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The map label for this gene is folK [H]

Identifier: 74318069

GI number: 74318069

Start: 2139395

End: 2139901

Strand: Direct

Name: folK [H]

Synonym: Tbd_2051

Alternate gene names: 74318069

Gene position: 2139395-2139901 (Clockwise)

Preceding gene: 74318068

Following gene: 74318070

Centisome position: 73.52

GC content: 70.02

Gene sequence:

>507_bases
ATGAAGGTCGTCGCCACCATCGGCCTCGGCGCCAACCTCAACGACCCGGCGGCACAGGTCGAATATGCGCTGGCCGAGCT
CGACCGCCTGCCCGCGACGCGCCTGCTTGCGCGCTCCAGCCTGTACGCCTCGTCCCCGGTCGGCTACGTCGACCAGCCCG
ACTTCATCAACGCCGTGGCGCAGGTCGAAACCGGCCTCGCACCGCGCGCGCTGCTCGCCGCGCTGCTCGACATCGAACAA
CGCCACGGGCGCGAGCGCAGTTTCCGCAACGCGCCGCGCACGCTCGACCTCGACCTGCTGCTATACGGCAGCGCACGCTT
CCACGAAGACGGCCTGACGCTGCCACATCCGCGCATGCACGAACGCGCGTTCGTGCTCCTGCCACTGCTCGAAATCGCCG
CACAGACCGTGATTCCCGGACGCGGGCCGGCGGAGGACTGGCTTGCCGCAGCGAGCGGGCAGAACGTCGCCCTGCTTCCC
CCTTCCCCTGCCGCCGCTCACGCATGA

Upstream 100 bases:

>100_bases
CACGCGCCGGAATGCTCCTCGCCGACACGGCCGCCAAGCCGCGGCGGCGCCGCAAGCGCAGGAAGCCCGGCGAGGAAGGC
GCGCGCGAGACGCAACCGGC

Downstream 100 bases:

>100_bases
CGTCATCCCGCTACCGTTACATCGTCGTCGAAGGCCCGATCGGCGCCGGCAAGACCAGTCTCACGCACAAGCTGGCCGAA
CGTCTCGGCGCCGACCTGCT

Product: 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 168; Mature: 168

Protein sequence:

>168_residues
MKVVATIGLGANLNDPAAQVEYALAELDRLPATRLLARSSLYASSPVGYVDQPDFINAVAQVETGLAPRALLAALLDIEQ
RHGRERSFRNAPRTLDLDLLLYGSARFHEDGLTLPHPRMHERAFVLLPLLEIAAQTVIPGRGPAEDWLAAASGQNVALLP
PSPAAAHA

Sequences:

>Translated_168_residues
MKVVATIGLGANLNDPAAQVEYALAELDRLPATRLLARSSLYASSPVGYVDQPDFINAVAQVETGLAPRALLAALLDIEQ
RHGRERSFRNAPRTLDLDLLLYGSARFHEDGLTLPHPRMHERAFVLLPLLEIAAQTVIPGRGPAEDWLAAASGQNVALLP
PSPAAAHA
>Mature_168_residues
MKVVATIGLGANLNDPAAQVEYALAELDRLPATRLLARSSLYASSPVGYVDQPDFINAVAQVETGLAPRALLAALLDIEQ
RHGRERSFRNAPRTLDLDLLLYGSARFHEDGLTLPHPRMHERAFVLLPLLEIAAQTVIPGRGPAEDWLAAASGQNVALLP
PSPAAAHA

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=138, Percent_Identity=44.9275362318841, Blast_Score=112, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6324073, Length=134, Percent_Identity=37.3134328358209, Blast_Score=89, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 17997; Mature: 17997

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVVATIGLGANLNDPAAQVEYALAELDRLPATRLLARSSLYASSPVGYVDQPDFINAVA
CEEEEEECCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
QVETGLAPRALLAALLDIEQRHGRERSFRNAPRTLDLDLLLYGSARFHEDGLTLPHPRMH
HHHCCCCHHHHHHHHHHHHHHCCHHHHHHCCCCEECEEEEEECCCEECCCCCCCCCCCHH
ERAFVLLPLLEIAAQTVIPGRGPAEDWLAAASGQNVALLPPSPAAAHA
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCEEEEECCCCCCCCC
>Mature Secondary Structure
MKVVATIGLGANLNDPAAQVEYALAELDRLPATRLLARSSLYASSPVGYVDQPDFINAVA
CEEEEEECCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
QVETGLAPRALLAALLDIEQRHGRERSFRNAPRTLDLDLLLYGSARFHEDGLTLPHPRMH
HHHCCCCHHHHHHHHHHHHHHCCHHHHHHCCCCEECEEEEEECCCEECCCCCCCCCCCHH
ERAFVLLPLLEIAAQTVIPGRGPAEDWLAAASGQNVALLPPSPAAAHA
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 10080886 [H]