Definition Thiobacillus denitrificans ATCC 25259 chromosome, complete genome.
Accession NC_007404
Length 2,909,809

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The map label for this gene is fbp [H]

Identifier: 74318170

GI number: 74318170

Start: 2239119

End: 2239445

Strand: Direct

Name: fbp [H]

Synonym: Tbd_2152

Alternate gene names: 74318170

Gene position: 2239119-2239445 (Clockwise)

Preceding gene: 74318169

Following gene: 74318171

Centisome position: 76.95

GC content: 67.89

Gene sequence:

>327_bases
ATGAGCGAACTCGTCATCGAAGATCTCGTCGTCGGCAACGGCGACACCGCGACCCCCGGCCAATTCGTCTCGGTGCACTA
CACCGGCTGGCTCACCAACGGCCAGAAGTTCGACTCCAGCGTCGACCGCGGCGACCCGTTCGAATTCAAGCTCGGTGCCG
GCCAGGTCATCGCCGGCTGGGACCAGGGCGTCGCCGGCATGCAGATCGGCGGCAAGCGCAAGCTCACGATCCCGCCGAAC
CTCGGCTACGGCGCGCGCGGCGCAGGCGGCGTGATCCCGCCGAACGCGACGCTCGTGTTCGAGGTCGAGCTGCTCGGCGT
GAACTGA

Upstream 100 bases:

>100_bases
GACCTGACGTTTCGCCCCGGAACCGTGAGAAAATGAACGGCTTCACGCGCGCTCGGTCATACGCGCGTCGATCCGACTCC
ACTACTCCAGGACTGAATCC

Downstream 100 bases:

>100_bases
AGTCCGTCCCGGCGCCCGCCGGGATCGAGCCGTACCCCGCCGAACCTTCGAGCATGACGAACGCACTTTTTTCCCACCGC
AAGCACTGGGCCGCGCGCTT

Product: peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: Peptidyl-prolyl cis-trans isomerase; PPIase; Rotamase [H]

Number of amino acids: Translated: 108; Mature: 107

Protein sequence:

>108_residues
MSELVIEDLVVGNGDTATPGQFVSVHYTGWLTNGQKFDSSVDRGDPFEFKLGAGQVIAGWDQGVAGMQIGGKRKLTIPPN
LGYGARGAGGVIPPNATLVFEVELLGVN

Sequences:

>Translated_108_residues
MSELVIEDLVVGNGDTATPGQFVSVHYTGWLTNGQKFDSSVDRGDPFEFKLGAGQVIAGWDQGVAGMQIGGKRKLTIPPN
LGYGARGAGGVIPPNATLVFEVELLGVN
>Mature_107_residues
SELVIEDLVVGNGDTATPGQFVSVHYTGWLTNGQKFDSSVDRGDPFEFKLGAGQVIAGWDQGVAGMQIGGKRKLTIPPNL
GYGARGAGGVIPPNATLVFEVELLGVN

Specific function: PPIases accelerate the folding of proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Cytoplasm And Periplasmic Protein [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI17149836, Length=104, Percent_Identity=53.8461538461538, Blast_Score=112, Evalue=6e-26,
Organism=Homo sapiens, GI4503725, Length=104, Percent_Identity=53.8461538461538, Blast_Score=112, Evalue=6e-26,
Organism=Homo sapiens, GI4758380, Length=104, Percent_Identity=52.8846153846154, Blast_Score=112, Evalue=6e-26,
Organism=Homo sapiens, GI206725530, Length=92, Percent_Identity=57.6086956521739, Blast_Score=105, Evalue=1e-23,
Organism=Homo sapiens, GI17149844, Length=92, Percent_Identity=57.6086956521739, Blast_Score=105, Evalue=1e-23,
Organism=Homo sapiens, GI17149842, Length=92, Percent_Identity=57.6086956521739, Blast_Score=105, Evalue=1e-23,
Organism=Homo sapiens, GI4503729, Length=86, Percent_Identity=55.8139534883721, Blast_Score=103, Evalue=2e-23,
Organism=Homo sapiens, GI224809329, Length=96, Percent_Identity=55.2083333333333, Blast_Score=98, Evalue=1e-21,
Organism=Homo sapiens, GI224809327, Length=96, Percent_Identity=55.2083333333333, Blast_Score=98, Evalue=1e-21,
Organism=Homo sapiens, GI4758384, Length=96, Percent_Identity=55.2083333333333, Blast_Score=98, Evalue=1e-21,
Organism=Homo sapiens, GI224809331, Length=96, Percent_Identity=55.2083333333333, Blast_Score=98, Evalue=2e-21,
Organism=Homo sapiens, GI33469985, Length=108, Percent_Identity=45.3703703703704, Blast_Score=94, Evalue=3e-20,
Organism=Homo sapiens, GI192448443, Length=88, Percent_Identity=48.8636363636364, Blast_Score=92, Evalue=8e-20,
Organism=Homo sapiens, GI150010552, Length=109, Percent_Identity=39.4495412844037, Blast_Score=84, Evalue=3e-17,
Organism=Homo sapiens, GI206725547, Length=95, Percent_Identity=46.3157894736842, Blast_Score=82, Evalue=9e-17,
Organism=Homo sapiens, GI8923659, Length=92, Percent_Identity=46.7391304347826, Blast_Score=82, Evalue=1e-16,
Organism=Homo sapiens, GI31317231, Length=96, Percent_Identity=46.875, Blast_Score=79, Evalue=6e-16,
Organism=Homo sapiens, GI7706131, Length=107, Percent_Identity=38.3177570093458, Blast_Score=77, Evalue=2e-15,
Organism=Homo sapiens, GI4503727, Length=110, Percent_Identity=38.1818181818182, Blast_Score=74, Evalue=2e-14,
Organism=Homo sapiens, GI206725544, Length=103, Percent_Identity=36.8932038834951, Blast_Score=67, Evalue=2e-12,
Organism=Homo sapiens, GI17149839, Length=76, Percent_Identity=47.3684210526316, Blast_Score=67, Evalue=4e-12,
Organism=Homo sapiens, GI146229346, Length=103, Percent_Identity=36.8932038834951, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI87082390, Length=100, Percent_Identity=52, Blast_Score=95, Evalue=1e-21,
Organism=Escherichia coli, GI1789745, Length=105, Percent_Identity=46.6666666666667, Blast_Score=81, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71993519, Length=106, Percent_Identity=58.4905660377358, Blast_Score=119, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17540882, Length=92, Percent_Identity=51.0869565217391, Blast_Score=100, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17561782, Length=88, Percent_Identity=56.8181818181818, Blast_Score=96, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI71993555, Length=81, Percent_Identity=48.1481481481481, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17561778, Length=95, Percent_Identity=44.2105263157895, Blast_Score=75, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6324194, Length=114, Percent_Identity=54.3859649122807, Blast_Score=118, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6320727, Length=109, Percent_Identity=55.045871559633, Blast_Score=115, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6323482, Length=105, Percent_Identity=46.6666666666667, Blast_Score=94, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6323566, Length=105, Percent_Identity=46.6666666666667, Blast_Score=94, Evalue=6e-21,
Organism=Drosophila melanogaster, GI281363946, Length=96, Percent_Identity=62.5, Blast_Score=123, Evalue=2e-29,
Organism=Drosophila melanogaster, GI17352457, Length=96, Percent_Identity=62.5, Blast_Score=123, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24647110, Length=103, Percent_Identity=56.3106796116505, Blast_Score=114, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24655568, Length=89, Percent_Identity=58.4269662921348, Blast_Score=111, Evalue=8e-26,
Organism=Drosophila melanogaster, GI24583150, Length=104, Percent_Identity=50, Blast_Score=105, Evalue=4e-24,
Organism=Drosophila melanogaster, GI21356629, Length=104, Percent_Identity=57.6923076923077, Blast_Score=98, Evalue=1e-21,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179 [H]

Pfam domain/function: PF00254 FKBP_C [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 11274; Mature: 11143

Theoretical pI: Translated: 4.45; Mature: 4.45

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MSELVIEDLVVGNGDTATPGQFVSVHYTGWLTNGQKFDSSVDRGDPFEFKLGAGQVIAGW
CCCCEEEEEEECCCCCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCEEEEECCCEEEECC
DQGVAGMQIGGKRKLTIPPNLGYGARGAGGVIPPNATLVFEVELLGVN
CCCCCCEEECCCEEEEECCCCCCCCCCCCCCCCCCCEEEEEEEEEECC
>Mature Secondary Structure 
SELVIEDLVVGNGDTATPGQFVSVHYTGWLTNGQKFDSSVDRGDPFEFKLGAGQVIAGW
CCCEEEEEEECCCCCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCEEEEECCCEEEECC
DQGVAGMQIGGKRKLTIPPNLGYGARGAGGVIPPNATLVFEVELLGVN
CCCCCCEEECCCEEEEECCCCCCCCCCCCCCCCCCCEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]