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The map label for this gene is thiD [H]

Identifier: 74318573

GI number: 74318573

Start: 2629717

End: 2630559

Strand: Direct

Name: thiD [H]

Synonym: Tbd_2555

Alternate gene names: 74318573

Gene position: 2629717-2630559 (Clockwise)

Preceding gene: 74318565

Following gene: 74318574

Centisome position: 90.37

GC content: 68.21

Gene sequence:

>843_bases
ATGCCGCCTATCTTCGCCCCCAAACCAACGCCGCCGCTGGTGTTGAGCTTCGCCGCCTCCGACCCGAGCGGCGGCGCGGG
CCTGCAGGCCGACGTGCTGACGCTCGCGAGCATGGGCTGCCACCCGCTGTCGGTGGTCACCGCGATCACCGTGCAGGACA
CCGCCGGGGTCGACGAGGTGCTGGCCATCGACGCGGAGTGGGTCGCCGACCAGGCGCGCATGCTGCTCGAGGACGTCCCG
GTATCGGCCTTCAAACTCGGCATGCTCGGAAGCGCAGAATCGATCGCGATGATCGCCGAGATCCTCTCGGATTACCCGGA
CATCCCGGTCATCCTCGACCCGGTCCTCGCCTCGGGCCGTGGCGACGAGTTCGCGAACGACGACATGATCGCCGCGATGC
GCGACATGCTGATCCCGCAGACCAGCATCCTGACGCCGAACAGCCACGAGGCGCGCCGGCTGGCGCTGTTCGAGTCCGAC
GAGGACGATATGGACCTCGCGGCCTGCGCGCGCCATCTGACCGACCTCGGCTGTGAGTATGTCCTGATCACCGGCACGCA
CGAGGCAACGCCGCGTGTGCTCAACAGCCTTTACGACGCCAACGGACACGTGCAGACCGACGCCTGGGATCGCCTACCAG
GCAGCTACCACGGTTCGGGCTGCACGCTCGCCGCGGCCATCGCGGCGACGCTCGCCTACGGCCAGGACGTGCCGGCCGCC
GTTCGCGAAGCGCAGAACTTCACCTACGAAGCGCTCAAGGCGGCATTCCGCCCCGGCATGGGGCAGTACATCCCCGAACG
CTTCTTCTGGGCGCAGGACGCACAGGCGGAAGGGAACGGCTGA

Upstream 100 bases:

>100_bases
CCGCAGATCAGGCACATCCAGGTCTTGTATTCGGCGTTTTCGGGCATTGCGGCAGGGGGAATCGGCTAAAATCGGGGATT
GATTTTAAAGCAGCGCCGCC

Downstream 100 bases:

>100_bases
TTGCGCACCTTCCCCGGCGGCGTATACGCCCTCACCCGCGAGACCCCTGACACCGAGCGGCTGCTCGCCGAAGTCGAAGC
CGCGCTCGCGGGCGGCGTCG

Product: phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 280; Mature: 279

Protein sequence:

>280_residues
MPPIFAPKPTPPLVLSFAASDPSGGAGLQADVLTLASMGCHPLSVVTAITVQDTAGVDEVLAIDAEWVADQARMLLEDVP
VSAFKLGMLGSAESIAMIAEILSDYPDIPVILDPVLASGRGDEFANDDMIAAMRDMLIPQTSILTPNSHEARRLALFESD
EDDMDLAACARHLTDLGCEYVLITGTHEATPRVLNSLYDANGHVQTDAWDRLPGSYHGSGCTLAAAIAATLAYGQDVPAA
VREAQNFTYEALKAAFRPGMGQYIPERFFWAQDAQAEGNG

Sequences:

>Translated_280_residues
MPPIFAPKPTPPLVLSFAASDPSGGAGLQADVLTLASMGCHPLSVVTAITVQDTAGVDEVLAIDAEWVADQARMLLEDVP
VSAFKLGMLGSAESIAMIAEILSDYPDIPVILDPVLASGRGDEFANDDMIAAMRDMLIPQTSILTPNSHEARRLALFESD
EDDMDLAACARHLTDLGCEYVLITGTHEATPRVLNSLYDANGHVQTDAWDRLPGSYHGSGCTLAAAIAATLAYGQDVPAA
VREAQNFTYEALKAAFRPGMGQYIPERFFWAQDAQAEGNG
>Mature_279_residues
PPIFAPKPTPPLVLSFAASDPSGGAGLQADVLTLASMGCHPLSVVTAITVQDTAGVDEVLAIDAEWVADQARMLLEDVPV
SAFKLGMLGSAESIAMIAEILSDYPDIPVILDPVLASGRGDEFANDDMIAAMRDMLIPQTSILTPNSHEARRLALFESDE
DDMDLAACARHLTDLGCEYVLITGTHEATPRVLNSLYDANGHVQTDAWDRLPGSYHGSGCTLAAAIAATLAYGQDVPAAV
REAQNFTYEALKAAFRPGMGQYIPERFFWAQDAQAEGNG

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=241, Percent_Identity=34.0248962655602, Blast_Score=134, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6324517, Length=244, Percent_Identity=29.9180327868852, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6325378, Length=257, Percent_Identity=28.7937743190661, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6324997, Length=245, Percent_Identity=31.0204081632653, Blast_Score=83, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 29749; Mature: 29618

Theoretical pI: Translated: 4.01; Mature: 4.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPIFAPKPTPPLVLSFAASDPSGGAGLQADVLTLASMGCHPLSVVTAITVQDTAGVDEV
CCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCHHHHEEEEEECCCCCCHHH
LAIDAEWVADQARMLLEDVPVSAFKLGMLGSAESIAMIAEILSDYPDIPVILDPVLASGR
EEECHHHHHHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHHCCCCCCEEHHHHHHCCC
GDEFANDDMIAAMRDMLIPQTSILTPNSHEARRLALFESDEDDMDLAACARHLTDLGCEY
CCCCCCCHHHHHHHHHHCCCCCEECCCCCCHHEEEEECCCCCCHHHHHHHHHHHHCCCCE
VLITGTHEATPRVLNSLYDANGHVQTDAWDRLPGSYHGSGCTLAAAIAATLAYGQDVPAA
EEEECCCCCCHHHHHHHHCCCCCEECCHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCHH
VREAQNFTYEALKAAFRPGMGQYIPERFFWAQDAQAEGNG
HHHHHCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
PPIFAPKPTPPLVLSFAASDPSGGAGLQADVLTLASMGCHPLSVVTAITVQDTAGVDEV
CCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCHHHHEEEEEECCCCCCHHH
LAIDAEWVADQARMLLEDVPVSAFKLGMLGSAESIAMIAEILSDYPDIPVILDPVLASGR
EEECHHHHHHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHHCCCCCCEEHHHHHHCCC
GDEFANDDMIAAMRDMLIPQTSILTPNSHEARRLALFESDEDDMDLAACARHLTDLGCEY
CCCCCCCHHHHHHHHHHCCCCCEECCCCCCHHEEEEECCCCCCHHHHHHHHHHHHCCCCE
VLITGTHEATPRVLNSLYDANGHVQTDAWDRLPGSYHGSGCTLAAAIAATLAYGQDVPAA
EEEECCCCCCHHHHHHHHCCCCCEECCHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCHH
VREAQNFTYEALKAAFRPGMGQYIPERFFWAQDAQAEGNG
HHHHHCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11418146 [H]