Click here to switch to the map view.

The map label for this gene is sucD [H]

Identifier: 75674619

GI number: 75674619

Start: 472294

End: 473178

Strand: Direct

Name: sucD [H]

Synonym: Nwi_0421

Alternate gene names: 75674619

Gene position: 472294-473178 (Clockwise)

Preceding gene: 75674618

Following gene: 75674620

Centisome position: 13.88

GC content: 65.42

Gene sequence:

>885_bases
ATGCCGATTCTGATCGACAGGAATACGAGGGTCATCTGCCAGGGCTTCACCGGCAAGAACGGCACGTTCCATTCCGAGGC
CGCGATCGCCTACGGCACCAAAATGGTCGGCGGCACCTCGCCGGGCAAGGGCGGGCAGACCCATCTCGACCTGCCGGTGT
TCGACACCGTCCGCGAAGCGCGCGAGGCGACCGGCGCAGACGCCAGCGTGATCTACGTACCGCCGGCCGGCGCGGCGGAC
GCGATCTGCGAGGCGATCGACGCCGAGATCCCGCTGATCGTCTGCATCACCGAGGGTATTCCGGTGCTGGACATGGTGCG
GGTCAAGCGGTCGCTGACGGGATCGAAATCGCGCCTCATCGGGCCGAATTGCCCGGGCGTCGTGACGGCGGGTGAATGCA
AGATCGGCATCATGCCCGCGAACATCTTCAAGCCCGGTAACGTCGGCATCGTCTCCCGCTCGGGCACGCTGACCTATGAG
GCAGTGTTCCAGACCAGCCAGGAGGGCCTTGGCCAGACCACGGCGGTCGGCATCGGCGGCGATCCCGTCAAGGGCACCGA
GTTCATCGACATGCTGGAAATGTTTCTGGCCGATCCCAACACCAGCGCGATCGTGATGATCGGCGAGATCGGAGGGTCGG
CGGAGGAAGACGCCGCCCAGTTCCTGATCGATGAGGCCAGGCGCGGCCGAAACAAGCCTGTGGTCGGCTTCATCGCCGGG
GTCACGGCGCCGCCTGGCCGCCGCATGGGACATGCCGGCGCGATCATTTCCGGCGGAAAGGGTGACGCCGCCTCCAAGAC
GGCGGCCATGGAAGCAGCCGGAATAGCGGTTTCCCCGTCTCCCGCGCGACTGGGAAAAACGCTTGTCGAAAAACTGAAGC
ACTGA

Upstream 100 bases:

>100_bases
GCAAGAAGATCATCCGCGAGTCCGGCCTCAACGTGCTGCCCGCCGACGATCTCGACGATGCCGCGCAGAAGATCGTCAAA
GCCGTGAAAGAGGTCGCGTG

Downstream 100 bases:

>100_bases
TTCAGGTCTTGATCTTTTCAGCGGGAAGTTTCCCCTTAAATAGGGTAACGTCGAGTTCGCGCTGATCCTGCCGGGAAGGG
CTGGTCTCGCGGGGGAAAAG

Product: succinyl-CoA ligase, alpha subunit

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit alpha; SCS-alpha [H]

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MPILIDRNTRVICQGFTGKNGTFHSEAAIAYGTKMVGGTSPGKGGQTHLDLPVFDTVREAREATGADASVIYVPPAGAAD
AICEAIDAEIPLIVCITEGIPVLDMVRVKRSLTGSKSRLIGPNCPGVVTAGECKIGIMPANIFKPGNVGIVSRSGTLTYE
AVFQTSQEGLGQTTAVGIGGDPVKGTEFIDMLEMFLADPNTSAIVMIGEIGGSAEEDAAQFLIDEARRGRNKPVVGFIAG
VTAPPGRRMGHAGAIISGGKGDAASKTAAMEAAGIAVSPSPARLGKTLVEKLKH

Sequences:

>Translated_294_residues
MPILIDRNTRVICQGFTGKNGTFHSEAAIAYGTKMVGGTSPGKGGQTHLDLPVFDTVREAREATGADASVIYVPPAGAAD
AICEAIDAEIPLIVCITEGIPVLDMVRVKRSLTGSKSRLIGPNCPGVVTAGECKIGIMPANIFKPGNVGIVSRSGTLTYE
AVFQTSQEGLGQTTAVGIGGDPVKGTEFIDMLEMFLADPNTSAIVMIGEIGGSAEEDAAQFLIDEARRGRNKPVVGFIAG
VTAPPGRRMGHAGAIISGGKGDAASKTAAMEAAGIAVSPSPARLGKTLVEKLKH
>Mature_293_residues
PILIDRNTRVICQGFTGKNGTFHSEAAIAYGTKMVGGTSPGKGGQTHLDLPVFDTVREAREATGADASVIYVPPAGAADA
ICEAIDAEIPLIVCITEGIPVLDMVRVKRSLTGSKSRLIGPNCPGVVTAGECKIGIMPANIFKPGNVGIVSRSGTLTYEA
VFQTSQEGLGQTTAVGIGGDPVKGTEFIDMLEMFLADPNTSAIVMIGEIGGSAEEDAAQFLIDEARRGRNKPVVGFIAGV
TAPPGRRMGHAGAIISGGKGDAASKTAAMEAAGIAVSPSPARLGKTLVEKLKH

Specific function: Unknown

COG id: COG0074

COG function: function code C; Succinyl-CoA synthetase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the succinate/malate CoA ligase alpha subunit family [H]

Homologues:

Organism=Homo sapiens, GI109452591, Length=292, Percent_Identity=67.4657534246575, Blast_Score=342, Evalue=2e-94,
Organism=Homo sapiens, GI38569423, Length=258, Percent_Identity=29.4573643410853, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI38569421, Length=258, Percent_Identity=29.4573643410853, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI1786949, Length=293, Percent_Identity=67.9180887372014, Blast_Score=382, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI17550194, Length=287, Percent_Identity=64.1114982578397, Blast_Score=351, Evalue=2e-97,
Organism=Caenorhabditis elegans, GI17553126, Length=291, Percent_Identity=63.573883161512, Blast_Score=348, Evalue=2e-96,
Organism=Caenorhabditis elegans, GI17551266, Length=258, Percent_Identity=28.6821705426357, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17557344, Length=258, Percent_Identity=28.2945736434109, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6324716, Length=295, Percent_Identity=53.5593220338983, Blast_Score=300, Evalue=2e-82,
Organism=Drosophila melanogaster, GI21356559, Length=289, Percent_Identity=60.8996539792388, Blast_Score=348, Evalue=2e-96,
Organism=Drosophila melanogaster, GI28574296, Length=290, Percent_Identity=64.4827586206897, Blast_Score=338, Evalue=2e-93,
Organism=Drosophila melanogaster, GI281363477, Length=260, Percent_Identity=30.3846153846154, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI281363475, Length=260, Percent_Identity=30.3846153846154, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI281363473, Length=260, Percent_Identity=30.3846153846154, Blast_Score=89, Evalue=3e-18,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017440
- InterPro:   IPR003781
- InterPro:   IPR005810
- InterPro:   IPR005811
- InterPro:   IPR016040
- InterPro:   IPR016102 [H]

Pfam domain/function: PF02629 CoA_binding; PF00549 Ligase_CoA [H]

EC number: =6.2.1.5 [H]

Molecular weight: Translated: 30184; Mature: 30053

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS01216 SUCCINYL_COA_LIG_1 ; PS00399 SUCCINYL_COA_LIG_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPILIDRNTRVICQGFTGKNGTFHSEAAIAYGTKMVGGTSPGKGGQTHLDLPVFDTVREA
CCEEEECCCEEEEEECCCCCCCCCCCCCEEECCEECCCCCCCCCCCEEECCCHHHHHHHH
REATGADASVIYVPPAGAADAICEAIDAEIPLIVCITEGIPVLDMVRVKRSLTGSKSRLI
HHHCCCCCEEEEECCCCHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCEEC
GPNCPGVVTAGECKIGIMPANIFKPGNVGIVSRSGTLTYEAVFQTSQEGLGQTTAVGIGG
CCCCCCEEEECCEEEEEEECCCCCCCCEEEEECCCCEEEHHHHHHHHHCCCCEEEEECCC
DPVKGTEFIDMLEMFLADPNTSAIVMIGEIGGSAEEDAAQFLIDEARRGRNKPVVGFIAG
CCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEC
VTAPPGRRMGHAGAIISGGKGDAASKTAAMEAAGIAVSPSPARLGKTLVEKLKH
CCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHCCEEECCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
PILIDRNTRVICQGFTGKNGTFHSEAAIAYGTKMVGGTSPGKGGQTHLDLPVFDTVREA
CEEEECCCEEEEEECCCCCCCCCCCCCEEECCEECCCCCCCCCCCEEECCCHHHHHHHH
REATGADASVIYVPPAGAADAICEAIDAEIPLIVCITEGIPVLDMVRVKRSLTGSKSRLI
HHHCCCCCEEEEECCCCHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCEEC
GPNCPGVVTAGECKIGIMPANIFKPGNVGIVSRSGTLTYEAVFQTSQEGLGQTTAVGIGG
CCCCCCEEEECCEEEEEEECCCCCCCCEEEEECCCCEEEHHHHHHHHHCCCCEEEEECCC
DPVKGTEFIDMLEMFLADPNTSAIVMIGEIGGSAEEDAAQFLIDEARRGRNKPVVGFIAG
CCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEC
VTAPPGRRMGHAGAIISGGKGDAASKTAAMEAAGIAVSPSPARLGKTLVEKLKH
CCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHCCEEECCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]