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The map label for this gene is ndhH

Identifier: 75909405

GI number: 75909405

Start: 3976067

End: 3977251

Strand: Direct

Name: ndhH

Synonym: Ava_3198

Alternate gene names: 75909405

Gene position: 3976067-3977251 (Clockwise)

Preceding gene: 75909402

Following gene: 75909410

Centisome position: 62.46

GC content: 47.68

Gene sequence:

>1185_bases
ATGGCAAGAATAGAAACCCGCACTGAACCAATGGTGCTGAATATGGGGCCACACCATCCCTCAATGCACGGGGTTCTGCG
GCTAATTGTCACTTTGGATGGCGAAGATGTCGTTGATTGTGAACCGGTAATCGGCTATCTGCACCGAGGAATGGAGAAAA
TCGCCGAAAACCGCACCACAGTCATGTACGTCCCCTACGTTAGCCGATGGGACTACGCCGCAGGAATGTTTAATGAAGCT
GTCACCGTCAATGCACCGGAAAAGCTGGCTGGTGTTGCTGTTCCTAAACGCGCTAGCTACATCCGCGTCATCATGCTGGA
ATTGAACCGCATTGCTAACCACCTCCTGTGGTTCGGCCCCTTCCTAGCTGACGTAGGCGCACAAACTCCCTTCTTTTACC
AGTTCCGAGAACGGGAGATGATTTACGATTTGTGGGAAGCCGCCACAGGCTACCGCATGGTAAATAACAACTATTTCCGC
GTCGGTGGCGTAGCTGCGGATTTACCCTATGGTTGGGTAGATAAGTGTCTAGAATTTTGTGACTACTTCTTACCCGTAGT
TGATGAATACGAAAAGTTAGTTACCAATAATCCCATTTTCCGCCGTCGGATCGAAGGTATTGGCACAATTAGCCGCGAAG
AAGCAATTAACTGGGGACTTTCCGGCCCGATGTTACGTGCATCTGGTGTAAAATGGGACTTACGCAAAGTTGACCATTAC
GAATCCTACGATGATTTCGACTGGGATGTACAGTGGGAGACAGCCGGCGATTGTTTAGCCCGTTACACCGTGAGAATGCG
GGAAATGCGCGAATCTGTGAAGATTATCAAGCAAGCAATCAAAGGATTACCCGGAGGCCCCTACGAAAACCTCGAAGCCA
AGCGTTTAATAGCTGGTAAGAAATCAGAATGGGATGCTTTTGATTACCAATACATCGGCAAAAAAGTTTCTCCTACCTTC
AAAATGCCTAAAGGTGAAATCTACGCCCGTGTGGAAAGCGGTAAAGGTGAACTAGGCATTTATCTGATTGGTGATGATAA
CGTCTTTCCTTGGCGGTGGAAAATTCGCCCAGCCGATTTCAACAACCTGCAAATTCTGCCTCATTTATTACGGGGTATGA
AAGTTGCGGATATTGTGGTAATTCTCGGCAGTATTGACGTAATCATGGGTTCTGTAGATAGATAA

Upstream 100 bases:

>100_bases
ATGAACTATCAATCACCTCTGGTGGGCGGTTAAGCATCGTGTCGAGATGGCATCAACGCGGTTCAACTCAAAATTTTCAT
AATGGGAGAACACGGAATTT

Downstream 100 bases:

>100_bases
GCCATTAGGCTTTTTAACTGACAGTTACTCGTGAGGTTTGTTGACGGTTAATAGTCAACCGTCAACAAAAAAATATAGTT
TTCTTAATTTTGAACTGTAA

Product: NAD(P)H-quinone oxidoreductase subunit H

Products: NAD+; ubiquinol

Alternate protein names: NAD(P)H dehydrogenase subunit H; NADH-plastoquinone oxidoreductase subunit H; NDH-1 subunit H; NDH-H

Number of amino acids: Translated: 394; Mature: 393

Protein sequence:

>394_residues
MARIETRTEPMVLNMGPHHPSMHGVLRLIVTLDGEDVVDCEPVIGYLHRGMEKIAENRTTVMYVPYVSRWDYAAGMFNEA
VTVNAPEKLAGVAVPKRASYIRVIMLELNRIANHLLWFGPFLADVGAQTPFFYQFREREMIYDLWEAATGYRMVNNNYFR
VGGVAADLPYGWVDKCLEFCDYFLPVVDEYEKLVTNNPIFRRRIEGIGTISREEAINWGLSGPMLRASGVKWDLRKVDHY
ESYDDFDWDVQWETAGDCLARYTVRMREMRESVKIIKQAIKGLPGGPYENLEAKRLIAGKKSEWDAFDYQYIGKKVSPTF
KMPKGEIYARVESGKGELGIYLIGDDNVFPWRWKIRPADFNNLQILPHLLRGMKVADIVVILGSIDVIMGSVDR

Sequences:

>Translated_394_residues
MARIETRTEPMVLNMGPHHPSMHGVLRLIVTLDGEDVVDCEPVIGYLHRGMEKIAENRTTVMYVPYVSRWDYAAGMFNEA
VTVNAPEKLAGVAVPKRASYIRVIMLELNRIANHLLWFGPFLADVGAQTPFFYQFREREMIYDLWEAATGYRMVNNNYFR
VGGVAADLPYGWVDKCLEFCDYFLPVVDEYEKLVTNNPIFRRRIEGIGTISREEAINWGLSGPMLRASGVKWDLRKVDHY
ESYDDFDWDVQWETAGDCLARYTVRMREMRESVKIIKQAIKGLPGGPYENLEAKRLIAGKKSEWDAFDYQYIGKKVSPTF
KMPKGEIYARVESGKGELGIYLIGDDNVFPWRWKIRPADFNNLQILPHLLRGMKVADIVVILGSIDVIMGSVDR
>Mature_393_residues
ARIETRTEPMVLNMGPHHPSMHGVLRLIVTLDGEDVVDCEPVIGYLHRGMEKIAENRTTVMYVPYVSRWDYAAGMFNEAV
TVNAPEKLAGVAVPKRASYIRVIMLELNRIANHLLWFGPFLADVGAQTPFFYQFREREMIYDLWEAATGYRMVNNNYFRV
GGVAADLPYGWVDKCLEFCDYFLPVVDEYEKLVTNNPIFRRRIEGIGTISREEAINWGLSGPMLRASGVKWDLRKVDHYE
SYDDFDWDVQWETAGDCLARYTVRMREMRESVKIIKQAIKGLPGGPYENLEAKRLIAGKKSEWDAFDYQYIGKKVSPTFK
MPKGEIYARVESGKGELGIYLIGDDNVFPWRWKIRPADFNNLQILPHLLRGMKVADIVVILGSIDVIMGSVDR

Specific function: NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family

Homologues:

Organism=Homo sapiens, GI4758786, Length=393, Percent_Identity=40.9669211195929, Blast_Score=297, Evalue=1e-80,
Organism=Homo sapiens, GI260898743, Length=387, Percent_Identity=40.3100775193798, Blast_Score=286, Evalue=2e-77,
Organism=Escherichia coli, GI145693162, Length=401, Percent_Identity=39.4014962593516, Blast_Score=301, Evalue=3e-83,
Organism=Escherichia coli, GI1789076, Length=386, Percent_Identity=29.2746113989637, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1788832, Length=393, Percent_Identity=28.2442748091603, Blast_Score=131, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI17568379, Length=392, Percent_Identity=40.5612244897959, Blast_Score=305, Evalue=3e-83,
Organism=Caenorhabditis elegans, GI17555284, Length=392, Percent_Identity=40.5612244897959, Blast_Score=304, Evalue=5e-83,
Organism=Drosophila melanogaster, GI221459469, Length=385, Percent_Identity=44.4155844155844, Blast_Score=331, Evalue=6e-91,
Organism=Drosophila melanogaster, GI24638644, Length=394, Percent_Identity=41.6243654822335, Blast_Score=320, Evalue=1e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDHH_ANAVT (Q3M880)

Other databases:

- EMBL:   CP000117
- RefSeq:   YP_323701.1
- HSSP:   Q56220
- ProteinModelPortal:   Q3M880
- SMR:   Q3M880
- STRING:   Q3M880
- GeneID:   3680618
- GenomeReviews:   CP000117_GR
- KEGG:   ava:Ava_3198
- NMPDR:   fig|240292.3.peg.2300
- eggNOG:   COG0649
- HOGENOM:   HBG459705
- OMA:   FGPFLAD
- PhylomeDB:   Q3M880
- ProtClustDB:   PRK07415
- BioCyc:   AVAR240292:AVA_3198-MONOMER
- GO:   GO:0006810
- HAMAP:   MF_01358
- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885

Pfam domain/function: PF00346 Complex1_49kDa

EC number: 1.6.5.3

Molecular weight: Translated: 45243; Mature: 45112

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARIETRTEPMVLNMGPHHPSMHGVLRLIVTLDGEDVVDCEPVIGYLHRGMEKIAENRTT
CCCCCCCCCCEEEECCCCCCHHHHEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCE
VMYVPYVSRWDYAAGMFNEAVTVNAPEKLAGVAVPKRASYIRVIMLELNRIANHLLWFGP
EEEECCCCCCCHHHHHCCCCEEECCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
FLADVGAQTPFFYQFREREMIYDLWEAATGYRMVNNNYFRVGGVAADLPYGWVDKCLEFC
HHHHHCCCCCEEEHHHHHHHHHHHHHHHCCEEEECCCEEEECCEEECCCHHHHHHHHHHH
DYFLPVVDEYEKLVTNNPIFRRRIEGIGTISREEAINWGLSGPMLRASGVKWDLRKVDHY
HHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHCCCCCCCEEECCCCEEEHHHCCCC
ESYDDFDWDVQWETAGDCLARYTVRMREMRESVKIIKQAIKGLPGGPYENLEAKRLIAGK
CCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCC
KSEWDAFDYQYIGKKVSPTFKMPKGEIYARVESGKGELGIYLIGDDNVFPWRWKIRPADF
CCCCCCCCHHHHCCCCCCCCCCCCCEEEEEEECCCCCEEEEEEECCCEECEEEEECCCCC
NNLQILPHLLRGMKVADIVVILGSIDVIMGSVDR
CCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
ARIETRTEPMVLNMGPHHPSMHGVLRLIVTLDGEDVVDCEPVIGYLHRGMEKIAENRTT
CCCCCCCCCEEEECCCCCCHHHHEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCE
VMYVPYVSRWDYAAGMFNEAVTVNAPEKLAGVAVPKRASYIRVIMLELNRIANHLLWFGP
EEEECCCCCCCHHHHHCCCCEEECCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
FLADVGAQTPFFYQFREREMIYDLWEAATGYRMVNNNYFRVGGVAADLPYGWVDKCLEFC
HHHHHCCCCCEEEHHHHHHHHHHHHHHHCCEEEECCCEEEECCEEECCCHHHHHHHHHHH
DYFLPVVDEYEKLVTNNPIFRRRIEGIGTISREEAINWGLSGPMLRASGVKWDLRKVDHY
HHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHCCCCCCCEEECCCCEEEHHHCCCC
ESYDDFDWDVQWETAGDCLARYTVRMREMRESVKIIKQAIKGLPGGPYENLEAKRLIAGK
CCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCC
KSEWDAFDYQYIGKKVSPTFKMPKGEIYARVESGKGELGIYLIGDDNVFPWRWKIRPADF
CCCCCCCCHHHHCCCCCCCCCCCCCEEEEEEECCCCCEEEEEEECCCEECEEEEECCCCC
NNLQILPHLLRGMKVADIVVILGSIDVIMGSVDR
CCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; H+; ubiquinone

Specific reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA