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The map label for this gene is phoR [H]

Identifier: 75674703

GI number: 75674703

Start: 562171

End: 563424

Strand: Direct

Name: phoR [H]

Synonym: Nwi_0505

Alternate gene names: 75674703

Gene position: 562171-563424 (Clockwise)

Preceding gene: 75674702

Following gene: 75674704

Centisome position: 16.52

GC content: 65.79

Gene sequence:

>1254_bases
TTGCGCCGCGTCGCGCTCATTCTGCTGGTTGCCGGACTTGCATTGGCCGCGCTGGTTGTGTTCGGCGGCTTGCAACCTCT
GGGCGCCACCGTCGCTTTCGCCTGCATCGCCGGCGCGGCGCTGGTGCCCTGGCAGGTTCATGATCCGGATGCGTCGCGTG
AAATCGAGTTCGGAGCCAACCCGGTAGAGACGGATGTGGCGCGTGCTCTCGTGGCCGGCATGCCGGATCCCAATGTGCTG
CTTGATAGGGCCGGCCGCGTCATCCATCTCAATGCTGCGGCGGCGCAACTCGTACCGGCGCTGCGCCGGAATGAACTCGC
GCAGTTCGCGCTGCGGGCGCCTGAGATCGTCACCGCGTTGCGAGAGGCGATTGCGACCAGGGAGGCTCGGCGGGCGACCT
ATCTCAATCATGTTCCGGTCGATCGGTGGATGGAATTGATCATCACGCCGATTCCGGTGCCGACCGCATTCGGTGGTGTC
GACTATTGCATGCTTTTGACGTTTCACGATCAGACGCCGTTGCGCCGGGTCGAGGAAATGCGCGCCGATTTCGTCGCCAA
TGCGAGCCACGAGTTGCGCACGCCGCTCGCGGCGCTGTCAGGATTCATCGACACTCTCCAGGGGCCCGCGCGCGAGGACG
CCCGCGCCCGCGAGCGGTTTCTCGGCATCATGCATGCGCAGGCGGCGCGGATGGCGCGGCTGATCGACGATCTCCTGTCG
CTGTCGCGGGTCGAGCTATCGGTGCATGTGCGCCCGGAGACGATCGTCGACATTGTTCCGATCGTGCGCGAGGTCGTCGA
CGGACTTGAGCCGCTTGCGGCGGAACGTCACGTCGAGATCGAGACCGCATTGCCGGAAACCCCGGTGCTGATCTGCGGCG
ACCGTGAGGAATTGCTGCGATTGTTCGAGAACCTGATCGAGAACGCGCTGAAATACGGCGCGTCCGGTGGCCGGGTCATG
GTGTCGTCGATGCTCGACGTCTCGTCGGAGGGGAACCCGGAATTCCGGGTGGTGGTGCGGGATTTCGGTCCCGGCATCGC
ACCTGAGCATCTGCCCCGCCTGACCGAACGCTTCTATCGGGTCGACGCCGGCGACAGCCGGGCTCAGGGCGGCACAGGCC
TCGGCCTGTCGCTGGTGAAGCATATCCTCAACCGGCATCGCGGCCGTCTGCTGATCGAGAGCGTGCCCGGCCAGGGCGCG
AGCTTTACCGCCGGCTTCCCACCGGCGCGGGACGTGCCGGAGGCAAGAAGCTGA

Upstream 100 bases:

>100_bases
CACGGCGATTCTGGCGCCTGACAGCACTCAAGCGGTTGCGGAAGGAAACGCCGTCCGCGCCCCAGGGTTCGCCGCGAGGT
CCACATCCTGGCCGGACCGG

Downstream 100 bases:

>100_bases
ACAGATAGAGATGCTTGGCGCTGTCATCCCGCTGTCGTCAAGCGTTCGTAAAAGCGGCAAGGGTCGCATCTAAGAAGGTG
TCATGAGCGTCCTGCGCTCT

Product: Signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MRRVALILLVAGLALAALVVFGGLQPLGATVAFACIAGAALVPWQVHDPDASREIEFGANPVETDVARALVAGMPDPNVL
LDRAGRVIHLNAAAAQLVPALRRNELAQFALRAPEIVTALREAIATREARRATYLNHVPVDRWMELIITPIPVPTAFGGV
DYCMLLTFHDQTPLRRVEEMRADFVANASHELRTPLAALSGFIDTLQGPAREDARARERFLGIMHAQAARMARLIDDLLS
LSRVELSVHVRPETIVDIVPIVREVVDGLEPLAAERHVEIETALPETPVLICGDREELLRLFENLIENALKYGASGGRVM
VSSMLDVSSEGNPEFRVVVRDFGPGIAPEHLPRLTERFYRVDAGDSRAQGGTGLGLSLVKHILNRHRGRLLIESVPGQGA
SFTAGFPPARDVPEARS

Sequences:

>Translated_417_residues
MRRVALILLVAGLALAALVVFGGLQPLGATVAFACIAGAALVPWQVHDPDASREIEFGANPVETDVARALVAGMPDPNVL
LDRAGRVIHLNAAAAQLVPALRRNELAQFALRAPEIVTALREAIATREARRATYLNHVPVDRWMELIITPIPVPTAFGGV
DYCMLLTFHDQTPLRRVEEMRADFVANASHELRTPLAALSGFIDTLQGPAREDARARERFLGIMHAQAARMARLIDDLLS
LSRVELSVHVRPETIVDIVPIVREVVDGLEPLAAERHVEIETALPETPVLICGDREELLRLFENLIENALKYGASGGRVM
VSSMLDVSSEGNPEFRVVVRDFGPGIAPEHLPRLTERFYRVDAGDSRAQGGTGLGLSLVKHILNRHRGRLLIESVPGQGA
SFTAGFPPARDVPEARS
>Mature_417_residues
MRRVALILLVAGLALAALVVFGGLQPLGATVAFACIAGAALVPWQVHDPDASREIEFGANPVETDVARALVAGMPDPNVL
LDRAGRVIHLNAAAAQLVPALRRNELAQFALRAPEIVTALREAIATREARRATYLNHVPVDRWMELIITPIPVPTAFGGV
DYCMLLTFHDQTPLRRVEEMRADFVANASHELRTPLAALSGFIDTLQGPAREDARARERFLGIMHAQAARMARLIDDLLS
LSRVELSVHVRPETIVDIVPIVREVVDGLEPLAAERHVEIETALPETPVLICGDREELLRLFENLIENALKYGASGGRVM
VSSMLDVSSEGNPEFRVVVRDFGPGIAPEHLPRLTERFYRVDAGDSRAQGGTGLGLSLVKHILNRHRGRLLIESVPGQGA
SFTAGFPPARDVPEARS

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=347, Percent_Identity=34.0057636887608, Blast_Score=155, Evalue=4e-39,
Organism=Escherichia coli, GI1788393, Length=241, Percent_Identity=32.7800829875519, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1788713, Length=365, Percent_Identity=24.6575342465753, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI1786783, Length=250, Percent_Identity=30, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI145693157, Length=238, Percent_Identity=29.8319327731092, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1790346, Length=239, Percent_Identity=29.2887029288703, Blast_Score=92, Evalue=9e-20,
Organism=Escherichia coli, GI1789149, Length=237, Percent_Identity=28.6919831223629, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1789403, Length=203, Percent_Identity=31.5270935960591, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788549, Length=351, Percent_Identity=22.2222222222222, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI48994928, Length=241, Percent_Identity=26.9709543568465, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI1788279, Length=211, Percent_Identity=30.8056872037915, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1786912, Length=230, Percent_Identity=27.3913043478261, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1790436, Length=245, Percent_Identity=25.7142857142857, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI87082128, Length=248, Percent_Identity=26.6129032258064, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1787894, Length=248, Percent_Identity=27.8225806451613, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790861, Length=218, Percent_Identity=28.4403669724771, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1790300, Length=248, Percent_Identity=28.2258064516129, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1789808, Length=241, Percent_Identity=29.045643153527, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790551, Length=214, Percent_Identity=28.0373831775701, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87081816, Length=243, Percent_Identity=26.3374485596708, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 45345; Mature: 45345

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRVALILLVAGLALAALVVFGGLQPLGATVAFACIAGAALVPWQVHDPDASREIEFGAN
CCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEECCCCCCCCEECCCC
PVETDVARALVAGMPDPNVLLDRAGRVIHLNAAAAQLVPALRRNELAQFALRAPEIVTAL
CHHHHHHHHHHHCCCCCCHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
REAIATREARRATYLNHVPVDRWMELIITPIPVPTAFGGVDYCMLLTFHDQTPLRRVEEM
HHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHH
RADFVANASHELRTPLAALSGFIDTLQGPAREDARARERFLGIMHAQAARMARLIDDLLS
HHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSRVELSVHVRPETIVDIVPIVREVVDGLEPLAAERHVEIETALPETPVLICGDREELLR
HHHEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCEEEECCHHHHHH
LFENLIENALKYGASGGRVMVSSMLDVSSEGNPEFRVVVRDFGPGIAPEHLPRLTERFYR
HHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHC
VDAGDSRAQGGTGLGLSLVKHILNRHRGRLLIESVPGQGASFTAGFPPARDVPEARS
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRRVALILLVAGLALAALVVFGGLQPLGATVAFACIAGAALVPWQVHDPDASREIEFGAN
CCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEECCCCCCCCEECCCC
PVETDVARALVAGMPDPNVLLDRAGRVIHLNAAAAQLVPALRRNELAQFALRAPEIVTAL
CHHHHHHHHHHHCCCCCCHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
REAIATREARRATYLNHVPVDRWMELIITPIPVPTAFGGVDYCMLLTFHDQTPLRRVEEM
HHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHH
RADFVANASHELRTPLAALSGFIDTLQGPAREDARARERFLGIMHAQAARMARLIDDLLS
HHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSRVELSVHVRPETIVDIVPIVREVVDGLEPLAAERHVEIETALPETPVLICGDREELLR
HHHEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCEEEECCHHHHHH
LFENLIENALKYGASGGRVMVSSMLDVSSEGNPEFRVVVRDFGPGIAPEHLPRLTERFYR
HHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHC
VDAGDSRAQGGTGLGLSLVKHILNRHRGRLLIESVPGQGASFTAGFPPARDVPEARS
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]