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The map label for this gene is purE [H]

Identifier: 74318679

GI number: 74318679

Start: 2735363

End: 2735860

Strand: Direct

Name: purE [H]

Synonym: Tbd_2661

Alternate gene names: 74318679

Gene position: 2735363-2735860 (Clockwise)

Preceding gene: 74318676

Following gene: 74318680

Centisome position: 94.0

GC content: 68.47

Gene sequence:

>498_bases
ATGATGAGCGCGCCTGAGGTAGGGGTGGTGATGGGATCTTCCAGCGACTGGGAGGTGATGAAGCATGCGGCGATTCTGCT
CAAGCAGCTCGGCATCCACTTCGAAACCAAGGTGGTGTCGGCGCACCGTACCCCCGACCTGCTCTACGAATACGCGGCGA
GCGCCGAGGCGCGCGGCATCAAGGCGATCATCGCGGGCGCGGGCGGCGCGGCGCACCTGCCGGGCATGATCGCGGCGAAG
ACGATCGTTCCGGTGCTCGGCGTGCCGGTGCCGTCGAAATATCTCAAGGGCGTCGATTCGCTGCTCTCGATCGTGCAGAT
GCCGCGCGGCATCCCGGTCGCGACCTTCGCGATCGGCGAGGCCGGCGCCGCCAACGCCGCGCTCTTCGCGGCGGCGCTGA
TCGCGCGCGCCGACCCCGGCCTCGCGGCGCAGCTCAACGAATTCCGCCGCGGCCAGTCCGATTCGGTGCTCGCGATGGAG
CTGCCCGATGTCGAATGA

Upstream 100 bases:

>100_bases
CAGGGTCTGCAGGGAAGCGGGCATGGTCGTCTCCGATGGCGCGCGCCATTGTAGGGGCGGCGCGCAGTAAAATGCCGCCT
TTCGCATCGCAAGGACCGGC

Downstream 100 bases:

>100_bases
GGCGCAGCCGACGATGACTGCCCTGCCGATCCTGCCGGGTGCGACGCTCGGCATCCTGGGAGGCGGTCAACTCGGCCGCA
TGTTCACGATCGCCGCACGC

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 165; Mature: 165

Protein sequence:

>165_residues
MMSAPEVGVVMGSSSDWEVMKHAAILLKQLGIHFETKVVSAHRTPDLLYEYAASAEARGIKAIIAGAGGAAHLPGMIAAK
TIVPVLGVPVPSKYLKGVDSLLSIVQMPRGIPVATFAIGEAGAANAALFAAALIARADPGLAAQLNEFRRGQSDSVLAME
LPDVE

Sequences:

>Translated_165_residues
MMSAPEVGVVMGSSSDWEVMKHAAILLKQLGIHFETKVVSAHRTPDLLYEYAASAEARGIKAIIAGAGGAAHLPGMIAAK
TIVPVLGVPVPSKYLKGVDSLLSIVQMPRGIPVATFAIGEAGAANAALFAAALIARADPGLAAQLNEFRRGQSDSVLAME
LPDVE
>Mature_165_residues
MMSAPEVGVVMGSSSDWEVMKHAAILLKQLGIHFETKVVSAHRTPDLLYEYAASAEARGIKAIIAGAGGAAHLPGMIAAK
TIVPVLGVPVPSKYLKGVDSLLSIVQMPRGIPVATFAIGEAGAANAALFAAALIARADPGLAAQLNEFRRGQSDSVLAME
LPDVE

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=158, Percent_Identity=62.6582278481013, Blast_Score=159, Evalue=9e-41,
Organism=Saccharomyces cerevisiae, GI6324702, Length=156, Percent_Identity=55.1282051282051, Blast_Score=160, Evalue=7e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17041; Mature: 17041

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSAPEVGVVMGSSSDWEVMKHAAILLKQLGIHFETKVVSAHRTPDLLYEYAASAEARGI
CCCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCHHEEEECCCCCHHHHHHHHHCCCCCCE
KAIIAGAGGAAHLPGMIAAKTIVPVLGVPVPSKYLKGVDSLLSIVQMPRGIPVATFAIGE
EEEEECCCCCHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCC
AGAANAALFAAALIARADPGLAAQLNEFRRGQSDSVLAMELPDVE
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEEEECCCCC
>Mature Secondary Structure
MMSAPEVGVVMGSSSDWEVMKHAAILLKQLGIHFETKVVSAHRTPDLLYEYAASAEARGI
CCCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCHHEEEECCCCCHHHHHHHHHCCCCCCE
KAIIAGAGGAAHLPGMIAAKTIVPVLGVPVPSKYLKGVDSLLSIVQMPRGIPVATFAIGE
EEEEECCCCCHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCC
AGAANAALFAAALIARADPGLAAQLNEFRRGQSDSVLAMELPDVE
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3036807; 9384377 [H]