CCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
ITGHAEVVQIEYDPQLVSYEDLLAVFWDIHDPTTLNRQGPDKGEQYRSVIFFHNEQQAEA
HCCCEEEEEEECCCCEECHHHHHHHHHCCCCCCCCCCCCCCCCHHHEEEEEEECCHHHHH
ARQSKAKLQVSGRFERDIVTEIKHKSEYYLATEEHQQYFEKQAKR
HHHHHHEEEECCCCHHHHHHHHHCCCCEEEECHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]