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The map label for this gene is yusP [H]

Identifier: 75675345

GI number: 75675345

Start: 1263841

End: 1265391

Strand: Direct

Name: yusP [H]

Synonym: Nwi_1152

Alternate gene names: 75675345

Gene position: 1263841-1265391 (Clockwise)

Preceding gene: 75675344

Following gene: 75675346

Centisome position: 37.15

GC content: 66.22

Gene sequence:

>1551_bases
ATGAATACTTATGAGCGCCTGGGTCGGGGTCCGTCCGGTCCCCCGATTTCGTCCGGCGAAGGCGCGGCACGTCCCGGTTT
CGCTGAAGGCGAGGGCGATGCGCCGCCGGTCGTCGTGTCGCCCGCCCAGCCGGGCCGGAGCGAGATCCGCACCATCCTGG
TCAGCCTGATGCTGACCATGTTTCTCGCCGCCCTCGACCAGACCATCGTCGCAACCGCGCTGCCGACCATCGGCCGCCAG
TTCCACGACGTCACCACGCTGGCGTGGATCATCACGGCGTATCTTCTGGCGTCGACAGCGGTCGCGCCGTTGTTCGGCAC
GCTGAGCGATATTTACGGCCGCCGCGCCATGATCGTCACCGCGCTTGGCCTGTTCATCGCGGGTTCGGTCCTGTGTGCGC
TGGCGCAGAACATGGCGACGCTGATCGTGGCGCGCGGCGTGCAGGGCATCGGCGGCGGCGGCATCCTGCCCTTGGTGCAG
ACAATCATTTCCGATGTGGTGACGCCGCGGGAGCGCGGCCAGTACCAGGCTTATTTCAGCGGCGTGTGGACCGCGGCCGG
CATCGCCGGGCCGGTGCTTGGCGGCGTATTCGCCGAGCACCTGCACTGGTCGATGATCTTCTGGATCAACGTGCCGCTCG
GGCTCGTCTCGCTGGCGTTGCTGTTGCCGAAGATGGGCGGCATCCCGGCGTTTCACCGCCGCCGCAAAGTGGACTGGACC
GGCGGCCTGCTGTTGATGACGTCGGCTGTGGTATTCATGCTGGTGCTGACATGGGGCGGCAACCGTTTCGCCTGGTTCTC
GCGGGAAATCGTCGCCATGCTGGGAATCTCGCTGGTGCTTGCCGCCGTCTTCGTCTGGCACGCGCGCAAGGCGTCCGAAC
CCTTCCTGCCGCTGTCGCTGATAGGCGGTTCGGTGGTTCCGTATGCGATAGCCGCGAGTGCTCTCGCGCTCAGTGCGATC
ATCGGGATCACCGTGCATCTGCCGTTGTATTACCAGGCCGTCCATCATCTCGGCGTCAGCGAATCCGGACTGGCGCTGAT
TCCGATCGCGGCGGTTTCGACCGGCGGCGCGATGCTTGCGGGCCGCGCCATGACGCATACCCTCCATTACAAACGGATCG
CGATCGTCGGCACCGCGTTCGCGGCTGTGATGGCCGCGATCATGGCTGCGGTGACGATGCCGCTATGGCCGCTGCTGGCG
ATGCTCTCGCTGTTCGCGTTTGGTCTCGGCACCATCTTTCCGGTCAGCGTGGTGTCGCTGCAGAATGCGGTGATGCGCGA
GCAGGTCGGAACCGTCACCGGCGCGATGAACTTTTTTCGCGCGCTCGCCTGTTCCTTCGTCGTCGCCGCGTTCGCCGCCA
TCCTGCTGATGACACTGGGAACCGACGCCATGATCGGCCATGAGGGAGGCGGCCGGCTCAGTGCGATCCAGGCGTCGGAC
CTCACGAGGGCGTTCCGTTACGTGTTCGCCGCCACGGCCGCGATGATGGCCGCCGCCGCGTTGCTGCTGGTGCGAATGGA
AGAGCGGCCGCTGGCCGGCCCTTCGGCCTGA

Upstream 100 bases:

>100_bases
TTCTTTGCCCGTCGCTGTCGGAAGTCGCACCCCACCATTAAATAGCAAGTAGAAAACCGCGGCAGCCTCCGCGCCTTGAG
CCAGATCATATTCCGTCCGC

Downstream 100 bases:

>100_bases
TCCGCGCGGGGGAGGTTCGTCGCCGGGGACTTTCACAGCTTCACGGAAGCGCTGAAATCTCCAGCCTTTTGATCTGATGC
GTTTTCTTCACGCGAACCAG

Product: major facilitator transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 516; Mature: 516

Protein sequence:

>516_residues
MNTYERLGRGPSGPPISSGEGAARPGFAEGEGDAPPVVVSPAQPGRSEIRTILVSLMLTMFLAALDQTIVATALPTIGRQ
FHDVTTLAWIITAYLLASTAVAPLFGTLSDIYGRRAMIVTALGLFIAGSVLCALAQNMATLIVARGVQGIGGGGILPLVQ
TIISDVVTPRERGQYQAYFSGVWTAAGIAGPVLGGVFAEHLHWSMIFWINVPLGLVSLALLLPKMGGIPAFHRRRKVDWT
GGLLLMTSAVVFMLVLTWGGNRFAWFSREIVAMLGISLVLAAVFVWHARKASEPFLPLSLIGGSVVPYAIAASALALSAI
IGITVHLPLYYQAVHHLGVSESGLALIPIAAVSTGGAMLAGRAMTHTLHYKRIAIVGTAFAAVMAAIMAAVTMPLWPLLA
MLSLFAFGLGTIFPVSVVSLQNAVMREQVGTVTGAMNFFRALACSFVVAAFAAILLMTLGTDAMIGHEGGGRLSAIQASD
LTRAFRYVFAATAAMMAAAALLLVRMEERPLAGPSA

Sequences:

>Translated_516_residues
MNTYERLGRGPSGPPISSGEGAARPGFAEGEGDAPPVVVSPAQPGRSEIRTILVSLMLTMFLAALDQTIVATALPTIGRQ
FHDVTTLAWIITAYLLASTAVAPLFGTLSDIYGRRAMIVTALGLFIAGSVLCALAQNMATLIVARGVQGIGGGGILPLVQ
TIISDVVTPRERGQYQAYFSGVWTAAGIAGPVLGGVFAEHLHWSMIFWINVPLGLVSLALLLPKMGGIPAFHRRRKVDWT
GGLLLMTSAVVFMLVLTWGGNRFAWFSREIVAMLGISLVLAAVFVWHARKASEPFLPLSLIGGSVVPYAIAASALALSAI
IGITVHLPLYYQAVHHLGVSESGLALIPIAAVSTGGAMLAGRAMTHTLHYKRIAIVGTAFAAVMAAIMAAVTMPLWPLLA
MLSLFAFGLGTIFPVSVVSLQNAVMREQVGTVTGAMNFFRALACSFVVAAFAAILLMTLGTDAMIGHEGGGRLSAIQASD
LTRAFRYVFAATAAMMAAAALLLVRMEERPLAGPSA
>Mature_516_residues
MNTYERLGRGPSGPPISSGEGAARPGFAEGEGDAPPVVVSPAQPGRSEIRTILVSLMLTMFLAALDQTIVATALPTIGRQ
FHDVTTLAWIITAYLLASTAVAPLFGTLSDIYGRRAMIVTALGLFIAGSVLCALAQNMATLIVARGVQGIGGGGILPLVQ
TIISDVVTPRERGQYQAYFSGVWTAAGIAGPVLGGVFAEHLHWSMIFWINVPLGLVSLALLLPKMGGIPAFHRRRKVDWT
GGLLLMTSAVVFMLVLTWGGNRFAWFSREIVAMLGISLVLAAVFVWHARKASEPFLPLSLIGGSVVPYAIAASALALSAI
IGITVHLPLYYQAVHHLGVSESGLALIPIAAVSTGGAMLAGRAMTHTLHYKRIAIVGTAFAAVMAAIMAAVTMPLWPLLA
MLSLFAFGLGTIFPVSVVSLQNAVMREQVGTVTGAMNFFRALACSFVVAAFAAILLMTLGTDAMIGHEGGGRLSAIQASD
LTRAFRYVFAATAAMMAAAALLLVRMEERPLAGPSA

Specific function: Translocase That Confers Resistance To Substances Of High Hydrophobicity. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1789042, Length=344, Percent_Identity=27.906976744186, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1790195, Length=244, Percent_Identity=31.9672131147541, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788710, Length=467, Percent_Identity=25.0535331905782, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI87081983, Length=427, Percent_Identity=25.2927400468384, Blast_Score=96, Evalue=8e-21,
Organism=Escherichia coli, GI1788392, Length=328, Percent_Identity=28.0487804878049, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI1790146, Length=282, Percent_Identity=25.177304964539, Blast_Score=66, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6323735, Length=439, Percent_Identity=27.3348519362187, Blast_Score=144, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6322958, Length=449, Percent_Identity=26.0579064587973, Blast_Score=120, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6319770, Length=393, Percent_Identity=26.2086513994911, Blast_Score=112, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6325455, Length=253, Percent_Identity=29.6442687747036, Blast_Score=107, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6321663, Length=377, Percent_Identity=23.8726790450928, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6320324, Length=186, Percent_Identity=30.1075268817204, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322071, Length=217, Percent_Identity=24.4239631336406, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6325414, Length=213, Percent_Identity=24.4131455399061, Blast_Score=63, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 54048; Mature: 54048

Theoretical pI: Translated: 10.01; Mature: 10.01

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTYERLGRGPSGPPISSGEGAARPGFAEGEGDAPPVVVSPAQPGRSEIRTILVSLMLTM
CCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHH
FLAALDQTIVATALPTIGRQFHDVTTLAWIITAYLLASTAVAPLFGTLSDIYGRRAMIVT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
ALGLFIAGSVLCALAQNMATLIVARGVQGIGGGGILPLVQTIISDVVTPRERGQYQAYFS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHCCCHHHHHH
GVWTAAGIAGPVLGGVFAEHLHWSMIFWINVPLGLVSLALLLPKMGGIPAFHRRRKVDWT
HHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHCCCCCHHHHCCCCCCC
GGLLLMTSAVVFMLVLTWGGNRFAWFSREIVAMLGISLVLAAVFVWHARKASEPFLPLSL
CHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
IGGSVVPYAIAASALALSAIIGITVHLPLYYQAVHHLGVSESGLALIPIAAVSTGGAMLA
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHCCCCHHHH
GRAMTHTLHYKRIAIVGTAFAAVMAAIMAAVTMPLWPLLAMLSLFAFGLGTIFPVSVVSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QNAVMREQVGTVTGAMNFFRALACSFVVAAFAAILLMTLGTDAMIGHEGGGRLSAIQASD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCEEEEHHHH
LTRAFRYVFAATAAMMAAAALLLVRMEERPLAGPSA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MNTYERLGRGPSGPPISSGEGAARPGFAEGEGDAPPVVVSPAQPGRSEIRTILVSLMLTM
CCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHH
FLAALDQTIVATALPTIGRQFHDVTTLAWIITAYLLASTAVAPLFGTLSDIYGRRAMIVT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
ALGLFIAGSVLCALAQNMATLIVARGVQGIGGGGILPLVQTIISDVVTPRERGQYQAYFS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHCCCHHHHHH
GVWTAAGIAGPVLGGVFAEHLHWSMIFWINVPLGLVSLALLLPKMGGIPAFHRRRKVDWT
HHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHCCCCCHHHHCCCCCCC
GGLLLMTSAVVFMLVLTWGGNRFAWFSREIVAMLGISLVLAAVFVWHARKASEPFLPLSL
CHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
IGGSVVPYAIAASALALSAIIGITVHLPLYYQAVHHLGVSESGLALIPIAAVSTGGAMLA
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHCCCCHHHH
GRAMTHTLHYKRIAIVGTAFAAVMAAIMAAVTMPLWPLLAMLSLFAFGLGTIFPVSVVSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QNAVMREQVGTVTGAMNFFRALACSFVVAAFAAILLMTLGTDAMIGHEGGGRLSAIQASD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCEEEEHHHH
LTRAFRYVFAATAAMMAAAALLLVRMEERPLAGPSA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]