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The map label for this gene is ndhD1 [H]

Identifier: 75909008

GI number: 75909008

Start: 3450126

End: 3451739

Strand: Direct

Name: ndhD1 [H]

Synonym: Ava_2796

Alternate gene names: 75909008

Gene position: 3450126-3451739 (Clockwise)

Preceding gene: 75909007

Following gene: 75909010

Centisome position: 54.2

GC content: 45.48

Gene sequence:

>1614_bases
ATGAATCTCATTGAGTTTCCCTGGCTAACAGCCATAATTGCCTTACCCTTGGTGGCAGCCCTAGCCATCCCCATAATTCC
CGACAAAGAAGGAAAAACGGTTCGTTGGTATGGATTGGGTGTAGCCTTTGCAGACTTTGCCTTAATGATTGCCGCCTTCT
GGCATTATTACGACTTCCAAAGTTCGACATACCAATTTGTAGAAAAATACCATTGGCTTCCTCAAATAGGTTTGAATTGG
TCTGTAGCAGTTGACGGCTTATCAATGCCCTTACTGTTGTTAACAGGCTTAATTAACACACTCGCAATCTTCGCGGCTTG
GAAAGTAACCAACAAGCCGCGATTATTTTATGGATTGATGCTGGTGATGTACAGCGCCCAGTTAGGGGTGTTTGTTGCCC
AAGACTTGCTACTATTCTTCCTCATGTGGGAAATCGAGCTAGTTCCTGTCTACCTGCTGATTTCCATCTGGGGAGGCCCC
AAACGCCGTTATGCAGCGACCAAGTTCATCCTTTACACTGCTGCTGCTTCTATATTTATTCTCGTAGCTGGATTTGCACT
TGCATTCTCTGGAGATACAGTTACTTTCGACATTGCAGCTCTGGGAATGAAAGAATATCCCAAAGCGATTGAATTATTAG
CTTATGCAGGATTTTTAATTGCCTTCGGTGTAAAATTGCCAATATTCCCTCTCCACACATGGCTACCTGATGCTCACGGT
GAAGCATCTGCCCCTGGTTCCATGATTCTGGCTGGTGTGTTGCTGAAAATGGGTGGTTATGCCCTCATCCGCTTCAACAT
CGAAATGTTGCCTGATGCCCATGTTTATTTTGCGCCAGTCTTAGCAATCTTAGGTGTAGTTAACATTGTTTATGGTGCTT
GCTGCGCCTTTGCTCAAACCAACCTGAAACGCCGCCTAGCTTACTCTTCCATCGCCCACATGGGATTTGTGCTAATCGGT
CTAGCTTCCTACACAGAAATTGGTGTGAGTGGAGCAGTGTTACAGATGGTCTCCCACGGTTTGGTTGCGGCTAGCTTGTT
CTTCTTAACTGGTGTGACTTACGAACGTACCCACACCTTATTGATGGACAAAATGGGCGGTATTGGTAAGGTGATGCCCA
AAACCTTCGCTCTTTACACAGCAGGCGCAATGGCTTCTCTAGCCTTACCCGGAATGAGTGGCTTCGTAGGAGAGTTGATG
GTGTTCATTGGTATCGCTACCAGCGATGTCTACAGTTCCAGCTTCAAAGTCGTAGTTGTTCTACTGTCCGCAGTGGGTGT
AATTCTGACTCCAATTTACTTGCTGTCTCTATTGCGCCAAGTCTTCTACGGCAAACAAAGCGAAGAGTTACATCTTGATG
CTTTCATCCCTGATGTGAAACCTCGTGAATTGTTCATCACCGCTTCTTTATTACTTCCCATCATCGGTATCGGCTTGTAT
CCCAAATTGATTACCCAAACCTATGATGTGAAGACTGTAGAAATAGCAGCCCACGCTCGTCAAGTGTTACCAGTGGTTGC
AGGACAACAGCCATCAAGCCTGTACTCCCAAATTTTCACTGCACCAACACTGGCTAATGCTGAAGTTGAAAGTTTAGTTA
ATATCTCTAAGTAA

Upstream 100 bases:

>100_bases
CCAAAATTTAATTTTCCAGAGATAAATAAAGTTTACAAAAGTAACAATTCCTTAATATAATGTAATTAAAAGCGAAAAGA
AAAAACGATTGTCAGAAGTG

Downstream 100 bases:

>100_bases
ATATATCTCTCAGCAATGGTGCTGAAAGTAAATCCTAAATATGACGGAAACTAGGGGTGGTTGCCAAACTACCCCTAAAA
TTTTGTAAAAGTGGCGAGAA

Product: NAD(P)H-quinone oxidoreductase subunit 4

Products: NAD+; ubiquinol

Alternate protein names: NAD(P)H dehydrogenase I, chain 4 1; NDH-1, chain 4 1 [H]

Number of amino acids: Translated: 537; Mature: 537

Protein sequence:

>537_residues
MNLIEFPWLTAIIALPLVAALAIPIIPDKEGKTVRWYGLGVAFADFALMIAAFWHYYDFQSSTYQFVEKYHWLPQIGLNW
SVAVDGLSMPLLLLTGLINTLAIFAAWKVTNKPRLFYGLMLVMYSAQLGVFVAQDLLLFFLMWEIELVPVYLLISIWGGP
KRRYAATKFILYTAAASIFILVAGFALAFSGDTVTFDIAALGMKEYPKAIELLAYAGFLIAFGVKLPIFPLHTWLPDAHG
EASAPGSMILAGVLLKMGGYALIRFNIEMLPDAHVYFAPVLAILGVVNIVYGACCAFAQTNLKRRLAYSSIAHMGFVLIG
LASYTEIGVSGAVLQMVSHGLVAASLFFLTGVTYERTHTLLMDKMGGIGKVMPKTFALYTAGAMASLALPGMSGFVGELM
VFIGIATSDVYSSSFKVVVVLLSAVGVILTPIYLLSLLRQVFYGKQSEELHLDAFIPDVKPRELFITASLLLPIIGIGLY
PKLITQTYDVKTVEIAAHARQVLPVVAGQQPSSLYSQIFTAPTLANAEVESLVNISK

Sequences:

>Translated_537_residues
MNLIEFPWLTAIIALPLVAALAIPIIPDKEGKTVRWYGLGVAFADFALMIAAFWHYYDFQSSTYQFVEKYHWLPQIGLNW
SVAVDGLSMPLLLLTGLINTLAIFAAWKVTNKPRLFYGLMLVMYSAQLGVFVAQDLLLFFLMWEIELVPVYLLISIWGGP
KRRYAATKFILYTAAASIFILVAGFALAFSGDTVTFDIAALGMKEYPKAIELLAYAGFLIAFGVKLPIFPLHTWLPDAHG
EASAPGSMILAGVLLKMGGYALIRFNIEMLPDAHVYFAPVLAILGVVNIVYGACCAFAQTNLKRRLAYSSIAHMGFVLIG
LASYTEIGVSGAVLQMVSHGLVAASLFFLTGVTYERTHTLLMDKMGGIGKVMPKTFALYTAGAMASLALPGMSGFVGELM
VFIGIATSDVYSSSFKVVVVLLSAVGVILTPIYLLSLLRQVFYGKQSEELHLDAFIPDVKPRELFITASLLLPIIGIGLY
PKLITQTYDVKTVEIAAHARQVLPVVAGQQPSSLYSQIFTAPTLANAEVESLVNISK
>Mature_537_residues
MNLIEFPWLTAIIALPLVAALAIPIIPDKEGKTVRWYGLGVAFADFALMIAAFWHYYDFQSSTYQFVEKYHWLPQIGLNW
SVAVDGLSMPLLLLTGLINTLAIFAAWKVTNKPRLFYGLMLVMYSAQLGVFVAQDLLLFFLMWEIELVPVYLLISIWGGP
KRRYAATKFILYTAAASIFILVAGFALAFSGDTVTFDIAALGMKEYPKAIELLAYAGFLIAFGVKLPIFPLHTWLPDAHG
EASAPGSMILAGVLLKMGGYALIRFNIEMLPDAHVYFAPVLAILGVVNIVYGACCAFAQTNLKRRLAYSSIAHMGFVLIG
LASYTEIGVSGAVLQMVSHGLVAASLFFLTGVTYERTHTLLMDKMGGIGKVMPKTFALYTAGAMASLALPGMSGFVGELM
VFIGIATSDVYSSSFKVVVVLLSAVGVILTPIYLLSLLRQVFYGKQSEELHLDAFIPDVKPRELFITASLLLPIIGIGLY
PKLITQTYDVKTVEIAAHARQVLPVVAGQQPSSLYSQIFTAPTLANAEVESLVNISK

Specific function: NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton tran

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cellular thylakoid membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=383, Percent_Identity=30.8093994778068, Blast_Score=165, Evalue=1e-40,
Organism=Homo sapiens, GI251831117, Length=386, Percent_Identity=24.6113989637306, Blast_Score=83, Evalue=5e-16,
Organism=Escherichia coli, GI1788613, Length=428, Percent_Identity=41.1214953271028, Blast_Score=307, Evalue=1e-84,
Organism=Escherichia coli, GI1788831, Length=302, Percent_Identity=29.8013245033113, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI1788827, Length=202, Percent_Identity=32.1782178217822, Blast_Score=105, Evalue=8e-24,
Organism=Escherichia coli, GI1788614, Length=443, Percent_Identity=25.7336343115124, Blast_Score=99, Evalue=7e-22,
Organism=Escherichia coli, GI1788829, Length=296, Percent_Identity=28.0405405405405, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI2367154, Length=292, Percent_Identity=26.3698630136986, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI145693160, Length=302, Percent_Identity=31.4569536423841, Blast_Score=79, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022997
- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: 1.6.5.3

Molecular weight: Translated: 58533; Mature: 58533

Theoretical pI: Translated: 7.74; Mature: 7.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLIEFPWLTAIIALPLVAALAIPIIPDKEGKTVRWYGLGVAFADFALMIAAFWHYYDFQ
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHCCC
SSTYQFVEKYHWLPQIGLNWSVAVDGLSMPLLLLTGLINTLAIFAAWKVTNKPRLFYGLM
CHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
LVMYSAQLGVFVAQDLLLFFLMWEIELVPVYLLISIWGGPKRRYAATKFILYTAAASIFI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
LVAGFALAFSGDTVTFDIAALGMKEYPKAIELLAYAGFLIAFGVKLPIFPLHTWLPDAHG
HHHHHHHEECCCEEEEEHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHCCCCCC
EASAPGSMILAGVLLKMGGYALIRFNIEMLPDAHVYFAPVLAILGVVNIVYGACCAFAQT
CCCCCHHHHHHHHHHHHCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
NLKRRLAYSSIAHMGFVLIGLASYTEIGVSGAVLQMVSHGLVAASLFFLTGVTYERTHTL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
LMDKMGGIGKVMPKTFALYTAGAMASLALPGMSGFVGELMVFIGIATSDVYSSSFKVVVV
HHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHH
LLSAVGVILTPIYLLSLLRQVFYGKQSEELHLDAFIPDVKPRELFITASLLLPIIGIGLY
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHEEHHHHHHHHHHHCCC
PKLITQTYDVKTVEIAAHARQVLPVVAGQQPSSLYSQIFTAPTLANAEVESLVNISK
HHHHHCCCCCEEEHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHCCCC
>Mature Secondary Structure
MNLIEFPWLTAIIALPLVAALAIPIIPDKEGKTVRWYGLGVAFADFALMIAAFWHYYDFQ
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHCCC
SSTYQFVEKYHWLPQIGLNWSVAVDGLSMPLLLLTGLINTLAIFAAWKVTNKPRLFYGLM
CHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
LVMYSAQLGVFVAQDLLLFFLMWEIELVPVYLLISIWGGPKRRYAATKFILYTAAASIFI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
LVAGFALAFSGDTVTFDIAALGMKEYPKAIELLAYAGFLIAFGVKLPIFPLHTWLPDAHG
HHHHHHHEECCCEEEEEHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHCCCCCC
EASAPGSMILAGVLLKMGGYALIRFNIEMLPDAHVYFAPVLAILGVVNIVYGACCAFAQT
CCCCCHHHHHHHHHHHHCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
NLKRRLAYSSIAHMGFVLIGLASYTEIGVSGAVLQMVSHGLVAASLFFLTGVTYERTHTL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
LMDKMGGIGKVMPKTFALYTAGAMASLALPGMSGFVGELMVFIGIATSDVYSSSFKVVVV
HHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHH
LLSAVGVILTPIYLLSLLRQVFYGKQSEELHLDAFIPDVKPRELFITASLLLPIIGIGLY
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHEEHHHHHHHHHHHCCC
PKLITQTYDVKTVEIAAHARQVLPVVAGQQPSSLYSQIFTAPTLANAEVESLVNISK
HHHHHCCCCCEEEHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; H+; ubiquinone

Specific reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]