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The map label for this gene is intA [H]

Identifier: 74318091

GI number: 74318091

Start: 2165580

End: 2166917

Strand: Reverse

Name: intA [H]

Synonym: Tbd_2073

Alternate gene names: 74318091

Gene position: 2166917-2165580 (Counterclockwise)

Preceding gene: 74318101

Following gene: 74318090

Centisome position: 74.47

GC content: 64.65

Gene sequence:

>1338_bases
TTGTTGCCTCATGCAGTTGCATGGCATAGCATGGAAATACCCACAGAACGAGGGTACGGCGGCGGGTACATGTCGAACGC
GCCAAGCCGATACCCTCAGAAACGGTATCCCATGCCACTAACCGACACCGCGATCAAGAAAGCCAAGCCCTCGGTCAAAC
CCTACAAGCTCACTGACGGGGGCGGGCTGTACCTCCTTGTCACCGGGACGGGGCGTTACTGGCGCTACAACTACCGATTC
GGCGGCAAGTTCAAGACCCTTGCTCTGGGCACCTATCCCGATGTGAGCCTGGGACGCGCCCGAGAGAAGCACGCCGACGC
GCGCCGGCAGTGGGCGGACGGCATTGACCCTGGCGCGCTGAAGAGAGCCGCCAAGGTACGTGCCGCCGAATGCGCGGCCA
ACAGTTTCGAGGCGGTAGCGCGCTCATGGTTTGCCAAGGCCTACGCCGACAAGGCACAGACGACGCGCGACAAGACCCTC
ACCCGACTGGAACAGGATGTCTTCCCGTGGATTGGGGCGCGGCCAGTGTCGGAGATTAAGGCGCCCGACGTGCTCGAGGT
GATCCGGCGCATCGAGCAGCGAGGGGCCCTCGACATTGCCCGACGGGTGTTCAACTACATCAGCCGCACGCTGCGCTATG
CCGATAGCCACGGCATGGTCGACCGGGACGTGTCGGCCAGCATCGATTTAAGCCTCGTGCTCACCCAGCGCGAAACCCGA
CACCACGCCGCCATCACCAGCCCGCAGGCAGTCGGCGGCCTCATGCGCGCAATAGACGGGTTCACCGGCGGATTCGTTAC
TCTGTGCGCCCTGAAACTCTCCGCGCTGACCTTCGTGCGCCCCGGCGAGCTGAGGCATGCCGAGTGGGAGGAGTTCGACC
TCGACGGCGGGACCTGGAGCATCCCCGGCCGCAAGATGAAGATGGACAACGACCACATCGTCCCGCTGTCCGCTCAGGCC
CTGGCGATCCTGCGCGAGCTGCACAACCTCACCGGCCGGGGGCGCTACGTCTTCCCCTCCGAACGCGGCGGATCGCGCTC
GATGAGCGAGAACACCGTCAACGGAGCCTTGCGCCGGCTCGGCTTCACCAAGGACGAAATGACGGCCCACGGCTTCCGCG
CGGTGGCGCGCACGCTGCTCGACGAAGAGCTCGGATTCCGGCCTGACTTCATCGAACACCAGCTGGCGCATGCCGTGAAA
GACCCGAACGGCCGCGCCTACAACCGTACCGCGCACCTGGGCGAGCGTCGGAAAATGATGCAGGCCTGGGCCGATTACTT
GGACAAGCTGAAAGCGGGGGCCGACGTGATCCCGCTACGTGGAAAAACCGCCGCCTGA

Upstream 100 bases:

>100_bases
CAGTGTGGGGGTTCGAGTCCCCCTCCCGGCACCAAGTGGACGTAGCAAGCAGCAGCAACACGCAACACAAACCCGCATAT
GGCAATGGAGTGCGGGTTTT

Downstream 100 bases:

>100_bases
CGGCCTCAGGCAAAGCGGGCTGGACGGGTGCGCGAACACCCGTCCAGTCCTGACCACACCGCAACCTATCGAGGAGATTG
CATCATGGCTGCACGTCATT

Product: putative integrase prophage protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MLPHAVAWHSMEIPTERGYGGGYMSNAPSRYPQKRYPMPLTDTAIKKAKPSVKPYKLTDGGGLYLLVTGTGRYWRYNYRF
GGKFKTLALGTYPDVSLGRAREKHADARRQWADGIDPGALKRAAKVRAAECAANSFEAVARSWFAKAYADKAQTTRDKTL
TRLEQDVFPWIGARPVSEIKAPDVLEVIRRIEQRGALDIARRVFNYISRTLRYADSHGMVDRDVSASIDLSLVLTQRETR
HHAAITSPQAVGGLMRAIDGFTGGFVTLCALKLSALTFVRPGELRHAEWEEFDLDGGTWSIPGRKMKMDNDHIVPLSAQA
LAILRELHNLTGRGRYVFPSERGGSRSMSENTVNGALRRLGFTKDEMTAHGFRAVARTLLDEELGFRPDFIEHQLAHAVK
DPNGRAYNRTAHLGERRKMMQAWADYLDKLKAGADVIPLRGKTAA

Sequences:

>Translated_445_residues
MLPHAVAWHSMEIPTERGYGGGYMSNAPSRYPQKRYPMPLTDTAIKKAKPSVKPYKLTDGGGLYLLVTGTGRYWRYNYRF
GGKFKTLALGTYPDVSLGRAREKHADARRQWADGIDPGALKRAAKVRAAECAANSFEAVARSWFAKAYADKAQTTRDKTL
TRLEQDVFPWIGARPVSEIKAPDVLEVIRRIEQRGALDIARRVFNYISRTLRYADSHGMVDRDVSASIDLSLVLTQRETR
HHAAITSPQAVGGLMRAIDGFTGGFVTLCALKLSALTFVRPGELRHAEWEEFDLDGGTWSIPGRKMKMDNDHIVPLSAQA
LAILRELHNLTGRGRYVFPSERGGSRSMSENTVNGALRRLGFTKDEMTAHGFRAVARTLLDEELGFRPDFIEHQLAHAVK
DPNGRAYNRTAHLGERRKMMQAWADYLDKLKAGADVIPLRGKTAA
>Mature_445_residues
MLPHAVAWHSMEIPTERGYGGGYMSNAPSRYPQKRYPMPLTDTAIKKAKPSVKPYKLTDGGGLYLLVTGTGRYWRYNYRF
GGKFKTLALGTYPDVSLGRAREKHADARRQWADGIDPGALKRAAKVRAAECAANSFEAVARSWFAKAYADKAQTTRDKTL
TRLEQDVFPWIGARPVSEIKAPDVLEVIRRIEQRGALDIARRVFNYISRTLRYADSHGMVDRDVSASIDLSLVLTQRETR
HHAAITSPQAVGGLMRAIDGFTGGFVTLCALKLSALTFVRPGELRHAEWEEFDLDGGTWSIPGRKMKMDNDHIVPLSAQA
LAILRELHNLTGRGRYVFPSERGGSRSMSENTVNGALRRLGFTKDEMTAHGFRAVARTLLDEELGFRPDFIEHQLAHAVK
DPNGRAYNRTAHLGERRKMMQAWADYLDKLKAGADVIPLRGKTAA

Specific function: Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In conjunction with excisionase, integrase is also necessary for excision of the prophage from the host genome [H]

COG id: COG0582

COG function: function code L; Integrase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'phage' integrase family [H]

Homologues:

Organism=Escherichia coli, GI1788974, Length=406, Percent_Identity=36.2068965517241, Blast_Score=248, Evalue=5e-67,
Organism=Escherichia coli, GI145693166, Length=398, Percent_Identity=35.427135678392, Blast_Score=212, Evalue=4e-56,
Organism=Escherichia coli, GI1788690, Length=396, Percent_Identity=33.0808080808081, Blast_Score=190, Evalue=2e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011010
- InterPro:   IPR013762
- InterPro:   IPR002104
- InterPro:   IPR023109 [H]

Pfam domain/function: PF00589 Phage_integrase [H]

EC number: NA

Molecular weight: Translated: 49685; Mature: 49685

Theoretical pI: Translated: 10.36; Mature: 10.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPHAVAWHSMEIPTERGYGGGYMSNAPSRYPQKRYPMPLTDTAIKKAKPSVKPYKLTDG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCEEEECC
GGLYLLVTGTGRYWRYNYRFGGKFKTLALGTYPDVSLGRAREKHADARRQWADGIDPGAL
CCEEEEEECCCCEEEEEEEECCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCHHHH
KRAAKVRAAECAANSFEAVARSWFAKAYADKAQTTRDKTLTRLEQDVFPWIGARPVSEIK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCC
APDVLEVIRRIEQRGALDIARRVFNYISRTLRYADSHGMVDRDVSASIDLSLVLTQRETR
CCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECHHHH
HHAAITSPQAVGGLMRAIDGFTGGFVTLCALKLSALTFVRPGELRHAEWEEFDLDGGTWS
HHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEECCCCCCCCCCCCEECCCCEEC
IPGRKMKMDNDHIVPLSAQALAILRELHNLTGRGRYVFPSERGGSRSMSENTVNGALRRL
CCCCEEECCCCCEECCHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCHHHHHHHHHHHH
GFTKDEMTAHGFRAVARTLLDEELGFRPDFIEHQLAHAVKDPNGRAYNRTAHLGERRKMM
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCEECHHHHHHHHHHHH
QAWADYLDKLKAGADVIPLRGKTAA
HHHHHHHHHHHCCCCEEECCCCCCC
>Mature Secondary Structure
MLPHAVAWHSMEIPTERGYGGGYMSNAPSRYPQKRYPMPLTDTAIKKAKPSVKPYKLTDG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCEEEECC
GGLYLLVTGTGRYWRYNYRFGGKFKTLALGTYPDVSLGRAREKHADARRQWADGIDPGAL
CCEEEEEECCCCEEEEEEEECCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCHHHH
KRAAKVRAAECAANSFEAVARSWFAKAYADKAQTTRDKTLTRLEQDVFPWIGARPVSEIK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCC
APDVLEVIRRIEQRGALDIARRVFNYISRTLRYADSHGMVDRDVSASIDLSLVLTQRETR
CCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECHHHH
HHAAITSPQAVGGLMRAIDGFTGGFVTLCALKLSALTFVRPGELRHAEWEEFDLDGGTWS
HHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEECCCCCCCCCCCCEECCCCEEC
IPGRKMKMDNDHIVPLSAQALAILRELHNLTGRGRYVFPSERGGSRSMSENTVNGALRRL
CCCCEEECCCCCEECCHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCHHHHHHHHHHHH
GFTKDEMTAHGFRAVARTLLDEELGFRPDFIEHQLAHAVKDPNGRAYNRTAHLGERRKMM
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCEECHHHHHHHHHHHH
QAWADYLDKLKAGADVIPLRGKTAA
HHHHHHHHHHHCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7511583; 9278503; 9205837; 7524073 [H]