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The map label for this gene is tynA [C]

Identifier: 75909657

GI number: 75909657

Start: 4280227

End: 4282209

Strand: Direct

Name: tynA [C]

Synonym: Ava_3451

Alternate gene names: 75909657

Gene position: 4280227-4282209 (Clockwise)

Preceding gene: 75909656

Following gene: 75909660

Centisome position: 67.24

GC content: 42.06

Gene sequence:

>1983_bases
ATGATGAAGCGGCTAAGACTATTTTTCTTGTTAGCTATTACTATTATTATCTGCTGTGGTACGTCACTTATATTAATAGA
AACAGTGACCTCACAACAGCCAGTAATTTCCCATCCTTTGACAGCTTTAACCGAGGCAGAAATTAAAACGGCGGTTGCGG
TGATTAGAAAGGAAAAGTCTTTAACTGACATGGCTGCTTTTCCCTTAATTACCTTGGCAGAACCAGATAAACAAGCAGTT
AGAAATTTTACACAAGGTCAATCTTTTGAGCGCAAGGCTTTTCTGGTAGTATATGAACGCGAGCAAAACAAAACCTATGA
GGGTATTGTTGACCTGAAAACGCAAAAAATAGCGTCCTGGCAAGAGAAACCCCATGTCCAACCGGCAATTTTGAACTCAG
AATATGAACTAGCACGAAATGTAGTGAAATCTGATTCCCGATGGCAAGAAGCGATGAAAAAGCGGGGAATTACAGATTTT
GACCAAGTTCAGGTTAGTTGCTGGGCGGCGGGAATTTTAAGTCAAGAGGAAGCAGAAAAAGGTAGCCGTTTGTGCCGGAC
TTTATTATTTTATCGGGGGGAACGCTGGAATTATTACGGCACTCCTATTGAGGGTGTAATAGCCACGGTTGATTTAAATA
AAGGTACAGTCACCAATTTTATCGACCAGGGGATAGTTCCCATTTCCAAAGAAAACTGGAATTATGACTTAGAGTCTTTA
GGTAAATTACTCCCACCGCCGAAACTCTTACAAATACTGCAACCAAAAGGAAAGAGTTTCCAAATACAGGGTAATGAAAT
TAGTTGGCAAGGTTGGAAGTTTCGGTATGTTATGCACCCCCGTGATGGGTTGGTACTGTATCAAGTAACTTACAAAGATG
GTGAGAATATCCGACCAGTATTATATCGTGCCAGCTTGTCGGAGATGGTTGTACCTTATGGCGATCCTGATCCTACTTGG
TCATTTAGAAACGCTTTTGATGTTGGTGAATATAACTTAGGGTTACTAGCCAGCACAATGGAGTTAGGGAAGGAAATTCC
CCAAAATGGCGTTTTACTTGACGCTGTGTTTGCGAATGAAGAAGGGGAACCCTATATTATGCCTGGGGTTGTGGGTATCT
ACGAACGGGATAACGGCATACTTTGGAAGCATTATGAGTATAATACTCAACGCAACGATGTGCGACGCGATCGCCAATTA
GTCATTACCATCACGGCGGCGGTTGATAACTATGATTACGGTATTAACTGGATTTTTCACCAAGACGGCACTTTAGAAGT
AGAGAATGATTTAACCGGTATTGTTTTGGTGCAGGGAACAGAAGCGGAAACCCAGTCTAGAGATAATTCCTATGGAAGAT
TGCTGGCTAAAAATATTTTTGGTGTCAATCACCAGCACTTTTTTAACTATCGCTTAGATATGGATGTGGATGGTCAAGCT
AATAATGTCATGGAAATGAACGTGGCAAACTTGCCGATAGGTAAGAACAATCCTTTAGGAAATGCCATCACAGTAGAAGA
CACGCCACTGACAACAGAAAAGGCTGCTGTCCGTGATTTAGATATCAAACACAGTCGAGAATGGATGATTGCCAGTGCAG
AGAAAAAGAATGCTTTAGGGGTTGCCCCTGCATATATGTTAATGCCGGGAGGTAACACAGTGTTTTTCCCGGTGGAGGGG
GCGAAAATTCGTCAGAAAGCTGAGTTTGCCACTCATCATGTTTGGGTGACTAAATATAAACCCCATGAGTTATATGCAGG
TGGTGATTATCCTAATCAAGCGTCACCAGGAAAAGGTTTGCCTGAATACATTGCCGATGATGAATCTTTGATGAGTCAAG
ATATTGTTTTGTGGTACACAATGGGTATTACTCATGTACCTAAGCCAGAAGATTGGCCTGTGATGCCGGTTCACAAGCTT
GGGTTTAAACTCTCTCCCAGAGCCTTTTTTAACCGTAATCCGGCGATTAATTTAGCGGAGTAG

Upstream 100 bases:

>100_bases
CCGACTTCTCAAAGAAGTCGGGGATCTGTCTTAACTATTCGGTTTTATATCTGAATTCTGGGAAATAACTAACTATAGAT
TTGTTTTTATATTCTCCAGA

Downstream 100 bases:

>100_bases
GGGACTTTTAAATCAAAAAATCTCCAAATGTAGGGTGCGTCAGTATGAATAATTTCTTGGTACGGTTAGGTTTTTTTGCA
CTGACGCACCCTACTAACTG

Product: tyramine oxidase

Products: NA

Alternate protein names: Copper amine oxidase [H]

Number of amino acids: Translated: 660; Mature: 660

Protein sequence:

>660_residues
MMKRLRLFFLLAITIIICCGTSLILIETVTSQQPVISHPLTALTEAEIKTAVAVIRKEKSLTDMAAFPLITLAEPDKQAV
RNFTQGQSFERKAFLVVYEREQNKTYEGIVDLKTQKIASWQEKPHVQPAILNSEYELARNVVKSDSRWQEAMKKRGITDF
DQVQVSCWAAGILSQEEAEKGSRLCRTLLFYRGERWNYYGTPIEGVIATVDLNKGTVTNFIDQGIVPISKENWNYDLESL
GKLLPPPKLLQILQPKGKSFQIQGNEISWQGWKFRYVMHPRDGLVLYQVTYKDGENIRPVLYRASLSEMVVPYGDPDPTW
SFRNAFDVGEYNLGLLASTMELGKEIPQNGVLLDAVFANEEGEPYIMPGVVGIYERDNGILWKHYEYNTQRNDVRRDRQL
VITITAAVDNYDYGINWIFHQDGTLEVENDLTGIVLVQGTEAETQSRDNSYGRLLAKNIFGVNHQHFFNYRLDMDVDGQA
NNVMEMNVANLPIGKNNPLGNAITVEDTPLTTEKAAVRDLDIKHSREWMIASAEKKNALGVAPAYMLMPGGNTVFFPVEG
AKIRQKAEFATHHVWVTKYKPHELYAGGDYPNQASPGKGLPEYIADDESLMSQDIVLWYTMGITHVPKPEDWPVMPVHKL
GFKLSPRAFFNRNPAINLAE

Sequences:

>Translated_660_residues
MMKRLRLFFLLAITIIICCGTSLILIETVTSQQPVISHPLTALTEAEIKTAVAVIRKEKSLTDMAAFPLITLAEPDKQAV
RNFTQGQSFERKAFLVVYEREQNKTYEGIVDLKTQKIASWQEKPHVQPAILNSEYELARNVVKSDSRWQEAMKKRGITDF
DQVQVSCWAAGILSQEEAEKGSRLCRTLLFYRGERWNYYGTPIEGVIATVDLNKGTVTNFIDQGIVPISKENWNYDLESL
GKLLPPPKLLQILQPKGKSFQIQGNEISWQGWKFRYVMHPRDGLVLYQVTYKDGENIRPVLYRASLSEMVVPYGDPDPTW
SFRNAFDVGEYNLGLLASTMELGKEIPQNGVLLDAVFANEEGEPYIMPGVVGIYERDNGILWKHYEYNTQRNDVRRDRQL
VITITAAVDNYDYGINWIFHQDGTLEVENDLTGIVLVQGTEAETQSRDNSYGRLLAKNIFGVNHQHFFNYRLDMDVDGQA
NNVMEMNVANLPIGKNNPLGNAITVEDTPLTTEKAAVRDLDIKHSREWMIASAEKKNALGVAPAYMLMPGGNTVFFPVEG
AKIRQKAEFATHHVWVTKYKPHELYAGGDYPNQASPGKGLPEYIADDESLMSQDIVLWYTMGITHVPKPEDWPVMPVHKL
GFKLSPRAFFNRNPAINLAE
>Mature_660_residues
MMKRLRLFFLLAITIIICCGTSLILIETVTSQQPVISHPLTALTEAEIKTAVAVIRKEKSLTDMAAFPLITLAEPDKQAV
RNFTQGQSFERKAFLVVYEREQNKTYEGIVDLKTQKIASWQEKPHVQPAILNSEYELARNVVKSDSRWQEAMKKRGITDF
DQVQVSCWAAGILSQEEAEKGSRLCRTLLFYRGERWNYYGTPIEGVIATVDLNKGTVTNFIDQGIVPISKENWNYDLESL
GKLLPPPKLLQILQPKGKSFQIQGNEISWQGWKFRYVMHPRDGLVLYQVTYKDGENIRPVLYRASLSEMVVPYGDPDPTW
SFRNAFDVGEYNLGLLASTMELGKEIPQNGVLLDAVFANEEGEPYIMPGVVGIYERDNGILWKHYEYNTQRNDVRRDRQL
VITITAAVDNYDYGINWIFHQDGTLEVENDLTGIVLVQGTEAETQSRDNSYGRLLAKNIFGVNHQHFFNYRLDMDVDGQA
NNVMEMNVANLPIGKNNPLGNAITVEDTPLTTEKAAVRDLDIKHSREWMIASAEKKNALGVAPAYMLMPGGNTVFFPVEG
AKIRQKAEFATHHVWVTKYKPHELYAGGDYPNQASPGKGLPEYIADDESLMSQDIVLWYTMGITHVPKPEDWPVMPVHKL
GFKLSPRAFFNRNPAINLAE

Specific function: Oxidizes histamine. Other amines including phenethylamine, tyramine, tryptamine, putrescine, and benzylamine also serve as substrate [H]

COG id: COG3733

COG function: function code Q; Cu2+-containing amine oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the copper/topaquinone oxidase family [H]

Homologues:

Organism=Homo sapiens, GI73486661, Length=421, Percent_Identity=26.3657957244656, Blast_Score=134, Evalue=3e-31,
Organism=Homo sapiens, GI60498984, Length=447, Percent_Identity=24.8322147651007, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI60498982, Length=444, Percent_Identity=24.3243243243243, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI4502119, Length=421, Percent_Identity=22.5653206650831, Blast_Score=97, Evalue=7e-20,
Organism=Escherichia coli, GI1787651, Length=634, Percent_Identity=33.1230283911672, Blast_Score=367, Evalue=1e-102,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000269
- InterPro:   IPR015798
- InterPro:   IPR016182
- InterPro:   IPR015800
- InterPro:   IPR015801
- InterPro:   IPR015802 [H]

Pfam domain/function: PF01179 Cu_amine_oxid; PF02727 Cu_amine_oxidN2; PF02728 Cu_amine_oxidN3 [H]

EC number: =1.4.3.22 [H]

Molecular weight: Translated: 74790; Mature: 74790

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS01165 COPPER_AMINE_OXID_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKRLRLFFLLAITIIICCGTSLILIETVTSQQPVISHPLTALTEAEIKTAVAVIRKEKS
CCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHCCHHHHHHHHHHHHHHHHHHHCC
LTDMAAFPLITLAEPDKQAVRNFTQGQSFERKAFLVVYEREQNKTYEGIVDLKTQKIASW
HHHHHHCCEEEECCCCHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCEEEECHHHHHHH
QEKPHVQPAILNSEYELARNVVKSDSRWQEAMKKRGITDFDQVQVSCWAAGILSQEEAEK
HHCCCCCCEEECCHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHEEEEHHHHHCCHHHHHH
GSRLCRTLLFYRGERWNYYGTPIEGVIATVDLNKGTVTNFIDQGIVPISKENWNYDLESL
HHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHCCCEEECCCCCCCCHHHH
GKLLPPPKLLQILQPKGKSFQIQGNEISWQGWKFRYVMHPRDGLVLYQVTYKDGENIRPV
HHHCCCHHHHHHHCCCCCEEEEECCEEEECCEEEEEEECCCCCEEEEEEEECCCCCCCCE
LYRASLSEMVVPYGDPDPTWSFRNAFDVGEYNLGLLASTMELGKEIPQNGVLLDAVFANE
EEECCHHHEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEECC
EGEPYIMPGVVGIYERDNGILWKHYEYNTQRNDVRRDRQLVITITAAVDNYDYGINWIFH
CCCCEECCCEEEEEECCCCEEEEEEECCCCHHHHCCCCEEEEEEEEEECCCCCCEEEEEE
QDGTLEVENDLTGIVLVQGTEAETQSRDNSYGRLLAKNIFGVNHQHFFNYRLDMDVDGQA
CCCEEEECCCCEEEEEEECCCCHHHCCCCHHHHHHHHHHCCCCCCEEEEEEEEEECCCCC
NNVMEMNVANLPIGKNNPLGNAITVEDTPLTTEKAAVRDLDIKHSREWMIASAEKKNALG
CCEEEEEEEECCCCCCCCCCCEEEECCCCCCCCHHHHHCCCCCCCCCEEEEECCCCCCCC
VAPAYMLMPGGNTVFFPVEGAKIRQKAEFATHHVWVTKYKPHELYAGGDYPNQASPGKGL
CCCEEEEECCCCEEEEECCCHHHHHHHHHCEEEEEEEEECCCEEEECCCCCCCCCCCCCC
PEYIADDESLMSQDIVLWYTMGITHVPKPEDWPVMPVHKLGFKLSPRAFFNRNPAINLAE
HHHHCCCHHHHHCCEEEEEEECCCCCCCCCCCCCCCHHHCCCEECCHHHCCCCCCEEECC
>Mature Secondary Structure
MMKRLRLFFLLAITIIICCGTSLILIETVTSQQPVISHPLTALTEAEIKTAVAVIRKEKS
CCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHCCHHHHHHHHHHHHHHHHHHHCC
LTDMAAFPLITLAEPDKQAVRNFTQGQSFERKAFLVVYEREQNKTYEGIVDLKTQKIASW
HHHHHHCCEEEECCCCHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCEEEECHHHHHHH
QEKPHVQPAILNSEYELARNVVKSDSRWQEAMKKRGITDFDQVQVSCWAAGILSQEEAEK
HHCCCCCCEEECCHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHEEEEHHHHHCCHHHHHH
GSRLCRTLLFYRGERWNYYGTPIEGVIATVDLNKGTVTNFIDQGIVPISKENWNYDLESL
HHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHCCCEEECCCCCCCCHHHH
GKLLPPPKLLQILQPKGKSFQIQGNEISWQGWKFRYVMHPRDGLVLYQVTYKDGENIRPV
HHHCCCHHHHHHHCCCCCEEEEECCEEEECCEEEEEEECCCCCEEEEEEEECCCCCCCCE
LYRASLSEMVVPYGDPDPTWSFRNAFDVGEYNLGLLASTMELGKEIPQNGVLLDAVFANE
EEECCHHHEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEECC
EGEPYIMPGVVGIYERDNGILWKHYEYNTQRNDVRRDRQLVITITAAVDNYDYGINWIFH
CCCCEECCCEEEEEECCCCEEEEEEECCCCHHHHCCCCEEEEEEEEEECCCCCCEEEEEE
QDGTLEVENDLTGIVLVQGTEAETQSRDNSYGRLLAKNIFGVNHQHFFNYRLDMDVDGQA
CCCEEEECCCCEEEEEEECCCCHHHCCCCHHHHHHHHHHCCCCCCEEEEEEEEEECCCCC
NNVMEMNVANLPIGKNNPLGNAITVEDTPLTTEKAAVRDLDIKHSREWMIASAEKKNALG
CCEEEEEEEECCCCCCCCCCCEEEECCCCCCCCHHHHHCCCCCCCCCEEEEECCCCCCCC
VAPAYMLMPGGNTVFFPVEGAKIRQKAEFATHHVWVTKYKPHELYAGGDYPNQASPGKGL
CCCEEEEECCCCEEEEECCCHHHHHHHHHCEEEEEEEEECCCEEEECCCCCCCCCCCCCC
PEYIADDESLMSQDIVLWYTMGITHVPKPEDWPVMPVHKLGFKLSPRAFFNRNPAINLAE
HHHHCCCHHHHHCCEEEEEEECCCCCCCCCCCCCCCHHHCCCEECCHHHCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7876243 [H]