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The map label for this gene is sppA [H]

Identifier: 75908676

GI number: 75908676

Start: 3056252

End: 3058081

Strand: Direct

Name: sppA [H]

Synonym: Ava_2462

Alternate gene names: 75908676

Gene position: 3056252-3058081 (Clockwise)

Preceding gene: 75908675

Following gene: 75908685

Centisome position: 48.01

GC content: 42.68

Gene sequence:

>1830_bases
ATGAGTAACTTCTTTAAACAAACTCTTGCTAGCTTACTAGGCACATTATTAGGACTGTTTCTGTTCGCTGGTGCAGGTAC
TACAGGACTTTTATTATTATTATTTGCTGCTGCTAGTTCCAGCAATACCAGCCCAGTAGTTAAAGATAAATCAGTAGTGG
TTCTAGACTTGTCCATGAACATCACCGATAGAGAACCAAGTGCTGGCGAGGAACTACAAAATAGATTTTCCGGTGTAACA
CAAGAGCGGATGACACTTCGTAATGTTATCGATAGTTTAGAAAAAGCACAACGAGATAAACGCATCGTTGCTATTTACCT
AGACGGTAGTCGTGGAGGAAATAATCTGGGTTTTGCATCGTTGAAAGAAATCCGCAAAGCTCTAGAAGAATTCCGTAAAT
CCGGGAAAAAGGTAATCGCCTATGGTGTGTCTTGGAACGAGCGGGAATATTACCTCAGTTCGGTAGCTGATACTATTGCA
CTTAACCCCTTGGGTGGACTAGAAATCAACGGTTTGAGTAGCCAACCAATGTTCGTCGCCGGAGCCTTGCAAAAGTATGG
TATTGGCGTTCAGGTTGTAAGAGCCGGAAAATTTAAGGGAGCAGTTGAACCATTCGTGTTAAACAAACTAAGTCCCGAAA
ACCGCGAACAAACTCAAAAATTATTGGACGATGTTTGGGGTGAATGGCGTACCACCGTTGGCAATAGCCGTAAAATTAAC
CCACAAAAACTACAAGCGATCGCCGATAATCAATCATTATTGGAACCAACAGAAGCTAAAACTAACGGCTTAGTCGATCA
GGTAGCGTACAACGATCAAGTAGTTGCTGACCTGAAGAAATTAACAGGTAGCGATAAAAAGGATAATACATTTACTCAAA
TTAGCCTGCGCCGATATGCTCAAGTACCCGGACAGTCTTTAGGTGTGGCAAGAAACTCTAAAAATAAGATTGCCGTAGTT
TATGCCGAAGGCGATATTGTCGATGGTAAAGGCGATGATGGGCAAATAGGAGGCGATCGCTTTGCCCGCATCTTTAATAA
AATTAGACAAGATGAAAATGTCAAAGCAGTCGTTTTACGCATCAATAGTCCTGGTGGTAGTGCTACAGCATCGGAGGTAA
TGCAGCGAGAAATACGCCTGACTCGTGAAAGTAAACCCGTTGTTGTATCTATGGGTGATTATGCCGCTTCTGGTGGTTAC
TGGATAGCCACCGACTCTAACCGAATTTTTGCCGAACCTAATACAATCACAGGTTCCATCGGTGTGTTTGGCGTGCTATT
TAACGGGCAAAAGCTAGCAAACGATAATGGTATCACTTGGGATGCTGTCAAAACGGCACGTTATGCAGATTCTCAAACCG
TCGCTCGTCCCAAATCACCCCAAGAGATAGCAATTTACCAGCGCAGTGTTGACCGCATTTACAATATGTTTGTCAACAAA
GTTGCTCAAGGTCGCAAGTTACCCACACAAAAAGTAGCCCAAATCGCCCAAGGTAGAGTTTGGTCTGGTGTAACTGCAAA
ACAAATTGGTTTAGTTGATGAAATCGGTGGTCTAAACGCCGCCATAGAATACGCAGCTAAAGCAGCGAAACTAGGTAAAG
ATTGGCAATTAAGAGAATATCCCAGAGAAAGCTCATTTGAAGAGCGCTTTTTTGGCGGAGTAGTCGAGGAAATTAGTACG
ACTTTGGGAATTGAGAAGTTAGACGTTAAACCAAATGACCCATTAACAGTGCAAATCCGAAAAATCCAACAGGAAATCTC
TGTTTTACAGACCATGAACGACCCACAAGGTGTTTATGCGCGGTTACCAGTTAACTTAAAAATAGAGTAA

Upstream 100 bases:

>100_bases
TTAAAACACTCTGGCAGTTTACAGCGCCTACAATAAATGAATAGGTAAGAATGGTTAGGCGTGATTGACTTACCACTAAT
GACTAAATAACTAATAACTA

Downstream 100 bases:

>100_bases
TTCTACAGATTAACTATAAGGTTTGATATTCCTTAAAGTCTCCTTTTTAAGATAGATTAAGGTGAATTAAAAATCCGTTA
ACTAAAAACCTACATTGATC

Product: peptidase S49, protease IV

Products: NA

Alternate protein names: Endopeptidase IV; Protease IV homolog; Signal peptide peptidase [H]

Number of amino acids: Translated: 609; Mature: 608

Protein sequence:

>609_residues
MSNFFKQTLASLLGTLLGLFLFAGAGTTGLLLLLFAAASSSNTSPVVKDKSVVVLDLSMNITDREPSAGEELQNRFSGVT
QERMTLRNVIDSLEKAQRDKRIVAIYLDGSRGGNNLGFASLKEIRKALEEFRKSGKKVIAYGVSWNEREYYLSSVADTIA
LNPLGGLEINGLSSQPMFVAGALQKYGIGVQVVRAGKFKGAVEPFVLNKLSPENREQTQKLLDDVWGEWRTTVGNSRKIN
PQKLQAIADNQSLLEPTEAKTNGLVDQVAYNDQVVADLKKLTGSDKKDNTFTQISLRRYAQVPGQSLGVARNSKNKIAVV
YAEGDIVDGKGDDGQIGGDRFARIFNKIRQDENVKAVVLRINSPGGSATASEVMQREIRLTRESKPVVVSMGDYAASGGY
WIATDSNRIFAEPNTITGSIGVFGVLFNGQKLANDNGITWDAVKTARYADSQTVARPKSPQEIAIYQRSVDRIYNMFVNK
VAQGRKLPTQKVAQIAQGRVWSGVTAKQIGLVDEIGGLNAAIEYAAKAAKLGKDWQLREYPRESSFEERFFGGVVEEIST
TLGIEKLDVKPNDPLTVQIRKIQQEISVLQTMNDPQGVYARLPVNLKIE

Sequences:

>Translated_609_residues
MSNFFKQTLASLLGTLLGLFLFAGAGTTGLLLLLFAAASSSNTSPVVKDKSVVVLDLSMNITDREPSAGEELQNRFSGVT
QERMTLRNVIDSLEKAQRDKRIVAIYLDGSRGGNNLGFASLKEIRKALEEFRKSGKKVIAYGVSWNEREYYLSSVADTIA
LNPLGGLEINGLSSQPMFVAGALQKYGIGVQVVRAGKFKGAVEPFVLNKLSPENREQTQKLLDDVWGEWRTTVGNSRKIN
PQKLQAIADNQSLLEPTEAKTNGLVDQVAYNDQVVADLKKLTGSDKKDNTFTQISLRRYAQVPGQSLGVARNSKNKIAVV
YAEGDIVDGKGDDGQIGGDRFARIFNKIRQDENVKAVVLRINSPGGSATASEVMQREIRLTRESKPVVVSMGDYAASGGY
WIATDSNRIFAEPNTITGSIGVFGVLFNGQKLANDNGITWDAVKTARYADSQTVARPKSPQEIAIYQRSVDRIYNMFVNK
VAQGRKLPTQKVAQIAQGRVWSGVTAKQIGLVDEIGGLNAAIEYAAKAAKLGKDWQLREYPRESSFEERFFGGVVEEIST
TLGIEKLDVKPNDPLTVQIRKIQQEISVLQTMNDPQGVYARLPVNLKIE
>Mature_608_residues
SNFFKQTLASLLGTLLGLFLFAGAGTTGLLLLLFAAASSSNTSPVVKDKSVVVLDLSMNITDREPSAGEELQNRFSGVTQ
ERMTLRNVIDSLEKAQRDKRIVAIYLDGSRGGNNLGFASLKEIRKALEEFRKSGKKVIAYGVSWNEREYYLSSVADTIAL
NPLGGLEINGLSSQPMFVAGALQKYGIGVQVVRAGKFKGAVEPFVLNKLSPENREQTQKLLDDVWGEWRTTVGNSRKINP
QKLQAIADNQSLLEPTEAKTNGLVDQVAYNDQVVADLKKLTGSDKKDNTFTQISLRRYAQVPGQSLGVARNSKNKIAVVY
AEGDIVDGKGDDGQIGGDRFARIFNKIRQDENVKAVVLRINSPGGSATASEVMQREIRLTRESKPVVVSMGDYAASGGYW
IATDSNRIFAEPNTITGSIGVFGVLFNGQKLANDNGITWDAVKTARYADSQTVARPKSPQEIAIYQRSVDRIYNMFVNKV
AQGRKLPTQKVAQIAQGRVWSGVTAKQIGLVDEIGGLNAAIEYAAKAAKLGKDWQLREYPRESSFEERFFGGVVEEISTT
LGIEKLDVKPNDPLTVQIRKIQQEISVLQTMNDPQGVYARLPVNLKIE

Specific function: Digestion of the cleaved signal peptides. This activity is necessary to maintain proper secretion of mature proteins across the membrane [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1788064, Length=568, Percent_Identity=34.8591549295775, Blast_Score=299, Evalue=3e-82,
Organism=Escherichia coli, GI1787527, Length=167, Percent_Identity=28.7425149700599, Blast_Score=74, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004634
- InterPro:   IPR004635
- InterPro:   IPR002142 [H]

Pfam domain/function: PF01343 Peptidase_S49 [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 66708; Mature: 66577

Theoretical pI: Translated: 9.85; Mature: 9.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNFFKQTLASLLGTLLGLFLFAGAGTTGLLLLLFAAASSSNTSPVVKDKSVVVLDLSMN
CCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCEECCCEEEEEEEEC
ITDREPSAGEELQNRFSGVTQERMTLRNVIDSLEKAQRDKRIVAIYLDGSRGGNNLGFAS
CCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHH
LKEIRKALEEFRKSGKKVIAYGVSWNEREYYLSSVADTIALNPLGGLEINGLSSQPMFVA
HHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHEECCCCCEEECCCCCCCCHHH
GALQKYGIGVQVVRAGKFKGAVEPFVLNKLSPENREQTQKLLDDVWGEWRTTVGNSRKIN
HHHHHHCCCEEEEEECCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
PQKLQAIADNQSLLEPTEAKTNGLVDQVAYNDQVVADLKKLTGSDKKDNTFTQISLRRYA
HHHHHHHHCCCHHCCCCHHHHCCCHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHH
QVPGQSLGVARNSKNKIAVVYAEGDIVDGKGDDGQIGGDRFARIFNKIRQDENVKAVVLR
HCCCCCCCCEECCCCCEEEEEECCEEECCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEE
INSPGGSATASEVMQREIRLTRESKPVVVSMGDYAASGGYWIATDSNRIFAEPNTITGSI
EECCCCCHHHHHHHHHHHHHHCCCCCEEEEECCEECCCCEEEEECCCEEEECCCCEEECC
GVFGVLFNGQKLANDNGITWDAVKTARYADSQTVARPKSPQEIAIYQRSVDRIYNMFVNK
EEEEEEECCCEECCCCCCEEHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
VAQGRKLPTQKVAQIAQGRVWSGVTAKQIGLVDEIGGLNAAIEYAAKAAKLGKDWQLREY
HHCCCCCCHHHHHHHHCCCCCCCCCHHHHCCHHHHCCCHHHHHHHHHHHHCCCCCCHHCC
PRESSFEERFFGGVVEEISTTLGIEKLDVKPNDPLTVQIRKIQQEISVLQTMNDPQGVYA
CCCCCHHHHHHHHHHHHHHHHCCCEEECCCCCCCCEEHHHHHHHHHHHHHHCCCCCCEEE
RLPVNLKIE
ECCEEEEEC
>Mature Secondary Structure 
SNFFKQTLASLLGTLLGLFLFAGAGTTGLLLLLFAAASSSNTSPVVKDKSVVVLDLSMN
CHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCEECCCEEEEEEEEC
ITDREPSAGEELQNRFSGVTQERMTLRNVIDSLEKAQRDKRIVAIYLDGSRGGNNLGFAS
CCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHH
LKEIRKALEEFRKSGKKVIAYGVSWNEREYYLSSVADTIALNPLGGLEINGLSSQPMFVA
HHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHEECCCCCEEECCCCCCCCHHH
GALQKYGIGVQVVRAGKFKGAVEPFVLNKLSPENREQTQKLLDDVWGEWRTTVGNSRKIN
HHHHHHCCCEEEEEECCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
PQKLQAIADNQSLLEPTEAKTNGLVDQVAYNDQVVADLKKLTGSDKKDNTFTQISLRRYA
HHHHHHHHCCCHHCCCCHHHHCCCHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHH
QVPGQSLGVARNSKNKIAVVYAEGDIVDGKGDDGQIGGDRFARIFNKIRQDENVKAVVLR
HCCCCCCCCEECCCCCEEEEEECCEEECCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEE
INSPGGSATASEVMQREIRLTRESKPVVVSMGDYAASGGYWIATDSNRIFAEPNTITGSI
EECCCCCHHHHHHHHHHHHHHCCCCCEEEEECCEECCCCEEEEECCCEEEECCCCEEECC
GVFGVLFNGQKLANDNGITWDAVKTARYADSQTVARPKSPQEIAIYQRSVDRIYNMFVNK
EEEEEEECCCEECCCCCCEEHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
VAQGRKLPTQKVAQIAQGRVWSGVTAKQIGLVDEIGGLNAAIEYAAKAAKLGKDWQLREY
HHCCCCCCHHHHHHHHCCCCCCCCCHHHHCCHHHHCCCHHHHHHHHHHHHCCCCCCHHCC
PRESSFEERFFGGVVEEISTTLGIEKLDVKPNDPLTVQIRKIQQEISVLQTMNDPQGVYA
CCCCCHHHHHHHHHHHHHHHHCCCEEECCCCCCCCEEHHHHHHHHHHHHHHCCCCCCEEE
RLPVNLKIE
ECCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]