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The map label for this gene is garR [H]

Identifier: 75909413

GI number: 75909413

Start: 3985463

End: 3986311

Strand: Direct

Name: garR [H]

Synonym: Ava_3206

Alternate gene names: 75909413

Gene position: 3985463-3986311 (Clockwise)

Preceding gene: 75909412

Following gene: 75909415

Centisome position: 62.61

GC content: 45.35

Gene sequence:

>849_bases
ATGGGACTACCAATGGCCCAAAGATTGTTAGCAGCAAATATAGAGGTAGTTGCCTATAACCGCACCCCAGAAAAACTAGC
ACCATTACAAGCAGCTGGCGCGGAAGTGGTGACACATCCCCGCTACGCAATTCGAGAAGCTGAGTGTGTCATCCTCATGC
TGACCAACGCCGCAGCAATATATCATGTGTTGCTTTCGGATACTTCTTGGCGGACTCTCCAAGGACGCACCATCATTCAG
ATGGGAACAATTACCTCCACTCAAAGCCAAGAAATTCGAGATTCCATAGTGGGTGGTGGCGGCGAATATATAGAAGCACC
AGTATTAGGAAGTATCCCCGAAGCCAAAGCGGGTACGCTGACAGTGATGGTAGGCGCTGAACCTAAACAGTATGAACGCT
GTCTAGATTTACTCAAGAATTTTGGCCCAGACCCATTATTAATAGGGCCAGTGGGAACGGCATCGGGATTAAAGCTAGCC
CTAAATCAGCTAATTGCTTCCTTAACTACTAGTTTTGCCCTGAGTTTAGCTTTTGTGCAGCGTCAAGGTATTGATGTAGA
TAAATTTATGCAAGTCTTAAGGGAGAGTGCGCTGTATGCGCCTACCTTTGATAAAAAGCTGCAAAGGATGTTGGATGGTA
ATTATAGCAATCCCAACTTTCCCACAAAACACTTGCTCAAAGATACCGACTTGTTTATTTCCGAAGCCCAATACCTGGGA
CTGGATCTCAGCAGTATTGAAACTGTGCAGAAACTTTTACAAACAACCATGAAAATGTCATTTGCCAATGACGATTACTC
TGCCCTATTTTCTGTTATCAGAGATTGGGGGGAAGCAAGTGGCGGTTAG

Upstream 100 bases:

>100_bases
TTAATGAGCTACTCCCTGACAACCTACAATCAAACGATGGAAAAGCGGCTGAATCAAAGGAACGTAAAACATGAAGGTGG
CATTTCTGGGAACTGGACTT

Downstream 100 bases:

>100_bases
AGGGATGGAGACGGGGAGAACAACAAATAACTATTGAATATTGACTAGAGCAAAGGTAGTAAAATTTCAAATTTTGTACC
GATTCCTAGTTTGGAAGAGA

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 282; Mature: 281

Protein sequence:

>282_residues
MGLPMAQRLLAANIEVVAYNRTPEKLAPLQAAGAEVVTHPRYAIREAECVILMLTNAAAIYHVLLSDTSWRTLQGRTIIQ
MGTITSTQSQEIRDSIVGGGGEYIEAPVLGSIPEAKAGTLTVMVGAEPKQYERCLDLLKNFGPDPLLIGPVGTASGLKLA
LNQLIASLTTSFALSLAFVQRQGIDVDKFMQVLRESALYAPTFDKKLQRMLDGNYSNPNFPTKHLLKDTDLFISEAQYLG
LDLSSIETVQKLLQTTMKMSFANDDYSALFSVIRDWGEASGG

Sequences:

>Translated_282_residues
MGLPMAQRLLAANIEVVAYNRTPEKLAPLQAAGAEVVTHPRYAIREAECVILMLTNAAAIYHVLLSDTSWRTLQGRTIIQ
MGTITSTQSQEIRDSIVGGGGEYIEAPVLGSIPEAKAGTLTVMVGAEPKQYERCLDLLKNFGPDPLLIGPVGTASGLKLA
LNQLIASLTTSFALSLAFVQRQGIDVDKFMQVLRESALYAPTFDKKLQRMLDGNYSNPNFPTKHLLKDTDLFISEAQYLG
LDLSSIETVQKLLQTTMKMSFANDDYSALFSVIRDWGEASGG
>Mature_281_residues
GLPMAQRLLAANIEVVAYNRTPEKLAPLQAAGAEVVTHPRYAIREAECVILMLTNAAAIYHVLLSDTSWRTLQGRTIIQM
GTITSTQSQEIRDSIVGGGGEYIEAPVLGSIPEAKAGTLTVMVGAEPKQYERCLDLLKNFGPDPLLIGPVGTASGLKLAL
NQLIASLTTSFALSLAFVQRQGIDVDKFMQVLRESALYAPTFDKKLQRMLDGNYSNPNFPTKHLLKDTDLFISEAQYLGL
DLSSIETVQKLLQTTMKMSFANDDYSALFSVIRDWGEASGG

Specific function: D-galactarate metabolism; third step. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40556376, Length=274, Percent_Identity=23.7226277372263, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI23308751, Length=283, Percent_Identity=25.0883392226148, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI145693186, Length=272, Percent_Identity=28.3088235294118, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1786719, Length=279, Percent_Identity=27.2401433691756, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1789092, Length=277, Percent_Identity=24.9097472924188, Blast_Score=68, Evalue=5e-13,
Organism=Drosophila melanogaster, GI28574115, Length=273, Percent_Identity=23.8095238095238, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24655230, Length=283, Percent_Identity=23.321554770318, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI19922568, Length=283, Percent_Identity=23.321554770318, Blast_Score=72, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 30716; Mature: 30585

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLPMAQRLLAANIEVVAYNRTPEKLAPLQAAGAEVVTHPRYAIREAECVILMLTNAAAI
CCCHHHHHHHHCCCEEEEECCCHHHHCCHHHCCCHHHCCCHHHHCCCCEEEEEECCHHHH
YHVLLSDTSWRTLQGRTIIQMGTITSTQSQEIRDSIVGGGGEYIEAPVLGSIPEAKAGTL
HHHHHCCCCCEEECCCEEEEECCCCCCHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCEE
TVMVGAEPKQYERCLDLLKNFGPDPLLIGPVGTASGLKLALNQLIASLTTSFALSLAFVQ
EEEECCCHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RQGIDVDKFMQVLRESALYAPTFDKKLQRMLDGNYSNPNFPTKHLLKDTDLFISEAQYLG
HCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHC
LDLSSIETVQKLLQTTMKMSFANDDYSALFSVIRDWGEASGG
CCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
GLPMAQRLLAANIEVVAYNRTPEKLAPLQAAGAEVVTHPRYAIREAECVILMLTNAAAI
CCHHHHHHHHCCCEEEEECCCHHHHCCHHHCCCHHHCCCHHHHCCCCEEEEEECCHHHH
YHVLLSDTSWRTLQGRTIIQMGTITSTQSQEIRDSIVGGGGEYIEAPVLGSIPEAKAGTL
HHHHHCCCCCEEECCCEEEEECCCCCCHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCEE
TVMVGAEPKQYERCLDLLKNFGPDPLLIGPVGTASGLKLALNQLIASLTTSFALSLAFVQ
EEEECCCHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RQGIDVDKFMQVLRESALYAPTFDKKLQRMLDGNYSNPNFPTKHLLKDTDLFISEAQYLG
HCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHC
LDLSSIETVQKLLQTTMKMSFANDDYSALFSVIRDWGEASGG
CCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]