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The map label for this gene is hslU [H]

Identifier: 74318560

GI number: 74318560

Start: 2612084

End: 2613400

Strand: Direct

Name: hslU [H]

Synonym: Tbd_2542

Alternate gene names: 74318560

Gene position: 2612084-2613400 (Clockwise)

Preceding gene: 74318559

Following gene: 74318561

Centisome position: 89.77

GC content: 66.67

Gene sequence:

>1317_bases
ATGACTCCCAAGGAAATCGTCCACGAACTCGACAAGCACATCGTCGGCCAGGCCGCCGCCAAGCGCGCGGTCGCCGTCGC
GCTGCGCAACCGCTGGCGGCGCCAGCAGGTCGCGGAGCCGTTGCGCCAGGAAATCACGCCCAAGAACATCCTGATGATCG
GCCCGACCGGGGTCGGCAAGACCGAGATCGCGCGGCGCCTGGCGCGGCTTGCCAACGCCCCGTTCATCAAGATCGAGGCG
ACGAAGTTCACCGAGGTCGGCTACGTCGGGCGCGACGTCGACACGATCGTCCGCGACCTCATGGAGACGGCTGTCAAGCA
GATGCGCGAACAGGCGACCGCGAAGGTGCGGTTCCGCGCCGAGGAAGGCGCCGAGGAGCGCATTCTCGACGCGCTGCTGC
CGCCGTCGCGCGGCTTCGGCGAAACCGAACCGCCCCGCAGCGACGGCGCGGCGCGGCAGCGCTTCCGCAAGATGCTGCGC
GAGGGTCAGCTCGACGACAAGGAAATCGAGATCGAGGTCGCAGCGGTCACCCCGAGCATGGAAATTTTCGCACCGCCGGG
CATGGAAGACCTGTCGCAGCAACTGCAGGGCATGTTCCAGAACCTCGGGCAGAGCCGCAAGCAGATGCGCAAGCTCAAGG
TGCGCGAAGCCGTGAAGCTCGTGACCGAAGAGGAAGCCACCCGCCTCATCAACGACGAGGAGACGAAGCAACAGGCGCTC
GAGGCGGTCGAGCAGAACGGCATCGTTTTCCTCGACGAGATCGACAAGATCGCCACGCGCAGCGACGCGCACGGCAGCGA
CGTCTCGCGCCAGGGCGTGCAGCGCGACCTGCTGCCGCTGATCGAGGGCACGACGGTCTCGACCAAGTACGGCATGGTCA
AGACCGATCACATCCTCTTCATCGCGAGCGGCGCGTTTCACCTCTCGAAGCCGTCGGACCTGATTCCGGAACTGCAGGGG
CGGCTGCCGATCCGCGTCGAATTGCAGGCGCTTTCGGTGGACGACTTCGAGCGCATCCTAACCGCGACCGACGCCTGCCT
GACGCGGCAGTACGAAGCGTTGCTGGCGACCGAAGGCGTGGCCCTGCGCTTCACCGAAGGCGGCATCCGGCGGATCGCCG
AGATCGCGTTCGAGGTCAACGAGCGCACCGAGAACATTGGCGCCCGCCGCCTGCACACGGTCATGGAAAAGCTGCTCGAG
GATATTTCCTTCGACGCCGGGAGCGTTACCGGCGAGCACGTCATCGATGCCGAGGCGGTCAGCAGCCGGCTCGCGGCGCT
CGCCGCACGCGAGGACCTCGCCCGCTACGTGCTGTAG

Upstream 100 bases:

>100_bases
CAGGGGTCAGGGAATGAGCGGCCTCCGGCCGCGCCCCTAAAAGAAGCCGCGAAGCGACAACGCCCCCCTGATCCCTGAAT
CCTGAATCCCGGCCCCTAAA

Downstream 100 bases:

>100_bases
GCAACTGCTGTTAGCATAGGCGGCCGCCGTGACGCCGCGCGTGCGGCTACGCCTGACGCCGCGGCCCCTACCGATTCACT
TTTCTTGTTCAGCGTAATCC

Product: ATP-dependent protease ATP-binding subunit HslU

Products: NA

Alternate protein names: Unfoldase HslU [H]

Number of amino acids: Translated: 438; Mature: 437

Protein sequence:

>438_residues
MTPKEIVHELDKHIVGQAAAKRAVAVALRNRWRRQQVAEPLRQEITPKNILMIGPTGVGKTEIARRLARLANAPFIKIEA
TKFTEVGYVGRDVDTIVRDLMETAVKQMREQATAKVRFRAEEGAEERILDALLPPSRGFGETEPPRSDGAARQRFRKMLR
EGQLDDKEIEIEVAAVTPSMEIFAPPGMEDLSQQLQGMFQNLGQSRKQMRKLKVREAVKLVTEEEATRLINDEETKQQAL
EAVEQNGIVFLDEIDKIATRSDAHGSDVSRQGVQRDLLPLIEGTTVSTKYGMVKTDHILFIASGAFHLSKPSDLIPELQG
RLPIRVELQALSVDDFERILTATDACLTRQYEALLATEGVALRFTEGGIRRIAEIAFEVNERTENIGARRLHTVMEKLLE
DISFDAGSVTGEHVIDAEAVSSRLAALAAREDLARYVL

Sequences:

>Translated_438_residues
MTPKEIVHELDKHIVGQAAAKRAVAVALRNRWRRQQVAEPLRQEITPKNILMIGPTGVGKTEIARRLARLANAPFIKIEA
TKFTEVGYVGRDVDTIVRDLMETAVKQMREQATAKVRFRAEEGAEERILDALLPPSRGFGETEPPRSDGAARQRFRKMLR
EGQLDDKEIEIEVAAVTPSMEIFAPPGMEDLSQQLQGMFQNLGQSRKQMRKLKVREAVKLVTEEEATRLINDEETKQQAL
EAVEQNGIVFLDEIDKIATRSDAHGSDVSRQGVQRDLLPLIEGTTVSTKYGMVKTDHILFIASGAFHLSKPSDLIPELQG
RLPIRVELQALSVDDFERILTATDACLTRQYEALLATEGVALRFTEGGIRRIAEIAFEVNERTENIGARRLHTVMEKLLE
DISFDAGSVTGEHVIDAEAVSSRLAALAAREDLARYVL
>Mature_437_residues
TPKEIVHELDKHIVGQAAAKRAVAVALRNRWRRQQVAEPLRQEITPKNILMIGPTGVGKTEIARRLARLANAPFIKIEAT
KFTEVGYVGRDVDTIVRDLMETAVKQMREQATAKVRFRAEEGAEERILDALLPPSRGFGETEPPRSDGAARQRFRKMLRE
GQLDDKEIEIEVAAVTPSMEIFAPPGMEDLSQQLQGMFQNLGQSRKQMRKLKVREAVKLVTEEEATRLINDEETKQQALE
AVEQNGIVFLDEIDKIATRSDAHGSDVSRQGVQRDLLPLIEGTTVSTKYGMVKTDHILFIASGAFHLSKPSDLIPELQGR
LPIRVELQALSVDDFERILTATDACLTRQYEALLATEGVALRFTEGGIRRIAEIAFEVNERTENIGARRLHTVMEKLLED
ISFDAGSVTGEHVIDAEAVSSRLAALAAREDLARYVL

Specific function: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N

COG id: COG1220

COG function: function code O; ATP-dependent protease HslVU (ClpYQ), ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family. HslU subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790366, Length=440, Percent_Identity=68.4090909090909, Blast_Score=622, Evalue=1e-179,
Organism=Escherichia coli, GI1786642, Length=104, Percent_Identity=44.2307692307692, Blast_Score=95, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6319704, Length=141, Percent_Identity=34.0425531914894, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24648291, Length=129, Percent_Identity=36.4341085271318, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24648289, Length=129, Percent_Identity=36.4341085271318, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR019489
- InterPro:   IPR004491 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 48876; Mature: 48744

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPKEIVHELDKHIVGQAAAKRAVAVALRNRWRRQQVAEPLRQEITPKNILMIGPTGVGK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCH
TEIARRLARLANAPFIKIEATKFTEVGYVGRDVDTIVRDLMETAVKQMREQATAKVRFRA
HHHHHHHHHHHCCCEEEEEECCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEC
EEGAEERILDALLPPSRGFGETEPPRSDGAARQRFRKMLREGQLDDKEIEIEVAAVTPSM
CCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEEEECCCC
EIFAPPGMEDLSQQLQGMFQNLGQSRKQMRKLKVREAVKLVTEEEATRLINDEETKQQAL
EEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
EAVEQNGIVFLDEIDKIATRSDAHGSDVSRQGVQRDLLPLIEGTTVSTKYGMVKTDHILF
HHHHHCCCEEEECHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEECCCCCEEECCEEE
IASGAFHLSKPSDLIPELQGRLPIRVELQALSVDDFERILTATDACLTRQYEALLATEGV
EEECCCCCCCCHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCE
ALRFTEGGIRRIAEIAFEVNERTENIGARRLHTVMEKLLEDISFDAGSVTGEHVIDAEAV
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
SSRLAALAAREDLARYVL
HHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TPKEIVHELDKHIVGQAAAKRAVAVALRNRWRRQQVAEPLRQEITPKNILMIGPTGVGK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCH
TEIARRLARLANAPFIKIEATKFTEVGYVGRDVDTIVRDLMETAVKQMREQATAKVRFRA
HHHHHHHHHHHCCCEEEEEECCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEC
EEGAEERILDALLPPSRGFGETEPPRSDGAARQRFRKMLREGQLDDKEIEIEVAAVTPSM
CCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEEEECCCC
EIFAPPGMEDLSQQLQGMFQNLGQSRKQMRKLKVREAVKLVTEEEATRLINDEETKQQAL
EEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
EAVEQNGIVFLDEIDKIATRSDAHGSDVSRQGVQRDLLPLIEGTTVSTKYGMVKTDHILF
HHHHHCCCEEEECHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEECCCCCEEECCEEE
IASGAFHLSKPSDLIPELQGRLPIRVELQALSVDDFERILTATDACLTRQYEALLATEGV
EEECCCCCCCCHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCE
ALRFTEGGIRRIAEIAFEVNERTENIGARRLHTVMEKLLEDISFDAGSVTGEHVIDAEAV
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
SSRLAALAAREDLARYVL
HHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA