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The map label for this gene is trxC [C]

Identifier: 74318419

GI number: 74318419

Start: 2474424

End: 2474852

Strand: Direct

Name: trxC [C]

Synonym: Tbd_2401

Alternate gene names: 74318419

Gene position: 2474424-2474852 (Clockwise)

Preceding gene: 74318418

Following gene: 74318420

Centisome position: 85.04

GC content: 69.46

Gene sequence:

>429_bases
ATGGAACTCGCCTGCCCCCACTGCCTCGCCGTCAACCGCGTGCCCGACGAGCGCCTCGCCGAGTCGCCGAAGTGCGGCAA
GTGCGGCGCCGTGCTCCTGCCGGCAAAGCCACTCGACCTGACGGCCGACAGCTTCGACCGCTTCATCGCACGCGCCGGCC
TGCCGGTTCTCGTCGACTTCTGGGCCGAGTGGTGCGGCCCATGCAAGATGATGGCGCCCGTGTTCCAGCAGGTCGCAGCC
GAGATGGCGACGCGGGTGCGCTTCGCCAAGGTCGACACCGAGGCCGAGCCGCAGGTCTCGATGCGCCATCACATCAAGGG
CATCCCGAGCCTGATCCTGTTCCGCAACGGCGCCGAGGCCGCGCGCACGTCGGGCGCGATGGACGGCCATGCGCTGAAAC
GCTGGCTCGCGGCGCAAGGGATTCGATAG

Upstream 100 bases:

>100_bases
GTTGCTCGCGCGCGACTGACCGCAGCGGCGGGCGCCACTTGAATTTTCCGGCGCCTTCCCCCACCTTGAAGCGAAGCCCT
TTCGTTTCGAGGACGCCGCC

Downstream 100 bases:

>100_bases
CGCGTTAAAATAAGCCTTCCGGAGCCTGCGGCTCCGGTTTTCTTATTCAGGGGGAGACCATGAGCGACGCGCAGCAGCCC
GTATTCAACATCGAGAAACT

Product: thioredoxin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 142; Mature: 142

Protein sequence:

>142_residues
MELACPHCLAVNRVPDERLAESPKCGKCGAVLLPAKPLDLTADSFDRFIARAGLPVLVDFWAEWCGPCKMMAPVFQQVAA
EMATRVRFAKVDTEAEPQVSMRHHIKGIPSLILFRNGAEAARTSGAMDGHALKRWLAAQGIR

Sequences:

>Translated_142_residues
MELACPHCLAVNRVPDERLAESPKCGKCGAVLLPAKPLDLTADSFDRFIARAGLPVLVDFWAEWCGPCKMMAPVFQQVAA
EMATRVRFAKVDTEAEPQVSMRHHIKGIPSLILFRNGAEAARTSGAMDGHALKRWLAAQGIR
>Mature_142_residues
MELACPHCLAVNRVPDERLAESPKCGKCGAVLLPAKPLDLTADSFDRFIARAGLPVLVDFWAEWCGPCKMMAPVFQQVAA
EMATRVRFAKVDTEAEPQVSMRHHIKGIPSLILFRNGAEAARTSGAMDGHALKRWLAAQGIR

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI224493972, Length=105, Percent_Identity=33.3333333333333, Blast_Score=71, Evalue=4e-13,
Organism=Homo sapiens, GI4758304, Length=87, Percent_Identity=39.0804597701149, Blast_Score=70, Evalue=6e-13,
Organism=Homo sapiens, GI21361657, Length=94, Percent_Identity=39.3617021276596, Blast_Score=70, Evalue=7e-13,
Organism=Homo sapiens, GI21361403, Length=132, Percent_Identity=26.5151515151515, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI42794771, Length=121, Percent_Identity=32.2314049586777, Blast_Score=69, Evalue=2e-12,
Organism=Escherichia coli, GI1788936, Length=136, Percent_Identity=41.9117647058824, Blast_Score=135, Evalue=8e-34,
Organism=Escherichia coli, GI87082331, Length=104, Percent_Identity=44.2307692307692, Blast_Score=103, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI193209454, Length=103, Percent_Identity=33.0097087378641, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI25144092, Length=87, Percent_Identity=35.632183908046, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17556044, Length=82, Percent_Identity=32.9268292682927, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI212646193, Length=96, Percent_Identity=28.125, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17569137, Length=100, Percent_Identity=34, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI32566189, Length=100, Percent_Identity=34, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17507915, Length=105, Percent_Identity=34.2857142857143, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323072, Length=100, Percent_Identity=40, Blast_Score=79, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6321648, Length=99, Percent_Identity=34.3434343434343, Blast_Score=71, Evalue=7e-14,
Organism=Drosophila melanogaster, GI28573567, Length=96, Percent_Identity=34.375, Blast_Score=79, Evalue=9e-16,
Organism=Drosophila melanogaster, GI21358065, Length=98, Percent_Identity=32.6530612244898, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17647799, Length=88, Percent_Identity=35.2272727272727, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17648013, Length=75, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24583090, Length=75, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI19921434, Length=92, Percent_Identity=30.4347826086957, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: 1.8.1.8 [C]

Molecular weight: Translated: 15525; Mature: 15525

Theoretical pI: Translated: 8.40; Mature: 8.40

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.2 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
8.5 %Cys+Met (Translated Protein)
4.2 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
8.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELACPHCLAVNRVPDERLAESPKCGKCGAVLLPAKPLDLTADSFDRFIARAGLPVLVDF
CCCCCCCHHHCCCCCHHHHHCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHCCCHHHHHH
WAEWCGPCKMMAPVFQQVAAEMATRVRFAKVDTEAEPQVSMRHHIKGIPSLILFRNGAEA
HHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCEEEECCCCHH
ARTSGAMDGHALKRWLAAQGIR
HHHCCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MELACPHCLAVNRVPDERLAESPKCGKCGAVLLPAKPLDLTADSFDRFIARAGLPVLVDF
CCCCCCCHHHCCCCCHHHHHCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHCCCHHHHHH
WAEWCGPCKMMAPVFQQVAAEMATRVRFAKVDTEAEPQVSMRHHIKGIPSLILFRNGAEA
HHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCEEEECCCCHH
ARTSGAMDGHALKRWLAAQGIR
HHHCCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8652661 [H]