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The map label for this gene is ribD [H]

Identifier: 74318186

GI number: 74318186

Start: 2252976

End: 2254055

Strand: Direct

Name: ribD [H]

Synonym: Tbd_2168

Alternate gene names: 74318186

Gene position: 2252976-2254055 (Clockwise)

Preceding gene: 74318185

Following gene: 74318187

Centisome position: 77.43

GC content: 73.24

Gene sequence:

>1080_bases
ATGAGATTTACCGCCGCCGATTCCCGTTTCATGTCGCGCGCCCTGCAACTCGCGGCGCGCGGGCTTTTCACGACGAGCCC
CAATCCGCGCGTCGGCTGCGTCCTCGTCAAGGATGATCGCATCGTCGGCGAAGGCTGGCACGAACGCGCCGGCACGCCGC
ACGCCGAAATCCATGCCCTGCGCGCCGCGGGCGAAGCCGCGCGCGGCGCAACGGCCTACGTCACGCTCGAGCCCTGCTCG
CACCATGGCCGCACGCCGCCCTGCGCGGAGGCGCTCATCGACGCCGGCGTCAGCCGCGTCGTCGCGGCGATGACCGATCC
CAACCCGCTGGTCGCCGGCGGTGGCATTTCGATGCTGACGCTCGCGGGGATCGCGGCCGAGGTCGGGTTGATGGAGGCCG
AGGCGCGCGCGCTCAATCCCGGCTTCGTTTCGCGCATGACGCGGCGCCGTCCCTGGGTGCGGCTCAAGACCGCGTCGACG
CTGGACGGCAAGACCGCGCTCGCCAACGGCGCCTCGCAGTGGATCACCGGCGAGGCCGCACGCGCCGACGTCCAAAGACT
GCGCGCGCGCGCCTGCGCAATCCTGACCGGCAGCGGCACGGTGCTCGCCGACGATCCGCGCATGAACGTGCGTGACTTCG
ACATCGGCCGGGCGCCGCTACGCGTCGTCGTCGATTCGACCCTGCGCACGCCGGCCAGCGCGGCGATCCTGCCCGCGCTC
GTCGCCTGCCGCGACGCCTCGCCGGCTACGCGGACGGCGCTCGAAGCGGCGGGGGCGGAGGTGATCGAGATGCCGGGCGT
AGATGGCCGCGTCGACCTCGCCGCGCTGCTCGCGCTCCTCGCGCAGCGCGGCGTCAACGAAGTCCACGTCGAAGCCGGTG
CGGCGCTGAACGGCGCGCTGCTCGCGGCCGGCTTGGTCGACGAGTGGGTCGCCTACCTCGCGCCGCTCGCGGTCGGCGAT
GACGCGCGCGGGCTGTTCGCCCACGCGCCGCTCGCCACGCTCGCCGAGGCCGCGCGTTTCCGGTTGCAAGACCTGCGGCA
GATCGGCGGCGACCTGCGCCTGACCCTGCTGCCGGCATGA

Upstream 100 bases:

>100_bases
TTCGCCGCACGGCGGGGGCGCGCCAGGGGATCTGTCACGCTGCGCAGAGCGGGCCCGCCGTGCTACTGTTCACGCGGTTT
CGTATCTGCTCCGCACGTCG

Downstream 100 bases:

>100_bases
CGGGCTTCAAGGACCATTTCTCGTCGGGGTCCGAAGGCTACGCGGCATACCGGCCCGACTATCCCGCCACGCTCTTCGCC
TGGCTCTCTAGCCTCTGTGC

Product: 5-amino-6-(5-phosphoribosylamino)uracil reductase / diaminohydroxyphosphoribosylaminopyrimidine deaminase

Products: NA

Alternate protein names: Diaminohydroxyphosphoribosylaminopyrimidine deaminase; DRAP deaminase; Riboflavin-specific deaminase; 5-amino-6-(5-phosphoribosylamino)uracil reductase; HTP reductase [H]

Number of amino acids: Translated: 359; Mature: 359

Protein sequence:

>359_residues
MRFTAADSRFMSRALQLAARGLFTTSPNPRVGCVLVKDDRIVGEGWHERAGTPHAEIHALRAAGEAARGATAYVTLEPCS
HHGRTPPCAEALIDAGVSRVVAAMTDPNPLVAGGGISMLTLAGIAAEVGLMEAEARALNPGFVSRMTRRRPWVRLKTAST
LDGKTALANGASQWITGEAARADVQRLRARACAILTGSGTVLADDPRMNVRDFDIGRAPLRVVVDSTLRTPASAAILPAL
VACRDASPATRTALEAAGAEVIEMPGVDGRVDLAALLALLAQRGVNEVHVEAGAALNGALLAAGLVDEWVAYLAPLAVGD
DARGLFAHAPLATLAEAARFRLQDLRQIGGDLRLTLLPA

Sequences:

>Translated_359_residues
MRFTAADSRFMSRALQLAARGLFTTSPNPRVGCVLVKDDRIVGEGWHERAGTPHAEIHALRAAGEAARGATAYVTLEPCS
HHGRTPPCAEALIDAGVSRVVAAMTDPNPLVAGGGISMLTLAGIAAEVGLMEAEARALNPGFVSRMTRRRPWVRLKTAST
LDGKTALANGASQWITGEAARADVQRLRARACAILTGSGTVLADDPRMNVRDFDIGRAPLRVVVDSTLRTPASAAILPAL
VACRDASPATRTALEAAGAEVIEMPGVDGRVDLAALLALLAQRGVNEVHVEAGAALNGALLAAGLVDEWVAYLAPLAVGD
DARGLFAHAPLATLAEAARFRLQDLRQIGGDLRLTLLPA
>Mature_359_residues
MRFTAADSRFMSRALQLAARGLFTTSPNPRVGCVLVKDDRIVGEGWHERAGTPHAEIHALRAAGEAARGATAYVTLEPCS
HHGRTPPCAEALIDAGVSRVVAAMTDPNPLVAGGGISMLTLAGIAAEVGLMEAEARALNPGFVSRMTRRRPWVRLKTAST
LDGKTALANGASQWITGEAARADVQRLRARACAILTGSGTVLADDPRMNVRDFDIGRAPLRVVVDSTLRTPASAAILPAL
VACRDASPATRTALEAAGAEVIEMPGVDGRVDLAALLALLAQRGVNEVHVEAGAALNGALLAAGLVDEWVAYLAPLAVGD
DARGLFAHAPLATLAEAARFRLQDLRQIGGDLRLTLLPA

Specific function: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate [H]

COG id: COG0117

COG function: function code H; Pyrimidine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the HTP reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786616, Length=365, Percent_Identity=51.5068493150685, Blast_Score=347, Evalue=1e-96,
Organism=Escherichia coli, GI145693172, Length=166, Percent_Identity=36.144578313253, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193
- InterPro:   IPR004794
- InterPro:   IPR011549
- InterPro:   IPR002734 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1; PF01872 RibD_C [H]

EC number: =3.5.4.26; =1.1.1.193 [H]

Molecular weight: Translated: 37449; Mature: 37449

Theoretical pI: Translated: 7.93; Mature: 7.93

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFTAADSRFMSRALQLAARGLFTTSPNPRVGCVLVKDDRIVGEGWHERAGTPHAEIHAL
CCCCCHHHHHHHHHHHHHHHCCEECCCCCCEEEEEEECCEEECCCCHHHCCCCHHHHHHH
RAAGEAARGATAYVTLEPCSHHGRTPPCAEALIDAGVSRVVAAMTDPNPLVAGGGISMLT
HHHCHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEECCCHHHHH
LAGIAAEVGLMEAEARALNPGFVSRMTRRRPWVRLKTASTLDGKTALANGASQWITGEAA
HHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEECCCCCCCCHHHHCCCHHHCCCHHH
RADVQRLRARACAILTGSGTVLADDPRMNVRDFDIGRAPLRVVVDSTLRTPASAAILPAL
HHHHHHHHHHHEEEEECCCCEEECCCCCCCEECCCCCCCHHEEEHHHHCCCHHHHHHHHH
VACRDASPATRTALEAAGAEVIEMPGVDGRVDLAALLALLAQRGVNEVHVEAGAALNGAL
HHHCCCCCHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCHHH
LAAGLVDEWVAYLAPLAVGDDARGLFAHAPLATLAEAARFRLQDLRQIGGDLRLTLLPA
HHHHHHHHHHHHHHHHHCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECC
>Mature Secondary Structure
MRFTAADSRFMSRALQLAARGLFTTSPNPRVGCVLVKDDRIVGEGWHERAGTPHAEIHAL
CCCCCHHHHHHHHHHHHHHHCCEECCCCCCEEEEEEECCEEECCCCHHHCCCCHHHHHHH
RAAGEAARGATAYVTLEPCSHHGRTPPCAEALIDAGVSRVVAAMTDPNPLVAGGGISMLT
HHHCHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEECCCHHHHH
LAGIAAEVGLMEAEARALNPGFVSRMTRRRPWVRLKTASTLDGKTALANGASQWITGEAA
HHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEECCCCCCCCHHHHCCCHHHCCCHHH
RADVQRLRARACAILTGSGTVLADDPRMNVRDFDIGRAPLRVVVDSTLRTPASAAILPAL
HHHHHHHHHHHEEEEECCCCEEECCCCCCCEECCCCCCCHHEEEHHHHCCCHHHHHHHHH
VACRDASPATRTALEAAGAEVIEMPGVDGRVDLAALLALLAQRGVNEVHVEAGAALNGAL
HHHCCCCCHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCHHH
LAAGLVDEWVAYLAPLAVGDDARGLFAHAPLATLAEAARFRLQDLRQIGGDLRLTLLPA
HHHHHHHHHHHHHHHHHCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1406588; 9278503; 9068650 [H]