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The map label for this gene is strD [H]

Identifier: 75909562

GI number: 75909562

Start: 4175875

End: 4176951

Strand: Direct

Name: strD [H]

Synonym: Ava_3356

Alternate gene names: 75909562

Gene position: 4175875-4176951 (Clockwise)

Preceding gene: 75909561

Following gene: 75909563

Centisome position: 65.6

GC content: 40.3

Gene sequence:

>1077_bases
ATGAAAGCACTAATTCTCTCTGGCGGTAGAGGTACACGTCTACGTCCACTCACCTATACTGGAGCAAAGCAACTTGTCCC
AGTTGCGAACAAACCTATTCTATGGTATGGGATTGAAGAAATGGTTGCGGCTGGTATTACTGATATCGGTATAATTATCA
GCCCAGAAACAGGGGCAGAAGTACAAAGTAAAACTGGAGATGGAAAACTTTTTGGAGCGAACATCACCTATATTTTACAA
GAACAACCGGCCGGTCTAGCTCATGCCGTTACTGTTGCTCGTCCCTTCTTAAAAGATTCACCTTTTGTCATGTATCTGGG
GGATAACCTAATTCAACAAGGAGACTTAAGCAACTTTTTACAACAGTTTATCCAAGAACAACCTGATGCTTTAATTCTCT
TGCGTGAGGTTATCAACCCTAGCGCCTTTGGTGTAGCTAAGGTGGATGATACCGGGCGAGTACTACAATTAATCGAAAAA
CCCAAAGTTCCTCCATCCAATCTAGCTCTAGTAGGGGTTTATTTCTTTTCCCCGATTATTCATGATTCTATTGCTCGTAT
CCAGCCTTCAAACCGAGGAGAACTGGAAATTACTGATGCTATTCAACGCTTAATAGACGATAAAAGACAAGTATTAGCTT
GTAATTTATATGGTTGGTGGTTAGACACTGGTAAAAAAGATGATTTATTAGAAGCTAACCGCTTAATTCTTGATACCTGT
TTAACAACGTCTAACTTAGGGGAAGTGGATGCTAAAAGTCAAATCATTGGACGAGTTCAAATTGGAGTCAATTCCCAAAT
CATCAATTGTACAATACGTGGCCCCGTGGTTATTGGCGATAATTGTTATTTAGAAAATTGCTTTATTGGCCCTTATAGCA
GCATCGCCAACAATACAACACTCATCGACTCAGATTTAGAACACAGCGTAATTTTAGAAGGTGCTAAAATATCCGGAATC
GATCAGCGAATCATTGATAGTGTAATTGGACAACGCGCGCAACTAACAATTGCTCCCCGTCGCCCAAAAGCATTACGCTT
TTTGATTGGTGATGATTGTCAAATAGAACTGACATAA

Upstream 100 bases:

>100_bases
CTTGTGAGAAAATGTCACAAGTTTTGGGAACTGCTCCCCCCCATTGGCAAGAAAGACTGCGGTTGATGCTTCAAGACTGG
CTCTCCAAATATTCTTCATT

Downstream 100 bases:

>100_bases
CCCCTAAAAACTTAGGGCAAAGATAAAGCTATGTTAAGCAAGACAAGGTTTTTACATCGGCTTGTAGTAGGGTTCAGCCT
GCGATATTCTCCTACGCGAC

Product: glucose-1-phosphate thymidylyltransferase, short form

Products: NA

Alternate protein names: Sugar-nucleotidylation enzyme; dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MKALILSGGRGTRLRPLTYTGAKQLVPVANKPILWYGIEEMVAAGITDIGIIISPETGAEVQSKTGDGKLFGANITYILQ
EQPAGLAHAVTVARPFLKDSPFVMYLGDNLIQQGDLSNFLQQFIQEQPDALILLREVINPSAFGVAKVDDTGRVLQLIEK
PKVPPSNLALVGVYFFSPIIHDSIARIQPSNRGELEITDAIQRLIDDKRQVLACNLYGWWLDTGKKDDLLEANRLILDTC
LTTSNLGEVDAKSQIIGRVQIGVNSQIINCTIRGPVVIGDNCYLENCFIGPYSSIANNTTLIDSDLEHSVILEGAKISGI
DQRIIDSVIGQRAQLTIAPRRPKALRFLIGDDCQIELT

Sequences:

>Translated_358_residues
MKALILSGGRGTRLRPLTYTGAKQLVPVANKPILWYGIEEMVAAGITDIGIIISPETGAEVQSKTGDGKLFGANITYILQ
EQPAGLAHAVTVARPFLKDSPFVMYLGDNLIQQGDLSNFLQQFIQEQPDALILLREVINPSAFGVAKVDDTGRVLQLIEK
PKVPPSNLALVGVYFFSPIIHDSIARIQPSNRGELEITDAIQRLIDDKRQVLACNLYGWWLDTGKKDDLLEANRLILDTC
LTTSNLGEVDAKSQIIGRVQIGVNSQIINCTIRGPVVIGDNCYLENCFIGPYSSIANNTTLIDSDLEHSVILEGAKISGI
DQRIIDSVIGQRAQLTIAPRRPKALRFLIGDDCQIELT
>Mature_358_residues
MKALILSGGRGTRLRPLTYTGAKQLVPVANKPILWYGIEEMVAAGITDIGIIISPETGAEVQSKTGDGKLFGANITYILQ
EQPAGLAHAVTVARPFLKDSPFVMYLGDNLIQQGDLSNFLQQFIQEQPDALILLREVINPSAFGVAKVDDTGRVLQLIEK
PKVPPSNLALVGVYFFSPIIHDSIARIQPSNRGELEITDAIQRLIDDKRQVLACNLYGWWLDTGKKDDLLEANRLILDTC
LTTSNLGEVDAKSQIIGRVQIGVNSQIINCTIRGPVVIGDNCYLENCFIGPYSSIANNTTLIDSDLEHSVILEGAKISGI
DQRIIDSVIGQRAQLTIAPRRPKALRFLIGDDCQIELT

Specific function: Involved in the biosynthesis of the streptose moiety of streptomycin. Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=350, Percent_Identity=28.8571428571429, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI11761619, Length=327, Percent_Identity=29.3577981651376, Blast_Score=121, Evalue=1e-27,
Organism=Escherichia coli, GI1790224, Length=237, Percent_Identity=37.9746835443038, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI1788351, Length=236, Percent_Identity=36.4406779661017, Blast_Score=161, Evalue=7e-41,
Organism=Escherichia coli, GI1787488, Length=270, Percent_Identity=30.7407407407407, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1788355, Length=274, Percent_Identity=27.7372262773723, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1789837, Length=197, Percent_Identity=28.9340101522843, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI133931050, Length=339, Percent_Identity=29.7935103244838, Blast_Score=124, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6320148, Length=345, Percent_Identity=28.695652173913, Blast_Score=114, Evalue=3e-26,
Organism=Drosophila melanogaster, GI21355443, Length=338, Percent_Identity=28.4023668639053, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24644084, Length=338, Percent_Identity=28.4023668639053, Blast_Score=115, Evalue=6e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005908
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 39129; Mature: 39129

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS01319 RBFA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALILSGGRGTRLRPLTYTGAKQLVPVANKPILWYGIEEMVAAGITDIGIIISPETGAE
CCEEEEECCCCCEEEEEEECCCCCEEECCCCCEEEECHHHHHHCCCCEEEEEECCCCCCC
VQSKTGDGKLFGANITYILQEQPAGLAHAVTVARPFLKDSPFVMYLGDNLIQQGDLSNFL
CCCCCCCCEEEECCEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEECCCHHCCCCHHHHH
QQFIQEQPDALILLREVINPSAFGVAKVDDTGRVLQLIEKPKVPPSNLALVGVYFFSPII
HHHHHHCCCCEEHHHHHCCCCCCEEEEECCCHHHHHHHHCCCCCCCCEEEEHHHHHHHHH
HDSIARIQPSNRGELEITDAIQRLIDDKRQVLACNLYGWWLDTGKKDDLLEANRLILDTC
HHHHHHCCCCCCCCEEHHHHHHHHHCCCCEEEEEEEEEEEECCCCCCCHHHHHHHHEEHH
LTTSNLGEVDAKSQIIGRVQIGVNSQIINCTIRGPVVIGDNCYLENCFIGPYSSIANNTT
HCCCCCCCCCCHHHEEEEEEECCCCEEEEEEEECCEEECCCEEEEEEECCCCHHHCCCCE
LIDSDLEHSVILEGAKISGIDQRIIDSVIGQRAQLTIAPRRPKALRFLIGDDCQIELT
EEECCCCCEEEEECCEECCHHHHHHHHHHCCCEEEEECCCCCCEEEEEECCCCEEEEC
>Mature Secondary Structure
MKALILSGGRGTRLRPLTYTGAKQLVPVANKPILWYGIEEMVAAGITDIGIIISPETGAE
CCEEEEECCCCCEEEEEEECCCCCEEECCCCCEEEECHHHHHHCCCCEEEEEECCCCCCC
VQSKTGDGKLFGANITYILQEQPAGLAHAVTVARPFLKDSPFVMYLGDNLIQQGDLSNFL
CCCCCCCCEEEECCEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEECCCHHCCCCHHHHH
QQFIQEQPDALILLREVINPSAFGVAKVDDTGRVLQLIEKPKVPPSNLALVGVYFFSPII
HHHHHHCCCCEEHHHHHCCCCCCEEEEECCCHHHHHHHHCCCCCCCCEEEEHHHHHHHHH
HDSIARIQPSNRGELEITDAIQRLIDDKRQVLACNLYGWWLDTGKKDDLLEANRLILDTC
HHHHHHCCCCCCCCEEHHHHHHHHHCCCCEEEEEEEEEEEECCCCCCCHHHHHHHHEEHH
LTTSNLGEVDAKSQIIGRVQIGVNSQIINCTIRGPVVIGDNCYLENCFIGPYSSIANNTT
HCCCCCCCCCCHHHEEEEEEECCCCEEEEEEEECCEEECCCEEEEEEECCCCHHHCCCCE
LIDSDLEHSVILEGAKISGIDQRIIDSVIGQRAQLTIAPRRPKALRFLIGDDCQIELT
EEECCCCCEEEEECCEECCHHHHHHHHHHCCCEEEEECCCCCCEEEEEECCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3118332 [H]