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The map label for this gene is mutL

Identifier: 74317535

GI number: 74317535

Start: 1604264

End: 1606060

Strand: Reverse

Name: mutL

Synonym: Tbd_1517

Alternate gene names: 74317535

Gene position: 1606060-1604264 (Counterclockwise)

Preceding gene: 74317536

Following gene: 74317534

Centisome position: 55.19

GC content: 69.62

Gene sequence:

>1797_bases
GTGAGCATTCAGGTTCTGTCGGATGTGCTGATTTCCCAGATCGCGGCGGGCGAGGTCGTCGAGCGTCCGGCCGCGGCGCT
CAAGGAAATCCTCGAGAACAGCCTCGACGCCGGTGCGACCGCGATCGACGTCGAACTCGAGCAGGGCGGCGTCAAGCGCA
TCCGGGTCAGCGACGACGGCGTCGGCATCCCGCGCGACGAACTGGCATTGGCCCTGACGCGGCACGCGACGAGCAAGATC
GCGACGCTGGCGGACCTCGAGCAGGTCGCCAGCCTCGGCTTTCGCGGCGAGGCGCTGGCGTCGATCGCGTCGGTCGCGCG
CGTTCGCCTGACCAGCCGTCACGCCGGGAGCGACCACGCCTGGACGATCCACGTCGACGGCGGACCGTTGCAGCCTTCGT
CACCCGCAGCGCGCAGCGGCGGGACGACGATCGACATCGAGGATATGTTCTTCAACACGCCGGCGCGGCGCAAATTCCTC
AAGACAGAAGCGACCGAGTATGCCCACTGCGCCGAAACCGTGAGGCGCCTCGCACTGGCCTGGCCGCAGGTCGCGTTCAC
GCTCGTGCACAACGGGCGCGCGCAACTGCGTCTGAAGGCCGAAGCCGCCGCCGCCCGCGTGCGTCACGTGCTCGGCGAGG
TGTTCGAGCAGCACGCCATCGCCGTCGACGCCGCTGCCGGCGCGCTGCGCCTGAGCGGGTGGGTCGTCCGCCCGGTCGCG
GCGACGGCGAGCCGCGACGCCCAGCACGTCTTCGTCAACGGACGTTACGTCCGCGACAAGCTGATCGTGCACGCGCTGCG
CGAAGCCTATCGCGACGTGCTCCACCATCAGCTCAACCCGGCATATTGCCTGTTCGTCGAGTTGCCGCCAGAGCACGTCG
ACGTCAATGTGCACCCCGCCAAAACCGAGATCCGTTTCCGCGACAGCCGCGGCGTGCACCAGTTTCTCTATCATGCCGTC
GAGCGCCTGCTCGCGGCGCCGGTAGCCCCAGCGGCACCGCCATCCGGGCCTGACGCGCGGCCCCCTACCTTCCTGCAGCC
GCGGCAGGCTGCGATGTCGCTGCAGGTCGAGGAGGCGATGGCGTTTTATGCGCCCTTCGCCGCGATGGCGCCGGGCGAGG
GGGACGAAGCCCGGCACGTACCTCAGGCATCTGCGGCAGGGCTGGCAGGCCGCGCCGGCCCCCCGCGCGCTTTCGCGAGC
GACTCCTCCGCGGTGCCGCCGCTCGGCTACGCGCTCGGCCAATTGCATGGCGTCTACGTGCTCGCCCAGAACGCGCACGG
CCTCGTGCTCGTCGACATGCACGCGGCGCACGAACGCGTCGTTTACGAAAAACTCAAGACCGCGCTCGACCGCCGCGCGG
TGCCGGCGCAGGCCCTGCTGATCCCGGTCGCGCTCACGGCTGACCCGCGCGAGGTCGCGGAAATCGCCCCGCATCTCGAC
CAACTCCGCGAGATCGGCTTCGAGCTGTCGATCACTTCGCCCAATTCGGTCGCGGTGCGCGCGGTGCCGTCGCTGCTCAA
GAACGCCGATCCCGTCGAGCTGACGCGAGCGATTCTCGCCGAAATCGCCGAGTTCGGCGTCGCCCGGCTCCTCGCCGAGC
GCCGCAACGAGCTGTTGGCGACGCTGGCGTGCCACGGCGCCGTGCGCGCCCACCGCACGCTCAGCGTGCCGGAAATGAAC
GCGCTGCTGCGTGAAATGGAAGCGACCGAGCGTGCCGGGCAGTGCAATCACGGGCGGCCGACCTGGTTCCAGCTCAGGCT
CGACGAACTCGACGCGATGTTCATGCGCGGACGCTGA

Upstream 100 bases:

>100_bases
GTGTGCTGCCGCTCGCTCGTGCCCATCTCGGGGCCGATGCGCTCGAGCGGCTCGGGCGTGCGATGGCCGCGCGCCGCGGC
ATCCCCTTCGAAGCCAGGTC

Downstream 100 bases:

>100_bases
GCGGCCGAGCGTTTTGCTATAATCCCGACCATATTAGTCGGGTATTAAACAAGGATTCCTCATGAGCGAGCCGAGCGAGC
GCAAAACCATCCCGATTCAG

Product: DNA mismatch repair protein MutL

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 598; Mature: 597

Protein sequence:

>598_residues
MSIQVLSDVLISQIAAGEVVERPAAALKEILENSLDAGATAIDVELEQGGVKRIRVSDDGVGIPRDELALALTRHATSKI
ATLADLEQVASLGFRGEALASIASVARVRLTSRHAGSDHAWTIHVDGGPLQPSSPAARSGGTTIDIEDMFFNTPARRKFL
KTEATEYAHCAETVRRLALAWPQVAFTLVHNGRAQLRLKAEAAAARVRHVLGEVFEQHAIAVDAAAGALRLSGWVVRPVA
ATASRDAQHVFVNGRYVRDKLIVHALREAYRDVLHHQLNPAYCLFVELPPEHVDVNVHPAKTEIRFRDSRGVHQFLYHAV
ERLLAAPVAPAAPPSGPDARPPTFLQPRQAAMSLQVEEAMAFYAPFAAMAPGEGDEARHVPQASAAGLAGRAGPPRAFAS
DSSAVPPLGYALGQLHGVYVLAQNAHGLVLVDMHAAHERVVYEKLKTALDRRAVPAQALLIPVALTADPREVAEIAPHLD
QLREIGFELSITSPNSVAVRAVPSLLKNADPVELTRAILAEIAEFGVARLLAERRNELLATLACHGAVRAHRTLSVPEMN
ALLREMEATERAGQCNHGRPTWFQLRLDELDAMFMRGR

Sequences:

>Translated_598_residues
MSIQVLSDVLISQIAAGEVVERPAAALKEILENSLDAGATAIDVELEQGGVKRIRVSDDGVGIPRDELALALTRHATSKI
ATLADLEQVASLGFRGEALASIASVARVRLTSRHAGSDHAWTIHVDGGPLQPSSPAARSGGTTIDIEDMFFNTPARRKFL
KTEATEYAHCAETVRRLALAWPQVAFTLVHNGRAQLRLKAEAAAARVRHVLGEVFEQHAIAVDAAAGALRLSGWVVRPVA
ATASRDAQHVFVNGRYVRDKLIVHALREAYRDVLHHQLNPAYCLFVELPPEHVDVNVHPAKTEIRFRDSRGVHQFLYHAV
ERLLAAPVAPAAPPSGPDARPPTFLQPRQAAMSLQVEEAMAFYAPFAAMAPGEGDEARHVPQASAAGLAGRAGPPRAFAS
DSSAVPPLGYALGQLHGVYVLAQNAHGLVLVDMHAAHERVVYEKLKTALDRRAVPAQALLIPVALTADPREVAEIAPHLD
QLREIGFELSITSPNSVAVRAVPSLLKNADPVELTRAILAEIAEFGVARLLAERRNELLATLACHGAVRAHRTLSVPEMN
ALLREMEATERAGQCNHGRPTWFQLRLDELDAMFMRGR
>Mature_597_residues
SIQVLSDVLISQIAAGEVVERPAAALKEILENSLDAGATAIDVELEQGGVKRIRVSDDGVGIPRDELALALTRHATSKIA
TLADLEQVASLGFRGEALASIASVARVRLTSRHAGSDHAWTIHVDGGPLQPSSPAARSGGTTIDIEDMFFNTPARRKFLK
TEATEYAHCAETVRRLALAWPQVAFTLVHNGRAQLRLKAEAAAARVRHVLGEVFEQHAIAVDAAAGALRLSGWVVRPVAA
TASRDAQHVFVNGRYVRDKLIVHALREAYRDVLHHQLNPAYCLFVELPPEHVDVNVHPAKTEIRFRDSRGVHQFLYHAVE
RLLAAPVAPAAPPSGPDARPPTFLQPRQAAMSLQVEEAMAFYAPFAAMAPGEGDEARHVPQASAAGLAGRAGPPRAFASD
SSAVPPLGYALGQLHGVYVLAQNAHGLVLVDMHAAHERVVYEKLKTALDRRAVPAQALLIPVALTADPREVAEIAPHLDQ
LREIGFELSITSPNSVAVRAVPSLLKNADPVELTRAILAEIAEFGVARLLAERRNELLATLACHGAVRAHRTLSVPEMNA
LLREMEATERAGQCNHGRPTWFQLRLDELDAMFMRGR

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family

Homologues:

Organism=Homo sapiens, GI4557757, Length=310, Percent_Identity=34.1935483870968, Blast_Score=190, Evalue=4e-48,
Organism=Homo sapiens, GI4505913, Length=328, Percent_Identity=28.3536585365854, Blast_Score=138, Evalue=2e-32,
Organism=Homo sapiens, GI310128478, Length=328, Percent_Identity=28.3536585365854, Blast_Score=138, Evalue=2e-32,
Organism=Homo sapiens, GI4505911, Length=342, Percent_Identity=28.0701754385965, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI189458898, Length=342, Percent_Identity=28.0701754385965, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI189458896, Length=333, Percent_Identity=26.4264264264264, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI310128480, Length=293, Percent_Identity=25.2559726962457, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI263191589, Length=216, Percent_Identity=30.0925925925926, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI91992162, Length=351, Percent_Identity=26.2108262108262, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI91992160, Length=351, Percent_Identity=26.2108262108262, Blast_Score=95, Evalue=2e-19,
Organism=Escherichia coli, GI1790612, Length=540, Percent_Identity=40.5555555555556, Blast_Score=331, Evalue=9e-92,
Organism=Caenorhabditis elegans, GI71991825, Length=321, Percent_Identity=34.8909657320872, Blast_Score=189, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI17562796, Length=344, Percent_Identity=25.2906976744186, Blast_Score=133, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6323819, Length=324, Percent_Identity=33.641975308642, Blast_Score=184, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6324247, Length=345, Percent_Identity=27.8260869565217, Blast_Score=128, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6325093, Length=264, Percent_Identity=25, Blast_Score=100, Evalue=9e-22,
Organism=Saccharomyces cerevisiae, GI6323063, Length=365, Percent_Identity=23.5616438356164, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17136968, Length=330, Percent_Identity=35.4545454545455, Blast_Score=201, Evalue=1e-51,
Organism=Drosophila melanogaster, GI17136970, Length=356, Percent_Identity=27.247191011236, Blast_Score=120, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTL_THIDA (Q3SIQ5)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_315275.1
- ProteinModelPortal:   Q3SIQ5
- STRING:   Q3SIQ5
- GeneID:   3671996
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_1517
- NMPDR:   fig|292415.3.peg.1517
- eggNOG:   COG0323
- HOGENOM:   HBG520262
- OMA:   ITHPEIN
- PhylomeDB:   Q3SIQ5
- BioCyc:   TDEN292415:TBD_1517-MONOMER
- HAMAP:   MF_00149
- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR10073
- SMART:   SM00387
- SMART:   SM00853
- TIGRFAMs:   TIGR00585

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 64621; Mature: 64489

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIQVLSDVLISQIAAGEVVERPAAALKEILENSLDAGATAIDVELEQGGVKRIRVSDDG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCEEEEECCCC
VGIPRDELALALTRHATSKIATLADLEQVASLGFRGEALASIASVARVRLTSRHAGSDHA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCE
WTIHVDGGPLQPSSPAARSGGTTIDIEDMFFNTPARRKFLKTEATEYAHCAETVRRLALA
EEEEECCCCCCCCCCCCCCCCCEEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
WPQVAFTLVHNGRAQLRLKAEAAAARVRHVLGEVFEQHAIAVDAAAGALRLSGWVVRPVA
HHHHHEEEEECCCEEEEEEHHHHHHHHHHHHHHHHHHHHEEEECCCCHHEECCEEEECHH
ATASRDAQHVFVNGRYVRDKLIVHALREAYRDVLHHQLNPAYCLFVELPPEHVDVNVHPA
HHCCCCCCEEEECCEEHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEEECC
KTEIRFRDSRGVHQFLYHAVERLLAAPVAPAAPPSGPDARPPTFLQPRQAAMSLQVEEAM
CEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
AFYAPFAAMAPGEGDEARHVPQASAAGLAGRAGPPRAFASDSSAVPPLGYALGQLHGVYV
HHHHCHHHCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCEEEE
LAQNAHGLVLVDMHAAHERVVYEKLKTALDRRAVPAQALLIPVALTADPREVAEIAPHLD
EEECCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCHHHEEEEEEECCCHHHHHHHHHHHH
QLREIGFELSITSPNSVAVRAVPSLLKNADPVELTRAILAEIAEFGVARLLAERRNELLA
HHHHCCEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLACHGAVRAHRTLSVPEMNALLREMEATERAGQCNHGRPTWFQLRLDELDAMFMRGR
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHCCC
>Mature Secondary Structure 
SIQVLSDVLISQIAAGEVVERPAAALKEILENSLDAGATAIDVELEQGGVKRIRVSDDG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCEEEEECCCC
VGIPRDELALALTRHATSKIATLADLEQVASLGFRGEALASIASVARVRLTSRHAGSDHA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCE
WTIHVDGGPLQPSSPAARSGGTTIDIEDMFFNTPARRKFLKTEATEYAHCAETVRRLALA
EEEEECCCCCCCCCCCCCCCCCEEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
WPQVAFTLVHNGRAQLRLKAEAAAARVRHVLGEVFEQHAIAVDAAAGALRLSGWVVRPVA
HHHHHEEEEECCCEEEEEEHHHHHHHHHHHHHHHHHHHHEEEECCCCHHEECCEEEECHH
ATASRDAQHVFVNGRYVRDKLIVHALREAYRDVLHHQLNPAYCLFVELPPEHVDVNVHPA
HHCCCCCCEEEECCEEHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEEECC
KTEIRFRDSRGVHQFLYHAVERLLAAPVAPAAPPSGPDARPPTFLQPRQAAMSLQVEEAM
CEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
AFYAPFAAMAPGEGDEARHVPQASAAGLAGRAGPPRAFASDSSAVPPLGYALGQLHGVYV
HHHHCHHHCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCEEEE
LAQNAHGLVLVDMHAAHERVVYEKLKTALDRRAVPAQALLIPVALTADPREVAEIAPHLD
EEECCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCHHHEEEEEEECCCHHHHHHHHHHHH
QLREIGFELSITSPNSVAVRAVPSLLKNADPVELTRAILAEIAEFGVARLLAERRNELLA
HHHHCCEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLACHGAVRAHRTLSVPEMNALLREMEATERAGQCNHGRPTWFQLRLDELDAMFMRGR
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA