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The map label for this gene is gnd [H]

Identifier: 75908741

GI number: 75908741

Start: 3125432

End: 3126862

Strand: Direct

Name: gnd [H]

Synonym: Ava_2527

Alternate gene names: 75908741

Gene position: 3125432-3126862 (Clockwise)

Preceding gene: 75908738

Following gene: 75908743

Centisome position: 49.1

GC content: 46.47

Gene sequence:

>1431_bases
ATGACACTACAAAGCTTTGGTGTGATTGGTTTAGCCGTTATGGGCGAGAATATCGCTCTAAACGTGGAGCGTAATGGCTT
CCCAATTGCAGTTTATAACCGTTCCAGAGAGAAAACCGATGCTTTCATGGCACAGCGTGCTGGTGGACGCAACGTTAAAG
CTGCTTTTACCCTGGAAGAGTTTGTTGCTGCACTAGAACGTCCCCGCAAGATTCTAGTGATGGTGCAAGCTGGTAAACCA
GTGGATGCAGTAATTCAGCAGCTCAAGCCTCTACTAGATGAAGGCGATATCATCATCGACGGTGGTAACTCTTGGTTTGA
AGATACCCAAAGACGGACTCAAGAACTAGAACCAGCAGGCTTACGCTTCCTGGGGATGGGTGTCAGTGGTGGTGAAGAAG
GCGCACTCAATGGCCCTTCACTGATGCCCGGTGGTACACAAAGTTCTTACGAGTATCTGTCCCCCATTTTCAACAAAATT
GCTGCTCAAGTTGATGATGGCCCTTGTGTAACTTATGTTGGCCCTGGTGGTTCCGGTCACTATGTCAAAATGGTACACAA
CGGTATTGAGTATGGCGATATGCAGTTGATTGCAGAAGCCTACGACTTGCTGAAAACTGCTGGTGGGCTGGATGCTAAAC
AACTACATGAAGTATTTGCCCAATGGAATACTACCGATGAACTCAATTCATTTTTGATTGAGATTACAGCCAATATCTTC
CCCTATGTTGACCCAGATACCAAGTTACCCTTGGTGGATTTGATTGTTGATGCAGCTGGTCAAAAGGGAACTGGACGCTG
GACTGTACAAACTGCTTTGGAATTGGGTGTTTCTATCCCCACCATTACAGCAGCAGTGAATGCTCGGATTATCTCTTCCA
TTCGAGATGAGCGCATAGCAGCATCTAAGCAGTTGACAGGCCCTAGTGGCAAATATGACGGCGATACCAAAGAGTTTATT
AACAAAGTCCGGGATGCACTTTACTGCTCCAAGATTTGTTCTTATGCTCAAGGGATGGCTTTGCTATCTACAGCTTCCAC
AACATTTAATTGGAATTTGAATCTGAGTGAATTGGCGCGGATTTGGAAAGGTGGTTGTATTATTCGCGCTGGCTTCTTGA
ATAAGATTAAGAAGGCATTTAACGAAAATCCCGCATTACCCAACTTGCTACTCGCTCCAGAATTTAAGCAAACAATTCTC
GACAGACAAGCAGCTTGGCGGGAAGTAATCATCACTGCGGCTAAACTCGGAATCCCAGTACCCGCATTTAGTGCATCCTT
GGATTATTTTGACAGCTATCGCCGCGATCGCCTACCCCAGAACCTCACACAGGCACAACGCGACTACTTCGGCGCACACA
CCTACTTGCGTACCGATAAAGCTGGCGCTTTCCACACTGAATGGGTTCCCATTGCTGAAGCCAAGAAATAA

Upstream 100 bases:

>100_bases
TCTTTAAATTAACTCTTAATGTCTTCTTTAGGGGAGAAGAGAAAAACTCGGTCTACCCTTAAAGATGAAAGAACCTGCAA
GAGTTAGCCAAACATAGTTT

Downstream 100 bases:

>100_bases
GCTGGTAATTCTCTAAATTCTGAACTTAATTTATTAGTGGCTCTAAATATTAGAGTCACTTTTTTATCAAGTTAAGTCCT
CTCGTACAGTCACACAAGAA

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 476; Mature: 475

Protein sequence:

>476_residues
MTLQSFGVIGLAVMGENIALNVERNGFPIAVYNRSREKTDAFMAQRAGGRNVKAAFTLEEFVAALERPRKILVMVQAGKP
VDAVIQQLKPLLDEGDIIIDGGNSWFEDTQRRTQELEPAGLRFLGMGVSGGEEGALNGPSLMPGGTQSSYEYLSPIFNKI
AAQVDDGPCVTYVGPGGSGHYVKMVHNGIEYGDMQLIAEAYDLLKTAGGLDAKQLHEVFAQWNTTDELNSFLIEITANIF
PYVDPDTKLPLVDLIVDAAGQKGTGRWTVQTALELGVSIPTITAAVNARIISSIRDERIAASKQLTGPSGKYDGDTKEFI
NKVRDALYCSKICSYAQGMALLSTASTTFNWNLNLSELARIWKGGCIIRAGFLNKIKKAFNENPALPNLLLAPEFKQTIL
DRQAAWREVIITAAKLGIPVPAFSASLDYFDSYRRDRLPQNLTQAQRDYFGAHTYLRTDKAGAFHTEWVPIAEAKK

Sequences:

>Translated_476_residues
MTLQSFGVIGLAVMGENIALNVERNGFPIAVYNRSREKTDAFMAQRAGGRNVKAAFTLEEFVAALERPRKILVMVQAGKP
VDAVIQQLKPLLDEGDIIIDGGNSWFEDTQRRTQELEPAGLRFLGMGVSGGEEGALNGPSLMPGGTQSSYEYLSPIFNKI
AAQVDDGPCVTYVGPGGSGHYVKMVHNGIEYGDMQLIAEAYDLLKTAGGLDAKQLHEVFAQWNTTDELNSFLIEITANIF
PYVDPDTKLPLVDLIVDAAGQKGTGRWTVQTALELGVSIPTITAAVNARIISSIRDERIAASKQLTGPSGKYDGDTKEFI
NKVRDALYCSKICSYAQGMALLSTASTTFNWNLNLSELARIWKGGCIIRAGFLNKIKKAFNENPALPNLLLAPEFKQTIL
DRQAAWREVIITAAKLGIPVPAFSASLDYFDSYRRDRLPQNLTQAQRDYFGAHTYLRTDKAGAFHTEWVPIAEAKK
>Mature_475_residues
TLQSFGVIGLAVMGENIALNVERNGFPIAVYNRSREKTDAFMAQRAGGRNVKAAFTLEEFVAALERPRKILVMVQAGKPV
DAVIQQLKPLLDEGDIIIDGGNSWFEDTQRRTQELEPAGLRFLGMGVSGGEEGALNGPSLMPGGTQSSYEYLSPIFNKIA
AQVDDGPCVTYVGPGGSGHYVKMVHNGIEYGDMQLIAEAYDLLKTAGGLDAKQLHEVFAQWNTTDELNSFLIEITANIFP
YVDPDTKLPLVDLIVDAAGQKGTGRWTVQTALELGVSIPTITAAVNARIISSIRDERIAASKQLTGPSGKYDGDTKEFIN
KVRDALYCSKICSYAQGMALLSTASTTFNWNLNLSELARIWKGGCIIRAGFLNKIKKAFNENPALPNLLLAPEFKQTILD
RQAAWREVIITAAKLGIPVPAFSASLDYFDSYRRDRLPQNLTQAQRDYFGAHTYLRTDKAGAFHTEWVPIAEAKK

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=471, Percent_Identity=52.6539278131635, Blast_Score=473, Evalue=1e-133,
Organism=Escherichia coli, GI1788341, Length=470, Percent_Identity=57.6595744680851, Blast_Score=551, Evalue=1e-158,
Organism=Caenorhabditis elegans, GI17542558, Length=472, Percent_Identity=51.6949152542373, Blast_Score=483, Evalue=1e-136,
Organism=Saccharomyces cerevisiae, GI6321695, Length=452, Percent_Identity=52.4336283185841, Blast_Score=484, Evalue=1e-138,
Organism=Saccharomyces cerevisiae, GI6321977, Length=452, Percent_Identity=52.6548672566372, Blast_Score=475, Evalue=1e-135,
Organism=Drosophila melanogaster, GI24639279, Length=463, Percent_Identity=51.1879049676026, Blast_Score=451, Evalue=1e-127,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 52119; Mature: 51988

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLQSFGVIGLAVMGENIALNVERNGFPIAVYNRSREKTDAFMAQRAGGRNVKAAFTLEE
CCCCCCCCEEEEEECCCEEEEEECCCCEEEEECCCCHHHHHHHHHHCCCCCCEEEEEHHH
FVAALERPRKILVMVQAGKPVDAVIQQLKPLLDEGDIIIDGGNSWFEDTQRRTQELEPAG
HHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHCCCCC
LRFLGMGVSGGEEGALNGPSLMPGGTQSSYEYLSPIFNKIAAQVDDGPCVTYVGPGGSGH
CEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCC
YVKMVHNGIEYGDMQLIAEAYDLLKTAGGLDAKQLHEVFAQWNTTDELNSFLIEITANIF
EEHEECCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHC
PYVDPDTKLPLVDLIVDAAGQKGTGRWTVQTALELGVSIPTITAAVNARIISSIRDERIA
CCCCCCCCCCHHHHHHHCCCCCCCCCEEHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
ASKQLTGPSGKYDGDTKEFINKVRDALYCSKICSYAQGMALLSTASTTFNWNLNLSELAR
HHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHEEECCEEEEECCCHHHHHH
IWKGGCIIRAGFLNKIKKAFNENPALPNLLLAPEFKQTILDRQAAWREVIITAAKLGIPV
HHCCCCEEEHHHHHHHHHHHCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCC
PAFSASLDYFDSYRRDRLPQNLTQAQRDYFGAHTYLRTDKAGAFHTEWVPIAEAKK
CHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHEEECCCCCCEECCCCCCCCCCC
>Mature Secondary Structure 
TLQSFGVIGLAVMGENIALNVERNGFPIAVYNRSREKTDAFMAQRAGGRNVKAAFTLEE
CCCCCCCEEEEEECCCEEEEEECCCCEEEEECCCCHHHHHHHHHHCCCCCCEEEEEHHH
FVAALERPRKILVMVQAGKPVDAVIQQLKPLLDEGDIIIDGGNSWFEDTQRRTQELEPAG
HHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHCCCCC
LRFLGMGVSGGEEGALNGPSLMPGGTQSSYEYLSPIFNKIAAQVDDGPCVTYVGPGGSGH
CEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCC
YVKMVHNGIEYGDMQLIAEAYDLLKTAGGLDAKQLHEVFAQWNTTDELNSFLIEITANIF
EEHEECCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHC
PYVDPDTKLPLVDLIVDAAGQKGTGRWTVQTALELGVSIPTITAAVNARIISSIRDERIA
CCCCCCCCCCHHHHHHHCCCCCCCCCEEHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
ASKQLTGPSGKYDGDTKEFINKVRDALYCSKICSYAQGMALLSTASTTFNWNLNLSELAR
HHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHEEECCEEEEECCCHHHHHH
IWKGGCIIRAGFLNKIKKAFNENPALPNLLLAPEFKQTILDRQAAWREVIITAAKLGIPV
HHCCCCEEEHHHHHHHHHHHCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCC
PAFSASLDYFDSYRRDRLPQNLTQAQRDYFGAHTYLRTDKAGAFHTEWVPIAEAKK
CHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHEEECCCCCCEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2113917 [H]