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The map label for this gene is proC [H]

Identifier: 74318435

GI number: 74318435

Start: 2488480

End: 2489295

Strand: Reverse

Name: proC [H]

Synonym: Tbd_2417

Alternate gene names: 74318435

Gene position: 2489295-2488480 (Counterclockwise)

Preceding gene: 74318436

Following gene: 74318434

Centisome position: 85.55

GC content: 71.94

Gene sequence:

>816_bases
ATGCATAAAGTCAGCTTCATCGGCGGCGGCAACGTGGCCGCCGCGATCATCGGCGGCCTCGTCGCGAGCGGCACCGCGCC
GACCGATATCGAGGTCGTCGAAATCAACGCGGACGCGCGCGACAAGCTCGCGACGCGCTTCGGCGTCGTCACCCATACCG
ATCTTTCGCAGGCCCGCCTGCACGCGCTCGTCGTGCTCGCGGTCAAGCCGCAGACCTTGCCCGAAGTCGCGGCCGCGCTC
GCGCAGCGGCTGAGCGGCCAGCTCGTCGTCTCGATCGCGGCCGGCGTGCGCGTCGCCGATCTCGCGCGCTGGCTCGGCGG
TCATGCGCGCATCGTGCGCGCGATGCCCAATACCCCGGCGCTGGTGCAGGCCGGGATCACGGGCCTGTTCGCCCCCGACG
CCGTCAGCCAGGAGTCGCGTTCGCAGGCCGAGAGCGTGCTCCGCGCAGTCGGCGGCGTCGTTTGGGTCGACGACGAACCG
CAGCTCGACGCGGTCACGGCCGTGTCGGGCAGCGGCCCTGCCTACGTCTTCTATTTCATCGAATCGCTCGAAGCCGCGGC
CGAGGCCCAGGGTCTCGCACCGGGGGTCGCGCGTCAGCTCGCGCTGCAGACCTTCTTCGGTGCGACCAAGCTCGCGCTCG
AATCGGGCGAGGAGCCGGCGCTGCTGCGCCAGCGCGTCACGTCCAAGGGGGGCACGACCGAACGCGGGCTTGCCGCGCTC
GACGCGGCCGGGGTCAAGCAGGCGGTCGGCCAGGCGGTCGACGCCGCCAGCCGGCGCGGCGCCGAACTCGGCGACGAATT
GGGACGCCTCGCATGA

Upstream 100 bases:

>100_bases
GGGTATGTCGGCGGATCTCGAGGCGGCGATTCTGGAGGGCGCGACGATCGTTCGCGTCGGCACCGCCCTGTTTGGCGAAA
GGAAATACCCGAGGTGAAAC

Downstream 100 bases:

>100_bases
TCGCCGGCGCCCTGACCTTCCTGGTCCAGACCCTCGGCAACCTGTTCGCGATCGCGGTGCTGCTGCGTTTCATGATGCAG
CTCTTTCGCGTGCCCTTCCG

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 271; Mature: 271

Protein sequence:

>271_residues
MHKVSFIGGGNVAAAIIGGLVASGTAPTDIEVVEINADARDKLATRFGVVTHTDLSQARLHALVVLAVKPQTLPEVAAAL
AQRLSGQLVVSIAAGVRVADLARWLGGHARIVRAMPNTPALVQAGITGLFAPDAVSQESRSQAESVLRAVGGVVWVDDEP
QLDAVTAVSGSGPAYVFYFIESLEAAAEAQGLAPGVARQLALQTFFGATKLALESGEEPALLRQRVTSKGGTTERGLAAL
DAAGVKQAVGQAVDAASRRGAELGDELGRLA

Sequences:

>Translated_271_residues
MHKVSFIGGGNVAAAIIGGLVASGTAPTDIEVVEINADARDKLATRFGVVTHTDLSQARLHALVVLAVKPQTLPEVAAAL
AQRLSGQLVVSIAAGVRVADLARWLGGHARIVRAMPNTPALVQAGITGLFAPDAVSQESRSQAESVLRAVGGVVWVDDEP
QLDAVTAVSGSGPAYVFYFIESLEAAAEAQGLAPGVARQLALQTFFGATKLALESGEEPALLRQRVTSKGGTTERGLAAL
DAAGVKQAVGQAVDAASRRGAELGDELGRLA
>Mature_271_residues
MHKVSFIGGGNVAAAIIGGLVASGTAPTDIEVVEINADARDKLATRFGVVTHTDLSQARLHALVVLAVKPQTLPEVAAAL
AQRLSGQLVVSIAAGVRVADLARWLGGHARIVRAMPNTPALVQAGITGLFAPDAVSQESRSQAESVLRAVGGVVWVDDEP
QLDAVTAVSGSGPAYVFYFIESLEAAAEAQGLAPGVARQLALQTFFGATKLALESGEEPALLRQRVTSKGGTTERGLAAL
DAAGVKQAVGQAVDAASRRGAELGDELGRLA

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=271, Percent_Identity=34.6863468634686, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI24797097, Length=275, Percent_Identity=33.4545454545455, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI24797095, Length=275, Percent_Identity=33.4545454545455, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI21361454, Length=271, Percent_Identity=32.1033210332103, Blast_Score=108, Evalue=7e-24,
Organism=Escherichia coli, GI1786585, Length=264, Percent_Identity=38.6363636363636, Blast_Score=154, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI17569021, Length=270, Percent_Identity=35.9259259259259, Blast_Score=136, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17540664, Length=282, Percent_Identity=32.2695035460993, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6320861, Length=205, Percent_Identity=30.7317073170732, Blast_Score=102, Evalue=7e-23,
Organism=Drosophila melanogaster, GI21358587, Length=264, Percent_Identity=34.0909090909091, Blast_Score=138, Evalue=4e-33,
Organism=Drosophila melanogaster, GI24648116, Length=280, Percent_Identity=35, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24647700, Length=169, Percent_Identity=37.2781065088757, Blast_Score=101, Evalue=6e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 27711; Mature: 27711

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
0.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHKVSFIGGGNVAAAIIGGLVASGTAPTDIEVVEINADARDKLATRFGVVTHTDLSQARL
CCEEEEECCCHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHCCEEECCHHHHHH
HALVVLAVKPQTLPEVAAALAQRLSGQLVVSIAAGVRVADLARWLGGHARIVRAMPNTPA
HEEEEEEECCCCHHHHHHHHHHHCCCCEEEEHHCCCHHHHHHHHHCCHHEEEEECCCCCH
LVQAGITGLFAPDAVSQESRSQAESVLRAVGGVVWVDDEPQLDAVTAVSGSGPAYVFYFI
HHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEECCCCCCCEEEEECCCCCEEEHHHH
ESLEAAAEAQGLAPGVARQLALQTFFGATKLALESGEEPALLRQRVTSKGGTTERGLAAL
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHH
DAAGVKQAVGQAVDAASRRGAELGDELGRLA
HHHHHHHHHHHHHHHHHHCCHHHHHHHHCCC
>Mature Secondary Structure
MHKVSFIGGGNVAAAIIGGLVASGTAPTDIEVVEINADARDKLATRFGVVTHTDLSQARL
CCEEEEECCCHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHCCEEECCHHHHHH
HALVVLAVKPQTLPEVAAALAQRLSGQLVVSIAAGVRVADLARWLGGHARIVRAMPNTPA
HEEEEEEECCCCHHHHHHHHHHHCCCCEEEEHHCCCHHHHHHHHHCCHHEEEEECCCCCH
LVQAGITGLFAPDAVSQESRSQAESVLRAVGGVVWVDDEPQLDAVTAVSGSGPAYVFYFI
HHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEECCCCCCCEEEEECCCCCEEEHHHH
ESLEAAAEAQGLAPGVARQLALQTFFGATKLALESGEEPALLRQRVTSKGGTTERGLAAL
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHH
DAAGVKQAVGQAVDAASRRGAELGDELGRLA
HHHHHHHHHHHHHHHHHHCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2107123; 10984043; 1676385 [H]