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The map label for this gene is panC

Identifier: 74318072

GI number: 74318072

Start: 2141329

End: 2142180

Strand: Direct

Name: panC

Synonym: Tbd_2054

Alternate gene names: 74318072

Gene position: 2141329-2142180 (Clockwise)

Preceding gene: 74318071

Following gene: 74318073

Centisome position: 73.59

GC content: 69.37

Gene sequence:

>852_bases
ATGCAGGTCGTCCATACCGTCGCCGACCTGCGCGCGGCGCTTTCGGAAGCGGACCGCAGCGCATTCGTGCCGACGATGGG
CAACCTCCACGCCGGCCACGTCTCGCTCGTCGAACTCGCGAAGCGGCACGGCGGCCCGGTCGTCGCGAGCATCTTCGTCA
ACCCGCTGCAGTTCGGCGCCGGCGAGGACTTCGAACGCTATCCGCGCACGCTCGCCGCCGACTGCGACAAACTCGCCGAA
GCGGGCTGCGACCTCGTCTTCGCGCCGGACACGAGCGCGCTCTATCCGGTCGCGCAGACGTTCAGGGTCGACGTTCCCGC
CGCGCTCGCCGAGGATCTCTGCGGCGCGTTTCGACCCGGACACTTCGCTGGCGTGGCGACCGTCGTGCTCAAGCTCTTCA
ATCTGGTTCGCCCGCAGGTCGCGGTGTTCGGCCGCAAGGATTACCAGCAGCTCCTGGTCGTCCGGGAAATGGTGCGGCAG
TTCAACCTGCCGATCGACATCGTGGCCGGGGCGACGCTGCGCGACCCCGACGGCCTCGCGATGAGCTCGCGCAACGGCTA
TCTGAGCGCCGCCGAACGCGCGCAGGCACCGCAACTGCAGCGCGAACTCGCCGCGATCGTCGCTGCGATCGACGGTGGCG
CACGGAATTTCGCCGCCCTCGCGGCGGCCGCGCGGCAGCGTCTGACGGGCGCCGGATGGCGCGTCGACTATGTCGAAATC
CGGGACGCAGAAAGTCTGAAGACCGCGACGCAGGAGACCGAGGCGCTGGTCGTGCTCGCGGCAGCCTGGCTCGGGCAGAC
CCGCCTCATCGACAACCTCGAAGTCACGTCCGCAGCCGGCATCGCCGCCTGA

Upstream 100 bases:

>100_bases
AGAATTTTCTCGCCGGCGCCGGCAGCGTCGACGCCGCCGTGCGCGCCTACGTCGCGGCAGTCAAGGACGGCAGCTTCCCC
GCCGCCGAACACGCGTTCTG

Downstream 100 bases:

>100_bases
GCGTCACAGGCGCCGCCCTTTGGCCCCTTCCCCCCGAAGGGTATAATGTCGCTCCTTTTTGTGATTGTGAGGGCACCGTC
ATGCAAAGAACGATGCTCAA

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 283; Mature: 283

Protein sequence:

>283_residues
MQVVHTVADLRAALSEADRSAFVPTMGNLHAGHVSLVELAKRHGGPVVASIFVNPLQFGAGEDFERYPRTLAADCDKLAE
AGCDLVFAPDTSALYPVAQTFRVDVPAALAEDLCGAFRPGHFAGVATVVLKLFNLVRPQVAVFGRKDYQQLLVVREMVRQ
FNLPIDIVAGATLRDPDGLAMSSRNGYLSAAERAQAPQLQRELAAIVAAIDGGARNFAALAAAARQRLTGAGWRVDYVEI
RDAESLKTATQETEALVVLAAAWLGQTRLIDNLEVTSAAGIAA

Sequences:

>Translated_283_residues
MQVVHTVADLRAALSEADRSAFVPTMGNLHAGHVSLVELAKRHGGPVVASIFVNPLQFGAGEDFERYPRTLAADCDKLAE
AGCDLVFAPDTSALYPVAQTFRVDVPAALAEDLCGAFRPGHFAGVATVVLKLFNLVRPQVAVFGRKDYQQLLVVREMVRQ
FNLPIDIVAGATLRDPDGLAMSSRNGYLSAAERAQAPQLQRELAAIVAAIDGGARNFAALAAAARQRLTGAGWRVDYVEI
RDAESLKTATQETEALVVLAAAWLGQTRLIDNLEVTSAAGIAA
>Mature_283_residues
MQVVHTVADLRAALSEADRSAFVPTMGNLHAGHVSLVELAKRHGGPVVASIFVNPLQFGAGEDFERYPRTLAADCDKLAE
AGCDLVFAPDTSALYPVAQTFRVDVPAALAEDLCGAFRPGHFAGVATVVLKLFNLVRPQVAVFGRKDYQQLLVVREMVRQ
FNLPIDIVAGATLRDPDGLAMSSRNGYLSAAERAQAPQLQRELAAIVAAIDGGARNFAALAAAARQRLTGAGWRVDYVEI
RDAESLKTATQETEALVVLAAAWLGQTRLIDNLEVTSAAGIAA

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=279, Percent_Identity=48.0286738351254, Blast_Score=253, Evalue=9e-69,
Organism=Saccharomyces cerevisiae, GI6322046, Length=309, Percent_Identity=33.9805825242718, Blast_Score=157, Evalue=3e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_THIDA (Q3SH82)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_315812.1
- HSSP:   P0A5R0
- ProteinModelPortal:   Q3SH82
- SMR:   Q3SH82
- STRING:   Q3SH82
- GeneID:   3672225
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_2054
- NMPDR:   fig|292415.3.peg.2194
- eggNOG:   COG0414
- HOGENOM:   HBG428839
- OMA:   EDFGSYP
- PhylomeDB:   Q3SH82
- ProtClustDB:   PRK00380
- BioCyc:   TDEN292415:TBD_2054-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR004821
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00125
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 30118; Mature: 30118

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: NA

Important sites: ACT_SITE 33-33 BINDING 57-57 BINDING 57-57 BINDING 150-150 BINDING 173-173

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVVHTVADLRAALSEADRSAFVPTMGNLHAGHVSLVELAKRHGGPVVASIFVNPLQFGA
CCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEHHHHHHCCC
GEDFERYPRTLAADCDKLAEAGCDLVFAPDTSALYPVAQTFRVDVPAALAEDLCGAFRPG
CCCHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCC
HFAGVATVVLKLFNLVRPQVAVFGRKDYQQLLVVREMVRQFNLPIDIVAGATLRDPDGLA
HHHHHHHHHHHHHHHHCHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEECCEEECCCCCE
MSSRNGYLSAAERAQAPQLQRELAAIVAAIDGGARNFAALAAAARQRLTGAGWRVDYVEI
ECCCCCCHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEEEEE
RDAESLKTATQETEALVVLAAAWLGQTRLIDNLEVTSAAGIAA
CCHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCHHCCCCCCC
>Mature Secondary Structure
MQVVHTVADLRAALSEADRSAFVPTMGNLHAGHVSLVELAKRHGGPVVASIFVNPLQFGA
CCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEHHHHHHCCC
GEDFERYPRTLAADCDKLAEAGCDLVFAPDTSALYPVAQTFRVDVPAALAEDLCGAFRPG
CCCHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCC
HFAGVATVVLKLFNLVRPQVAVFGRKDYQQLLVVREMVRQFNLPIDIVAGATLRDPDGLA
HHHHHHHHHHHHHHHHCHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEECCEEECCCCCE
MSSRNGYLSAAERAQAPQLQRELAAIVAAIDGGARNFAALAAAARQRLTGAGWRVDYVEI
ECCCCCCHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEEEEE
RDAESLKTATQETEALVVLAAAWLGQTRLIDNLEVTSAAGIAA
CCHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA