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The map label for this gene is rppH

Identifier: 74318128

GI number: 74318128

Start: 2198973

End: 2199524

Strand: Reverse

Name: rppH

Synonym: Tbd_2110

Alternate gene names: 74318128

Gene position: 2199524-2198973 (Counterclockwise)

Preceding gene: 74318129

Following gene: 74318127

Centisome position: 75.59

GC content: 62.86

Gene sequence:

>552_bases
ATGATCGATCGAGAAGGGTACCGCCCGAACGTAGGCATCATATTGTGCAATGCGCGCAACCAGGTCTTCTGGGGCAAGCG
CGTCAACCAGCACGCCTGGCAGTTTCCCCAAGGCGGCATCAACGCCGGGGAAACGCCGGAACAGGCCATGTTCCGGGAAC
TCGAAGAAGAAGTCGGCCTGTTGCCGGGCCATGTCCGCATCCTCGGACGGACGCGCGAGTGGCTGCGTTACGACGTACCG
CCCCACTGGACGCGCCGGGACAATCGCGGGCTGTATCGGGGCCAGAAGCAGATATGGTTTTTGCTGCGTCTGACCGGCCG
CGACTGCGACGTGTCACTGCGCGCGAGCGCCCACCCGGAATTCGACGCCTGGCGCTGGAACGAATACTGGGTTCCGATGG
AGGCGGTCGTCGATTTCAAGCGCGAGGTCTATCGCCTTGCGCTCGAGGAACTCGAGCGCTACCTTCACAGGGACCTCCGG
TATCTGCGACAACACACGCGGCGACCGGGCGAACGACGCGAAGTCCCTTTCGACCTACAGCTCAAGCCTTGA

Upstream 100 bases:

>100_bases
AAAACAAGAACTAAACGCGTTTTTCCGGGCGCCCGAGGTTTGCAATTTGCGACGGGTGTGGAAGAATGCAAGCAACTGAA
CTGAATTTATGGTGGCGGCC

Downstream 100 bases:

>100_bases
ACGCGCTTGGCGGGAGGCAGAATGAAGATCCGTATCCATGCTTCAGACAGACTAGCCCCCGCCCCGTCCCCGGCACTGCC
GCTGTGGCAACTTGCGCCGA

Product: dinucleoside polyphosphate hydrolase

Products: NA

Alternate protein names: (Di)nucleoside polyphosphate hydrolase

Number of amino acids: Translated: 183; Mature: 183

Protein sequence:

>183_residues
MIDREGYRPNVGIILCNARNQVFWGKRVNQHAWQFPQGGINAGETPEQAMFRELEEEVGLLPGHVRILGRTREWLRYDVP
PHWTRRDNRGLYRGQKQIWFLLRLTGRDCDVSLRASAHPEFDAWRWNEYWVPMEAVVDFKREVYRLALEELERYLHRDLR
YLRQHTRRPGERREVPFDLQLKP

Sequences:

>Translated_183_residues
MIDREGYRPNVGIILCNARNQVFWGKRVNQHAWQFPQGGINAGETPEQAMFRELEEEVGLLPGHVRILGRTREWLRYDVP
PHWTRRDNRGLYRGQKQIWFLLRLTGRDCDVSLRASAHPEFDAWRWNEYWVPMEAVVDFKREVYRLALEELERYLHRDLR
YLRQHTRRPGERREVPFDLQLKP
>Mature_183_residues
MIDREGYRPNVGIILCNARNQVFWGKRVNQHAWQFPQGGINAGETPEQAMFRELEEEVGLLPGHVRILGRTREWLRYDVP
PHWTRRDNRGLYRGQKQIWFLLRLTGRDCDVSLRASAHPEFDAWRWNEYWVPMEAVVDFKREVYRLALEELERYLHRDLR
YLRQHTRRPGERREVPFDLQLKP

Specific function: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain

Homologues:

Organism=Escherichia coli, GI1789194, Length=169, Percent_Identity=52.0710059171598, Blast_Score=186, Evalue=1e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RPPH_THIDA (Q3SH26)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_315868.1
- ProteinModelPortal:   Q3SH26
- SMR:   Q3SH26
- STRING:   Q3SH26
- GeneID:   3672882
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_2110
- NMPDR:   fig|292415.3.peg.2286
- eggNOG:   COG0494
- HOGENOM:   HBG302451
- OMA:   GQKQIWY
- PhylomeDB:   Q3SH26
- ProtClustDB:   PRK00714
- BioCyc:   TDEN292415:TBD_2110-MONOMER
- HAMAP:   MF_00298
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797
- InterPro:   IPR022927
- Gene3D:   G3DSA:3.90.79.10
- PRINTS:   PR00502

Pfam domain/function: PF00293 NUDIX; SSF55811 NUDIX_hydrolase

EC number: 3.6.1.- [C]

Molecular weight: Translated: 22164; Mature: 22164

Theoretical pI: Translated: 9.67; Mature: 9.67

Prosite motif: PS51462 NUDIX; PS00893 NUDIX_BOX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDREGYRPNVGIILCNARNQVFWGKRVNQHAWQFPQGGINAGETPEQAMFRELEEEVGL
CCCCCCCCCCCCEEEECCCCCEEECCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCC
LPGHVRILGRTREWLRYDVPPHWTRRDNRGLYRGQKQIWFLLRLTGRDCDVSLRASAHPE
CCCCEEEEECCHHHHEECCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCEEEECCCCCC
FDAWRWNEYWVPMEAVVDFKREVYRLALEELERYLHRDLRYLRQHTRRPGERREVPFDLQ
CCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEE
LKP
ECC
>Mature Secondary Structure
MIDREGYRPNVGIILCNARNQVFWGKRVNQHAWQFPQGGINAGETPEQAMFRELEEEVGL
CCCCCCCCCCCCEEEECCCCCEEECCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCC
LPGHVRILGRTREWLRYDVPPHWTRRDNRGLYRGQKQIWFLLRLTGRDCDVSLRASAHPE
CCCCEEEEECCHHHHEECCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCEEEECCCCCC
FDAWRWNEYWVPMEAVVDFKREVYRLALEELERYLHRDLRYLRQHTRRPGERREVPFDLQ
CCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEE
LKP
ECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA