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The map label for this gene is icfA [H]

Identifier: 75908384

GI number: 75908384

Start: 2678940

End: 2679614

Strand: Direct

Name: icfA [H]

Synonym: Ava_2165

Alternate gene names: 75908384

Gene position: 2678940-2679614 (Clockwise)

Preceding gene: 75908383

Following gene: 75908388

Centisome position: 42.08

GC content: 39.41

Gene sequence:

>675_bases
GTGCCGATTAAGCGCATTATCGCTGGGCTAAATGAATTTCATGACAACTATTTTGTAGCTCATCGTGAGTTATTTGAGCA
TTTGTCTCATGGGCAAAATCCTGAGCTTTTGTTTATCACTTGCTCAGACTCAAGAATAGATCCGTTCTTAATCACACAAA
GCCAACCAGGGGACTTATTTGTGATTCGCAATGTTGGTAATATTATCCCACCTTATAGTAGGTTGAACGGTGGGGAAGCT
GCGGGGATAGAATATGCTGTTGAGGCTTTAGGTATTAAAGATATTGTTATTTGTGGACATTCTCATTGTGGTGCGATGAA
GGGATTACTGCAAATAGGGAATCTTGCCCAACAAATGCCTTCAGTTTATGAATGGTTGAGGTGTCATGCTGAAGCTACCC
GCCGCCTTGTGATGGACAACTACCAAGGTTATTCTCACGAGAAACTGTTAAAAATTGCTATTGAGCAAAACGTTCTTACA
CAGATAGAAAATTTAGAGACTTACCCCGTAATCCGTTCTAAACTTCATAGTGGTCAGCTGACACTTCATGCTTGGATTTA
TGAAATTGAAACTGGAGAAGTGTTTGCTTATGATGCTGAAAATAGTCAATTTAAAGTTATAGAGAATCGTCTATTTCCTG
TGCCTAATCCTTTGACAAATTTACACTCAGCCTAA

Upstream 100 bases:

>100_bases
TATTAAGCATAATTGGAGTTACAATTCATAATTGAGTCATGAATCAGTTGGAAACACATAAGCAACAATATATTAATAGT
TGATTAAGGAGAATTTAACT

Downstream 100 bases:

>100_bases
AAATATAGGCTTTATAGTAGTTTTTCTCAGTATAAATATGTGGAACTTTATTAGGGCTTACGCACCCAGATTTTCTGTTG
AGACAGGGTGTAAGGGTGTA

Product: carbonic anhydrase

Products: NA

Alternate protein names: Carbonate dehydratase [H]

Number of amino acids: Translated: 224; Mature: 223

Protein sequence:

>224_residues
MPIKRIIAGLNEFHDNYFVAHRELFEHLSHGQNPELLFITCSDSRIDPFLITQSQPGDLFVIRNVGNIIPPYSRLNGGEA
AGIEYAVEALGIKDIVICGHSHCGAMKGLLQIGNLAQQMPSVYEWLRCHAEATRRLVMDNYQGYSHEKLLKIAIEQNVLT
QIENLETYPVIRSKLHSGQLTLHAWIYEIETGEVFAYDAENSQFKVIENRLFPVPNPLTNLHSA

Sequences:

>Translated_224_residues
MPIKRIIAGLNEFHDNYFVAHRELFEHLSHGQNPELLFITCSDSRIDPFLITQSQPGDLFVIRNVGNIIPPYSRLNGGEA
AGIEYAVEALGIKDIVICGHSHCGAMKGLLQIGNLAQQMPSVYEWLRCHAEATRRLVMDNYQGYSHEKLLKIAIEQNVLT
QIENLETYPVIRSKLHSGQLTLHAWIYEIETGEVFAYDAENSQFKVIENRLFPVPNPLTNLHSA
>Mature_223_residues
PIKRIIAGLNEFHDNYFVAHRELFEHLSHGQNPELLFITCSDSRIDPFLITQSQPGDLFVIRNVGNIIPPYSRLNGGEAA
GIEYAVEALGIKDIVICGHSHCGAMKGLLQIGNLAQQMPSVYEWLRCHAEATRRLVMDNYQGYSHEKLLKIAIEQNVLTQ
IENLETYPVIRSKLHSGQLTLHAWIYEIETGEVFAYDAENSQFKVIENRLFPVPNPLTNLHSA

Specific function: Reversible hydration of carbon dioxide. Essential to photosynthetic carbon dioxide fixation [H]

COG id: COG0288

COG function: function code P; Carbonic anhydrase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-class carbonic anhydrase family [H]

Homologues:

Organism=Escherichia coli, GI1786534, Length=203, Percent_Identity=44.3349753694581, Blast_Score=181, Evalue=2e-47,
Organism=Escherichia coli, GI1786318, Length=192, Percent_Identity=30.2083333333333, Blast_Score=88, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI25147564, Length=257, Percent_Identity=29.1828793774319, Blast_Score=100, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI115532990, Length=243, Percent_Identity=29.6296296296296, Blast_Score=97, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6324292, Length=176, Percent_Identity=27.8409090909091, Blast_Score=69, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24645213, Length=238, Percent_Identity=26.4705882352941, Blast_Score=96, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001765
- InterPro:   IPR015892 [H]

Pfam domain/function: PF00484 Pro_CA [H]

EC number: =4.2.1.1 [H]

Molecular weight: Translated: 25351; Mature: 25220

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS00704 PROK_CO2_ANHYDRASE_1 ; PS00705 PROK_CO2_ANHYDRASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIKRIIAGLNEFHDNYFVAHRELFEHLSHGQNPELLFITCSDSRIDPFLITQSQPGDLF
CCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEECCCCCCEE
VIRNVGNIIPPYSRLNGGEAAGIEYAVEALGIKDIVICGHSHCGAMKGLLQIGNLAQQMP
EECCCCCCCCCHHHCCCCCCCCHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHH
SVYEWLRCHAEATRRLVMDNYQGYSHEKLLKIAIEQNVLTQIENLETYPVIRSKLHSGQL
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCE
TLHAWIYEIETGEVFAYDAENSQFKVIENRLFPVPNPLTNLHSA
EEEEEEEEEECCCEEEEECCCCEEEEECCCCCCCCCCHHHCCCC
>Mature Secondary Structure 
PIKRIIAGLNEFHDNYFVAHRELFEHLSHGQNPELLFITCSDSRIDPFLITQSQPGDLF
CHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEECCCCCCEE
VIRNVGNIIPPYSRLNGGEAAGIEYAVEALGIKDIVICGHSHCGAMKGLLQIGNLAQQMP
EECCCCCCCCCHHHCCCCCCCCHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHH
SVYEWLRCHAEATRRLVMDNYQGYSHEKLLKIAIEQNVLTQIENLETYPVIRSKLHSGQL
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCE
TLHAWIYEIETGEVFAYDAENSQFKVIENRLFPVPNPLTNLHSA
EEEEEEEEEECCCEEEEECCCCEEEEECCCCCCCCCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1584776 [H]