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The map label for this gene is trpF

Identifier: 74317933

GI number: 74317933

Start: 2010953

End: 2011570

Strand: Reverse

Name: trpF

Synonym: Tbd_1915

Alternate gene names: 74317933

Gene position: 2011570-2010953 (Counterclockwise)

Preceding gene: 74317934

Following gene: 74317932

Centisome position: 69.13

GC content: 66.34

Gene sequence:

>618_bases
ATGGCCGTTCGCGTAAAAATCTGCGGAATTACCCGCGTCGACGACCTGCACGCTGCGTGCGACGCCGGCGCAGATGCGCT
TGGCTTCGTTTTCTACGAGAAGAGCCCGCGTCATCTGACGCTCGACGCCGCCGCCGCGCTGCTGCGGGAAGTCCCGCCAT
TCGTTCAGACTGTGGGCCTTTTCGTCGACGCCAACCCGGCCTTTGTCGACTCGGTGTTGCGCGCTGTGCCGCTCGATCTG
CTGCAGTTTCATGGCGACGAGAAGCCCGCCGACTGCGCGCGCCACGGCCGGCCCTGGATCAAGGCCATACGCGTCAGAGC
GGACACGGATTTGCTAAAATGCGCGGCTGACTTCGCGGCCGCGAGCGGGCTTCTGCTCGACGCCTACGTGCCCGGCGTGC
CCGGTGGCACCGGGGCGCGCTTCGACTGGCGGCTGATTCCGCCGCGTCTGCCCCAGCGGGTTATTTTGTCCGGAGGGCTC
ACGCCGGATAACGTTGCCGACGCGGTCCGGCGCGTCCGTCCCTGGGCGGTCGACGTGTCCTCGGGCGTCGAGGCGGCGAA
AGGCATCAAGGACGCGCAGAAGATCGCGCGATTCATCTCACAGGCGAAAGCATCATGA

Upstream 100 bases:

>100_bases
GCGACCGCACGCGTGCCGCGCCGACCTTCGAGGCGGCAGGACTGTACCTCACGCACATCCGGTATCCTGCGCGCTTTGCC
CTGCCGGAAAGCTCCGAACG

Downstream 100 bases:

>100_bases
AGCTGACTGACCTTCCCGATTCCCGCGGCCACTTCGGTCCCTACGGCGGCATTTTCGTTTCCGAAACGCTGATGGCCGCG
CTCGACGCGCTGCGTGTCGA

Product: phosphoribosylanthranilate isomerase

Products: NA

Alternate protein names: PRAI

Number of amino acids: Translated: 205; Mature: 204

Protein sequence:

>205_residues
MAVRVKICGITRVDDLHAACDAGADALGFVFYEKSPRHLTLDAAAALLREVPPFVQTVGLFVDANPAFVDSVLRAVPLDL
LQFHGDEKPADCARHGRPWIKAIRVRADTDLLKCAADFAAASGLLLDAYVPGVPGGTGARFDWRLIPPRLPQRVILSGGL
TPDNVADAVRRVRPWAVDVSSGVEAAKGIKDAQKIARFISQAKAS

Sequences:

>Translated_205_residues
MAVRVKICGITRVDDLHAACDAGADALGFVFYEKSPRHLTLDAAAALLREVPPFVQTVGLFVDANPAFVDSVLRAVPLDL
LQFHGDEKPADCARHGRPWIKAIRVRADTDLLKCAADFAAASGLLLDAYVPGVPGGTGARFDWRLIPPRLPQRVILSGGL
TPDNVADAVRRVRPWAVDVSSGVEAAKGIKDAQKIARFISQAKAS
>Mature_204_residues
AVRVKICGITRVDDLHAACDAGADALGFVFYEKSPRHLTLDAAAALLREVPPFVQTVGLFVDANPAFVDSVLRAVPLDLL
QFHGDEKPADCARHGRPWIKAIRVRADTDLLKCAADFAAASGLLLDAYVPGVPGGTGARFDWRLIPPRLPQRVILSGGLT
PDNVADAVRRVRPWAVDVSSGVEAAKGIKDAQKIARFISQAKAS

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0135

COG function: function code E; Phosphoribosylanthranilate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpF family

Homologues:

Organism=Escherichia coli, GI87081863, Length=201, Percent_Identity=32.8358208955224, Blast_Score=87, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320210, Length=219, Percent_Identity=32.8767123287671, Blast_Score=85, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPF_THIDA (Q3SHL8)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_315673.1
- ProteinModelPortal:   Q3SHL8
- SMR:   Q3SHL8
- STRING:   Q3SHL8
- GeneID:   3674025
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_1915
- NMPDR:   fig|292415.3.peg.2012
- eggNOG:   COG0135
- HOGENOM:   HBG554803
- OMA:   SKICGIT
- PhylomeDB:   Q3SHL8
- BioCyc:   TDEN292415:TBD_1915-MONOMER
- HAMAP:   MF_00135_B
- InterPro:   IPR013785
- InterPro:   IPR001240
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00697 PRAI; SSF51366 RibP_bind_barrel

EC number: =5.3.1.24

Molecular weight: Translated: 21928; Mature: 21797

Theoretical pI: Translated: 8.66; Mature: 8.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVRVKICGITRVDDLHAACDAGADALGFVFYEKSPRHLTLDAAAALLREVPPFVQTVGL
CEEEEEECCCCCHHHHHHHHHCCCCCEEEEEEECCCCEEEHHHHHHHHHHCCHHHHHHHH
FVDANPAFVDSVLRAVPLDLLQFHGDEKPADCARHGRPWIKAIRVRADTDLLKCAADFAA
HEECCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHH
ASGLLLDAYVPGVPGGTGARFDWRLIPPRLPQRVILSGGLTPDNVADAVRRVRPWAVDVS
HCCEEEEEECCCCCCCCCCEEEEEECCCCCCCHHHHCCCCCCHHHHHHHHHHCCCEEEHH
SGVEAAKGIKDAQKIARFISQAKAS
HCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AVRVKICGITRVDDLHAACDAGADALGFVFYEKSPRHLTLDAAAALLREVPPFVQTVGL
EEEEEECCCCCHHHHHHHHHCCCCCEEEEEEECCCCEEEHHHHHHHHHHCCHHHHHHHH
FVDANPAFVDSVLRAVPLDLLQFHGDEKPADCARHGRPWIKAIRVRADTDLLKCAADFAA
HEECCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHH
ASGLLLDAYVPGVPGGTGARFDWRLIPPRLPQRVILSGGLTPDNVADAVRRVRPWAVDVS
HCCEEEEEECCCCCCCCCCEEEEEECCCCCCCHHHHCCCCCCHHHHHHHHHHCCCEEEHH
SGVEAAKGIKDAQKIARFISQAKAS
HCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA