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The map label for this gene is gpsA

Identifier: 74318422

GI number: 74318422

Start: 2475834

End: 2476820

Strand: Direct

Name: gpsA

Synonym: Tbd_2404

Alternate gene names: 74318422

Gene position: 2475834-2476820 (Clockwise)

Preceding gene: 74318421

Following gene: 74318426

Centisome position: 85.09

GC content: 70.42

Gene sequence:

>987_bases
ATGAAGCTCACCGTACTCGGCGCCGGCGCGTGGGGAACGGCGCTGGCCGCGAGCTGGGCGTCGCAGCATGCGGTGACGCT
GTGGGGGCGCAATGCACGCGATGTCGACACGATGCGCGCCTCCCGCGTCAATACCCACTATCTGCCCGGCTGCCCACTTC
CTTCGTCGCTCGCCCTGAGCGCCGATTTCGACCGCGCGCTCGAGGCGGCCGAACTCATCGTCATCGCCGTACCCAGCAGC
GGCCTGCGCGCGACGCTCGCAGCGCTGGCCCGCCGGCCCGCGCTGCCGCCCATCCTCTGGGTATGCAAGGGCTTCGAGCC
GGGCACCCGGCGGCTTCCGCACCAACTCGTCGCCGAACTTCTGCCGGCGGGCGCCGAGACTGGCGTGCTGTCGGGCCCGA
GCTTTGCCCAGGAGGTGGCGCACGGCTATCCCACCGCGCTCACCCTGGCGTCGGCAGACATTGCGCTGGCGCAGCGGCTC
GCCGAGGCGCTGTCCGGAAACCGCCTGCGACTTTACGCGCACGACGACGTCGTCGGAGTCGAGATCGGGGGCGCGCTGAA
GAACGTCATGGCGATCGCCGCGGGCATCTGCGACGGACTCAATTTCGGCCACAACGCGCGCGCCGCGCTGATCACGCGCG
GACTCGCCGAAATGACCCGGCTCGGGGTCGACTCCGGCGGCCGATTCGAAACCTTCATGGGGCTGTCCGGCCTCGGCGAT
CTCATCCTCACGACCACGGGCGATCTCTCGCGCAATCGTCAGGTCGGCCTGCGCGTCGCCAAGGGGCAGCCGCTCGACCG
CATCCTCGACGAACTCGGCCACGTCGCCGAAGGCGTCACGACCGCACGCGAGGTCGCCGCGCTGGCGGCCGAGCGCGGCG
TGGAGATGCCGATCGCGCGCATGGTCTGCCGCATCCTGTTCGAGGGCCTGCCCGCGAGCGAAGCCGTCGACTCGCTGCTC
AACCGCGAAATCCGCTCGGAATTCTAG

Upstream 100 bases:

>100_bases
TGCTCGGGGTGACCGGCGAACCCGACGCCTACGGCTGGCTGCCCGTCAAGCACGCCGACGGCATGGCCGGTTGGCTGCCC
TTGCACGAGGTCTGGGGTCG

Downstream 100 bases:

>100_bases
GCGCGCTCAGGCCTCGGGCGCCGACGCTAGCGGATCCCATTCCCGCAGCCGGCGCTCGGGATCACAGCCACCAGCGCGCG
GCTGAACAGGTAGCCTTGGG

Product: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Products: NA

Alternate protein names: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MKLTVLGAGAWGTALAASWASQHAVTLWGRNARDVDTMRASRVNTHYLPGCPLPSSLALSADFDRALEAAELIVIAVPSS
GLRATLAALARRPALPPILWVCKGFEPGTRRLPHQLVAELLPAGAETGVLSGPSFAQEVAHGYPTALTLASADIALAQRL
AEALSGNRLRLYAHDDVVGVEIGGALKNVMAIAAGICDGLNFGHNARAALITRGLAEMTRLGVDSGGRFETFMGLSGLGD
LILTTTGDLSRNRQVGLRVAKGQPLDRILDELGHVAEGVTTAREVAALAAERGVEMPIARMVCRILFEGLPASEAVDSLL
NREIRSEF

Sequences:

>Translated_328_residues
MKLTVLGAGAWGTALAASWASQHAVTLWGRNARDVDTMRASRVNTHYLPGCPLPSSLALSADFDRALEAAELIVIAVPSS
GLRATLAALARRPALPPILWVCKGFEPGTRRLPHQLVAELLPAGAETGVLSGPSFAQEVAHGYPTALTLASADIALAQRL
AEALSGNRLRLYAHDDVVGVEIGGALKNVMAIAAGICDGLNFGHNARAALITRGLAEMTRLGVDSGGRFETFMGLSGLGD
LILTTTGDLSRNRQVGLRVAKGQPLDRILDELGHVAEGVTTAREVAALAAERGVEMPIARMVCRILFEGLPASEAVDSLL
NREIRSEF
>Mature_328_residues
MKLTVLGAGAWGTALAASWASQHAVTLWGRNARDVDTMRASRVNTHYLPGCPLPSSLALSADFDRALEAAELIVIAVPSS
GLRATLAALARRPALPPILWVCKGFEPGTRRLPHQLVAELLPAGAETGVLSGPSFAQEVAHGYPTALTLASADIALAQRL
AEALSGNRLRLYAHDDVVGVEIGGALKNVMAIAAGICDGLNFGHNARAALITRGLAEMTRLGVDSGGRFETFMGLSGLGD
LILTTTGDLSRNRQVGLRVAKGQPLDRILDELGHVAEGVTTAREVAALAAERGVEMPIARMVCRILFEGLPASEAVDSLL
NREIRSEF

Specific function: De novo phospholipid biosynthesis; glycerol-3 phosphate formation. [C]

COG id: COG0240

COG function: function code C; Glycerol-3-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family

Homologues:

Organism=Homo sapiens, GI33695088, Length=351, Percent_Identity=32.1937321937322, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI24307999, Length=345, Percent_Identity=28.695652173913, Blast_Score=123, Evalue=2e-28,
Organism=Escherichia coli, GI1790037, Length=330, Percent_Identity=43.030303030303, Blast_Score=252, Evalue=3e-68,
Organism=Caenorhabditis elegans, GI32564399, Length=354, Percent_Identity=29.6610169491525, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI193210136, Length=363, Percent_Identity=28.9256198347107, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI32564403, Length=363, Percent_Identity=28.9256198347107, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17507425, Length=355, Percent_Identity=28.169014084507, Blast_Score=111, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI193210134, Length=350, Percent_Identity=27.7142857142857, Blast_Score=92, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6324513, Length=345, Percent_Identity=30.1449275362319, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6320181, Length=358, Percent_Identity=29.8882681564246, Blast_Score=103, Evalue=4e-23,
Organism=Drosophila melanogaster, GI17136204, Length=351, Percent_Identity=28.2051282051282, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI17136202, Length=351, Percent_Identity=28.2051282051282, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI17136200, Length=351, Percent_Identity=28.2051282051282, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI22026922, Length=347, Percent_Identity=26.2247838616715, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI281362270, Length=240, Percent_Identity=27.0833333333333, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI45551945, Length=240, Percent_Identity=27.0833333333333, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24648969, Length=185, Percent_Identity=29.1891891891892, Blast_Score=72, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GPDA_THIDA (Q3SG93)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_316162.1
- HSSP:   P21695
- ProteinModelPortal:   Q3SG93
- SMR:   Q3SG93
- STRING:   Q3SG93
- GeneID:   3672284
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_2404
- NMPDR:   fig|292415.3.peg.2477
- eggNOG:   COG0240
- HOGENOM:   HBG586392
- OMA:   NVAKGIE
- PhylomeDB:   Q3SG93
- ProtClustDB:   PRK00094
- BioCyc:   TDEN292415:TBD_2404-MONOMER
- HAMAP:   MF_00394
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR006168
- InterPro:   IPR006109
- InterPro:   IPR011128
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR11728
- PIRSF:   PIRSF000114
- PRINTS:   PR00077

Pfam domain/function: PF07479 NAD_Gly3P_dh_C; PF01210 NAD_Gly3P_dh_N; SSF48179 6DGDH_C_like

EC number: =1.1.1.94

Molecular weight: Translated: 34505; Mature: 34505

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS00957 NAD_G3PDH

Important sites: ACT_SITE 187-187 BINDING 103-103 BINDING 103-103 BINDING 136-136 BINDING 251-251 BINDING 277-277

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLTVLGAGAWGTALAASWASQHAVTLWGRNARDVDTMRASRVNTHYLPGCPLPSSLALS
CEEEEEECCCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEC
ADFDRALEAAELIVIAVPSSGLRATLAALARRPALPPILWVCKGFEPGTRRLPHQLVAEL
CCHHHHHHHHCEEEEEECCCCHHHHHHHHHHCCCCCHHHHHCCCCCCHHHCCHHHHHHHH
LPAGAETGVLSGPSFAQEVAHGYPTALTLASADIALAQRLAEALSGNRLRLYAHDDVVGV
HCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEE
EIGGALKNVMAIAAGICDGLNFGHNARAALITRGLAEMTRLGVDSGGRFETFMGLSGLGD
EHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCC
LILTTTGDLSRNRQVGLRVAKGQPLDRILDELGHVAEGVTTAREVAALAAERGVEMPIAR
EEEEECCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
MVCRILFEGLPASEAVDSLLNREIRSEF
HHHHHHHCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKLTVLGAGAWGTALAASWASQHAVTLWGRNARDVDTMRASRVNTHYLPGCPLPSSLALS
CEEEEEECCCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEC
ADFDRALEAAELIVIAVPSSGLRATLAALARRPALPPILWVCKGFEPGTRRLPHQLVAEL
CCHHHHHHHHCEEEEEECCCCHHHHHHHHHHCCCCCHHHHHCCCCCCHHHCCHHHHHHHH
LPAGAETGVLSGPSFAQEVAHGYPTALTLASADIALAQRLAEALSGNRLRLYAHDDVVGV
HCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEE
EIGGALKNVMAIAAGICDGLNFGHNARAALITRGLAEMTRLGVDSGGRFETFMGLSGLGD
EHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCC
LILTTTGDLSRNRQVGLRVAKGQPLDRILDELGHVAEGVTTAREVAALAAERGVEMPIAR
EEEEECCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
MVCRILFEGLPASEAVDSLLNREIRSEF
HHHHHHHCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA