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The map label for this gene is ilvC

Identifier: 74318007

GI number: 74318007

Start: 2079592

End: 2080608

Strand: Reverse

Name: ilvC

Synonym: Tbd_1989

Alternate gene names: 74318007

Gene position: 2080608-2079592 (Counterclockwise)

Preceding gene: 74318008

Following gene: 74318006

Centisome position: 71.5

GC content: 64.21

Gene sequence:

>1017_bases
ATGAAAGTTTATTACGACAAGGACGCCGACCTTTCCCTCATCAAGCAGCGCAAGGTCGCGATCGTCGGTTACGGTTCGCA
GGGCCACGCCCACGCCAACAACCTCAAGGATTCCGGCGTCGACGTCACGGTCGCCCTGCGCCCGGGTTCGGCTTCGGCGA
AGAAGGCCGAGAACGCCGGCCTGACCGTCAAGAGCGTGCCCGAAGCCGTCGCCGGGGCCGACCTCGTCATGATCCTCACG
CCCGACGAGTTCCAGTCGCGGCTCTACCGCGACGAGATCGAGCCGAACATCAAGCAGGGTGCGACGCTCGCGTTCGCCCA
CGGCTTCTCGATCCACTACAACCAGGTCGTGCCGCGCGCCGACCTCGACGTGATCATGATCGCGCCCAAAGCCCCGGGCC
ACACCGTGCGTTCCGAGTTCGTCAAGGGCGGCGGCATCCCCGACCTCATCGCGATCTATCAGGACGCGTCGGGCAAGGCC
AAGGAAACCGCGCTCTCCTATGCATCGGCGATCGGCGGCGGCCGCACCGGCATCATCGAGACGACCTTCAAGGACGAGAC
CGAGACCGACCTCTTCGGCGAGCAGGCCGTGCTGTGCGGCGGCGCGGTCGAGCTGGTGAAGGCCGGCTTCGACACGCTCG
TCGAGGCGGGCTACGCGCCCGAAATGGCCTACTTCGAGTGCCTGCACGAACTCAAGCTGATCGTCGACCTGATGTACGAA
GGCGGCATCGCCAACATGAACTACTCGATCTCCAACAACGCCGAGTACGGCGAGTACGTGACCGGCGTCAAGGTCATCAA
CGAGCAGTCGCGCGCGGCGATGAAGGAGTGCCTCGCCAACATCCAGAACGGCGCCTACGCCAAGCGCTTCATCCTCGAAG
GCCAGGCCAACTACCCCGAAATGACCGCATGGCGCCGCAACAACGCCGCGCATCAGATCGAAGTCGTCGGCGCCAAGCTG
CGCTCGATGATGCCGTGGATCGCCGCGAACAAGCTCGTCGACCATTCGAAGAACTGA

Upstream 100 bases:

>100_bases
CGAGACCGTGCGCACCGGAGCGTCCGGCATCGGACGCGGTGAGCGCAGCCTCAAAGTCTGATTTTCAATTCGCATTCATT
TTTTTGCCCAGGAATTCACC

Downstream 100 bases:

>100_bases
GGGGCAGGGGTCAGGGGTCGGGGATCTGGGATCAGGGGGTGTGCGGCTGCGCCGGCCTCTTCCCCCCGGATCCCTGAATC
CTGAATCCTGAACCCTGAAT

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MKVYYDKDADLSLIKQRKVAIVGYGSQGHAHANNLKDSGVDVTVALRPGSASAKKAENAGLTVKSVPEAVAGADLVMILT
PDEFQSRLYRDEIEPNIKQGATLAFAHGFSIHYNQVVPRADLDVIMIAPKAPGHTVRSEFVKGGGIPDLIAIYQDASGKA
KETALSYASAIGGGRTGIIETTFKDETETDLFGEQAVLCGGAVELVKAGFDTLVEAGYAPEMAYFECLHELKLIVDLMYE
GGIANMNYSISNNAEYGEYVTGVKVINEQSRAAMKECLANIQNGAYAKRFILEGQANYPEMTAWRRNNAAHQIEVVGAKL
RSMMPWIAANKLVDHSKN

Sequences:

>Translated_338_residues
MKVYYDKDADLSLIKQRKVAIVGYGSQGHAHANNLKDSGVDVTVALRPGSASAKKAENAGLTVKSVPEAVAGADLVMILT
PDEFQSRLYRDEIEPNIKQGATLAFAHGFSIHYNQVVPRADLDVIMIAPKAPGHTVRSEFVKGGGIPDLIAIYQDASGKA
KETALSYASAIGGGRTGIIETTFKDETETDLFGEQAVLCGGAVELVKAGFDTLVEAGYAPEMAYFECLHELKLIVDLMYE
GGIANMNYSISNNAEYGEYVTGVKVINEQSRAAMKECLANIQNGAYAKRFILEGQANYPEMTAWRRNNAAHQIEVVGAKL
RSMMPWIAANKLVDHSKN
>Mature_338_residues
MKVYYDKDADLSLIKQRKVAIVGYGSQGHAHANNLKDSGVDVTVALRPGSASAKKAENAGLTVKSVPEAVAGADLVMILT
PDEFQSRLYRDEIEPNIKQGATLAFAHGFSIHYNQVVPRADLDVIMIAPKAPGHTVRSEFVKGGGIPDLIAIYQDASGKA
KETALSYASAIGGGRTGIIETTFKDETETDLFGEQAVLCGGAVELVKAGFDTLVEAGYAPEMAYFECLHELKLIVDLMYE
GGIANMNYSISNNAEYGEYVTGVKVINEQSRAAMKECLANIQNGAYAKRFILEGQANYPEMTAWRRNNAAHQIEVVGAKL
RSMMPWIAANKLVDHSKN

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=321, Percent_Identity=34.5794392523364, Blast_Score=162, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6323387, Length=332, Percent_Identity=32.2289156626506, Blast_Score=135, Evalue=1e-32,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_THIDA (Q3SHE4)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_315747.1
- ProteinModelPortal:   Q3SHE4
- SMR:   Q3SHE4
- STRING:   Q3SHE4
- GeneID:   3671741
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_1989
- NMPDR:   fig|292415.3.peg.2105
- eggNOG:   COG0059
- HOGENOM:   HBG286525
- OMA:   MAYAKGI
- PhylomeDB:   Q3SHE4
- ProtClustDB:   PRK05479
- BioCyc:   TDEN292415:TBD_1989-MONOMER
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 36566; Mature: 36566

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: NA

Important sites: ACT_SITE 107-107

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVYYDKDADLSLIKQRKVAIVGYGSQGHAHANNLKDSGVDVTVALRPGSASAKKAENAG
CEEEECCCCCHHHHHCCEEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHCCC
LTVKSVPEAVAGADLVMILTPDEFQSRLYRDEIEPNIKQGATLAFAHGFSIHYNQVVPRA
CCHHHCCHHHCCCCEEEEECCHHHHHHHHHHHCCCCHHCCCEEEEEECCEEEECCCCCCC
DLDVIMIAPKAPGHTVRSEFVKGGGIPDLIAIYQDASGKAKETALSYASAIGGGRTGIIE
CCCEEEECCCCCCHHHHHHHHCCCCCCHHHHEEECCCCCHHHHHHHHHHHCCCCCCCEEE
TTFKDETETDLFGEQAVLCGGAVELVKAGFDTLVEAGYAPEMAYFECLHELKLIVDLMYE
ECCCCCCCHHHCCCCEEEECHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHC
GGIANMNYSISNNAEYGEYVTGVKVINEQSRAAMKECLANIQNGAYAKRFILEGQANYPE
CCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCC
MTAWRRNNAAHQIEVVGAKLRSMMPWIAANKLVDHSKN
CHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKVYYDKDADLSLIKQRKVAIVGYGSQGHAHANNLKDSGVDVTVALRPGSASAKKAENAG
CEEEECCCCCHHHHHCCEEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHCCC
LTVKSVPEAVAGADLVMILTPDEFQSRLYRDEIEPNIKQGATLAFAHGFSIHYNQVVPRA
CCHHHCCHHHCCCCEEEEECCHHHHHHHHHHHCCCCHHCCCEEEEEECCEEEECCCCCCC
DLDVIMIAPKAPGHTVRSEFVKGGGIPDLIAIYQDASGKAKETALSYASAIGGGRTGIIE
CCCEEEECCCCCCHHHHHHHHCCCCCCHHHHEEECCCCCHHHHHHHHHHHCCCCCCCEEE
TTFKDETETDLFGEQAVLCGGAVELVKAGFDTLVEAGYAPEMAYFECLHELKLIVDLMYE
ECCCCCCCHHHCCCCEEEECHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHC
GGIANMNYSISNNAEYGEYVTGVKVINEQSRAAMKECLANIQNGAYAKRFILEGQANYPE
CCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCC
MTAWRRNNAAHQIEVVGAKLRSMMPWIAANKLVDHSKN
CHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA