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The map label for this gene is accC [H]

Identifier: 75675945

GI number: 75675945

Start: 1922196

End: 1923551

Strand: Direct

Name: accC [H]

Synonym: Nwi_1753

Alternate gene names: 75675945

Gene position: 1922196-1923551 (Clockwise)

Preceding gene: 75675944

Following gene: 75675946

Centisome position: 56.5

GC content: 62.83

Gene sequence:

>1356_bases
ATGTTCGATAAGATCCTGATAGCCAATCGCGGCGAGATCGCCCTGCGCATCCTGCGCGCCTGCAAGGAGCTGGGTATCGC
GACCGTTGCGGTCCATTCCACCGCCGACGCCGACGCCATGCATGTCCGCCTCGCGGACGAAAGCGTCTGCATCGGGCCGC
CGACGACGAAGGACAGCTACCTCAACATCCCGGCGCTGCTGGCAGCCTGCGAGATCACAGGCGCCGAGGCCGTGCATCCG
GGGTACGGCTTTTTGTCCGAGAATGCCCGTTTCGCCGAAATCCTCGCTGACCATCGCCTGCATTTCATCGGCCCCAAGGC
CGAACATATCCGCCTCATGGGCGACAAGATCGAAGCCAAGAAGACCGCGAAGCGCCTCGGCATTCCCGTGGTTCCGGGCT
CCGATGGCGGCATCGGTCCCGATGACAACGCCATGGCCATCGCCAAGGCGATCGGCTTTCCTGTCCTGGTGAAAGCGGCC
GCCGGCGGCGGCGGGCGCGGCATGAAGATCGTCAAGACGCCCGACGACCTGATGATGGCGATCTCGGCCGCGGGGAACGA
GGCCCGAGCGGCGTTCGGCGACGCCTCCGTTTATCTGGAAAAGTACTTGCAGAAGCCGCGCCACATCGAAATCCAGGTGC
TTGGCGACGGGCGCGGCGGCGCCATTCATCTTGGAGAACGCGACTGCTCGCTCCAGCGCCGCCACCAGAAGGTTTGGGAA
GAAGGTCCATCGCCCGCGTTGACGGCGGCAGCCCGAAACAAGATCGGCGAGACCGTTGCCAAGGCGATGAGCGAGATAAA
GTATCTCGGCGTCGGAACGGTCGAATTCCTCTACGAGGACGGCAGATTCTATTTCATCGAAATGAATACGCGCATTCAGG
TCGAGCATCCCGTCACCGAGATGATCACCGACATCGATCTCGTGCTGGAGCAGATCCGCATCGCCGCCGGCGGCGACCTT
CCCGCCGCCCAGAAGGAAATCGCCGTCAACGGCCACGCCATCGAGTGCCGAATCAACGCGGAAAACCCCGTTACCTTCCG
CCCATCTCCTGGCAAGATTTTGCAATTCCATCCGCCGGGCGGGCTCGGCGTCCGGATCGATTCCGCCGTTTATCAGGGGT
ATGTGATCCCGCCCTACTACGACTCGCTGGTGGGCAAGCTGATCGTGCACGGCAAGACGCGCGCCGAATGCCTGATGCGG
CTGCGCAGAGCCCTCGACGAGATGGTCGTGGAAGGCGTCGAGACCACCTTGCCGCTGTTCCGGGCGCTGGTCCGCGAAGC
GAGCATTATCGACGGCGACTACCATATCCATTGGCTGGAGCAGTATCTCTCCAGCGGCGGTCTAAAAGGAGCCTGA

Upstream 100 bases:

>100_bases
GGCACCGTCACGCAGATTCTCGTCGAGGATGGCCAGCCCGTCGAGTTCGGCGAGCCGCTGGTCATCATTGAATGACGCCG
TTCGAACCGCGGACGCAGTG

Downstream 100 bases:

>100_bases
GCCGTTTCGAGCCCGGACCGGGATTGTTTTAGGAACAAAAGACACGGAACCGATTGCGCGCTGAGGGGTTTAGCAAAAGG
CCGGTAAACGCGCGGGGGCG

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MFDKILIANRGEIALRILRACKELGIATVAVHSTADADAMHVRLADESVCIGPPTTKDSYLNIPALLAACEITGAEAVHP
GYGFLSENARFAEILADHRLHFIGPKAEHIRLMGDKIEAKKTAKRLGIPVVPGSDGGIGPDDNAMAIAKAIGFPVLVKAA
AGGGGRGMKIVKTPDDLMMAISAAGNEARAAFGDASVYLEKYLQKPRHIEIQVLGDGRGGAIHLGERDCSLQRRHQKVWE
EGPSPALTAAARNKIGETVAKAMSEIKYLGVGTVEFLYEDGRFYFIEMNTRIQVEHPVTEMITDIDLVLEQIRIAAGGDL
PAAQKEIAVNGHAIECRINAENPVTFRPSPGKILQFHPPGGLGVRIDSAVYQGYVIPPYYDSLVGKLIVHGKTRAECLMR
LRRALDEMVVEGVETTLPLFRALVREASIIDGDYHIHWLEQYLSSGGLKGA

Sequences:

>Translated_451_residues
MFDKILIANRGEIALRILRACKELGIATVAVHSTADADAMHVRLADESVCIGPPTTKDSYLNIPALLAACEITGAEAVHP
GYGFLSENARFAEILADHRLHFIGPKAEHIRLMGDKIEAKKTAKRLGIPVVPGSDGGIGPDDNAMAIAKAIGFPVLVKAA
AGGGGRGMKIVKTPDDLMMAISAAGNEARAAFGDASVYLEKYLQKPRHIEIQVLGDGRGGAIHLGERDCSLQRRHQKVWE
EGPSPALTAAARNKIGETVAKAMSEIKYLGVGTVEFLYEDGRFYFIEMNTRIQVEHPVTEMITDIDLVLEQIRIAAGGDL
PAAQKEIAVNGHAIECRINAENPVTFRPSPGKILQFHPPGGLGVRIDSAVYQGYVIPPYYDSLVGKLIVHGKTRAECLMR
LRRALDEMVVEGVETTLPLFRALVREASIIDGDYHIHWLEQYLSSGGLKGA
>Mature_451_residues
MFDKILIANRGEIALRILRACKELGIATVAVHSTADADAMHVRLADESVCIGPPTTKDSYLNIPALLAACEITGAEAVHP
GYGFLSENARFAEILADHRLHFIGPKAEHIRLMGDKIEAKKTAKRLGIPVVPGSDGGIGPDDNAMAIAKAIGFPVLVKAA
AGGGGRGMKIVKTPDDLMMAISAAGNEARAAFGDASVYLEKYLQKPRHIEIQVLGDGRGGAIHLGERDCSLQRRHQKVWE
EGPSPALTAAARNKIGETVAKAMSEIKYLGVGTVEFLYEDGRFYFIEMNTRIQVEHPVTEMITDIDLVLEQIRIAAGGDL
PAAQKEIAVNGHAIECRINAENPVTFRPSPGKILQFHPPGGLGVRIDSAVYQGYVIPPYYDSLVGKLIVHGKTRAECLMR
LRRALDEMVVEGVETTLPLFRALVREASIIDGDYHIHWLEQYLSSGGLKGA

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI65506442, Length=453, Percent_Identity=48.3443708609272, Blast_Score=413, Evalue=1e-115,
Organism=Homo sapiens, GI189095269, Length=449, Percent_Identity=48.3296213808463, Blast_Score=413, Evalue=1e-115,
Organism=Homo sapiens, GI295821183, Length=453, Percent_Identity=48.3443708609272, Blast_Score=413, Evalue=1e-115,
Organism=Homo sapiens, GI116805327, Length=442, Percent_Identity=42.9864253393665, Blast_Score=378, Evalue=1e-105,
Organism=Homo sapiens, GI106049528, Length=445, Percent_Identity=44.7191011235955, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI106049295, Length=445, Percent_Identity=44.7191011235955, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI106049292, Length=445, Percent_Identity=44.7191011235955, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI38679977, Length=513, Percent_Identity=29.6296296296296, Blast_Score=222, Evalue=5e-58,
Organism=Homo sapiens, GI38679967, Length=513, Percent_Identity=29.6296296296296, Blast_Score=222, Evalue=5e-58,
Organism=Homo sapiens, GI38679974, Length=513, Percent_Identity=29.6296296296296, Blast_Score=222, Evalue=6e-58,
Organism=Homo sapiens, GI38679960, Length=513, Percent_Identity=29.6296296296296, Blast_Score=222, Evalue=6e-58,
Organism=Homo sapiens, GI38679971, Length=513, Percent_Identity=29.6296296296296, Blast_Score=222, Evalue=7e-58,
Organism=Homo sapiens, GI134142062, Length=505, Percent_Identity=29.1089108910891, Blast_Score=217, Evalue=2e-56,
Organism=Escherichia coli, GI1789654, Length=444, Percent_Identity=60.5855855855856, Blast_Score=531, Evalue=1e-152,
Organism=Caenorhabditis elegans, GI17567343, Length=449, Percent_Identity=45.2115812917595, Blast_Score=387, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI71987519, Length=439, Percent_Identity=42.8246013667426, Blast_Score=355, Evalue=2e-98,
Organism=Caenorhabditis elegans, GI17562816, Length=450, Percent_Identity=42.2222222222222, Blast_Score=346, Evalue=1e-95,
Organism=Caenorhabditis elegans, GI71997168, Length=507, Percent_Identity=28.2051282051282, Blast_Score=201, Evalue=9e-52,
Organism=Caenorhabditis elegans, GI71997163, Length=507, Percent_Identity=28.2051282051282, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI133931226, Length=491, Percent_Identity=27.0875763747454, Blast_Score=184, Evalue=7e-47,
Organism=Saccharomyces cerevisiae, GI6319685, Length=427, Percent_Identity=42.8571428571429, Blast_Score=345, Evalue=6e-96,
Organism=Saccharomyces cerevisiae, GI6319695, Length=447, Percent_Identity=41.6107382550336, Blast_Score=318, Evalue=9e-88,
Organism=Saccharomyces cerevisiae, GI6321376, Length=447, Percent_Identity=42.5055928411633, Blast_Score=316, Evalue=5e-87,
Organism=Saccharomyces cerevisiae, GI6324343, Length=522, Percent_Identity=29.3103448275862, Blast_Score=214, Evalue=3e-56,
Organism=Saccharomyces cerevisiae, GI6323863, Length=469, Percent_Identity=31.5565031982942, Blast_Score=213, Evalue=5e-56,
Organism=Drosophila melanogaster, GI24652212, Length=447, Percent_Identity=45.413870246085, Blast_Score=378, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652210, Length=447, Percent_Identity=45.413870246085, Blast_Score=378, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652214, Length=447, Percent_Identity=45.413870246085, Blast_Score=378, Evalue=1e-105,
Organism=Drosophila melanogaster, GI19921944, Length=447, Percent_Identity=45.413870246085, Blast_Score=378, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652216, Length=447, Percent_Identity=45.413870246085, Blast_Score=378, Evalue=1e-105,
Organism=Drosophila melanogaster, GI281363050, Length=447, Percent_Identity=45.413870246085, Blast_Score=378, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652224, Length=447, Percent_Identity=45.413870246085, Blast_Score=378, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652222, Length=447, Percent_Identity=45.413870246085, Blast_Score=378, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652220, Length=447, Percent_Identity=45.413870246085, Blast_Score=378, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652218, Length=447, Percent_Identity=45.413870246085, Blast_Score=378, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24651757, Length=446, Percent_Identity=43.2735426008969, Blast_Score=373, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24651759, Length=410, Percent_Identity=42.1951219512195, Blast_Score=333, Evalue=1e-91,
Organism=Drosophila melanogaster, GI161076409, Length=497, Percent_Identity=28.7726358148893, Blast_Score=206, Evalue=3e-53,
Organism=Drosophila melanogaster, GI24586458, Length=497, Percent_Identity=28.7726358148893, Blast_Score=206, Evalue=3e-53,
Organism=Drosophila melanogaster, GI161076407, Length=497, Percent_Identity=28.7726358148893, Blast_Score=206, Evalue=4e-53,
Organism=Drosophila melanogaster, GI24586460, Length=497, Percent_Identity=28.7726358148893, Blast_Score=206, Evalue=4e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 48775; Mature: 48775

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDKILIANRGEIALRILRACKELGIATVAVHSTADADAMHVRLADESVCIGPPTTKDSY
CCCCEEEECCCHHHHHHHHHHHHCCEEEEEEECCCCCCEEEEEECCCCEECCCCCCCCCC
LNIPALLAACEITGAEAVHPGYGFLSENARFAEILADHRLHFIGPKAEHIRLMGDKIEAK
CCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCEEEECCCHHHEEEECCHHHHH
KTAKRLGIPVVPGSDGGIGPDDNAMAIAKAIGFPVLVKAAAGGGGRGMKIVKTPDDLMMA
HHHHHCCCEECCCCCCCCCCCCCHHHHHHHCCCCEEEEEECCCCCCCEEEEECCHHHHHH
ISAAGNEARAAFGDASVYLEKYLQKPRHIEIQVLGDGRGGAIHLGERDCSLQRRHQKVWE
HHCCCCCHHHHCCHHHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCHHHHHHHHHHHH
EGPSPALTAAARNKIGETVAKAMSEIKYLGVGTVEFLYEDGRFYFIEMNTRIQVEHPVTE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEEEECCEEEECCCHHH
MITDIDLVLEQIRIAAGGDLPAAQKEIAVNGHAIECRINAENPVTFRPSPGKILQFHPPG
HHHHHHHHHHHHHHHCCCCCCCCCCEEEECCEEEEEEECCCCCEEECCCCCCEEEECCCC
GLGVRIDSAVYQGYVIPPYYDSLVGKLIVHGKTRAECLMRLRRALDEMVVEGVETTLPLF
CCEEEEEHHHHCCEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RALVREASIIDGDYHIHWLEQYLSSGGLKGA
HHHHHHHHCCCCCEEHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MFDKILIANRGEIALRILRACKELGIATVAVHSTADADAMHVRLADESVCIGPPTTKDSY
CCCCEEEECCCHHHHHHHHHHHHCCEEEEEEECCCCCCEEEEEECCCCEECCCCCCCCCC
LNIPALLAACEITGAEAVHPGYGFLSENARFAEILADHRLHFIGPKAEHIRLMGDKIEAK
CCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCEEEECCCHHHEEEECCHHHHH
KTAKRLGIPVVPGSDGGIGPDDNAMAIAKAIGFPVLVKAAAGGGGRGMKIVKTPDDLMMA
HHHHHCCCEECCCCCCCCCCCCCHHHHHHHCCCCEEEEEECCCCCCCEEEEECCHHHHHH
ISAAGNEARAAFGDASVYLEKYLQKPRHIEIQVLGDGRGGAIHLGERDCSLQRRHQKVWE
HHCCCCCHHHHCCHHHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCHHHHHHHHHHHH
EGPSPALTAAARNKIGETVAKAMSEIKYLGVGTVEFLYEDGRFYFIEMNTRIQVEHPVTE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEEEECCEEEECCCHHH
MITDIDLVLEQIRIAAGGDLPAAQKEIAVNGHAIECRINAENPVTFRPSPGKILQFHPPG
HHHHHHHHHHHHHHHCCCCCCCCCCEEEECCEEEEEEECCCCCEEECCCCCCEEEECCCC
GLGVRIDSAVYQGYVIPPYYDSLVGKLIVHGKTRAECLMRLRRALDEMVVEGVETTLPLF
CCEEEEEHHHHCCEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RALVREASIIDGDYHIHWLEQYLSSGGLKGA
HHHHHHHHCCCCCEEHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7693652; 10984043 [H]