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The map label for this gene is ctaD [H]

Identifier: 75674423

GI number: 75674423

Start: 255257

End: 256876

Strand: Direct

Name: ctaD [H]

Synonym: Nwi_0224

Alternate gene names: 75674423

Gene position: 255257-256876 (Clockwise)

Preceding gene: 75674422

Following gene: 75674424

Centisome position: 7.5

GC content: 61.67

Gene sequence:

>1620_bases
ATGGCAACAGCATCTGCTCACGACCATGCCCATGACGATCATGGCGACCATGCGCACCACCCGACAGGGTGGAAGCGCTT
TGCGTATTCGACCAATCACAAGGACATCGGGACCATGTACCTGGTGTTCGCCATCGTTGCGGGGATCATCGGCGGCCTGA
TGTCGATGGGCATCCGGGCGGAACTGATGTACCCCGGGATACAGGTTTTTGATCCCGCGCATACCTACAACGTGTTTGCG
ACCAATCACGGCCTGATCATGATCTTCTTCATGGTGATGCCGGCGATGATCGGCGGCTTCGGCAACTGGTTCGTGCCGCT
GATGATCGGCGCGCCCGACATGGCGTTCCCGCGCATGAACAACATCTCGTTCTGGCTGCTGCCGGCGGCGTTTGCGCTGC
TGCTGATCTCCTCATTCATGGAGGGCGAGCCGGGCGCGACCGGAGCGGGCACGGGCTGGACGCTGTATGCGCCGCTGTCG
ACGAGCGGTCATCCGGGTCCGGCGGTGGACTTCAGCATCCTGTCGATCCACCTTGCGGGCGCCTCCTCGATCCTCGGGGC
GATCAACTTCATCACCACGATCTTCAACATGCGCGCGCCTGGCATGACCATGCACAAGATGCCGCTGTTCGTCTGGTCGA
TCCTGGTCACCGTGTTCCTGCTGCTGCTGTCGCTGCCGGTTCTGGCGGGCGCGATCACGATGCTGCTGACCGACCGTAAC
TTCGGCACCACGTTCTTCGCGGCCGATGGTGGCGGCGATCCGGTGCTGTTCCAGCATCTGTTCTGGTTCTTCGGCCATCC
CGAGGTGTACATCCTGATTCTGCCGGGCTTCGGCATGATCAGCCATGTGATCTCGACGTTCTCGAAGAAGCCGATCTTCG
GATATCTGGGCATGGCCTACGCCATGGTGGCGATCGGCGGCATCGGCTTCGTGGTGTGGGCGCACCACATGTACACGGTC
GGCATGGTGTCCTCGGCGCAGGCTTACTTCGTCGCGGCGACCATGGTGATCGCGGTGCCGACGGGCGTGAAGGTGTTCTC
GTGGATCGCCACGATGTGGGGCGGCTCGATCGAGTTCAAGACGCCGATGCTGTTTGCGATCGGCTTCATCTTCCTGTTCA
CGGTCGGCGGCGTGACCGGCGTTGTGCTGGCCAATGCGGGCGTTGATCGCGTGATGCAGGAGACCTACTACGTCATCGCG
CACTTCCACTACGTGATGGGCATTGCCGCGGTGTTCGCGATCTTCTCGGGCTGGTACTACTGGTTCCCGAAGATGTCGGG
CTACATGTACAACGAGACCATCGGCAAGCTGCACTTCTGGGTGATGTTCATCGGCGCCAACATCCTGTTCTTCCCGCAGC
ACTTCCTCGGCTTGCAGGGCATGATGCGGCGCATGGTGGACTATCCGGATGCGTTCGCCGGCTGGAACGAGATCTCGTCC
TACGGCGCCTTCATCACGGGCTTCGGCGTCATCATCTTCCTCTACGGCCTGGTCGACGCCTTCGCGCGCAAGCAGCAGGC
GGCCGACAATCCGTGGGGTGAAGGCGCGACGACGCTGGAATGGACGCTGTCCTCACCGCCTCCGTTCCACCAGTTCTCCA
CCCTGCCGAAGGTGCAGTAA

Upstream 100 bases:

>100_bases
GCGTCGCGTCGGGCGATTTCGACGACGAGGGGCGGCGCCTGCGAAGGGGTCGCCCGCCAGGGTTCGAAGGACTTCAAGGG
ACGAAAGACAGGATTAGACA

Downstream 100 bases:

>100_bases
GCAGTCATGTGAATGTGCGCGGCGCGCTCACGCGCCGCGCACCCAACAAAGCGGGTAGTATCGTGTCGGTTGTCGATCAA
AAAGCCGTTGAGCTGCCGCC

Product: cytochrome c oxidase, subunit I

Products: NA

Alternate protein names: Cytochrome aa3 subunit 1; Cytochrome c oxidase polypeptide I [H]

Number of amino acids: Translated: 539; Mature: 538

Protein sequence:

>539_residues
MATASAHDHAHDDHGDHAHHPTGWKRFAYSTNHKDIGTMYLVFAIVAGIIGGLMSMGIRAELMYPGIQVFDPAHTYNVFA
TNHGLIMIFFMVMPAMIGGFGNWFVPLMIGAPDMAFPRMNNISFWLLPAAFALLLISSFMEGEPGATGAGTGWTLYAPLS
TSGHPGPAVDFSILSIHLAGASSILGAINFITTIFNMRAPGMTMHKMPLFVWSILVTVFLLLLSLPVLAGAITMLLTDRN
FGTTFFAADGGGDPVLFQHLFWFFGHPEVYILILPGFGMISHVISTFSKKPIFGYLGMAYAMVAIGGIGFVVWAHHMYTV
GMVSSAQAYFVAATMVIAVPTGVKVFSWIATMWGGSIEFKTPMLFAIGFIFLFTVGGVTGVVLANAGVDRVMQETYYVIA
HFHYVMGIAAVFAIFSGWYYWFPKMSGYMYNETIGKLHFWVMFIGANILFFPQHFLGLQGMMRRMVDYPDAFAGWNEISS
YGAFITGFGVIIFLYGLVDAFARKQQAADNPWGEGATTLEWTLSSPPPFHQFSTLPKVQ

Sequences:

>Translated_539_residues
MATASAHDHAHDDHGDHAHHPTGWKRFAYSTNHKDIGTMYLVFAIVAGIIGGLMSMGIRAELMYPGIQVFDPAHTYNVFA
TNHGLIMIFFMVMPAMIGGFGNWFVPLMIGAPDMAFPRMNNISFWLLPAAFALLLISSFMEGEPGATGAGTGWTLYAPLS
TSGHPGPAVDFSILSIHLAGASSILGAINFITTIFNMRAPGMTMHKMPLFVWSILVTVFLLLLSLPVLAGAITMLLTDRN
FGTTFFAADGGGDPVLFQHLFWFFGHPEVYILILPGFGMISHVISTFSKKPIFGYLGMAYAMVAIGGIGFVVWAHHMYTV
GMVSSAQAYFVAATMVIAVPTGVKVFSWIATMWGGSIEFKTPMLFAIGFIFLFTVGGVTGVVLANAGVDRVMQETYYVIA
HFHYVMGIAAVFAIFSGWYYWFPKMSGYMYNETIGKLHFWVMFIGANILFFPQHFLGLQGMMRRMVDYPDAFAGWNEISS
YGAFITGFGVIIFLYGLVDAFARKQQAADNPWGEGATTLEWTLSSPPPFHQFSTLPKVQ
>Mature_538_residues
ATASAHDHAHDDHGDHAHHPTGWKRFAYSTNHKDIGTMYLVFAIVAGIIGGLMSMGIRAELMYPGIQVFDPAHTYNVFAT
NHGLIMIFFMVMPAMIGGFGNWFVPLMIGAPDMAFPRMNNISFWLLPAAFALLLISSFMEGEPGATGAGTGWTLYAPLST
SGHPGPAVDFSILSIHLAGASSILGAINFITTIFNMRAPGMTMHKMPLFVWSILVTVFLLLLSLPVLAGAITMLLTDRNF
GTTFFAADGGGDPVLFQHLFWFFGHPEVYILILPGFGMISHVISTFSKKPIFGYLGMAYAMVAIGGIGFVVWAHHMYTVG
MVSSAQAYFVAATMVIAVPTGVKVFSWIATMWGGSIEFKTPMLFAIGFIFLFTVGGVTGVVLANAGVDRVMQETYYVIAH
FHYVMGIAAVFAIFSGWYYWFPKMSGYMYNETIGKLHFWVMFIGANILFFPQHFLGLQGMMRRMVDYPDAFAGWNEISSY
GAFITGFGVIIFLYGLVDAFARKQQAADNPWGEGATTLEWTLSSPPPFHQFSTLPKVQ

Specific function: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=511, Percent_Identity=60.4696673189824, Blast_Score=578, Evalue=1e-165,
Organism=Escherichia coli, GI1786634, Length=523, Percent_Identity=43.2122370936902, Blast_Score=389, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6226519, Length=537, Percent_Identity=54.7486033519553, Blast_Score=585, Evalue=1e-168,
Organism=Saccharomyces cerevisiae, GI6226524, Length=327, Percent_Identity=59.9388379204893, Blast_Score=395, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6226523, Length=252, Percent_Identity=55.1587301587302, Blast_Score=255, Evalue=1e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014241 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 59162; Mature: 59031

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
6.3 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
6.1 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATASAHDHAHDDHGDHAHHPTGWKRFAYSTNHKDIGTMYLVFAIVAGIIGGLMSMGIRA
CCCCCCCCCCCCCCCCCCCCCCCHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCEE
ELMYPGIQVFDPAHTYNVFATNHGLIMIFFMVMPAMIGGFGNWFVPLMIGAPDMAFPRMN
EEECCCCEEECCCCEEEEEEECCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCC
NISFWLLPAAFALLLISSFMEGEPGATGAGTGWTLYAPLSTSGHPGPAVDFSILSIHLAG
CCEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEEEEECC
ASSILGAINFITTIFNMRAPGMTMHKMPLFVWSILVTVFLLLLSLPVLAGAITMLLTDRN
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCC
FGTTFFAADGGGDPVLFQHLFWFFGHPEVYILILPGFGMISHVISTFSKKPIFGYLGMAY
CCCEEEEECCCCCHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCHHHHHHHHH
AMVAIGGIGFVVWAHHMYTVGMVSSAQAYFVAATMVIAVPTGVKVFSWIATMWGGSIEFK
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEC
TPMLFAIGFIFLFTVGGVTGVVLANAGVDRVMQETYYVIAHFHYVMGIAAVFAIFSGWYY
CHHHHHHHHHHHHHHHCHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHH
WFPKMSGYMYNETIGKLHFWVMFIGANILFFPQHFLGLQGMMRRMVDYPDAFAGWNEISS
CCCCCCCEEHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHCCCCHHCCHHHHHH
YGAFITGFGVIIFLYGLVDAFARKQQAADNPWGEGATTLEWTLSSPPPFHQFSTLPKVQ
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCHHHCCCCCCC
>Mature Secondary Structure 
ATASAHDHAHDDHGDHAHHPTGWKRFAYSTNHKDIGTMYLVFAIVAGIIGGLMSMGIRA
CCCCCCCCCCCCCCCCCCCCCCHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCEE
ELMYPGIQVFDPAHTYNVFATNHGLIMIFFMVMPAMIGGFGNWFVPLMIGAPDMAFPRMN
EEECCCCEEECCCCEEEEEEECCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCC
NISFWLLPAAFALLLISSFMEGEPGATGAGTGWTLYAPLSTSGHPGPAVDFSILSIHLAG
CCEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEEEEECC
ASSILGAINFITTIFNMRAPGMTMHKMPLFVWSILVTVFLLLLSLPVLAGAITMLLTDRN
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCC
FGTTFFAADGGGDPVLFQHLFWFFGHPEVYILILPGFGMISHVISTFSKKPIFGYLGMAY
CCCEEEEECCCCCHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCHHHHHHHHH
AMVAIGGIGFVVWAHHMYTVGMVSSAQAYFVAATMVIAVPTGVKVFSWIATMWGGSIEFK
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEC
TPMLFAIGFIFLFTVGGVTGVVLANAGVDRVMQETYYVIAHFHYVMGIAAVFAIFSGWYY
CHHHHHHHHHHHHHHHCHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHH
WFPKMSGYMYNETIGKLHFWVMFIGANILFFPQHFLGLQGMMRRMVDYPDAFAGWNEISS
CCCCCCCEEHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHCCCCHHCCHHHHHH
YGAFITGFGVIIFLYGLVDAFARKQQAADNPWGEGATTLEWTLSSPPPFHQFSTLPKVQ
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2172930; 1965217; 12597275 [H]