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The map label for this gene is nhaA [H]

Identifier: 74317578

GI number: 74317578

Start: 1642916

End: 1643857

Strand: Reverse

Name: nhaA [H]

Synonym: Tbd_1560

Alternate gene names: 74317578

Gene position: 1643857-1642916 (Counterclockwise)

Preceding gene: 74317579

Following gene: 74317577

Centisome position: 56.49

GC content: 65.82

Gene sequence:

>942_bases
ATGAGCGAACCTCAACCCAACTGGGAACGCGACGTCCTGCAAAAGCTCGCACTGGCCGCGGTGCAGGAGCAACGCCGCAG
CCGCCACTGGAGCATCCTCTTCAAGTCGCTCGGCTTTCTGTATCTGTTCATCGTGCTGTTCCTCGTGGCCGGCTGGTTCG
GCGACGACGGCGTCGGCATCCCCAAGGCACACACGGCGTTGGTCGACCTGCAGGGCGTGATCGCGTCCGACCAGGCGAGC
GCCGACGCCGTGATCACGAGCCTGCAGAGCGCCTTCGAGGACAAGAAGACCAAGGGCGTGGTGCTGCGGATCAACAGCCC
AGGCGGCAGCCCCGTGCAGGCCGGCCAGATCTACGACGAGATCCGGCGCCTGCGCAAGCTCCACCCGCAGGTGCCGCTTT
ATGCGGTGGTCGACGACATCTGCGCGTCCGGCGGCTACTACGTCGCAGTCGGCGCCGACAAGATCTTCGTCGACAAGGCG
AGCATCGTCGGCTCGATCGGCGTGTTGATGGATGGCTTCGGCTTCACCGAGACGATGCAGAAACTCGGCGTCGAGCGCCG
CCTGCTGACCGCTGGTGAAAACAAGGGCTTCCTCGATCCGTTCTCGCCCGTCAACCCCGAGCAGCAGGCCTACGCCAAGC
AGATGCTGGAGGAGATCCACGGCCAGTTCATCGCCACCGTACGCGAGGGCCGCGGCAAGCGCCTGAAGGAGACGCCCGAC
ATGTTCACCGGTCTGGTCTGGAGCGGCGAGCGCAGCATCCAGCTGGGGCTCGCTGACGAAATCGGCAGCCTCGATACGGT
CGCACGCGACGTCATCAAGGCCGAGGACATCGTCGACTTCACGAAGGAGGAGAGCCTCGCCGAGCGCCTCGCGGGCCGCC
TCGGCGCGACGATGGCCAAAGCGATGGGGTTGACGGATCGCGCGGGCGTGCAGTTGCGGTGA

Upstream 100 bases:

>100_bases
CGCGCGACGGCCGCTGTGTCGGCGGGCGCTGCGCCGGCCGAGGCCTGATCCCCCTATCCGTCGTTGAACGCGACGGCAAT
GTTTACCTGATGGAAGAAGA

Downstream 100 bases:

>100_bases
GCGAGACGCCTTACGCGCCCATTCCCTGCGCGCAACACGAGCGTCTCGAGTTCGCCGCGCTCACCGGGCAATGGCTCGAG
GTCAAGATCGATGGGCAAAA

Product: protease

Products: NA

Alternate protein names: Sodium/proton antiporter nhaA [H]

Number of amino acids: Translated: 313; Mature: 312

Protein sequence:

>313_residues
MSEPQPNWERDVLQKLALAAVQEQRRSRHWSILFKSLGFLYLFIVLFLVAGWFGDDGVGIPKAHTALVDLQGVIASDQAS
ADAVITSLQSAFEDKKTKGVVLRINSPGGSPVQAGQIYDEIRRLRKLHPQVPLYAVVDDICASGGYYVAVGADKIFVDKA
SIVGSIGVLMDGFGFTETMQKLGVERRLLTAGENKGFLDPFSPVNPEQQAYAKQMLEEIHGQFIATVREGRGKRLKETPD
MFTGLVWSGERSIQLGLADEIGSLDTVARDVIKAEDIVDFTKEESLAERLAGRLGATMAKAMGLTDRAGVQLR

Sequences:

>Translated_313_residues
MSEPQPNWERDVLQKLALAAVQEQRRSRHWSILFKSLGFLYLFIVLFLVAGWFGDDGVGIPKAHTALVDLQGVIASDQAS
ADAVITSLQSAFEDKKTKGVVLRINSPGGSPVQAGQIYDEIRRLRKLHPQVPLYAVVDDICASGGYYVAVGADKIFVDKA
SIVGSIGVLMDGFGFTETMQKLGVERRLLTAGENKGFLDPFSPVNPEQQAYAKQMLEEIHGQFIATVREGRGKRLKETPD
MFTGLVWSGERSIQLGLADEIGSLDTVARDVIKAEDIVDFTKEESLAERLAGRLGATMAKAMGLTDRAGVQLR
>Mature_312_residues
SEPQPNWERDVLQKLALAAVQEQRRSRHWSILFKSLGFLYLFIVLFLVAGWFGDDGVGIPKAHTALVDLQGVIASDQASA
DAVITSLQSAFEDKKTKGVVLRINSPGGSPVQAGQIYDEIRRLRKLHPQVPLYAVVDDICASGGYYVAVGADKIFVDKAS
IVGSIGVLMDGFGFTETMQKLGVERRLLTAGENKGFLDPFSPVNPEQQAYAKQMLEEIHGQFIATVREGRGKRLKETPDM
FTGLVWSGERSIQLGLADEIGSLDTVARDVIKAEDIVDFTKEESLAERLAGRLGATMAKAMGLTDRAGVQLR

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1787527, Length=237, Percent_Identity=31.2236286919831, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788064, Length=216, Percent_Identity=27.7777777777778, Blast_Score=73, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670
- InterPro:   IPR002142 [H]

Pfam domain/function: PF06965 Na_H_antiport_1; PF01343 Peptidase_S49 [H]

EC number: 3.4.21.-

Molecular weight: Translated: 34210; Mature: 34078

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEPQPNWERDVLQKLALAAVQEQRRSRHWSILFKSLGFLYLFIVLFLVAGWFGDDGVGI
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PKAHTALVDLQGVIASDQASADAVITSLQSAFEDKKTKGVVLRINSPGGSPVQAGQIYDE
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHH
IRRLRKLHPQVPLYAVVDDICASGGYYVAVGADKIFVDKASIVGSIGVLMDGFGFTETMQ
HHHHHHHCCCCCHHHHHHHHHCCCCEEEEECCCEEEEEHHHHHHHHHHHHCCCCHHHHHH
KLGVERRLLTAGENKGFLDPFSPVNPEQQAYAKQMLEEIHGQFIATVREGRGKRLKETPD
HHCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
MFTGLVWSGERSIQLGLADEIGSLDTVARDVIKAEDIVDFTKEESLAERLAGRLGATMAK
HHHHHEECCCCEEEEECHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMGLTDRAGVQLR
HHCCCCCCCCCCC
>Mature Secondary Structure 
SEPQPNWERDVLQKLALAAVQEQRRSRHWSILFKSLGFLYLFIVLFLVAGWFGDDGVGI
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PKAHTALVDLQGVIASDQASADAVITSLQSAFEDKKTKGVVLRINSPGGSPVQAGQIYDE
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHH
IRRLRKLHPQVPLYAVVDDICASGGYYVAVGADKIFVDKASIVGSIGVLMDGFGFTETMQ
HHHHHHHCCCCCHHHHHHHHHCCCCEEEEECCCEEEEEHHHHHHHHHHHHCCCCHHHHHH
KLGVERRLLTAGENKGFLDPFSPVNPEQQAYAKQMLEEIHGQFIATVREGRGKRLKETPD
HHCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
MFTGLVWSGERSIQLGLADEIGSLDTVARDVIKAEDIVDFTKEESLAERLAGRLGATMAK
HHHHHEECCCCEEEEECHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMGLTDRAGVQLR
HHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA