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The map label for this gene is rnz [H]

Identifier: 75908619

GI number: 75908619

Start: 2987510

End: 2988547

Strand: Direct

Name: rnz [H]

Synonym: Ava_2403

Alternate gene names: 75908619

Gene position: 2987510-2988547 (Clockwise)

Preceding gene: 75908618

Following gene: 75908621

Centisome position: 46.93

GC content: 45.28

Gene sequence:

>1038_bases
TTGCCCAGCAACCATGCCACTATAGAAGACATAGCTTTAAACATAGCAAGAAAAAGGCTAGAAAACGCTGTGCAGATTAC
ATTTTTAGGGACAAGTTCTGGTGTACCCACAAGAGCGCGCAATGTTTCCAGCGTTGCGCTGAGACTACCGCAACGGGCAG
AGTTGTGGTTATTCGACTGTGGCGAAGGTACTCAACACCAAATTTTGCGGAGTGACTTAAAAGTCAGCCAATTGTCCCGA
ATATTTATTACCCATCTGCATGGTGATCACATTTTTGGTTTAATGGGTCTTCTTGCTAGTTGTGGCTTGGCGGGTAATGT
TCAAAGAGTTGATATTTATGGCCCATCGGGTTTAAACGAGTATATCCAATCCGCTTCTCGTTATTCTCATACACATTTCT
CCTATCCCATTAAAATCCATACTGTCCGCCCTGGTGTCATATATGAAGATGATGAATTTACCGTGACTTGTGGACTATTA
CATCATCGCATCACCGCCTTTGGCTATCGCGTAGCCGAAAAAGACCGAGCCGGACGCTTTGATATAGAAAAAGCCAAAGA
ATTGCAAATCCCACCTGGGAGAGTTTATGGTCAACTCAAGCGTGGTGAAACCGTTACCCTTGAAGATGGGCGTGTCATTA
ATGGCGCTGAATTATGCGGCCCCACAGAAATTGGGCGGAAAATGGCCTACTGCACAGACACAATATATTGTGATGGTGCT
GTTGAGTTAGCTCAGGATGCAGACGTGTTAATCCACGAAGCCACCTTTGCCCATCAAGATTCAGAAATGGCTTTTCAGCG
ATTACACTCAACAACCACAATGGCAGCGCAAACAGCCTTAGCTGCTGGAGTGCGTCGATTACTGATGACTCACTTCAGTC
CTCGCTATGCACCTGGTAACACCATAGAGTTAAAAGATTTGCTACAAGAAGCCCGTGCCATCTTTCCTCGTACAGATATG
GCCTATGATTTTATGACTTATGAAGTACCCAGGCGACGAGAACCAATTTTAAGCTCAGTCTCCTCAAGTTCGGTGTAG

Upstream 100 bases:

>100_bases
AAATTCCAGCGATCGCCCCAAATCCCCCAAGGAACCATCTGCGAATTATCTTGGCCAGTCAGTCAGTTTTGGAGATAGTA
ATCCCCAAATTCCCAGCAAT

Downstream 100 bases:

>100_bases
GGCTTGACAGGTAAACCCCAATGGCCTTAGGAGTTAATCTGGTGGGGTGCGTTACAACTAAAATCTATAACGCACCGGAA
ATCTCGGATGCTGCGTTGTG

Product: ribonuclease Z

Products: NA

Alternate protein names: RNase Z; tRNA 3 endonuclease; tRNase Z [H]

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MPSNHATIEDIALNIARKRLENAVQITFLGTSSGVPTRARNVSSVALRLPQRAELWLFDCGEGTQHQILRSDLKVSQLSR
IFITHLHGDHIFGLMGLLASCGLAGNVQRVDIYGPSGLNEYIQSASRYSHTHFSYPIKIHTVRPGVIYEDDEFTVTCGLL
HHRITAFGYRVAEKDRAGRFDIEKAKELQIPPGRVYGQLKRGETVTLEDGRVINGAELCGPTEIGRKMAYCTDTIYCDGA
VELAQDADVLIHEATFAHQDSEMAFQRLHSTTTMAAQTALAAGVRRLLMTHFSPRYAPGNTIELKDLLQEARAIFPRTDM
AYDFMTYEVPRRREPILSSVSSSSV

Sequences:

>Translated_345_residues
MPSNHATIEDIALNIARKRLENAVQITFLGTSSGVPTRARNVSSVALRLPQRAELWLFDCGEGTQHQILRSDLKVSQLSR
IFITHLHGDHIFGLMGLLASCGLAGNVQRVDIYGPSGLNEYIQSASRYSHTHFSYPIKIHTVRPGVIYEDDEFTVTCGLL
HHRITAFGYRVAEKDRAGRFDIEKAKELQIPPGRVYGQLKRGETVTLEDGRVINGAELCGPTEIGRKMAYCTDTIYCDGA
VELAQDADVLIHEATFAHQDSEMAFQRLHSTTTMAAQTALAAGVRRLLMTHFSPRYAPGNTIELKDLLQEARAIFPRTDM
AYDFMTYEVPRRREPILSSVSSSSV
>Mature_344_residues
PSNHATIEDIALNIARKRLENAVQITFLGTSSGVPTRARNVSSVALRLPQRAELWLFDCGEGTQHQILRSDLKVSQLSRI
FITHLHGDHIFGLMGLLASCGLAGNVQRVDIYGPSGLNEYIQSASRYSHTHFSYPIKIHTVRPGVIYEDDEFTVTCGLLH
HRITAFGYRVAEKDRAGRFDIEKAKELQIPPGRVYGQLKRGETVTLEDGRVINGAELCGPTEIGRKMAYCTDTIYCDGAV
ELAQDADVLIHEATFAHQDSEMAFQRLHSTTTMAAQTALAAGVRRLLMTHFSPRYAPGNTIELKDLLQEARAIFPRTDMA
YDFMTYEVPRRREPILSSVSSSSV

Specific function: Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA [H]

COG id: COG1234

COG function: function code R; Metal-dependent hydrolases of the beta-lactamase superfamily III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase Z family [H]

Homologues:

Organism=Homo sapiens, GI8922122, Length=364, Percent_Identity=35.4395604395604, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI260166619, Length=188, Percent_Identity=30.8510638297872, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI87082078, Length=308, Percent_Identity=44.1558441558442, Blast_Score=267, Evalue=9e-73,
Organism=Drosophila melanogaster, GI24652403, Length=230, Percent_Identity=28.695652173913, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR013471 [H]

Pfam domain/function: PF00753 Lactamase_B [H]

EC number: =3.1.26.11 [H]

Molecular weight: Translated: 38407; Mature: 38276

Theoretical pI: Translated: 7.20; Mature: 7.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSNHATIEDIALNIARKRLENAVQITFLGTSSGVPTRARNVSSVALRLPQRAELWLFDC
CCCCCCHHHHHHHHHHHHHHCCEEEEEEEECCCCCCHHHCCHHHHHHCCCCCCCEEEEEC
GEGTQHQILRSDLKVSQLSRIFITHLHGDHIFGLMGLLASCGLAGNVQRVDIYGPSGLNE
CCCCHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCHHH
YIQSASRYSHTHFSYPIKIHTVRPGVIYEDDEFTVTCGLLHHRITAFGYRVAEKDRAGRF
HHHHHHHCCCCEEECCEEEEEECCCEEEECCCEEEEHHHHHHHHHHHHHHHHCCCCCCCC
DIEKAKELQIPPGRVYGQLKRGETVTLEDGRVINGAELCGPTEIGRKMAYCTDTIYCDGA
CCCHHHHCCCCCHHHHHEECCCCEEEECCCEEECCHHHCCHHHHHHHHHHHCCEEEECCH
VELAQDADVLIHEATFAHQDSEMAFQRLHSTTTMAAQTALAAGVRRLLMTHFSPRYAPGN
HHHHCCCCEEEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
TIELKDLLQEARAIFPRTDMAYDFMTYEVPRRREPILSSVSSSSV
EEEHHHHHHHHHHHCCCCCCEEEHEEECCCCCCCHHHHHHHCCCC
>Mature Secondary Structure 
PSNHATIEDIALNIARKRLENAVQITFLGTSSGVPTRARNVSSVALRLPQRAELWLFDC
CCCCCHHHHHHHHHHHHHHCCEEEEEEEECCCCCCHHHCCHHHHHHCCCCCCCEEEEEC
GEGTQHQILRSDLKVSQLSRIFITHLHGDHIFGLMGLLASCGLAGNVQRVDIYGPSGLNE
CCCCHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCHHH
YIQSASRYSHTHFSYPIKIHTVRPGVIYEDDEFTVTCGLLHHRITAFGYRVAEKDRAGRF
HHHHHHHCCCCEEECCEEEEEECCCEEEECCCEEEEHHHHHHHHHHHHHHHHCCCCCCCC
DIEKAKELQIPPGRVYGQLKRGETVTLEDGRVINGAELCGPTEIGRKMAYCTDTIYCDGA
CCCHHHHCCCCCHHHHHEECCCCEEEECCCEEECCHHHCCHHHHHHHHHHHCCEEEECCH
VELAQDADVLIHEATFAHQDSEMAFQRLHSTTTMAAQTALAAGVRRLLMTHFSPRYAPGN
HHHHCCCCEEEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
TIELKDLLQEARAIFPRTDMAYDFMTYEVPRRREPILSSVSSSSV
EEEHHHHHHHHHHHCCCCCCEEEHEEECCCCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]