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The map label for this gene is glsA [H]

Identifier: 75908660

GI number: 75908660

Start: 3037234

End: 3038157

Strand: Direct

Name: glsA [H]

Synonym: Ava_2446

Alternate gene names: 75908660

Gene position: 3037234-3038157 (Clockwise)

Preceding gene: 75908658

Following gene: 75908662

Centisome position: 47.71

GC content: 43.4

Gene sequence:

>924_bases
GTGAGGGGATTTGATAGACTAGACACCGTGGATTTGTCTACTTGGGTAGCATTAGCAAAAACTAAGACAAATTGTGGACG
AGTGGTTGAGCGCATCCCAAGATTAGCTGTGGCTGACACCGCTTGGTTTGCTGTACACATCTGTTGTAAATCAGGTAAAT
TCTACAGCGAAGGAGATACCAATTGTGTATTTCCCCTAATGAGTGTGATTAAACCTTTTACTTTCCTGTATCTATTGGAA
CACATGGGAATGGAAAAGGTTTTAAGCTGGGTTGGTGTGAAACCATCAGATGCGCCTTTTAATTCCTTAGAACAACTAGT
GGCTGATGGTGGATATCCACGGAACCCGATGATTAATAGTGGGGCTATTACTCTCGCTGATAAATTACTAGGAGAGGATG
CAGATTATAGCACGCGCTCTTTTTGCGAATGGCTAAACCAATTGGCAGGTAGTCAGATTCAGTTAGATGAATCTATGCTG
GCTTCTGTCAGATTATCTCGCTCTCCTGCTAATCAGGCGATCGCTAATTATCTGGCAGAAAAGGGTTATTTAGGAAATCT
TGATGTAGCACTTGATACTTATGAACAGATATGCTGTCTCTCTGGGACGGTTGAAGATTTAGCTTTACTGGGGAAACTCT
TGGCTTTAGAAAGTAGCTCAATATCACCACAGCATCAACAGCTTGTTAACTCGGTCATGTTATCTTGTGGTTTATACCAA
GCTTCTGCTGAGTATGCTGACAAAATTGGTTTACCGATGAAATCTGGGATTGGTGGGGGTTTACTCGCTGTAGTCCCAAA
AGAAGGGGCGATCGCCTGTTATAGCCCAGCTTTAGATAGAATCGGTAATCCCGTAGGGGCGATCGCTTTTGTTGAGGTTT
TATCCCGTTCTCTAGGTCTGTGCGGGAGATTTTCCCACCTTTAG

Upstream 100 bases:

>100_bases
TAATAAAAAATATTTTGTTTTTAAGAGATGCAGAGGAGAGGAAAGAGGGTTTAGGGGAAAAATAGAATGACTACGATAAA
TCTTTGGGGCTGTATCTATT

Downstream 100 bases:

>100_bases
CCAAAAACTAACGCTTTGGATGATCAGCCATGCTTAAGGTTTGGCGATCGCACCAGTTCGCCAGCCGACAACTGGGTTAA
TATCTTCAGCAATCGCTTTG

Product: glutaminase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MRGFDRLDTVDLSTWVALAKTKTNCGRVVERIPRLAVADTAWFAVHICCKSGKFYSEGDTNCVFPLMSVIKPFTFLYLLE
HMGMEKVLSWVGVKPSDAPFNSLEQLVADGGYPRNPMINSGAITLADKLLGEDADYSTRSFCEWLNQLAGSQIQLDESML
ASVRLSRSPANQAIANYLAEKGYLGNLDVALDTYEQICCLSGTVEDLALLGKLLALESSSISPQHQQLVNSVMLSCGLYQ
ASAEYADKIGLPMKSGIGGGLLAVVPKEGAIACYSPALDRIGNPVGAIAFVEVLSRSLGLCGRFSHL

Sequences:

>Translated_307_residues
MRGFDRLDTVDLSTWVALAKTKTNCGRVVERIPRLAVADTAWFAVHICCKSGKFYSEGDTNCVFPLMSVIKPFTFLYLLE
HMGMEKVLSWVGVKPSDAPFNSLEQLVADGGYPRNPMINSGAITLADKLLGEDADYSTRSFCEWLNQLAGSQIQLDESML
ASVRLSRSPANQAIANYLAEKGYLGNLDVALDTYEQICCLSGTVEDLALLGKLLALESSSISPQHQQLVNSVMLSCGLYQ
ASAEYADKIGLPMKSGIGGGLLAVVPKEGAIACYSPALDRIGNPVGAIAFVEVLSRSLGLCGRFSHL
>Mature_307_residues
MRGFDRLDTVDLSTWVALAKTKTNCGRVVERIPRLAVADTAWFAVHICCKSGKFYSEGDTNCVFPLMSVIKPFTFLYLLE
HMGMEKVLSWVGVKPSDAPFNSLEQLVADGGYPRNPMINSGAITLADKLLGEDADYSTRSFCEWLNQLAGSQIQLDESML
ASVRLSRSPANQAIANYLAEKGYLGNLDVALDTYEQICCLSGTVEDLALLGKLLALESSSISPQHQQLVNSVMLSCGLYQ
ASAEYADKIGLPMKSGIGGGLLAVVPKEGAIACYSPALDRIGNPVGAIAFVEVLSRSLGLCGRFSHL

Specific function: Unknown

COG id: COG2066

COG function: function code E; Glutaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutaminase family [H]

Homologues:

Organism=Homo sapiens, GI156104878, Length=289, Percent_Identity=33.5640138408304, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI20336214, Length=281, Percent_Identity=31.3167259786477, Blast_Score=130, Evalue=2e-30,
Organism=Escherichia coli, GI1787804, Length=283, Percent_Identity=34.6289752650177, Blast_Score=166, Evalue=1e-42,
Organism=Escherichia coli, GI1786693, Length=306, Percent_Identity=33.9869281045752, Blast_Score=133, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17507019, Length=296, Percent_Identity=33.1081081081081, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17532727, Length=290, Percent_Identity=32.4137931034483, Blast_Score=128, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI193204073, Length=288, Percent_Identity=29.8611111111111, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI193204075, Length=290, Percent_Identity=29.3103448275862, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI281363241, Length=296, Percent_Identity=33.1081081081081, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI116008307, Length=296, Percent_Identity=33.1081081081081, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24653164, Length=296, Percent_Identity=33.1081081081081, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI281363239, Length=296, Percent_Identity=33.1081081081081, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24653158, Length=296, Percent_Identity=33.1081081081081, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24653162, Length=296, Percent_Identity=33.1081081081081, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24653156, Length=296, Percent_Identity=33.1081081081081, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24653166, Length=296, Percent_Identity=33.1081081081081, Blast_Score=139, Evalue=3e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR015868 [H]

Pfam domain/function: PF04960 Glutaminase [H]

EC number: =3.5.1.2 [H]

Molecular weight: Translated: 33114; Mature: 33114

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00146 BETA_LACTAMASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGFDRLDTVDLSTWVALAKTKTNCGRVVERIPRLAVADTAWFAVHICCKSGKFYSEGDT
CCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCC
NCVFPLMSVIKPFTFLYLLEHMGMEKVLSWVGVKPSDAPFNSLEQLVADGGYPRNPMINS
CHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCC
GAITLADKLLGEDADYSTRSFCEWLNQLAGSQIQLDESMLASVRLSRSPANQAIANYLAE
CHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEHHHHHHHHHHHCCCCHHHHHHHHHHH
KGYLGNLDVALDTYEQICCLSGTVEDLALLGKLLALESSSISPQHQQLVNSVMLSCGLYQ
CCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
ASAEYADKIGLPMKSGIGGGLLAVVPKEGAIACYSPALDRIGNPVGAIAFVEVLSRSLGL
HHHHHHHHCCCCHHCCCCCCEEEEECCCCCEEEECHHHHHHCCCHHHHHHHHHHHHHHHH
CGRFSHL
HHHCCCC
>Mature Secondary Structure
MRGFDRLDTVDLSTWVALAKTKTNCGRVVERIPRLAVADTAWFAVHICCKSGKFYSEGDT
CCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCC
NCVFPLMSVIKPFTFLYLLEHMGMEKVLSWVGVKPSDAPFNSLEQLVADGGYPRNPMINS
CHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCC
GAITLADKLLGEDADYSTRSFCEWLNQLAGSQIQLDESMLASVRLSRSPANQAIANYLAE
CHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEHHHHHHHHHHHCCCCHHHHHHHHHHH
KGYLGNLDVALDTYEQICCLSGTVEDLALLGKLLALESSSISPQHQQLVNSVMLSCGLYQ
CCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
ASAEYADKIGLPMKSGIGGGLLAVVPKEGAIACYSPALDRIGNPVGAIAFVEVLSRSLGL
HHHHHHHHCCCCHHCCCCCCEEEEECCCCCEEEECHHHHHHCCCHHHHHHHHHHHHHHHH
CGRFSHL
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]