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The map label for this gene is oxyR [H]

Identifier: 74318341

GI number: 74318341

Start: 2397821

End: 2398726

Strand: Reverse

Name: oxyR [H]

Synonym: Tbd_2323

Alternate gene names: 74318341

Gene position: 2398726-2397821 (Counterclockwise)

Preceding gene: 74318343

Following gene: 74318340

Centisome position: 82.44

GC content: 69.76

Gene sequence:

>906_bases
ATGACGCTCCAGGAACTGCGCTATCTCGTCGCCCTCGCCGATCACGGCCATTTCGGGCGGGCCGCCGAAGCCTGCTTCAT
CACCCAGTCGACGCTGTCGACGCAGATCAAGAAACTCGAGGACTTCCTCGGCGTGACGCTATTCGACCGCAGTCTCAAAC
GCGTGACGCCGACGCCGATCGGCCGCGAGATCCTGCAGGCCGCGCGCACGATCGTCGACGAGGCCGAGCGCATCCGCACG
CTCGCCAAGCACGCGCAGGACCCGATGACGCGGACCGTCCATCTCGGCGTCATCCCGACGCTCGGCCCTTACTACCTGCC
GCACGCGCTGACGCTCGTGCACAGAAAGCATCCGGGCCTGCGGCTCTTGCTGCGCGAGGAGATGACGCCGCAGATCCTCG
AACATCTGGCCGACGGGAAACTCGACGCCGGCCTGCTCGCGCTTCCAGTCACCGACGAGGGGCTGCGCGTCGAGCCGCTG
TTCCACGAGCCCTTCTACGCGGCCCTGCCGGCCGACCACGCGCTCGCCGCGCGCGAGGCCTTGAGCGTGGCCGACATCAT
GGCCGAGAAACTGCTGCTGCTCGACGAGGGCCACTGCCTGCGCGAGCAGGCGCTCGACGTCTGCGGCGCGCGCAGCAGCG
GGCGCGAGGAGGTCCGCGCGACCAGTCTCGAGACGCTGCGCCAGATGGTCGGCATGGGTCTGGGGCTGACCCTGTTGCCT
GCGCTCGCCGTCGACGCCGCGCCGCGCCAGACGAGAAAACTGGTCGAGATCCGGCCGTTCCGATCGCCCCCGCCCGGGCG
CACGATCGGCCTTGTCTGGCGCCGTCGCGCGCCGTTTCCCGAGACCTTCGAGCGCCTCGCCGCAACGCTCAAAGCCAGCT
TGCCGGCCGGCGTGGAGGCGGTCTGA

Upstream 100 bases:

>100_bases
GGTGTTCATGGCTTCAATTTAGCCGAGCGCGCCCTGGCACGCGCAGGGGGAACCGGCGGGGAGGGCTAGAATAGGCCGAT
CGCCTTAACCGACCGTCCGC

Downstream 100 bases:

>100_bases
CGACGTCCGATCTGAACGACCCGCGTATTTTTCGCCGCCGAGCGCACGCTCGGGGCGTGGAAACCGCACCGGCCTCACGC
TGATGGTGTTCGGCTTCGTG

Product: oxidative stress transcriptional regulator

Products: NA

Alternate protein names: Morphology and auto-aggregation control protein [H]

Number of amino acids: Translated: 301; Mature: 300

Protein sequence:

>301_residues
MTLQELRYLVALADHGHFGRAAEACFITQSTLSTQIKKLEDFLGVTLFDRSLKRVTPTPIGREILQAARTIVDEAERIRT
LAKHAQDPMTRTVHLGVIPTLGPYYLPHALTLVHRKHPGLRLLLREEMTPQILEHLADGKLDAGLLALPVTDEGLRVEPL
FHEPFYAALPADHALAAREALSVADIMAEKLLLLDEGHCLREQALDVCGARSSGREEVRATSLETLRQMVGMGLGLTLLP
ALAVDAAPRQTRKLVEIRPFRSPPPGRTIGLVWRRRAPFPETFERLAATLKASLPAGVEAV

Sequences:

>Translated_301_residues
MTLQELRYLVALADHGHFGRAAEACFITQSTLSTQIKKLEDFLGVTLFDRSLKRVTPTPIGREILQAARTIVDEAERIRT
LAKHAQDPMTRTVHLGVIPTLGPYYLPHALTLVHRKHPGLRLLLREEMTPQILEHLADGKLDAGLLALPVTDEGLRVEPL
FHEPFYAALPADHALAAREALSVADIMAEKLLLLDEGHCLREQALDVCGARSSGREEVRATSLETLRQMVGMGLGLTLLP
ALAVDAAPRQTRKLVEIRPFRSPPPGRTIGLVWRRRAPFPETFERLAATLKASLPAGVEAV
>Mature_300_residues
TLQELRYLVALADHGHFGRAAEACFITQSTLSTQIKKLEDFLGVTLFDRSLKRVTPTPIGREILQAARTIVDEAERIRTL
AKHAQDPMTRTVHLGVIPTLGPYYLPHALTLVHRKHPGLRLLLREEMTPQILEHLADGKLDAGLLALPVTDEGLRVEPLF
HEPFYAALPADHALAAREALSVADIMAEKLLLLDEGHCLREQALDVCGARSSGREEVRATSLETLRQMVGMGLGLTLLPA
LAVDAAPRQTRKLVEIRPFRSPPPGRTIGLVWRRRAPFPETFERLAATLKASLPAGVEAV

Specific function: Hydrogen peroxide sensor. Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS (a regulatory RNA), dps, fur and grxA. OxyR expression is negatively autoregulated by binding to a 43 bp region upstre

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790399, Length=302, Percent_Identity=44.0397350993377, Blast_Score=241, Evalue=5e-65,
Organism=Escherichia coli, GI145693105, Length=295, Percent_Identity=29.8305084745763, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1788887, Length=279, Percent_Identity=30.1075268817204, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1787530, Length=251, Percent_Identity=27.8884462151394, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI157672245, Length=239, Percent_Identity=30.1255230125523, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1788748, Length=247, Percent_Identity=27.1255060728745, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1787879, Length=249, Percent_Identity=30.1204819277108, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI2367136, Length=269, Percent_Identity=26.0223048327138, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787806, Length=278, Percent_Identity=24.8201438848921, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1790208, Length=261, Percent_Identity=26.0536398467433, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1790262, Length=256, Percent_Identity=26.953125, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1786713, Length=282, Percent_Identity=26.241134751773, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI87081904, Length=302, Percent_Identity=25.8278145695364, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1789173, Length=163, Percent_Identity=32.5153374233129, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1788296, Length=244, Percent_Identity=25.8196721311475, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788297, Length=249, Percent_Identity=25.7028112449799, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1786401, Length=254, Percent_Identity=26.3779527559055, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33197; Mature: 33066

Theoretical pI: Translated: 8.15; Mature: 8.15

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLQELRYLVALADHGHFGRAAEACFITQSTLSTQIKKLEDFLGVTLFDRSLKRVTPTPI
CCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GREILQAARTIVDEAERIRTLAKHAQDPMTRTVHLGVIPTLGPYYLPHALTLVHRKHPGL
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCC
RLLLREEMTPQILEHLADGKLDAGLLALPVTDEGLRVEPLFHEPFYAALPADHALAAREA
EEHHHHHCCHHHHHHHHCCCCCCCEEEEEECCCCCEECEECCCCCHHHCCCHHHHHHHHH
LSVADIMAEKLLLLDEGHCLREQALDVCGARSSGREEVRATSLETLRQMVGMGLGLTLLP
HHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHH
ALAVDAAPRQTRKLVEIRPFRSPPPGRTIGLVWRRRAPFPETFERLAATLKASLPAGVEA
HHHHCCCCHHHHHHHHCCCCCCCCCCCEEEHEECCCCCCHHHHHHHHHHHHHCCCCCCCC
V
C
>Mature Secondary Structure 
TLQELRYLVALADHGHFGRAAEACFITQSTLSTQIKKLEDFLGVTLFDRSLKRVTPTPI
CHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GREILQAARTIVDEAERIRTLAKHAQDPMTRTVHLGVIPTLGPYYLPHALTLVHRKHPGL
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCC
RLLLREEMTPQILEHLADGKLDAGLLALPVTDEGLRVEPLFHEPFYAALPADHALAAREA
EEHHHHHCCHHHHHHHHCCCCCCCEEEEEECCCCCEECEECCCCCHHHCCCHHHHHHHHH
LSVADIMAEKLLLLDEGHCLREQALDVCGARSSGREEVRATSLETLRQMVGMGLGLTLLP
HHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHH
ALAVDAAPRQTRKLVEIRPFRSPPPGRTIGLVWRRRAPFPETFERLAATLKASLPAGVEA
HHHHCCCCHHHHHHHHCCCCCCCCCCCEEEHEECCCCCCHHHHHHHHHHHHHCCCCCCCC
V
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]