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The map label for this gene is fabH

Identifier: 75908941

GI number: 75908941

Start: 3368428

End: 3369420

Strand: Direct

Name: fabH

Synonym: Ava_2729

Alternate gene names: 75908941

Gene position: 3368428-3369420 (Clockwise)

Preceding gene: 75908940

Following gene: 75908942

Centisome position: 52.92

GC content: 46.02

Gene sequence:

>993_bases
GTGCAAAACTTAGGCATCGCAATTACCGGAAGTGGTTCAGCAGCACCTGAAACTTCCCTTCACAACGAAGAATTAAGCCA
ACTGGTAGAGACATCAGACGAGTGGATAAGTACCAGAACGGGAATCCGCCAACGGCGTTTAGCCCTACCGACTGAATCAT
TAAGCAGTCTGGCGGCGGCAGCTAGTAGACAGGCGATCGCCTCGGCTGGAATTACAGCATCCGATATAGATTTGATTTTA
CTGGCAACTTCCACACCTGACGATCTGTTCGGTACTGCTACTAAAATCCAAGCTGAATTGGGAGCTACTAAAGCCGTAGC
TTTTGATTTAACAGCAGCCTGTTCCGGCTTCGTCTTTGGTCTAGTCACAGCAGCCCAATTTATCAGAACTGGCGTATATC
AGAATGTACTGTTGATCGGGGCTGATATCCTCTCCCGTTGGGTAGATTGGCAAGACAGACGTACTTGCGTGCTATTTGGT
GACGGTGCTGGGGCTATTGTATTGCAGTCCAACCAAAGCGATCGCTTATTAGGATTTGCCCTCAAAAGTGATGGGACACA
AAACCATTATCTCAACCTAGCTTATCAAGGCACTGCCCAAGAAATTCTCCCCAACATCAAGATCACTCAAGGCACATATC
AACCCGTAACCATGAACGGCAAAGAAGTTTACCGCTTTGCTGCTCAAAAAGTCCCAGAAATCATTGATAAAGCTTTATTT
GAAGCCAATATTACTGTTGACCAAATCGATTGGCTACTACTACATCAAGCAAATCAACGCATTCTTGATACTGTAGCTCA
ACGCCTAAATATTCCTGCACACAAAGTGATTAGTAATCTTGCTAATTACGGCAATACCTCCGCCGCATCCATCCCCCTAG
CCCTAGATGAAGCCGTGCGAGAAGGTAAAATAAAACCCAACGATATCATTGCTACATCCGGCTTTGGAGCCGGTCTAACA
TGGGGTGCAGCAATTTTCCAATGGGGAAGATAA

Upstream 100 bases:

>100_bases
CAGTTCTGCGGGTTATTAGTCAAAAGTAAATGACTAATGACTAATATCTACAGACGTTCTATACAACGTCTCTAATAACT
GATAGCTTGGGAGACTAGGA

Downstream 100 bases:

>100_bases
TCAATTAAAAATTCAAAATGCAAAATTCAAAAATTGGATTGTTCATTTTGAATTTTTAATTTTGAATTTTGAATTAGAGC
GAAGCGACTGACAAATGACA

Product: 3-oxoacyl-(acyl carrier protein) synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MQNLGIAITGSGSAAPETSLHNEELSQLVETSDEWISTRTGIRQRRLALPTESLSSLAAAASRQAIASAGITASDIDLIL
LATSTPDDLFGTATKIQAELGATKAVAFDLTAACSGFVFGLVTAAQFIRTGVYQNVLLIGADILSRWVDWQDRRTCVLFG
DGAGAIVLQSNQSDRLLGFALKSDGTQNHYLNLAYQGTAQEILPNIKITQGTYQPVTMNGKEVYRFAAQKVPEIIDKALF
EANITVDQIDWLLLHQANQRILDTVAQRLNIPAHKVISNLANYGNTSAASIPLALDEAVREGKIKPNDIIATSGFGAGLT
WGAAIFQWGR

Sequences:

>Translated_330_residues
MQNLGIAITGSGSAAPETSLHNEELSQLVETSDEWISTRTGIRQRRLALPTESLSSLAAAASRQAIASAGITASDIDLIL
LATSTPDDLFGTATKIQAELGATKAVAFDLTAACSGFVFGLVTAAQFIRTGVYQNVLLIGADILSRWVDWQDRRTCVLFG
DGAGAIVLQSNQSDRLLGFALKSDGTQNHYLNLAYQGTAQEILPNIKITQGTYQPVTMNGKEVYRFAAQKVPEIIDKALF
EANITVDQIDWLLLHQANQRILDTVAQRLNIPAHKVISNLANYGNTSAASIPLALDEAVREGKIKPNDIIATSGFGAGLT
WGAAIFQWGR
>Mature_330_residues
MQNLGIAITGSGSAAPETSLHNEELSQLVETSDEWISTRTGIRQRRLALPTESLSSLAAAASRQAIASAGITASDIDLIL
LATSTPDDLFGTATKIQAELGATKAVAFDLTAACSGFVFGLVTAAQFIRTGVYQNVLLIGADILSRWVDWQDRRTCVLFG
DGAGAIVLQSNQSDRLLGFALKSDGTQNHYLNLAYQGTAQEILPNIKITQGTYQPVTMNGKEVYRFAAQKVPEIIDKALF
EANITVDQIDWLLLHQANQRILDTVAQRLNIPAHKVISNLANYGNTSAASIPLALDEAVREGKIKPNDIIATSGFGAGLT
WGAAIFQWGR

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family

Homologues:

Organism=Escherichia coli, GI1787333, Length=322, Percent_Identity=40.6832298136646, Blast_Score=253, Evalue=1e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABH_ANAVT (Q3M9J4)

Other databases:

- EMBL:   CP000117
- RefSeq:   YP_323237.1
- ProteinModelPortal:   Q3M9J4
- SMR:   Q3M9J4
- STRING:   Q3M9J4
- GeneID:   3682090
- GenomeReviews:   CP000117_GR
- KEGG:   ava:Ava_2729
- NMPDR:   fig|240292.3.peg.1133
- eggNOG:   COG0332
- HOGENOM:   HBG649927
- OMA:   HYLNLAY
- PhylomeDB:   Q3M9J4
- ProtClustDB:   PRK09352
- BioCyc:   AVAR240292:AVA_2729-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01815
- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- TIGRFAMs:   TIGR00747

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C; SSF53901 Thiolase-like

EC number: =2.3.1.41

Molecular weight: Translated: 35385; Mature: 35385

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: NA

Important sites: ACT_SITE 114-114 ACT_SITE 255-255 ACT_SITE 285-285

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNLGIAITGSGSAAPETSLHNEELSQLVETSDEWISTRTGIRQRRLALPTESLSSLAAA
CCCCCEEEECCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
ASRQAIASAGITASDIDLILLATSTPDDLFGTATKIQAELGATKAVAFDLTAACSGFVFG
HHHHHHHHCCCCCCCCEEEEEEECCCHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHH
LVTAAQFIRTGVYQNVLLIGADILSRWVDWQDRRTCVLFGDGAGAIVLQSNQSDRLLGFA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEECCCCCCEEEEE
LKSDGTQNHYLNLAYQGTAQEILPNIKITQGTYQPVTMNGKEVYRFAAQKVPEIIDKALF
ECCCCCCCCEEEEEECCCHHHHCCCCEEECCCCCCEEECHHHHHHHHHHHHHHHHHHHHH
EANITVDQIDWLLLHQANQRILDTVAQRLNIPAHKVISNLANYGNTSAASIPLALDEAVR
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHH
EGKIKPNDIIATSGFGAGLTWGAAIFQWGR
HCCCCCCCEEEECCCCCCHHHHHHHHCCCC
>Mature Secondary Structure
MQNLGIAITGSGSAAPETSLHNEELSQLVETSDEWISTRTGIRQRRLALPTESLSSLAAA
CCCCCEEEECCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
ASRQAIASAGITASDIDLILLATSTPDDLFGTATKIQAELGATKAVAFDLTAACSGFVFG
HHHHHHHHCCCCCCCCEEEEEEECCCHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHH
LVTAAQFIRTGVYQNVLLIGADILSRWVDWQDRRTCVLFGDGAGAIVLQSNQSDRLLGFA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEECCCCCCEEEEE
LKSDGTQNHYLNLAYQGTAQEILPNIKITQGTYQPVTMNGKEVYRFAAQKVPEIIDKALF
ECCCCCCCCEEEEEECCCHHHHCCCCEEECCCCCCEEECHHHHHHHHHHHHHHHHHHHHH
EANITVDQIDWLLLHQANQRILDTVAQRLNIPAHKVISNLANYGNTSAASIPLALDEAVR
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHH
EGKIKPNDIIATSGFGAGLTWGAAIFQWGR
HCCCCCCCEEEECCCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA