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The map label for this gene is hemE [H]

Identifier: 74318797

GI number: 74318797

Start: 2858747

End: 2859817

Strand: Direct

Name: hemE [H]

Synonym: Tbd_2779

Alternate gene names: 74318797

Gene position: 2858747-2859817 (Clockwise)

Preceding gene: 74318796

Following gene: 74318798

Centisome position: 98.25

GC content: 68.63

Gene sequence:

>1071_bases
ATGTCCGCCCTCAAGAACGATACCTTCCTGCGCGCGCTGCTGCGCCAGCCGACCGAGTACACGCCGCTGTGGCTGATGCG
CCAGGCGGGGCGCTATCTGCCCGAGTACAACGCGACGCGCGCGCGGGCCGGCGATTTCCTGACGCTCTGCAAAACGCCCG
ACCTCGCGACCGAGGTCACCCTGCAGCCGCTCGCGCGCTACCCGCTCGACGCCGCGATCCTGTTCTCCGACATTCTGACG
GTCCCCGACGCGATGGGCCTGGGCCTGTACTTCTCGCAAGGCGAGGGGCCGCGCTTCGAGCGCCCGCTGCGCGACGAATG
GGAAATCCGCGATCTCTCGGCGCCCGATCCGACCGACCACCTGGGCTACGTGATGGACGCCGTGCGCTCGATCCGCCGCG
CCCTCGATGGCGCCGTGCCGCTGATCGGCTTTTCCGGCAGCCCCTACACGCTCGCCTGCTACATGATCGAAGGCGGCAGT
TCGGACGACTACCGCCACATCAAGACCATGCTCTACCGCCGCCCCGACCTCTTACATCGCGTCCTCGAGGTCAACACACG
TGCGGTCACCGATTACCTCAACGCCCAGATCGAAGCCGGCGCCCAGGCCGTGATGATCTTCGACTCCTGGGGCGGCAGCC
TCACGCCGCACGGCTACCGCGAGTTCTCGCTCGACTACATGGAACGCATCGTCAGTGGGCTGATCAAGGAGCGCGAAGGC
CGCCGCATTCCGAGCATCATCTTCACCAAGGGCGGGGGCAACTGGCTCGAAGCGATGGCGGGCGCCGGTGCCGACGCGGT
CGGGCTCGACTGGACGCTCGACATCGGCGAGGCGCGCCGCCGCGTCGGCGACCGCGTCGCGCTGCAGGGCAACCTCGACC
CCTGCGCGCTCCACGGCACGCCCGAGAGCATCCGCGCCGAGGCCGAACGCATCGTCGACGCCTACGGCAACCATCCGGGG
CACGTGTTCAATCTCGGGCACGGCATTTCGCAGTTCACCGATCCCGCCAACGTCGCAGTACTGGTCGACGCCGTCCACAG
CCGCAGCCGCGCAATCCGCGCCGGCGCGTGA

Upstream 100 bases:

>100_bases
CCTTCCGCCGTAGTTGAGGGGGCCGGCGCGGCCCGGCCAGCGGCGCCAAGCCTGTTAGAATTCAGGCTTTGCGTCCTGGC
CCTTTTTCCGGGCTACAGCC

Downstream 100 bases:

>100_bases
GCGGCCCGACGATCGAAAATTTCGAATGGTCCGCGTATAAAAAACGACTTTCCAATACGCCGGGCAGGTCCCACCATACC
GGGTCTCGTCGACCCCACGG

Product: uroporphyrinogen decarboxylase HemE

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 356; Mature: 355

Protein sequence:

>356_residues
MSALKNDTFLRALLRQPTEYTPLWLMRQAGRYLPEYNATRARAGDFLTLCKTPDLATEVTLQPLARYPLDAAILFSDILT
VPDAMGLGLYFSQGEGPRFERPLRDEWEIRDLSAPDPTDHLGYVMDAVRSIRRALDGAVPLIGFSGSPYTLACYMIEGGS
SDDYRHIKTMLYRRPDLLHRVLEVNTRAVTDYLNAQIEAGAQAVMIFDSWGGSLTPHGYREFSLDYMERIVSGLIKEREG
RRIPSIIFTKGGGNWLEAMAGAGADAVGLDWTLDIGEARRRVGDRVALQGNLDPCALHGTPESIRAEAERIVDAYGNHPG
HVFNLGHGISQFTDPANVAVLVDAVHSRSRAIRAGA

Sequences:

>Translated_356_residues
MSALKNDTFLRALLRQPTEYTPLWLMRQAGRYLPEYNATRARAGDFLTLCKTPDLATEVTLQPLARYPLDAAILFSDILT
VPDAMGLGLYFSQGEGPRFERPLRDEWEIRDLSAPDPTDHLGYVMDAVRSIRRALDGAVPLIGFSGSPYTLACYMIEGGS
SDDYRHIKTMLYRRPDLLHRVLEVNTRAVTDYLNAQIEAGAQAVMIFDSWGGSLTPHGYREFSLDYMERIVSGLIKEREG
RRIPSIIFTKGGGNWLEAMAGAGADAVGLDWTLDIGEARRRVGDRVALQGNLDPCALHGTPESIRAEAERIVDAYGNHPG
HVFNLGHGISQFTDPANVAVLVDAVHSRSRAIRAGA
>Mature_355_residues
SALKNDTFLRALLRQPTEYTPLWLMRQAGRYLPEYNATRARAGDFLTLCKTPDLATEVTLQPLARYPLDAAILFSDILTV
PDAMGLGLYFSQGEGPRFERPLRDEWEIRDLSAPDPTDHLGYVMDAVRSIRRALDGAVPLIGFSGSPYTLACYMIEGGSS
DDYRHIKTMLYRRPDLLHRVLEVNTRAVTDYLNAQIEAGAQAVMIFDSWGGSLTPHGYREFSLDYMERIVSGLIKEREGR
RIPSIIFTKGGGNWLEAMAGAGADAVGLDWTLDIGEARRRVGDRVALQGNLDPCALHGTPESIRAEAERIVDAYGNHPGH
VFNLGHGISQFTDPANVAVLVDAVHSRSRAIRAGA

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=354, Percent_Identity=47.4576271186441, Blast_Score=320, Evalue=2e-87,
Organism=Escherichia coli, GI2367337, Length=349, Percent_Identity=64.1833810888252, Blast_Score=465, Evalue=1e-132,
Organism=Saccharomyces cerevisiae, GI6320252, Length=353, Percent_Identity=38.8101983002833, Blast_Score=262, Evalue=5e-71,
Organism=Drosophila melanogaster, GI19921920, Length=348, Percent_Identity=41.0919540229885, Blast_Score=271, Evalue=7e-73,
Organism=Drosophila melanogaster, GI221330099, Length=348, Percent_Identity=41.0919540229885, Blast_Score=270, Evalue=8e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 39331; Mature: 39200

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2 ; PS00867 CPSASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSALKNDTFLRALLRQPTEYTPLWLMRQAGRYLPEYNATRARAGDFLTLCKTPDLATEVT
CCCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCHHCCCCEEEEECCCCCHHHHH
LQPLARYPLDAAILFSDILTVPDAMGLGLYFSQGEGPRFERPLRDEWEIRDLSAPDPTDH
HHHHHHCCCHHHHHHHHHHHCCCHHCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHH
LGYVMDAVRSIRRALDGAVPLIGFSGSPYTLACYMIEGGSSDDYRHIKTMLYRRPDLLHR
HHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEEEEEECCCCCHHHHHHHHHHCCHHHHHH
VLEVNTRAVTDYLNAQIEAGAQAVMIFDSWGGSLTPHGYREFSLDYMERIVSGLIKEREG
HHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHCHHHHHHHHHHHHHHHCC
RRIPSIIFTKGGGNWLEAMAGAGADAVGLDWTLDIGEARRRVGDRVALQGNLDPCALHGT
CCCCEEEEECCCCHHHHHHHCCCCCCCCCEEEEEHHHHHHHHCCEEEEECCCCEEEECCC
PESIRAEAERIVDAYGNHPGHVFNLGHGISQFTDPANVAVLVDAVHSRSRAIRAGA
HHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHCCCCCCEEEEHHHHHHHHHHCCCC
>Mature Secondary Structure 
SALKNDTFLRALLRQPTEYTPLWLMRQAGRYLPEYNATRARAGDFLTLCKTPDLATEVT
CCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCHHCCCCEEEEECCCCCHHHHH
LQPLARYPLDAAILFSDILTVPDAMGLGLYFSQGEGPRFERPLRDEWEIRDLSAPDPTDH
HHHHHHCCCHHHHHHHHHHHCCCHHCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHH
LGYVMDAVRSIRRALDGAVPLIGFSGSPYTLACYMIEGGSSDDYRHIKTMLYRRPDLLHR
HHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEEEEEECCCCCHHHHHHHHHHCCHHHHHH
VLEVNTRAVTDYLNAQIEAGAQAVMIFDSWGGSLTPHGYREFSLDYMERIVSGLIKEREG
HHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHCHHHHHHHHHHHHHHHCC
RRIPSIIFTKGGGNWLEAMAGAGADAVGLDWTLDIGEARRRVGDRVALQGNLDPCALHGT
CCCCEEEEECCCCHHHHHHHCCCCCCCCCEEEEEHHHHHHHHCCEEEEECCCCEEEECCC
PESIRAEAERIVDAYGNHPGHVFNLGHGISQFTDPANVAVLVDAVHSRSRAIRAGA
HHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHCCCCCCEEEEHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA