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The map label for this gene is cobS [H]

Identifier: 75674601

GI number: 75674601

Start: 449482

End: 450480

Strand: Direct

Name: cobS [H]

Synonym: Nwi_0403

Alternate gene names: 75674601

Gene position: 449482-450480 (Clockwise)

Preceding gene: 75674599

Following gene: 75674602

Centisome position: 13.21

GC content: 60.86

Gene sequence:

>999_bases
ATGACGACCGCCGCCATAACCAATACCGAGACTCCTACCGGCCTTCCCGACATGAAGGTCTCGGTGCGGCAGGTGTTCGG
GATCGACAGCGATCTCGAAGTCCCCGCCTATTCCGGGACCGATCCGCATGTGCCGGATGTTGATCCCGACTACCGGTTCG
ATCGCGCGACCACGCTGGCCATTCTCGCCGGCTTCGCCAAGAACCGCCGCGTCATGGTGACCGGCTATCACGGCACCGGC
AAGTCAACCCATATCGAGCAGGTGGCGGCGCGGTTGAACTGGCCTTGCGTGCGCGTCAATCTCGACAGTCACATCAGCCG
GATCGATCTCGTCGGCAAGGACGCGATCGTGCTCAAGGACGGCAAGCAGGTTACCGAGTTTCGCGACGGCATCCTGCCCT
GGGCCTACCAGAACAACGTCGCGTTGTGCTTCGACGAATACGATGCCGGCCGTCCGGATGTGATGTTCGTGATCCAGCGC
GTGCTGGAATCCTCAGGCCGCCTGACGCTGCTGGACCAGAGCCGGGTCATCAAGCCGCATCCGGCGTTCCGCCTGTTCGC
GACCGCGAACACCATCGGTCTCGGGGATACGTCGGGTCTTTACCATGGCACCCAGCAGATCAATCAGGCGCAGATGGACC
GCTGGAACATCGTCACCACGCTGAATTATCTGCCGCACGACAACGAGGTCGAGATCGTGCTGGCCAAGGCCAAGCATTAT
CGCACGCCGGAAGGTCGCGATATCGTCGGCAAGATGGTGCGGCTGGCGGATCTAACGCGCAACGCCTTCGCCAACGGCGA
TCTCTCGACGGTGATGAGCCCGCGCACGGTCATCACCTGGGCGGAGAACACCGAGATATTCGATGATCTGGGCTTTGCCT
TCCGAGTCACGTTCCTCAACAAATGCGACGAACTCGAGCGACCGCTGGTCGCTGAATTCTACCAGCGCTGCTTCAATGTC
GAACTGAGCGAATCCGCGGTCAATGTGGCTTTGAGTTGA

Upstream 100 bases:

>100_bases
GCTTCTGCCGGCTGCCTCTCTCTGCTAAATTTCGCGAGCCTCTCGTCCGCAGCCATGCGCAGTCCTGGTTTCGGGAGCGC
GCCCGAACCTCGGAGGATTG

Downstream 100 bases:

>100_bases
GACGTTTTCATCTCTCCCCGCGAGCGGGGGAGAGTTCTGCAAACCCGGCGGCGCACCAGCGCGCCTGAGCGAGCCGGGCG
AGGGATTTTTTTTTGGCTGT

Product: cobalt chelatase, pCobS small subunit

Products: NA

Alternate protein names: Hydrogenobyrinic acid a,c-diamide cobaltochelatase subunit CobS [H]

Number of amino acids: Translated: 332; Mature: 331

Protein sequence:

>332_residues
MTTAAITNTETPTGLPDMKVSVRQVFGIDSDLEVPAYSGTDPHVPDVDPDYRFDRATTLAILAGFAKNRRVMVTGYHGTG
KSTHIEQVAARLNWPCVRVNLDSHISRIDLVGKDAIVLKDGKQVTEFRDGILPWAYQNNVALCFDEYDAGRPDVMFVIQR
VLESSGRLTLLDQSRVIKPHPAFRLFATANTIGLGDTSGLYHGTQQINQAQMDRWNIVTTLNYLPHDNEVEIVLAKAKHY
RTPEGRDIVGKMVRLADLTRNAFANGDLSTVMSPRTVITWAENTEIFDDLGFAFRVTFLNKCDELERPLVAEFYQRCFNV
ELSESAVNVALS

Sequences:

>Translated_332_residues
MTTAAITNTETPTGLPDMKVSVRQVFGIDSDLEVPAYSGTDPHVPDVDPDYRFDRATTLAILAGFAKNRRVMVTGYHGTG
KSTHIEQVAARLNWPCVRVNLDSHISRIDLVGKDAIVLKDGKQVTEFRDGILPWAYQNNVALCFDEYDAGRPDVMFVIQR
VLESSGRLTLLDQSRVIKPHPAFRLFATANTIGLGDTSGLYHGTQQINQAQMDRWNIVTTLNYLPHDNEVEIVLAKAKHY
RTPEGRDIVGKMVRLADLTRNAFANGDLSTVMSPRTVITWAENTEIFDDLGFAFRVTFLNKCDELERPLVAEFYQRCFNV
ELSESAVNVALS
>Mature_331_residues
TTAAITNTETPTGLPDMKVSVRQVFGIDSDLEVPAYSGTDPHVPDVDPDYRFDRATTLAILAGFAKNRRVMVTGYHGTGK
STHIEQVAARLNWPCVRVNLDSHISRIDLVGKDAIVLKDGKQVTEFRDGILPWAYQNNVALCFDEYDAGRPDVMFVIQRV
LESSGRLTLLDQSRVIKPHPAFRLFATANTIGLGDTSGLYHGTQQINQAQMDRWNIVTTLNYLPHDNEVEIVLAKAKHYR
TPEGRDIVGKMVRLADLTRNAFANGDLSTVMSPRTVITWAENTEIFDDLGFAFRVTFLNKCDELERPLVAEFYQRCFNVE
LSESAVNVALS

Specific function: Catalyzes cobalt insertion in the corrin ring [H]

COG id: COG0714

COG function: function code R; MoxR-like ATPases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI24415404, Length=212, Percent_Identity=25.9433962264151, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI161076562, Length=211, Percent_Identity=27.4881516587678, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI161076560, Length=211, Percent_Identity=27.4881516587678, Blast_Score=72, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011704
- InterPro:   IPR006537 [H]

Pfam domain/function: PF07728 AAA_5 [H]

EC number: =6.6.1.2 [H]

Molecular weight: Translated: 37108; Mature: 36977

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTAAITNTETPTGLPDMKVSVRQVFGIDSDLEVPAYSGTDPHVPDVDPDYRFDRATTLA
CCCEEECCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
ILAGFAKNRRVMVTGYHGTGKSTHIEQVAARLNWPCVRVNLDSHISRIDLVGKDAIVLKD
HHHHHCCCCEEEEEEECCCCCCHHHHHHHHHCCCCEEEEEHHHCCCEEEECCCCEEEEEC
GKQVTEFRDGILPWAYQNNVALCFDEYDAGRPDVMFVIQRVLESSGRLTLLDQSRVIKPH
CCHHHHHHCCCCCEEECCCEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCC
PAFRLFATANTIGLGDTSGLYHGTQQINQAQMDRWNIVTTLNYLPHDNEVEIVLAKAKHY
CCEEEEEECCEECCCCCCCCCCCHHHHHHHHHCCEEEEEEEEECCCCCCEEEEEEECHHC
RTPEGRDIVGKMVRLADLTRNAFANGDLSTVMSPRTVITWAENTEIFDDLGFAFRVTFLN
CCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCEEEEECCCCCHHHHCCHHEEEHHHH
KCDELERPLVAEFYQRCFNVELSESAVNVALS
HHHHHCCCHHHHHHHHHCCCEECCCEEEEEEC
>Mature Secondary Structure 
TTAAITNTETPTGLPDMKVSVRQVFGIDSDLEVPAYSGTDPHVPDVDPDYRFDRATTLA
CCEEECCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
ILAGFAKNRRVMVTGYHGTGKSTHIEQVAARLNWPCVRVNLDSHISRIDLVGKDAIVLKD
HHHHHCCCCEEEEEEECCCCCCHHHHHHHHHCCCCEEEEEHHHCCCEEEECCCCEEEEEC
GKQVTEFRDGILPWAYQNNVALCFDEYDAGRPDVMFVIQRVLESSGRLTLLDQSRVIKPH
CCHHHHHHCCCCCEEECCCEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCC
PAFRLFATANTIGLGDTSGLYHGTQQINQAQMDRWNIVTTLNYLPHDNEVEIVLAKAKHY
CCEEEEEECCEECCCCCCCCCCCHHHHHHHHHCCEEEEEEEEECCCCCCEEEEEEECHHC
RTPEGRDIVGKMVRLADLTRNAFANGDLSTVMSPRTVITWAENTEIFDDLGFAFRVTFLN
CCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCEEEEECCCCCHHHHCCHHEEEHHHH
KCDELERPLVAEFYQRCFNVELSESAVNVALS
HHHHHCCCHHHHHHHHHCCCEECCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1917840 [H]