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The map label for this gene is lpdA [H]

Identifier: 75909666

GI number: 75909666

Start: 4290114

End: 4291490

Strand: Direct

Name: lpdA [H]

Synonym: Ava_3460

Alternate gene names: 75909666

Gene position: 4290114-4291490 (Clockwise)

Preceding gene: 75909665

Following gene: 75909668

Centisome position: 67.39

GC content: 50.4

Gene sequence:

>1377_bases
ATGGAAACAGCAGATGTCATTGTCATCGGCAGTGGTCAAGGAGGCATTCCACTGGCGGCTGATTTTGCCAATGAGGGACG
TAAGGTTGTTTTGTTTGAGCGCGATGCTTTAGGCGGCAGTTGCATCAACTATGGCTGCACTCCCTCTAAAGCATTCTTAG
CAGCAGCTCATACAGCAGGTCGAGCAAACCAGGGCAAGAAGTTAGGCATCCACACGGAGGTAGAAGTGGATTTTCCCGCC
GTCATGGAACGAGTTCGGGAAATCCGCAGCAGCTTTAATCAGGGGATTCGCCAGCGATTGGAGAGTGCGGGTGTCAAAGT
CATTTGTGCCGAAGCTTCTTTTGTGGGTGAACGGACGGTCAAAGGTGGGGATGTTACTCTTCAGGCTCCTCTGGTAATCA
TTAACACGGGCACATCATCGCTGATTCCTGACATTCCTGGACTTGCAGGAACTCCCTACCTGACCAACCGTAACTTCTTT
GACTTGAACACCTTACCAGCCCGTTTATTGGTGATTGGAGGCGGCTATATTGGCTTGGAATTGGGGCAAGGACTAGCGCG
TTTGGGCAGTCAGACCCACTTAATTGTCCGGGGCGATCGCGTTCTTGGACAGGAAGAGGCTGATGTTAGTGAGGTGTTAG
CAGAAGCATTAAAGCAGGATGGAATTGGACTTCACTTTGGAGTCAATGTGAATCACGTCGCCCACGAGAATAATGTGTTT
AAGCTGACCCTGAGCAGTGGCGAACAACTCCAGGGAGAAGCGTTGCTGGTTGTGATTGGACGGAAACCCAATACAGGTGC
ATTAAATGCAGCGAACAGTGGAATTGAGCTAGATGATAAGGGGTTTGTCAAAATTGATGACCAGTTCCATACCACCTGTT
CTGGAGTCTATGCGATCGGGGATGCTGCCAAACAACCTGCCTTTACCCATGTGTCGTGGGAGGACTATCGCCGCTTAAAA
GCAATTTTGTGTGGAGAAAACCGGACACGGAGCGATCGCGTCCTTGGGTATGCGGTTTACACAGAACCCCAGGTTGGGCG
AGTGGGTATGACCTTAGAACAGGCTCAAAAACAAGGCATCAACGCATGTGCTGTGACGTTACCCATGAGCCAAATTGCGC
GTGCGATCGAGTGGGGGCATGACCTCGGATTTTATCGTATGGTAATCGACAGCGACACAGACAAAATCCTGGGAGCAACC
CTAGTGGGGTACGAAACTGCTGAACTGGTGCATGTATTTTTATCCCTGATAGAAGCAGGAGCAACCTGGCAGTTATTAGA
GCGATCAGTTCACATCCATCCCACCTATGGGGAAGCTTTACCCAGTCTGGCACGGTTGCTGCTTGGAGATAATATGCCAG
GGTGTCCGAATATGTGA

Upstream 100 bases:

>100_bases
GTCATAACTCAATCCAAACCCTACCTCAATGGCAGAGAATTTTTGACTTTGAGTGTGAGAGTTTTATGAAAGCAAACTAT
CCCCAAGGAGTTTAGCACTG

Downstream 100 bases:

>100_bases
GGAGGTTTTATTGATGCACAACGTCAGTTGGCATTGATAAGTAGGGTCTGCTCCCTGACTGTCTAATTGGTGTTGTTTAC
AGGTAAGCTGAAAAAACATC

Product: FAD-dependent pyridine nucleotide-disulfide oxidoreductase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase [H]

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
METADVIVIGSGQGGIPLAADFANEGRKVVLFERDALGGSCINYGCTPSKAFLAAAHTAGRANQGKKLGIHTEVEVDFPA
VMERVREIRSSFNQGIRQRLESAGVKVICAEASFVGERTVKGGDVTLQAPLVIINTGTSSLIPDIPGLAGTPYLTNRNFF
DLNTLPARLLVIGGGYIGLELGQGLARLGSQTHLIVRGDRVLGQEEADVSEVLAEALKQDGIGLHFGVNVNHVAHENNVF
KLTLSSGEQLQGEALLVVIGRKPNTGALNAANSGIELDDKGFVKIDDQFHTTCSGVYAIGDAAKQPAFTHVSWEDYRRLK
AILCGENRTRSDRVLGYAVYTEPQVGRVGMTLEQAQKQGINACAVTLPMSQIARAIEWGHDLGFYRMVIDSDTDKILGAT
LVGYETAELVHVFLSLIEAGATWQLLERSVHIHPTYGEALPSLARLLLGDNMPGCPNM

Sequences:

>Translated_458_residues
METADVIVIGSGQGGIPLAADFANEGRKVVLFERDALGGSCINYGCTPSKAFLAAAHTAGRANQGKKLGIHTEVEVDFPA
VMERVREIRSSFNQGIRQRLESAGVKVICAEASFVGERTVKGGDVTLQAPLVIINTGTSSLIPDIPGLAGTPYLTNRNFF
DLNTLPARLLVIGGGYIGLELGQGLARLGSQTHLIVRGDRVLGQEEADVSEVLAEALKQDGIGLHFGVNVNHVAHENNVF
KLTLSSGEQLQGEALLVVIGRKPNTGALNAANSGIELDDKGFVKIDDQFHTTCSGVYAIGDAAKQPAFTHVSWEDYRRLK
AILCGENRTRSDRVLGYAVYTEPQVGRVGMTLEQAQKQGINACAVTLPMSQIARAIEWGHDLGFYRMVIDSDTDKILGAT
LVGYETAELVHVFLSLIEAGATWQLLERSVHIHPTYGEALPSLARLLLGDNMPGCPNM
>Mature_458_residues
METADVIVIGSGQGGIPLAADFANEGRKVVLFERDALGGSCINYGCTPSKAFLAAAHTAGRANQGKKLGIHTEVEVDFPA
VMERVREIRSSFNQGIRQRLESAGVKVICAEASFVGERTVKGGDVTLQAPLVIINTGTSSLIPDIPGLAGTPYLTNRNFF
DLNTLPARLLVIGGGYIGLELGQGLARLGSQTHLIVRGDRVLGQEEADVSEVLAEALKQDGIGLHFGVNVNHVAHENNVF
KLTLSSGEQLQGEALLVVIGRKPNTGALNAANSGIELDDKGFVKIDDQFHTTCSGVYAIGDAAKQPAFTHVSWEDYRRLK
AILCGENRTRSDRVLGYAVYTEPQVGRVGMTLEQAQKQGINACAVTLPMSQIARAIEWGHDLGFYRMVIDSDTDKILGAT
LVGYETAELVHVFLSLIEAGATWQLLERSVHIHPTYGEALPSLARLLLGDNMPGCPNM

Specific function: Unknown

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=461, Percent_Identity=29.0672451193059, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI50301238, Length=463, Percent_Identity=28.2937365010799, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI22035672, Length=469, Percent_Identity=27.5053304904051, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI291045266, Length=438, Percent_Identity=23.972602739726, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI33519430, Length=458, Percent_Identity=24.0174672489083, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI33519428, Length=458, Percent_Identity=24.0174672489083, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI33519426, Length=458, Percent_Identity=24.0174672489083, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI148277065, Length=458, Percent_Identity=24.0174672489083, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI148277071, Length=458, Percent_Identity=24.0174672489083, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI291045268, Length=428, Percent_Identity=23.1308411214953, Blast_Score=94, Evalue=3e-19,
Organism=Escherichia coli, GI87081717, Length=457, Percent_Identity=29.5404814004376, Blast_Score=217, Evalue=1e-57,
Organism=Escherichia coli, GI1786307, Length=467, Percent_Identity=28.9079229122056, Blast_Score=189, Evalue=2e-49,
Organism=Escherichia coli, GI1789915, Length=428, Percent_Identity=28.2710280373832, Blast_Score=154, Evalue=8e-39,
Organism=Escherichia coli, GI87082354, Length=449, Percent_Identity=25.3897550111359, Blast_Score=137, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI32565766, Length=461, Percent_Identity=29.5010845986985, Blast_Score=175, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI71983419, Length=435, Percent_Identity=27.5862068965517, Blast_Score=138, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI71983429, Length=435, Percent_Identity=27.5862068965517, Blast_Score=137, Evalue=8e-33,
Organism=Caenorhabditis elegans, GI17557007, Length=469, Percent_Identity=27.0788912579957, Blast_Score=134, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI71982272, Length=484, Percent_Identity=24.5867768595041, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17559934, Length=199, Percent_Identity=28.1407035175879, Blast_Score=65, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6325166, Length=463, Percent_Identity=28.0777537796976, Blast_Score=156, Evalue=6e-39,
Organism=Saccharomyces cerevisiae, GI6321091, Length=464, Percent_Identity=26.9396551724138, Blast_Score=149, Evalue=8e-37,
Organism=Saccharomyces cerevisiae, GI6325240, Length=480, Percent_Identity=24.375, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21358499, Length=454, Percent_Identity=30.1762114537445, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24640549, Length=477, Percent_Identity=26.2054507337526, Blast_Score=122, Evalue=7e-28,
Organism=Drosophila melanogaster, GI24640553, Length=477, Percent_Identity=26.2054507337526, Blast_Score=122, Evalue=7e-28,
Organism=Drosophila melanogaster, GI24640551, Length=477, Percent_Identity=26.2054507337526, Blast_Score=121, Evalue=8e-28,
Organism=Drosophila melanogaster, GI17737741, Length=479, Percent_Identity=24.6346555323591, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 49082; Mature: 49082

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METADVIVIGSGQGGIPLAADFANEGRKVVLFERDALGGSCINYGCTPSKAFLAAAHTAG
CCCCCEEEEECCCCCCCEEEHHCCCCCEEEEEECCCCCCCEEECCCCCCHHHHHHHHHCC
RANQGKKLGIHTEVEVDFPAVMERVREIRSSFNQGIRQRLESAGVKVICAEASFVGERTV
CCCCCCEECCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCEE
KGGDVTLQAPLVIINTGTSSLIPDIPGLAGTPYLTNRNFFDLNTLPARLLVIGGGYIGLE
CCCCEEEEEEEEEEECCCCCCCCCCCCCCCCCEECCCCEEECCCCCEEEEEEECCEEEEH
LGQGLARLGSQTHLIVRGDRVLGQEEADVSEVLAEALKQDGIGLHFGVNVNHVAHENNVF
HHHHHHHCCCCEEEEEECCHHCCCCCCCHHHHHHHHHHHCCCEEEECCCEEEEECCCCEE
KLTLSSGEQLQGEALLVVIGRKPNTGALNAANSGIELDDKGFVKIDDQFHTTCSGVYAIG
EEEECCCCCCCCCEEEEEEECCCCCCCCCCCCCCCEECCCCEEEECCCCCCHHCCEEEEC
DAAKQPAFTHVSWEDYRRLKAILCGENRTRSDRVLGYAVYTEPQVGRVGMTLEQAQKQGI
CCCCCCCEEECCHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHCCC
NACAVTLPMSQIARAIEWGHDLGFYRMVIDSDTDKILGATLVGYETAELVHVFLSLIEAG
CEEEEECCHHHHHHHHHCCCCCCEEEEEEECCCCHHHHEEEECCCHHHHHHHHHHHHHCC
ATWQLLERSVHIHPTYGEALPSLARLLLGDNMPGCPNM
CHHHHHHCCEEECCCHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
METADVIVIGSGQGGIPLAADFANEGRKVVLFERDALGGSCINYGCTPSKAFLAAAHTAG
CCCCCEEEEECCCCCCCEEEHHCCCCCEEEEEECCCCCCCEEECCCCCCHHHHHHHHHCC
RANQGKKLGIHTEVEVDFPAVMERVREIRSSFNQGIRQRLESAGVKVICAEASFVGERTV
CCCCCCEECCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCEE
KGGDVTLQAPLVIINTGTSSLIPDIPGLAGTPYLTNRNFFDLNTLPARLLVIGGGYIGLE
CCCCEEEEEEEEEEECCCCCCCCCCCCCCCCCEECCCCEEECCCCCEEEEEEECCEEEEH
LGQGLARLGSQTHLIVRGDRVLGQEEADVSEVLAEALKQDGIGLHFGVNVNHVAHENNVF
HHHHHHHCCCCEEEEEECCHHCCCCCCCHHHHHHHHHHHCCCEEEECCCEEEEECCCCEE
KLTLSSGEQLQGEALLVVIGRKPNTGALNAANSGIELDDKGFVKIDDQFHTTCSGVYAIG
EEEECCCCCCCCCEEEEEEECCCCCCCCCCCCCCCEECCCCEEEECCCCCCHHCCEEEEC
DAAKQPAFTHVSWEDYRRLKAILCGENRTRSDRVLGYAVYTEPQVGRVGMTLEQAQKQGI
CCCCCCCEEECCHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHCCC
NACAVTLPMSQIARAIEWGHDLGFYRMVIDSDTDKILGATLVGYETAELVHVFLSLIEAG
CEEEEECCHHHHHHHHHCCCCCCEEEEEEECCCCHHHHEEEECCCHHHHHHHHHHHHHCC
ATWQLLERSVHIHPTYGEALPSLARLLLGDNMPGCPNM
CHHHHHHCCEEECCCHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1339281; 1581034 [H]