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The map label for this gene is purL [H]

Identifier: 75675500

GI number: 75675500

Start: 1440187

End: 1442400

Strand: Direct

Name: purL [H]

Synonym: Nwi_1308

Alternate gene names: 75675500

Gene position: 1440187-1442400 (Clockwise)

Preceding gene: 75675499

Following gene: 75675501

Centisome position: 42.33

GC content: 65.09

Gene sequence:

>2214_bases
GTGATTGTCCGCAACGAACCTCCAATCACGCCTGAACTCGTCGCCTCGCACGGCCTCAAGCCGGACGAGTATGAGCGCAT
CCTGAAGCTGCTCGGCCGGACGCCGACATTCACCGAACTCGGTATCTTCTCGGCGATGTGGAACGAGCATTGCTCGTACA
AGTCCTCGCGTATCCATCTGCGCGGGCTGCCGACGAAGGCGCCTTGGGTGATCCAGGGCCCCGGCGAGAATGCCGGCGTC
ATCGACATCGGCGACGGGCAGGCGGTGGTGTTCAAGATGGAGAGCCACAACCATCCGAGCTACATCGAGCCTTATCAGGG
CGCGACCACCGGCGTCGGCGGCATCCTGCGCGATGTCTTCACCATGGGCGCGCGCCCGATCGCCTGCCTTAACGCGCTGA
GCTTCGGTGATCCGTCGCATCCGAAAACGCGACACCTCGTCTCCGGCGTGGTGGCTGGCGTCGGCGGCTACGGCAATTCG
TTCGGGGTGCCGACCGTGGGCGGGCAGGTGCGCTTTCACACCCGCTATGACGGCAACATCCTCGTCAACGCCATGGCGGT
CGGTCTCGCCGATGCCGACAGGATTTTCTATGCGGCGGCGTCGGGCGTGAACATGCCGATCGTCTATCTCGGCTCCAAGA
CCGGCCGCGACGGCATCCACGGCGCGACCATGGCGTCGGCCGAGTTCGACGACGACAGCGAGGAGAAGCGTCCGACCGTT
CAGGTCGGCGATCCCTTCGCTGAAAAGCTGCTGCTGGAAGCCTGTCTCGAAATCATGGCGAAGGGATGCGTCGTCGCCAT
CCAGGACATGGGCGCGGCGGGGCTGACGTGCTCGGCGGTGGAAATGGGCGCCAAGGGCGATCTCGGCGTCGATCTCGATC
TCGACAGCGTGCCGACGCGCGAAACCGGCATGAGCGCCTACGAGATGATGCTTTCGGAGAGCCAGGAGCGGATGCTCATG
GTGCTCAAGCCCGAGAAGGAAAAGGAAGCGGAGGCGATCTTCAGGAAGTGGGGGCTCGATTTCGCGATTGTCGGCTCCAC
CACGCCGGGCAGGCGCTTCGTGGTTCGGCACGGCGGCGATGTGATGGCCGACCTGCCGATCAAGGAGCTTGAATCGGAAG
CGCCCTTGTATGACCGGCCGCATGTGCCGTCGCCGCAATTGCCCGTCATTCAGGCGCGCGACGTCGCGCCGTCCCTGACG
ACAGCCGACGCGCTGGAGAAGCTGCTCGCGATGCCCGAACTGTGCTCCAAGCGCTGGGTATGGGAGCAGTACGACCATGT
CATCGGCGGCAACACGGTGCAGCGTCCCGGCGGCGATGCGGCGGTGGTGCGCGTCGAGGACGGGCCGAAGGGTCTCGCGC
TGACGGTTGATGTGACGCCGCGCTATTGCGAGGCCGATCCGTTTGAGGGCGGCAAGCAGGCGGTGGCCGAAGCCTGGCGC
AACATCACGGCAGTCGGCGGACGTCCGCTGGCGATCACCGACAACCTGAACTTCGGCAATCCGGAACGGCCTGAGAACAT
GGGCCAGTTCGTCGGCTGCCTGAAAGGCATCGCGGCGGCCTGCACCGCGCTGGATTTCCCGGTCGTGTCCGGCAACGTCT
CCCTTTATAACGAGACTAACGGCCGCGGCATTCTGCCGACGCCCACCATCGGCGGCGTCGGGCTGCTCGATGACTTCACG
AAATCGGCCTCGCTTGCCTTCAAGGCAGAGGGGCATCCGATCCTGCTGATCGGCGACACCCAGGGATGGCTCGGCCAGTC
GGTTTACCTGCGCGACATTTGCCGGCGCGAGGAGGGAGCGCCGCCGCCGGTCGATCTCGCCGCGGAGAAGCGCAACGGCG
ATGTGGTGCGCGGCATGATCCACGCCGGCACCGCGACGGCCGTTCATGACGTGTCTGACGGCGGGCTTCTCGTCGCGCTG
GCGGAAATGGCGATGGCTGATGGCATCGGCGCGGCACTCGATGCCGCTCCGGCGGCGATCGTGCCGTATGCGTGGTGGTT
CGGCGAGGATCAGGCGCGCTATATCGTGACCGTTCACGAGCGGGATCTGTTGAGCGTTTTTACCAAGCTCAAGGCGGTGA
ACGTGCCCTGCATTCAGATCGGGCTCACGGGTGGTCATGAGATCGCTATCGCAGGCGAGCGCGCTGTCGACCTCAAGGTC
TTGCGGCAAGGCTTTGAAAGCTGGCTGCCGGACTACATGGCCGGAAAGCCGTGA

Upstream 100 bases:

>100_bases
TAAATCGATCCGGCCATATGCTGAGCCAAGATAGAGATGTTATTATTCAGACGGCGAGAAAAATAATAGGGTTAGACAGT
GGCTCTGGAGCCTGCTTGTA

Downstream 100 bases:

>100_bases
TGCGCCGGGAGACGACGTATGGCGCACGCGGTTGCGGCGAACACGCAGGCGCGGGCCGTCTTGCCGCGGCCGTCTTGCGG
TTGAACCGGTTCGTGCAAAT

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II [H]

Number of amino acids: Translated: 737; Mature: 737

Protein sequence:

>737_residues
MIVRNEPPITPELVASHGLKPDEYERILKLLGRTPTFTELGIFSAMWNEHCSYKSSRIHLRGLPTKAPWVIQGPGENAGV
IDIGDGQAVVFKMESHNHPSYIEPYQGATTGVGGILRDVFTMGARPIACLNALSFGDPSHPKTRHLVSGVVAGVGGYGNS
FGVPTVGGQVRFHTRYDGNILVNAMAVGLADADRIFYAAASGVNMPIVYLGSKTGRDGIHGATMASAEFDDDSEEKRPTV
QVGDPFAEKLLLEACLEIMAKGCVVAIQDMGAAGLTCSAVEMGAKGDLGVDLDLDSVPTRETGMSAYEMMLSESQERMLM
VLKPEKEKEAEAIFRKWGLDFAIVGSTTPGRRFVVRHGGDVMADLPIKELESEAPLYDRPHVPSPQLPVIQARDVAPSLT
TADALEKLLAMPELCSKRWVWEQYDHVIGGNTVQRPGGDAAVVRVEDGPKGLALTVDVTPRYCEADPFEGGKQAVAEAWR
NITAVGGRPLAITDNLNFGNPERPENMGQFVGCLKGIAAACTALDFPVVSGNVSLYNETNGRGILPTPTIGGVGLLDDFT
KSASLAFKAEGHPILLIGDTQGWLGQSVYLRDICRREEGAPPPVDLAAEKRNGDVVRGMIHAGTATAVHDVSDGGLLVAL
AEMAMADGIGAALDAAPAAIVPYAWWFGEDQARYIVTVHERDLLSVFTKLKAVNVPCIQIGLTGGHEIAIAGERAVDLKV
LRQGFESWLPDYMAGKP

Sequences:

>Translated_737_residues
MIVRNEPPITPELVASHGLKPDEYERILKLLGRTPTFTELGIFSAMWNEHCSYKSSRIHLRGLPTKAPWVIQGPGENAGV
IDIGDGQAVVFKMESHNHPSYIEPYQGATTGVGGILRDVFTMGARPIACLNALSFGDPSHPKTRHLVSGVVAGVGGYGNS
FGVPTVGGQVRFHTRYDGNILVNAMAVGLADADRIFYAAASGVNMPIVYLGSKTGRDGIHGATMASAEFDDDSEEKRPTV
QVGDPFAEKLLLEACLEIMAKGCVVAIQDMGAAGLTCSAVEMGAKGDLGVDLDLDSVPTRETGMSAYEMMLSESQERMLM
VLKPEKEKEAEAIFRKWGLDFAIVGSTTPGRRFVVRHGGDVMADLPIKELESEAPLYDRPHVPSPQLPVIQARDVAPSLT
TADALEKLLAMPELCSKRWVWEQYDHVIGGNTVQRPGGDAAVVRVEDGPKGLALTVDVTPRYCEADPFEGGKQAVAEAWR
NITAVGGRPLAITDNLNFGNPERPENMGQFVGCLKGIAAACTALDFPVVSGNVSLYNETNGRGILPTPTIGGVGLLDDFT
KSASLAFKAEGHPILLIGDTQGWLGQSVYLRDICRREEGAPPPVDLAAEKRNGDVVRGMIHAGTATAVHDVSDGGLLVAL
AEMAMADGIGAALDAAPAAIVPYAWWFGEDQARYIVTVHERDLLSVFTKLKAVNVPCIQIGLTGGHEIAIAGERAVDLKV
LRQGFESWLPDYMAGKP
>Mature_737_residues
MIVRNEPPITPELVASHGLKPDEYERILKLLGRTPTFTELGIFSAMWNEHCSYKSSRIHLRGLPTKAPWVIQGPGENAGV
IDIGDGQAVVFKMESHNHPSYIEPYQGATTGVGGILRDVFTMGARPIACLNALSFGDPSHPKTRHLVSGVVAGVGGYGNS
FGVPTVGGQVRFHTRYDGNILVNAMAVGLADADRIFYAAASGVNMPIVYLGSKTGRDGIHGATMASAEFDDDSEEKRPTV
QVGDPFAEKLLLEACLEIMAKGCVVAIQDMGAAGLTCSAVEMGAKGDLGVDLDLDSVPTRETGMSAYEMMLSESQERMLM
VLKPEKEKEAEAIFRKWGLDFAIVGSTTPGRRFVVRHGGDVMADLPIKELESEAPLYDRPHVPSPQLPVIQARDVAPSLT
TADALEKLLAMPELCSKRWVWEQYDHVIGGNTVQRPGGDAAVVRVEDGPKGLALTVDVTPRYCEADPFEGGKQAVAEAWR
NITAVGGRPLAITDNLNFGNPERPENMGQFVGCLKGIAAACTALDFPVVSGNVSLYNETNGRGILPTPTIGGVGLLDDFT
KSASLAFKAEGHPILLIGDTQGWLGQSVYLRDICRREEGAPPPVDLAAEKRNGDVVRGMIHAGTATAVHDVSDGGLLVAL
AEMAMADGIGAALDAAPAAIVPYAWWFGEDQARYIVTVHERDLLSVFTKLKAVNVPCIQIGLTGGHEIAIAGERAVDLKV
LRQGFESWLPDYMAGKP

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family [H]

Homologues:

Organism=Homo sapiens, GI31657129, Length=685, Percent_Identity=25.5474452554745, Blast_Score=122, Evalue=2e-27,
Organism=Escherichia coli, GI48994899, Length=755, Percent_Identity=24.635761589404, Blast_Score=127, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17553022, Length=438, Percent_Identity=24.2009132420091, Blast_Score=92, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6321498, Length=736, Percent_Identity=23.2336956521739, Blast_Score=111, Evalue=5e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.5.3 [H]

Molecular weight: Translated: 78780; Mature: 78780

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVRNEPPITPELVASHGLKPDEYERILKLLGRTPTFTELGIFSAMWNEHCSYKSSRIHL
CCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCEEEE
RGLPTKAPWVIQGPGENAGVIDIGDGQAVVFKMESHNHPSYIEPYQGATTGVGGILRDVF
EECCCCCCEEEECCCCCCCEEEECCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHH
TMGARPIACLNALSFGDPSHPKTRHLVSGVVAGVGGYGNSFGVPTVGGQVRFHTRYDGNI
HHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCCE
LVNAMAVGLADADRIFYAAASGVNMPIVYLGSKTGRDGIHGATMASAEFDDDSEEKRPTV
EEEEEEECCCCCCCEEEEECCCCCCCEEEECCCCCCCCCCCCEEECCCCCCCCHHCCCEE
QVGDPFAEKLLLEACLEIMAKGCVVAIQDMGAAGLTCSAVEMGAKGDLGVDLDLDSVPTR
EECCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEHHEECCCCCCCCEEECCCCCCCC
ETGMSAYEMMLSESQERMLMVLKPEKEKEAEAIFRKWGLDFAIVGSTTPGRRFVVRHGGD
HHCHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEECCCCCCEEEEECCCC
VMADLPIKELESEAPLYDRPHVPSPQLPVIQARDVAPSLTTADALEKLLAMPELCSKRWV
EEECCCHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCC
WEQYDHVIGGNTVQRPGGDAAVVRVEDGPKGLALTVDVTPRYCEADPFEGGKQAVAEAWR
HHHHHHHHCCCEECCCCCCEEEEEECCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHH
NITAVGGRPLAITDNLNFGNPERPENMGQFVGCLKGIAAACTALDFPVVSGNVSLYNETN
CEEECCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEECCEEEEECCC
GRGILPTPTIGGVGLLDDFTKSASLAFKAEGHPILLIGDTQGWLGQSVYLRDICRREEGA
CCEECCCCCCCCCCHHHHHCCCCCEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHCCCC
PPPVDLAAEKRNGDVVRGMIHAGTATAVHDVSDGGLLVALAEMAMADGIGAALDAAPAAI
CCCCCCCCCCCCCCEEEEEEECCCCEEEEECCCCCHHHHHHHHHHHCCCCHHHHCCCCHH
VPYAWWFGEDQARYIVTVHERDLLSVFTKLKAVNVPCIQIGLTGGHEIAIAGERAVDLKV
HCEEEECCCCCCEEEEEECCHHHHHHHHHHHHCCCCEEEEEECCCCEEEEECCCHHHHHH
LRQGFESWLPDYMAGKP
HHHHHHHHCCHHHCCCC
>Mature Secondary Structure
MIVRNEPPITPELVASHGLKPDEYERILKLLGRTPTFTELGIFSAMWNEHCSYKSSRIHL
CCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCEEEE
RGLPTKAPWVIQGPGENAGVIDIGDGQAVVFKMESHNHPSYIEPYQGATTGVGGILRDVF
EECCCCCCEEEECCCCCCCEEEECCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHH
TMGARPIACLNALSFGDPSHPKTRHLVSGVVAGVGGYGNSFGVPTVGGQVRFHTRYDGNI
HHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCCE
LVNAMAVGLADADRIFYAAASGVNMPIVYLGSKTGRDGIHGATMASAEFDDDSEEKRPTV
EEEEEEECCCCCCCEEEEECCCCCCCEEEECCCCCCCCCCCCEEECCCCCCCCHHCCCEE
QVGDPFAEKLLLEACLEIMAKGCVVAIQDMGAAGLTCSAVEMGAKGDLGVDLDLDSVPTR
EECCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEHHEECCCCCCCCEEECCCCCCCC
ETGMSAYEMMLSESQERMLMVLKPEKEKEAEAIFRKWGLDFAIVGSTTPGRRFVVRHGGD
HHCHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEECCCCCCEEEEECCCC
VMADLPIKELESEAPLYDRPHVPSPQLPVIQARDVAPSLTTADALEKLLAMPELCSKRWV
EEECCCHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCC
WEQYDHVIGGNTVQRPGGDAAVVRVEDGPKGLALTVDVTPRYCEADPFEGGKQAVAEAWR
HHHHHHHHCCCEECCCCCCEEEEEECCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHH
NITAVGGRPLAITDNLNFGNPERPENMGQFVGCLKGIAAACTALDFPVVSGNVSLYNETN
CEEECCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEECCEEEEECCC
GRGILPTPTIGGVGLLDDFTKSASLAFKAEGHPILLIGDTQGWLGQSVYLRDICRREEGA
CCEECCCCCCCCCCHHHHHCCCCCEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHCCCC
PPPVDLAAEKRNGDVVRGMIHAGTATAVHDVSDGGLLVALAEMAMADGIGAALDAAPAAI
CCCCCCCCCCCCCCEEEEEEECCCCEEEEECCCCCHHHHHHHHHHHCCCCHHHHCCCCHH
VPYAWWFGEDQARYIVTVHERDLLSVFTKLKAVNVPCIQIGLTGGHEIAIAGERAVDLKV
HCEEEECCCCCCEEEEEECCHHHHHHHHHHHHCCCCEEEEEECCCCEEEEECCCHHHHHH
LRQGFESWLPDYMAGKP
HHHHHHHHCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA