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The map label for this gene is ushA [H]

Identifier: 74317639

GI number: 74317639

Start: 1705626

End: 1707359

Strand: Reverse

Name: ushA [H]

Synonym: Tbd_1621

Alternate gene names: 74317639

Gene position: 1707359-1705626 (Counterclockwise)

Preceding gene: 74317640

Following gene: 74317638

Centisome position: 58.68

GC content: 61.94

Gene sequence:

>1734_bases
GTGAAATTCAGGTCTACACGGCTGGCGGTGGCGGTATGTGCGGCGCTATCGCCTTTTTCACTGGCGCACGCAGGAAGCGG
CACTGGCGAGGTCACTCTCATCCACATGGGGGATCTCCATGGCCATCTGATCCCGCATCCGAATGTGCGCAGCGACGGCA
ACGGCCAGAGCGAGGGCGGCGTGGCGCGCATCGCTACGTTGATCAAGGACATCCGCCGGGCCAAACCGGAGCAGACGCTG
CTGGTGAATACCGGCGACACGCTGCACGGCGGCGCCGAGGCGCTGTTCACCCAGGGCGAGGCGATGATCAATGTCCTGAA
CCTGTTCGGCATCGATGCCTATGCGCCGGGCAACTGGGACTTCGTCTATGGCGCGGACAAGTTCATCGAGTATTTCGTCG
GTCGTCCGGCCATGGCCAACTGGAACCCGGTCATTTCGAATCTCTACTACGACAACTACCCCGGCGCCGAAGCGCGGAAC
GGACAGCACGTGGCGGCGCCCTACACGATCAAGACCGTCAACGGTCTGCGCATCGGGATTCTGGGATTCACCTCCGACCG
CGGACCCCAAGCGGGCGACCCCAACATCACGAAGGGTTTGAAGTTCACCAATGGTGCAGCGGAGTATGAAAAATACGTCA
AGCTGCTGCGCGAGCAGGACGTCGATCTGGTCGTGGTCATTTCCGAGCTGGGCCTGCACGGCAATTTGACCCTGGCCGAC
CGGATTCCGGGCGTCGACGTCATTCTGTCGTCCGACAAGCACGAGATCACGGTCAAACCCGTCGTGTCGAAACACGGCAC
GCTGCTGGTCGAGCAGGGCATGGACGGCCAGGTCGTGGGCGAATTGAGCATCCGTGTGAAAGAGGGTCGGGTCATCGACA
AGCAATACGTCTCTCATCGCATCACGGACCGGTTCCAGCCCGACCCCGCGATCGCCGCGGCCGTGCAGTCGGTGCGTCGG
CCCTACGTGACCGGACCGCAGTTCCAAGCTGGAAAGATCAAGAATCCGTTCAACGGCTCGTTCCTTCGTTATCCGATCGA
TACGGTGATCGGCCAGACCAAGGTCCCCCTGTATCGCAGCAATTTCAGCGATGAGGCGATGCCGGCCGTGACCGAAGGCA
GCTCCCACGATTTCCTGACCGACGCGTTTCGCGTGATGACGGGCGCGCAGCTCGGCGGCATCACCGGTTTCCGTTATGGC
ACCACGGTGGGAGCCGGACCGATCAAGCTTGAAGACCTCTATCACTTCATGCCGGTCGGACCGCAGATCGCCAAGGGTGA
ACTGACCGGCGCGCAGATCAAGAAGACCCTGGAGGGCGCGCCGCAGGAAGAGGCAGGGCGTACGAACACCTGGGTCAACG
GCTGGACTGCGGGCTACAGCGGGCTGACCGCGGACTTCGATCCGAAGGCGCCCCAGGGGAATCGCGTCTCAAACATCCGC
GTCAACGGCCAGCCGCTGGAGCCGCAGGCCCGCTACACGGTCGCCGGCTACTATTACGATCTGGTGCCGAATCTGATCAA
CCGCGTCCCGGCCAAAAACATCACCGTGCTGAAGGACGAGGATGGCAGCACACTCGATGGCACCGATGTGGTGAAGCGCT
ATATCGAATCCTTGCCAGGCAAAACGGTCACCCCTGAAAACCTGCCGCTGAATCGTATCCGGCTCGTCAATCCGCTGCCG
GCAGCAGAGCATGGCCTGCGCGAAATGCAACCCTTGGGGTCGGTGACGAAGTAG

Upstream 100 bases:

>100_bases
ACGCTATCGATGAATCATGCCGGATCCACAATCCGGCTGTGCGGGGCAGGGTCCCGATGCCCACCCTGACGGGCATCCCA
TTCAGTTCGAAAGGAATTTT

Downstream 100 bases:

>100_bases
GCGTCATCCCCCGTCAGGGGCGGCCCCGGGCCGCCCTTGCGCAGGTCCTGTTTGCGCCTCCGCATCGTGCCATCCGGCTG
ATTTGGAGAAGAGCGACATG

Product: 5'-nucleotidase/2' 3'-cyclic phosphodiesterase

Products: NA

Alternate protein names: UDP-sugar hydrolase; UDP-sugar diphosphatase; UDP-sugar pyrophosphatase; 5'-nucleotidase; 5'-NT [H]

Number of amino acids: Translated: 577; Mature: 577

Protein sequence:

>577_residues
MKFRSTRLAVAVCAALSPFSLAHAGSGTGEVTLIHMGDLHGHLIPHPNVRSDGNGQSEGGVARIATLIKDIRRAKPEQTL
LVNTGDTLHGGAEALFTQGEAMINVLNLFGIDAYAPGNWDFVYGADKFIEYFVGRPAMANWNPVISNLYYDNYPGAEARN
GQHVAAPYTIKTVNGLRIGILGFTSDRGPQAGDPNITKGLKFTNGAAEYEKYVKLLREQDVDLVVVISELGLHGNLTLAD
RIPGVDVILSSDKHEITVKPVVSKHGTLLVEQGMDGQVVGELSIRVKEGRVIDKQYVSHRITDRFQPDPAIAAAVQSVRR
PYVTGPQFQAGKIKNPFNGSFLRYPIDTVIGQTKVPLYRSNFSDEAMPAVTEGSSHDFLTDAFRVMTGAQLGGITGFRYG
TTVGAGPIKLEDLYHFMPVGPQIAKGELTGAQIKKTLEGAPQEEAGRTNTWVNGWTAGYSGLTADFDPKAPQGNRVSNIR
VNGQPLEPQARYTVAGYYYDLVPNLINRVPAKNITVLKDEDGSTLDGTDVVKRYIESLPGKTVTPENLPLNRIRLVNPLP
AAEHGLREMQPLGSVTK

Sequences:

>Translated_577_residues
MKFRSTRLAVAVCAALSPFSLAHAGSGTGEVTLIHMGDLHGHLIPHPNVRSDGNGQSEGGVARIATLIKDIRRAKPEQTL
LVNTGDTLHGGAEALFTQGEAMINVLNLFGIDAYAPGNWDFVYGADKFIEYFVGRPAMANWNPVISNLYYDNYPGAEARN
GQHVAAPYTIKTVNGLRIGILGFTSDRGPQAGDPNITKGLKFTNGAAEYEKYVKLLREQDVDLVVVISELGLHGNLTLAD
RIPGVDVILSSDKHEITVKPVVSKHGTLLVEQGMDGQVVGELSIRVKEGRVIDKQYVSHRITDRFQPDPAIAAAVQSVRR
PYVTGPQFQAGKIKNPFNGSFLRYPIDTVIGQTKVPLYRSNFSDEAMPAVTEGSSHDFLTDAFRVMTGAQLGGITGFRYG
TTVGAGPIKLEDLYHFMPVGPQIAKGELTGAQIKKTLEGAPQEEAGRTNTWVNGWTAGYSGLTADFDPKAPQGNRVSNIR
VNGQPLEPQARYTVAGYYYDLVPNLINRVPAKNITVLKDEDGSTLDGTDVVKRYIESLPGKTVTPENLPLNRIRLVNPLP
AAEHGLREMQPLGSVTK
>Mature_577_residues
MKFRSTRLAVAVCAALSPFSLAHAGSGTGEVTLIHMGDLHGHLIPHPNVRSDGNGQSEGGVARIATLIKDIRRAKPEQTL
LVNTGDTLHGGAEALFTQGEAMINVLNLFGIDAYAPGNWDFVYGADKFIEYFVGRPAMANWNPVISNLYYDNYPGAEARN
GQHVAAPYTIKTVNGLRIGILGFTSDRGPQAGDPNITKGLKFTNGAAEYEKYVKLLREQDVDLVVVISELGLHGNLTLAD
RIPGVDVILSSDKHEITVKPVVSKHGTLLVEQGMDGQVVGELSIRVKEGRVIDKQYVSHRITDRFQPDPAIAAAVQSVRR
PYVTGPQFQAGKIKNPFNGSFLRYPIDTVIGQTKVPLYRSNFSDEAMPAVTEGSSHDFLTDAFRVMTGAQLGGITGFRYG
TTVGAGPIKLEDLYHFMPVGPQIAKGELTGAQIKKTLEGAPQEEAGRTNTWVNGWTAGYSGLTADFDPKAPQGNRVSNIR
VNGQPLEPQARYTVAGYYYDLVPNLINRVPAKNITVLKDEDGSTLDGTDVVKRYIESLPGKTVTPENLPLNRIRLVNPLP
AAEHGLREMQPLGSVTK

Specific function: Degradation of external UDP-glucose to uridine monophosphate and glucose-1-phosphate, which can then be used by the cell [H]

COG id: COG0737

COG function: function code F; 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 5'-nucleotidase family [H]

Homologues:

Organism=Homo sapiens, GI4505467, Length=236, Percent_Identity=25.8474576271186, Blast_Score=71, Evalue=3e-12,
Organism=Escherichia coli, GI1786687, Length=541, Percent_Identity=20.3327171903882, Blast_Score=73, Evalue=4e-14,
Organism=Drosophila melanogaster, GI19921980, Length=505, Percent_Identity=22.5742574257426, Blast_Score=87, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24652512, Length=505, Percent_Identity=22.5742574257426, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI161076508, Length=509, Percent_Identity=22.7897838899804, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI28573524, Length=492, Percent_Identity=20.7317073170732, Blast_Score=72, Evalue=7e-13,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 20 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008334
- InterPro:   IPR006146
- InterPro:   IPR006179
- InterPro:   IPR004843 [H]

Pfam domain/function: PF02872 5_nucleotid_C; PF00149 Metallophos [H]

EC number: =3.6.1.45; =3.1.3.5 [H]

Molecular weight: Translated: 62532; Mature: 62532

Theoretical pI: Translated: 7.52; Mature: 7.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFRSTRLAVAVCAALSPFSLAHAGSGTGEVTLIHMGDLHGHLIPHPNVRSDGNGQSEGG
CCCCHHHHHHHHHHHCCCCHHHCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCH
VARIATLIKDIRRAKPEQTLLVNTGDTLHGGAEALFTQGEAMINVLNLFGIDAYAPGNWD
HHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHCCHHHHHHHHHHCCCCCCCCCCE
FVYGADKFIEYFVGRPAMANWNPVISNLYYDNYPGAEARNGQHVAAPYTIKTVNGLRIGI
EEECHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCCCCCCCEEECCEEEEEECCEEEEE
LGFTSDRGPQAGDPNITKGLKFTNGAAEYEKYVKLLREQDVDLVVVISELGLHGNLTLAD
EEECCCCCCCCCCCCHHCCCEECCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEECC
RIPGVDVILSSDKHEITVKPVVSKHGTLLVEQGMDGQVVGELSIRVKEGRVIDKQYVSHR
CCCCEEEEEECCCCEEEEEEECCCCCEEEEECCCCCEEEEEEEEEEECCCCHHHHHHHHH
ITDRFQPDPAIAAAVQSVRRPYVTGPQFQAGKIKNPFNGSFLRYPIDTVIGQTKVPLYRS
HHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECHHHHCCCCCCCEEEC
NFSDEAMPAVTEGSSHDFLTDAFRVMTGAQLGGITGFRYGTTVGAGPIKLEDLYHFMPVG
CCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHCCCCCCCCCCCCCCCCEEHHHHHHHCCCC
PQIAKGELTGAQIKKTLEGAPQEEAGRTNTWVNGWTAGYSGLTADFDPKAPQGNRVSNIR
CCCCCCCCCHHHHHHHHCCCCCHHCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCEEEEE
VNGQPLEPQARYTVAGYYYDLVPNLINRVPAKNITVLKDEDGSTLDGTDVVKRYIESLPG
ECCCCCCCCCCEEEEHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCC
KTVTPENLPLNRIRLVNPLPAAEHGLREMQPLGSVTK
CCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKFRSTRLAVAVCAALSPFSLAHAGSGTGEVTLIHMGDLHGHLIPHPNVRSDGNGQSEGG
CCCCHHHHHHHHHHHCCCCHHHCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCH
VARIATLIKDIRRAKPEQTLLVNTGDTLHGGAEALFTQGEAMINVLNLFGIDAYAPGNWD
HHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHCCHHHHHHHHHHCCCCCCCCCCE
FVYGADKFIEYFVGRPAMANWNPVISNLYYDNYPGAEARNGQHVAAPYTIKTVNGLRIGI
EEECHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCCCCCCCEEECCEEEEEECCEEEEE
LGFTSDRGPQAGDPNITKGLKFTNGAAEYEKYVKLLREQDVDLVVVISELGLHGNLTLAD
EEECCCCCCCCCCCCHHCCCEECCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEECC
RIPGVDVILSSDKHEITVKPVVSKHGTLLVEQGMDGQVVGELSIRVKEGRVIDKQYVSHR
CCCCEEEEEECCCCEEEEEEECCCCCEEEEECCCCCEEEEEEEEEEECCCCHHHHHHHHH
ITDRFQPDPAIAAAVQSVRRPYVTGPQFQAGKIKNPFNGSFLRYPIDTVIGQTKVPLYRS
HHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECHHHHCCCCCCCEEEC
NFSDEAMPAVTEGSSHDFLTDAFRVMTGAQLGGITGFRYGTTVGAGPIKLEDLYHFMPVG
CCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHCCCCCCCCCCCCCCCCEEHHHHHHHCCCC
PQIAKGELTGAQIKKTLEGAPQEEAGRTNTWVNGWTAGYSGLTADFDPKAPQGNRVSNIR
CCCCCCCCCHHHHHHHHCCCCCHHCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCEEEEE
VNGQPLEPQARYTVAGYYYDLVPNLINRVPAKNITVLKDEDGSTLDGTDVVKRYIESLPG
ECCCCCCCCCCEEEEHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCC
KTVTPENLPLNRIRLVNPLPAAEHGLREMQPLGSVTK
CCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA