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The map label for this gene is mutY [H]

Identifier: 74318148

GI number: 74318148

Start: 2217846

End: 2218880

Strand: Direct

Name: mutY [H]

Synonym: Tbd_2130

Alternate gene names: 74318148

Gene position: 2217846-2218880 (Clockwise)

Preceding gene: 74318147

Following gene: 74318149

Centisome position: 76.22

GC content: 68.5

Gene sequence:

>1035_bases
GTGAATTCATTCGCCTCCCGCATTATCCAGTGGCAGCGATGCCACGGCCGCCATAGCCTGCCTTGGCAGGCGACGCGCGA
CCCCTACCGTATCTGGCTGTCGGAAATCATGCTGCAGCAGACGCAGGTCGCAACCGTCATTCCCTATTACGCGCGCTTCG
TCGCGCGCTTTCCCGACCTCCCGGCGCTGGCGGCGGCGCACGAGGACGAAGTGCTTGCGCTCTGGAGCGGACTCGGCTAC
TACAGCCGCGCGCGCAACCTCTACGCGGCGGCACGCACGGTCCTCGACGAACACGCCGGCATCTTTCCCGACGTACCCGA
GACGATTGCCCGCCTGCCCGGCATCGGACGCTCGACCGCGGCCGCGATCGCCGCGCTCGCCTTCGGCCGTGCCTGCGCGA
TCCTCGACGGCAACGTCAAGCGCGTGCTCGCTCGCCACGCCGGGATCAACGGCTGGCCGGGGGAACGAAAGGTGGAACTC
GCGTTGTGGCAGCTCGCGGCGTCGCGCCTGCCGCAAGCCGGAGTCGAGACCTACACCCAGGGCATGATGGATCTCGGCGC
GCTGGTCTGCACGCGCGGCGTGCCTGCGTGTGTCCGCTGTCCGGTCAGCGACGACTGCGTCGCCCGCGTCGACGGCCGAA
TCGAGCAACTGCCGACCCCGCGCCCGCGGAAAGCGTTGCCGGAAAAAGAGGTGCAGATGCTTTTGTTCGTCGAAGACGGC
AGATTGCTGCTGGAAAAACGCCCGCCCAGGGGGATCTGGGGCGGCCTCTGGAGCCTGCCCGAACTCCCCGCAGAAGTCGA
CGCCGGCCGGCACTGCCGCGACCATTTCGGCTTCCGCACGATCTCGCTGCGCACACTCCCCCGGCTCAGCCACACCTTTA
CGCATTTCAAGCTGCACATTCACCCCGTCCGGCTCGACGTGAGCCCCGAGGGCTCCGCGCGTCCGGGGCCGGTGTGGCTG
CCGTTTTCCGCGGCACTGGCGACCGGGCTGCCCGCGCCGGTGCGCAAGCTGGTGCTGCAATTAGGGGAGGGGTGA

Upstream 100 bases:

>100_bases
GAACCTGTTCCGGCAGAAGCTGGGCGTCGCCTGAGCCGCCGCGCCGAACACGACCCGCGGACCACGTGTTGCGCCGCGCG
GGTGGTGTTACCCTGCGCGC

Downstream 100 bases:

>100_bases
ACCGAATTCGCATTGCGCGGTCTCAGCGACAGCCACGGCGCGATTCCGCGCCGTGAATGCGAATGCTATAAGTAGAAGTC
TTTCCGACGCAGGAGGATGA

Product: A/G-specific DNA-adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MNSFASRIIQWQRCHGRHSLPWQATRDPYRIWLSEIMLQQTQVATVIPYYARFVARFPDLPALAAAHEDEVLALWSGLGY
YSRARNLYAAARTVLDEHAGIFPDVPETIARLPGIGRSTAAAIAALAFGRACAILDGNVKRVLARHAGINGWPGERKVEL
ALWQLAASRLPQAGVETYTQGMMDLGALVCTRGVPACVRCPVSDDCVARVDGRIEQLPTPRPRKALPEKEVQMLLFVEDG
RLLLEKRPPRGIWGGLWSLPELPAEVDAGRHCRDHFGFRTISLRTLPRLSHTFTHFKLHIHPVRLDVSPEGSARPGPVWL
PFSAALATGLPAPVRKLVLQLGEG

Sequences:

>Translated_344_residues
MNSFASRIIQWQRCHGRHSLPWQATRDPYRIWLSEIMLQQTQVATVIPYYARFVARFPDLPALAAAHEDEVLALWSGLGY
YSRARNLYAAARTVLDEHAGIFPDVPETIARLPGIGRSTAAAIAALAFGRACAILDGNVKRVLARHAGINGWPGERKVEL
ALWQLAASRLPQAGVETYTQGMMDLGALVCTRGVPACVRCPVSDDCVARVDGRIEQLPTPRPRKALPEKEVQMLLFVEDG
RLLLEKRPPRGIWGGLWSLPELPAEVDAGRHCRDHFGFRTISLRTLPRLSHTFTHFKLHIHPVRLDVSPEGSARPGPVWL
PFSAALATGLPAPVRKLVLQLGEG
>Mature_344_residues
MNSFASRIIQWQRCHGRHSLPWQATRDPYRIWLSEIMLQQTQVATVIPYYARFVARFPDLPALAAAHEDEVLALWSGLGY
YSRARNLYAAARTVLDEHAGIFPDVPETIARLPGIGRSTAAAIAALAFGRACAILDGNVKRVLARHAGINGWPGERKVEL
ALWQLAASRLPQAGVETYTQGMMDLGALVCTRGVPACVRCPVSDDCVARVDGRIEQLPTPRPRKALPEKEVQMLLFVEDG
RLLLEKRPPRGIWGGLWSLPELPAEVDAGRHCRDHFGFRTISLRTLPRLSHTFTHFKLHIHPVRLDVSPEGSARPGPVWL
PFSAALATGLPAPVRKLVLQLGEG

Specific function: Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine:7,8-dihydro-8- oxoguanine (8-oxo-dGTP) [H]

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI115298650, Length=404, Percent_Identity=33.9108910891089, Blast_Score=178, Evalue=5e-45,
Organism=Homo sapiens, GI115298648, Length=404, Percent_Identity=33.9108910891089, Blast_Score=178, Evalue=6e-45,
Organism=Homo sapiens, GI6912520, Length=404, Percent_Identity=33.9108910891089, Blast_Score=178, Evalue=7e-45,
Organism=Homo sapiens, GI115298654, Length=404, Percent_Identity=33.9108910891089, Blast_Score=178, Evalue=7e-45,
Organism=Homo sapiens, GI115298652, Length=404, Percent_Identity=33.9108910891089, Blast_Score=178, Evalue=7e-45,
Organism=Homo sapiens, GI190358497, Length=404, Percent_Identity=33.9108910891089, Blast_Score=178, Evalue=7e-45,
Organism=Escherichia coli, GI1789331, Length=352, Percent_Identity=46.0227272727273, Blast_Score=317, Evalue=7e-88,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF10576 EndIII_4Fe-2S; PF00633 HHH; PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 38063; Mature: 38063

Theoretical pI: Translated: 9.69; Mature: 9.69

Prosite motif: PS01155 ENDONUCLEASE_III_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSFASRIIQWQRCHGRHSLPWQATRDPYRIWLSEIMLQQTQVATVIPYYARFVARFPDL
CCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PALAAAHEDEVLALWSGLGYYSRARNLYAAARTVLDEHAGIFPDVPETIARLPGIGRSTA
CHHHHCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCHHH
AAIAALAFGRACAILDGNVKRVLARHAGINGWPGERKVELALWQLAASRLPQAGVETYTQ
HHHHHHHHHCEEEEECCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHH
GMMDLGALVCTRGVPACVRCPVSDDCVARVDGRIEQLPTPRPRKALPEKEVQMLLFVEDG
HHHHHHHHHHHCCCCCEEECCCCCCHHHHHCCHHHHCCCCCCHHCCCCCCEEEEEEEECC
RLLLEKRPPRGIWGGLWSLPELPAEVDAGRHCRDHFGFRTISLRTLPRLSHTFTHFKLHI
EEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCEEEEEEHHHHHHHHCEEEEEEEE
HPVRLDVSPEGSARPGPVWLPFSAALATGLPAPVRKLVLQLGEG
EEEEEEECCCCCCCCCCEEECHHHHHHCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MNSFASRIIQWQRCHGRHSLPWQATRDPYRIWLSEIMLQQTQVATVIPYYARFVARFPDL
CCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PALAAAHEDEVLALWSGLGYYSRARNLYAAARTVLDEHAGIFPDVPETIARLPGIGRSTA
CHHHHCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCHHH
AAIAALAFGRACAILDGNVKRVLARHAGINGWPGERKVELALWQLAASRLPQAGVETYTQ
HHHHHHHHHCEEEEECCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHH
GMMDLGALVCTRGVPACVRCPVSDDCVARVDGRIEQLPTPRPRKALPEKEVQMLLFVEDG
HHHHHHHHHHHCCCCCEEECCCCCCHHHHHCCHHHHCCCCCCHHCCCCCCEEEEEEEECC
RLLLEKRPPRGIWGGLWSLPELPAEVDAGRHCRDHFGFRTISLRTLPRLSHTFTHFKLHI
EEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCEEEEEEHHHHHHHHCEEEEEEEE
HPVRLDVSPEGSARPGPVWLPFSAALATGLPAPVRKLVLQLGEG
EEEEEEECCCCCCCCCCEEECHHHHHHCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2197596; 2001994; 9278503; 9846876 [H]