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The map label for this gene is cbbZ [C]

Identifier: 74318247

GI number: 74318247

Start: 2309119

End: 2309802

Strand: Reverse

Name: cbbZ [C]

Synonym: Tbd_2229

Alternate gene names: 74318247

Gene position: 2309802-2309119 (Counterclockwise)

Preceding gene: 74318248

Following gene: 74318246

Centisome position: 79.38

GC content: 65.94

Gene sequence:

>684_bases
ATGAAAAGCTTCCCCCTTCCCATCAAGGCCGTCGTCATCGACCTCGACGGCACCCTGCTCAATACGGCGCCCGATCTCGC
GCATGCCGCCGAACTCATGATGGCAGAGCTCGGGCGGCCCTGCCCGTCGCTCGAGACCATTTCGACCTATATCGGCAACG
GCGTCTCGCGTCTGGTCAAGCGGGTGCTCACCGGCGAGATGGACGCCGAGCCGGATCCGGCGTTGTTCGCGCAGGCGATC
GCGTCCTACCAGAAGCATTACGGCGAGCACGTGTCGCTGCACTCGCGCCCCTTCGACGGCGTGGTCGAGGGCCTACAGGC
CTTCAAGGCGATGGGGTTGCACATGGCGTGCATCACCAACAAGGCCGAGCAGTTCACCGTCCCGCTCCTCAAGGGCACGG
GGCTGTACGACTACTTCGAGCTGATCCTCTCCGGCGATACGCTGCCCAAGCGCAAGCCCGACCCACTGCCGCTGTTGCAT
GCGTGCGAGGTGTTCGGCGTAGCCCCAGCCGAGCTGTTGCTGATCGGCGATTCGCTCAACGACACGCAGGCCGCGCGCGC
CGCAGGCTGCCCGGTATTCTGCGTGCCCTACGGCTACAACCGCGGGCGCCCGGTCACCGAACTCGATCTCGACGCAGTCG
TGCCGAGTCTCGCCGAGGCGGCGCTGATGGTGACGAAGGCGTGA

Upstream 100 bases:

>100_bases
CAGGGGTCGGGGGGCTTTGTGCTTCGCGCCTTTCGAAATTGTGCGGCCGCAGGCCGCTCGTCCCCTGAACCCCGACCCCT
GAATCCTGACCCCTACTCAA

Downstream 100 bases:

>100_bases
TGGCAAGGGGGCGGGATTCGGGGATCAGGATTCAGGGGCCGTGCCGCCGATGGCGGCGCTCGTCCTGACAAGACGCGCAG
CACATTCCCTGACCCCTGAA

Product: phosphoglycolate phosphatase

Products: NA

Alternate protein names: PGP; PGPase

Number of amino acids: Translated: 227; Mature: 227

Protein sequence:

>227_residues
MKSFPLPIKAVVIDLDGTLLNTAPDLAHAAELMMAELGRPCPSLETISTYIGNGVSRLVKRVLTGEMDAEPDPALFAQAI
ASYQKHYGEHVSLHSRPFDGVVEGLQAFKAMGLHMACITNKAEQFTVPLLKGTGLYDYFELILSGDTLPKRKPDPLPLLH
ACEVFGVAPAELLLIGDSLNDTQAARAAGCPVFCVPYGYNRGRPVTELDLDAVVPSLAEAALMVTKA

Sequences:

>Translated_227_residues
MKSFPLPIKAVVIDLDGTLLNTAPDLAHAAELMMAELGRPCPSLETISTYIGNGVSRLVKRVLTGEMDAEPDPALFAQAI
ASYQKHYGEHVSLHSRPFDGVVEGLQAFKAMGLHMACITNKAEQFTVPLLKGTGLYDYFELILSGDTLPKRKPDPLPLLH
ACEVFGVAPAELLLIGDSLNDTQAARAAGCPVFCVPYGYNRGRPVTELDLDAVVPSLAEAALMVTKA
>Mature_227_residues
MKSFPLPIKAVVIDLDGTLLNTAPDLAHAAELMMAELGRPCPSLETISTYIGNGVSRLVKRVLTGEMDAEPDPALFAQAI
ASYQKHYGEHVSLHSRPFDGVVEGLQAFKAMGLHMACITNKAEQFTVPLLKGTGLYDYFELILSGDTLPKRKPDPLPLLH
ACEVFGVAPAELLLIGDSLNDTQAARAAGCPVFCVPYGYNRGRPVTELDLDAVVPSLAEAALMVTKA

Specific function: Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stres

COG id: COG0546

COG function: function code R; Predicted phosphatases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family

Homologues:

Organism=Escherichia coli, GI1789787, Length=228, Percent_Identity=35.9649122807018, Blast_Score=136, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GPH_THIDA (Q3SGR5)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_315987.1
- ProteinModelPortal:   Q3SGR5
- SMR:   Q3SGR5
- STRING:   Q3SGR5
- GeneID:   3673919
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_2229
- NMPDR:   fig|292415.3.peg.2160
- eggNOG:   COG0546
- HOGENOM:   HBG742904
- OMA:   DSSNDAQ
- PhylomeDB:   Q3SGR5
- ProtClustDB:   PRK13222
- BioCyc:   TDEN292415:TBD_2229-MONOMER
- HAMAP:   MF_00495
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR006439
- InterPro:   IPR006402
- InterPro:   IPR005833
- InterPro:   IPR000150
- InterPro:   IPR006346
- InterPro:   IPR023198
- Gene3D:   G3DSA:3.40.50.1000
- Gene3D:   G3DSA:1.10.150.240
- PRINTS:   PR00413
- TIGRFAMs:   TIGR01549
- TIGRFAMs:   TIGR01509
- TIGRFAMs:   TIGR01449

Pfam domain/function: PF00702 Hydrolase; SSF56784 SSF56784

EC number: =3.1.3.18

Molecular weight: Translated: 24332; Mature: 24332

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS01228 COF_1

Important sites: ACT_SITE 14-14

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSFPLPIKAVVIDLDGTLLNTAPDLAHAAELMMAELGRPCPSLETISTYIGNGVSRLVK
CCCCCCCEEEEEEECCCCEECCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHHH
RVLTGEMDAEPDPALFAQAIASYQKHYGEHVSLHSRPFDGVVEGLQAFKAMGLHMACITN
HHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHCC
KAEQFTVPLLKGTGLYDYFELILSGDTLPKRKPDPLPLLHACEVFGVAPAELLLIGDSLN
CCHHEEEEHHCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEECCCCC
DTQAARAAGCPVFCVPYGYNRGRPVTELDLDAVVPSLAEAALMVTKA
CHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKSFPLPIKAVVIDLDGTLLNTAPDLAHAAELMMAELGRPCPSLETISTYIGNGVSRLVK
CCCCCCCEEEEEEECCCCEECCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHHH
RVLTGEMDAEPDPALFAQAIASYQKHYGEHVSLHSRPFDGVVEGLQAFKAMGLHMACITN
HHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHCC
KAEQFTVPLLKGTGLYDYFELILSGDTLPKRKPDPLPLLHACEVFGVAPAELLLIGDSLN
CCHHEEEEHHCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEECCCCC
DTQAARAAGCPVFCVPYGYNRGRPVTELDLDAVVPSLAEAALMVTKA
CHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA