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The map label for this gene is ctaB1

Identifier: 75674424

GI number: 75674424

Start: 256939

End: 257877

Strand: Direct

Name: ctaB1

Synonym: Nwi_0225

Alternate gene names: 75674424

Gene position: 256939-257877 (Clockwise)

Preceding gene: 75674423

Following gene: 75674425

Centisome position: 7.55

GC content: 67.31

Gene sequence:

>939_bases
GTGTCGGTTGTCGATCAAAAAGCCGTTGAGCTGCCGCCCCGGATCTCGGAGGCGGGTGTCGCCGATTACTTCGCGCTGCT
GAAGCCACGAGTGATGTCGCTCGTGATCTTCACCGCGCTGGTCGGGCTGATGATTGCGCCGGGCCATATTCACCCGGTGC
TGGGCTTCATCGCGATCCTGTGCATCGCGGTCGGAGCCGGCGCCTCCGGCGCGCTGAACATGGCGCTGGAAGGCGATATC
GACGTGCTGATGTCGCGCACGGCCAACCGGCCGATCCCGCGCGGCCGCATCACCCGCGGCGAGGCGATGGGGTTCGGCCT
CACGCTGTCGTTCTTCTCGGTGATGACGCTCGGCGCGCTGGTCAACTGGTACGCCGGGGGGCTGCTCGCCTTCACGATCT
TCTTTTACGTGGTGATCTACACGATGGGGCTGAAGCGGCGGACCGCGCAGAACATCGTGATCGGCGGCGCCGCCGGCGCG
CTGCCGCCGGTGGTGGCGTGGGCGGCCGCGACGGGGTCGTTGTCGGTTGAGCCGCTGCTTCTGTTCTTGATCATCTTCTT
CTGGACGCCGCCGCATTTCTGGGCGCTGGCGCTGTTCCGCTCCGACGATTACGCCCGCGCCGGGGTGCCGATGCTGCCGG
TGGTCGCCGGTCCCGACGCGACGCGGCTGCAGATCCTGCTCTACACCATCGTGCTGGTGGCGATCGCCGCCGCGCCCTGG
CCGCTCGGCTACTTCGACTGGGTCTATGGCGTCACCTCGCTGATCCTCGGCGCCGGCATGCTGGTGCTCGCGATCGAGGT
CTATCGCCACCGGACCGGAAGCCAGGCGCTGCGCGCCACGCGGCGGCTGTTCGCCTTCTCGATTCTCTATCTGTTCGCGC
TGTTCGCCGTTCTGCTGCTCGATGTGGTCGCGAAGGCCGTCGCGCCGTTGATCTGGTAG

Upstream 100 bases:

>100_bases
CGTTCCACCAGTTCTCCACCCTGCCGAAGGTGCAGTAAGCAGTCATGTGAATGTGCGCGGCGCGCTCACGCGCCGCGCAC
CCAACAAAGCGGGTAGTATC

Downstream 100 bases:

>100_bases
AGGGGCGCATGAACCGATGGACAGCAACGACAAGCCGGCCGGAGACCGGATCGTTCTCACCGAAGCTCAGAAGAAGCGCC
GGCGCGAACGCTCGATCGCG

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase 1; Heme O synthase 1

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MSVVDQKAVELPPRISEAGVADYFALLKPRVMSLVIFTALVGLMIAPGHIHPVLGFIAILCIAVGAGASGALNMALEGDI
DVLMSRTANRPIPRGRITRGEAMGFGLTLSFFSVMTLGALVNWYAGGLLAFTIFFYVVIYTMGLKRRTAQNIVIGGAAGA
LPPVVAWAAATGSLSVEPLLLFLIIFFWTPPHFWALALFRSDDYARAGVPMLPVVAGPDATRLQILLYTIVLVAIAAAPW
PLGYFDWVYGVTSLILGAGMLVLAIEVYRHRTGSQALRATRRLFAFSILYLFALFAVLLLDVVAKAVAPLIW

Sequences:

>Translated_312_residues
MSVVDQKAVELPPRISEAGVADYFALLKPRVMSLVIFTALVGLMIAPGHIHPVLGFIAILCIAVGAGASGALNMALEGDI
DVLMSRTANRPIPRGRITRGEAMGFGLTLSFFSVMTLGALVNWYAGGLLAFTIFFYVVIYTMGLKRRTAQNIVIGGAAGA
LPPVVAWAAATGSLSVEPLLLFLIIFFWTPPHFWALALFRSDDYARAGVPMLPVVAGPDATRLQILLYTIVLVAIAAAPW
PLGYFDWVYGVTSLILGAGMLVLAIEVYRHRTGSQALRATRRLFAFSILYLFALFAVLLLDVVAKAVAPLIW
>Mature_311_residues
SVVDQKAVELPPRISEAGVADYFALLKPRVMSLVIFTALVGLMIAPGHIHPVLGFIAILCIAVGAGASGALNMALEGDID
VLMSRTANRPIPRGRITRGEAMGFGLTLSFFSVMTLGALVNWYAGGLLAFTIFFYVVIYTMGLKRRTAQNIVIGGAAGAL
PPVVAWAAATGSLSVEPLLLFLIIFFWTPPHFWALALFRSDDYARAGVPMLPVVAGPDATRLQILLYTIVLVAIAAAPWP
LGYFDWVYGVTSLILGAGMLVLAIEVYRHRTGSQALRATRRLFAFSILYLFALFAVLLLDVVAKAVAPLIW

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=266, Percent_Identity=33.8345864661654, Blast_Score=106, Evalue=2e-23,
Organism=Escherichia coli, GI1786631, Length=287, Percent_Identity=28.9198606271777, Blast_Score=101, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI71998235, Length=268, Percent_Identity=27.9850746268657, Blast_Score=84, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6325085, Length=312, Percent_Identity=27.8846153846154, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI19921064, Length=290, Percent_Identity=30.6896551724138, Blast_Score=112, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COXX1_NITWN (Q3SW48)

Other databases:

- EMBL:   CP000115
- RefSeq:   YP_316845.1
- STRING:   Q3SW48
- GeneID:   3676682
- GenomeReviews:   CP000115_GR
- KEGG:   nwi:Nwi_0225
- HOGENOM:   HBG656003
- PhylomeDB:   Q3SW48
- ProtClustDB:   PRK04375
- BioCyc:   NWIN323098:NWI_0225-MONOMER
- HAMAP:   MF_00154
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3
- TIGRFAMs:   TIGR01473

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.-

Molecular weight: Translated: 33565; Mature: 33433

Theoretical pI: Translated: 9.86; Mature: 9.86

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xdb4535c)-; HASH(0xdf086b0)-; HASH(0xd9d10cc)-; HASH(0xdef9b8c)-; HASH(0xdef9d9c)-; HASH(0xd320578)-; HASH(0xd3202a8)-; HASH(0xdf14de0)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVVDQKAVELPPRISEAGVADYFALLKPRVMSLVIFTALVGLMIAPGHIHPVLGFIAIL
CCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
CIAVGAGASGALNMALEGDIDVLMSRTANRPIPRGRITRGEAMGFGLTLSFFSVMTLGAL
HHHHCCCCCCCEEEEECCCHHHHHHHHCCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHH
VNWYAGGLLAFTIFFYVVIYTMGLKRRTAQNIVIGGAAGALPPVVAWAAATGSLSVEPLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHCCCCCCHHHHH
LFLIIFFWTPPHFWALALFRSDDYARAGVPMLPVVAGPDATRLQILLYTIVLVAIAAAPW
HHHHHHHHCCHHHHHHHHHCCCCCHHCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHCCC
PLGYFDWVYGVTSLILGAGMLVLAIEVYRHRTGSQALRATRRLFAFSILYLFALFAVLLL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DVVAKAVAPLIW
HHHHHHHHHCCH
>Mature Secondary Structure 
SVVDQKAVELPPRISEAGVADYFALLKPRVMSLVIFTALVGLMIAPGHIHPVLGFIAIL
CCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
CIAVGAGASGALNMALEGDIDVLMSRTANRPIPRGRITRGEAMGFGLTLSFFSVMTLGAL
HHHHCCCCCCCEEEEECCCHHHHHHHHCCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHH
VNWYAGGLLAFTIFFYVVIYTMGLKRRTAQNIVIGGAAGALPPVVAWAAATGSLSVEPLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHCCCCCCHHHHH
LFLIIFFWTPPHFWALALFRSDDYARAGVPMLPVVAGPDATRLQILLYTIVLVAIAAAPW
HHHHHHHHCCHHHHHHHHHCCCCCHHCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHCCC
PLGYFDWVYGVTSLILGAGMLVLAIEVYRHRTGSQALRATRRLFAFSILYLFALFAVLLL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DVVAKAVAPLIW
HHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA